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The map label for this gene is pyrD

Identifier: 15605646

GI number: 15605646

Start: 29251

End: 30171

Strand: Direct

Name: pyrD

Synonym: aq_046

Alternate gene names: 15605646

Gene position: 29251-30171 (Clockwise)

Preceding gene: 15605639

Following gene: 15605647

Centisome position: 1.89

GC content: 46.69

Gene sequence:

>921_bases
ATGGACCTGAGCGTGGAACTCTTCGGCATACGCTTTAAGAATCCCGTCTGGGTTGCAAGCGGGACCTTTGGCTACGGCGT
GGAAGCTGCGGAAATCTACGATATATCAAAACTCGGAGCAGTAGTCACAAAAGGTCTCTCACTCAAGGAAAGGCTCGGGA
ACGAAACCCCGAGAATTGTGGAAACCCCCTGTGGCATGCTCAACTCCATAGGTCTTCAAAATCCGGGAGTGGAAAAGTTC
CTAAAAGAGATTTACCCCAAGATAAAAGACGTGGACACTCACTTCATAGCTAACGTCTTCGGTGAAACGGAAGAGGAGTA
CGTGGAAGTTTGTATGGCTCTGGAAGATGCTGACAAGATTGTGGCTTACGAGCTGAATGTTTCCTGTCCCAACGTGAAGA
AGGGAGGAATCCTCTTCGGACACGACCCTGTAATCCTCGGAAATCTCGTTGACAGAATAAAGGCGAAAATAAAAAAACCC
CTCCTTGTAAAACTCTCTCCAAATGTGACCGACGTTACCGAGTTTGCGAAGGTATGTATAGAAAACGGAGCTGATGGACT
CGTTTTGATAAACACATTAATGGGAATGAAGATAAACATATGGAAGAGGAAACCAGACCTTGCCACCAAAACGGGAGGAC
TATCCGGACCTGCGATACTGCCCATAGCGGTGAGGATGATTTATCAGGTTTACGAGAAGTTCGGCGACAGAATTCCCATA
ATAGGAGTGGGAGGGATAACCACATGGGAAGACGCCATGGAACACGTAATGGCGGGGGCAAGTGCAGTTCAGGTGGGAAC
CGCAAACTTCTACGAGCCCTTAGCACCCTTAAAGGTCATAGAAGGGATTGAAAACTTTATGAAATCTCAGAATATCAAAG
ACTTCAAAGAATTAATCGGGATTGCCCACAGAGTAGAATAA

Upstream 100 bases:

>100_bases
AACCAAACTATATTTTACTACTCGGCGGTGAAAATTTTTATAAAAATTTCGTTATATATACATAAAGTTAATTAAAGGTT
AGGAAGTTAAAATAAACTTG

Downstream 100 bases:

>100_bases
AGACATTATGGTTAGGAAGCTGAGCGAAGAAGAAGTAAAGAGGGAACTTGAAAATCTGGAAGGCTGGGAATTCTGTAAAG
ATTACATACAGAAGGAGTTT

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MDLSVELFGIRFKNPVWVASGTFGYGVEAAEIYDISKLGAVVTKGLSLKERLGNETPRIVETPCGMLNSIGLQNPGVEKF
LKEIYPKIKDVDTHFIANVFGETEEEYVEVCMALEDADKIVAYELNVSCPNVKKGGILFGHDPVILGNLVDRIKAKIKKP
LLVKLSPNVTDVTEFAKVCIENGADGLVLINTLMGMKINIWKRKPDLATKTGGLSGPAILPIAVRMIYQVYEKFGDRIPI
IGVGGITTWEDAMEHVMAGASAVQVGTANFYEPLAPLKVIEGIENFMKSQNIKDFKELIGIAHRVE

Sequences:

>Translated_306_residues
MDLSVELFGIRFKNPVWVASGTFGYGVEAAEIYDISKLGAVVTKGLSLKERLGNETPRIVETPCGMLNSIGLQNPGVEKF
LKEIYPKIKDVDTHFIANVFGETEEEYVEVCMALEDADKIVAYELNVSCPNVKKGGILFGHDPVILGNLVDRIKAKIKKP
LLVKLSPNVTDVTEFAKVCIENGADGLVLINTLMGMKINIWKRKPDLATKTGGLSGPAILPIAVRMIYQVYEKFGDRIPI
IGVGGITTWEDAMEHVMAGASAVQVGTANFYEPLAPLKVIEGIENFMKSQNIKDFKELIGIAHRVE
>Mature_306_residues
MDLSVELFGIRFKNPVWVASGTFGYGVEAAEIYDISKLGAVVTKGLSLKERLGNETPRIVETPCGMLNSIGLQNPGVEKF
LKEIYPKIKDVDTHFIANVFGETEEEYVEVCMALEDADKIVAYELNVSCPNVKKGGILFGHDPVILGNLVDRIKAKIKKP
LLVKLSPNVTDVTEFAKVCIENGADGLVLINTLMGMKINIWKRKPDLATKTGGLSGPAILPIAVRMIYQVYEKFGDRIPI
IGVGGITTWEDAMEHVMAGASAVQVGTANFYEPLAPLKVIEGIENFMKSQNIKDFKELIGIAHRVE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=299, Percent_Identity=29.7658862876254, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI45006951, Length=326, Percent_Identity=30.0613496932515, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI87082059, Length=328, Percent_Identity=29.5731707317073, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1787177, Length=285, Percent_Identity=27.0175438596491, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71984108, Length=295, Percent_Identity=30.5084745762712, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17509475, Length=331, Percent_Identity=24.1691842900302, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322633, Length=275, Percent_Identity=31.2727272727273, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24640763, Length=290, Percent_Identity=31.7241379310345, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18858217, Length=290, Percent_Identity=31.7241379310345, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281361352, Length=293, Percent_Identity=30.3754266211604, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137316, Length=293, Percent_Identity=30.3754266211604, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_AQUAE (O66461)

Other databases:

- EMBL:   AE000657
- PIR:   B70304
- RefSeq:   NP_213021.1
- ProteinModelPortal:   O66461
- GeneID:   1192658
- GenomeReviews:   AE000657_GR
- KEGG:   aae:aq_046
- NMPDR:   fig|224324.1.peg.36
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- PhylomeDB:   O66461
- ProtClustDB:   PRK07259
- BioCyc:   AAEO224324:AQ_046-MONOMER
- BRENDA:   1.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 33524; Mature: 33524

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSVELFGIRFKNPVWVASGTFGYGVEAAEIYDISKLGAVVTKGLSLKERLGNETPRIV
CCCEEEEEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEE
ETPCGMLNSIGLQNPGVEKFLKEIYPKIKDVDTHFIANVFGETEEEYVEVCMALEDADKI
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCE
VAYELNVSCPNVKKGGILFGHDPVILGNLVDRIKAKIKKPLLVKLSPNVTDVTEFAKVCI
EEEEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
ENGADGLVLINTLMGMKINIWKRKPDLATKTGGLSGPAILPIAVRMIYQVYEKFGDRIPI
HCCCCCEEEEEHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
IGVGGITTWEDAMEHVMAGASAVQVGTANFYEPLAPLKVIEGIENFMKSQNIKDFKELIG
EECCCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IAHRVE
HHHCCC
>Mature Secondary Structure
MDLSVELFGIRFKNPVWVASGTFGYGVEAAEIYDISKLGAVVTKGLSLKERLGNETPRIV
CCCEEEEEEEEECCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEE
ETPCGMLNSIGLQNPGVEKFLKEIYPKIKDVDTHFIANVFGETEEEYVEVCMALEDADKI
CCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCE
VAYELNVSCPNVKKGGILFGHDPVILGNLVDRIKAKIKKPLLVKLSPNVTDVTEFAKVCI
EEEEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
ENGADGLVLINTLMGMKINIWKRKPDLATKTGGLSGPAILPIAVRMIYQVYEKFGDRIPI
HCCCCCEEEEEHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCE
IGVGGITTWEDAMEHVMAGASAVQVGTANFYEPLAPLKVIEGIENFMKSQNIKDFKELIG
EECCCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
IAHRVE
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320