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The map label for this gene is hibD [H]

Identifier: 15605639

GI number: 15605639

Start: 23541

End: 24407

Strand: Direct

Name: hibD [H]

Synonym: aq_038

Alternate gene names: 15605639

Gene position: 23541-24407 (Clockwise)

Preceding gene: 15605638

Following gene: 15605646

Centisome position: 1.52

GC content: 42.91

Gene sequence:

>867_bases
ATGAAGGTAGGTTTTATAGGTTTAGGACATCTTGGAAGAGCCATAGCAAAAAGATTGATAGAACAAGGTGTAGAATTAAT
AGTCTGGAACAGAACGCTTTCAAAAGCTCATGAATTTGCCAAAGAAACGGGTGCGGAGGTTACAAGCTCCCCCGCGGATT
TAATAAACAAGGTGGACAGAGTTTTCGTTATAGTTTTTGACTCTCAGGCTTCAGAAGAAGTGATATTCGGAGAAAAGGGA
CTCGTAAAAGGAGACATAAAGGGAAAAACCGTTATAGACATGACTACGAACCACTACCTTTACGCACAGAAGGCTTACGA
AGAACTTAAAAAACTTGGAGCTTTCTATCTGGACGCTCCCGTCCTCGGAAGTGTTATACCAGCCCTTAAAGGGGAACTCA
CTATAGTCGTGGGAGGGGATAAGGAAAAGTTTGAAGAGAATAAACCTCTTTTTGAAAAGTTTTGCAGGGCGATTTACTAC
CTAGGCGAGGCGGGAATGGGAAGTAAGATGAAACTCGTAAACAACATAGTTCTGGGCGGGATAATGGAAGTCCTGGCTGA
AGCCATAGCCATAGGTGAAAAGGCGGGAATTGACAAGGAAACATTAATAAACGTCCTCAACGACGGAGCGGGGAAATCCT
ACATCTTGGACGTTAAGAAGAAAAAACTCCTCGAGGAAGACTTCTCAACGCACTTTTCCGTTAACCTCATATACAAGGAT
CTCCACTACGCTCAGGATTTAATAAAAGACTTGGGACTCTTCTCCTTTACAACCGCTGCGGTAAAAGAAACATACGGACT
CGCAAGGAAGGAAGGGTTTGGAAATCTGGACTTTTCAGCAGTTTACAAGCTCTTCAAAGAAGACTAA

Upstream 100 bases:

>100_bases
GGAAGCGAAGATATACGATTTTGACGAAGAGTTCGAACTTTTAGAAGGTCTCAAATTAAGGCTTTCCGAAGTCCTGTCTT
CATAAAGTAAAATTTTCCCT

Downstream 100 bases:

>100_bases
ATAACGCCTTTCGTTGAGGGCACTCCGCTTCCCTCTACTTTTACCGCTTCTTTTAAAGTAATCGCAAAGGACTTAAAGCA
AGCTTCCGCCACGTGGTGGA

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MKVGFIGLGHLGRAIAKRLIEQGVELIVWNRTLSKAHEFAKETGAEVTSSPADLINKVDRVFVIVFDSQASEEVIFGEKG
LVKGDIKGKTVIDMTTNHYLYAQKAYEELKKLGAFYLDAPVLGSVIPALKGELTIVVGGDKEKFEENKPLFEKFCRAIYY
LGEAGMGSKMKLVNNIVLGGIMEVLAEAIAIGEKAGIDKETLINVLNDGAGKSYILDVKKKKLLEEDFSTHFSVNLIYKD
LHYAQDLIKDLGLFSFTTAAVKETYGLARKEGFGNLDFSAVYKLFKED

Sequences:

>Translated_288_residues
MKVGFIGLGHLGRAIAKRLIEQGVELIVWNRTLSKAHEFAKETGAEVTSSPADLINKVDRVFVIVFDSQASEEVIFGEKG
LVKGDIKGKTVIDMTTNHYLYAQKAYEELKKLGAFYLDAPVLGSVIPALKGELTIVVGGDKEKFEENKPLFEKFCRAIYY
LGEAGMGSKMKLVNNIVLGGIMEVLAEAIAIGEKAGIDKETLINVLNDGAGKSYILDVKKKKLLEEDFSTHFSVNLIYKD
LHYAQDLIKDLGLFSFTTAAVKETYGLARKEGFGNLDFSAVYKLFKED
>Mature_288_residues
MKVGFIGLGHLGRAIAKRLIEQGVELIVWNRTLSKAHEFAKETGAEVTSSPADLINKVDRVFVIVFDSQASEEVIFGEKG
LVKGDIKGKTVIDMTTNHYLYAQKAYEELKKLGAFYLDAPVLGSVIPALKGELTIVVGGDKEKFEENKPLFEKFCRAIYY
LGEAGMGSKMKLVNNIVLGGIMEVLAEAIAIGEKAGIDKETLINVLNDGAGKSYILDVKKKKLLEEDFSTHFSVNLIYKD
LHYAQDLIKDLGLFSFTTAAVKETYGLARKEGFGNLDFSAVYKLFKED

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=284, Percent_Identity=31.6901408450704, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI23308751, Length=294, Percent_Identity=30.952380952381, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI1786719, Length=283, Percent_Identity=34.6289752650177, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI145693186, Length=281, Percent_Identity=32.3843416370107, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1790315, Length=285, Percent_Identity=28.7719298245614, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789092, Length=287, Percent_Identity=29.9651567944251, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17557316, Length=295, Percent_Identity=28.8135593220339, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321695, Length=239, Percent_Identity=26.7782426778243, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321977, Length=238, Percent_Identity=26.890756302521, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28574115, Length=280, Percent_Identity=30.7142857142857, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=27.2108843537415, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=27.2108843537415, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31788; Mature: 31788

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGFIGLGHLGRAIAKRLIEQGVELIVWNRTLSKAHEFAKETGAEVTSSPADLINKVDR
CEEEEEEHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHCE
VFVIVFDSQASEEVIFGEKGLVKGDIKGKTVIDMTTNHYLYAQKAYEELKKLGAFYLDAP
EEEEEECCCCCCCEEECCCCCEECCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHCCHH
VLGSVIPALKGELTIVVGGDKEKFEENKPLFEKFCRAIYYLGEAGMGSKMKLVNNIVLGG
HHHHHHHHCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IMEVLAEAIAIGEKAGIDKETLINVLNDGAGKSYILDVKKKKLLEEDFSTHFSVNLIYKD
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCEEEEHHHHH
LHYAQDLIKDLGLFSFTTAAVKETYGLARKEGFGNLDFSAVYKLFKED
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKVGFIGLGHLGRAIAKRLIEQGVELIVWNRTLSKAHEFAKETGAEVTSSPADLINKVDR
CEEEEEEHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHCE
VFVIVFDSQASEEVIFGEKGLVKGDIKGKTVIDMTTNHYLYAQKAYEELKKLGAFYLDAP
EEEEEECCCCCCCEEECCCCCEECCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHCCHH
VLGSVIPALKGELTIVVGGDKEKFEENKPLFEKFCRAIYYLGEAGMGSKMKLVNNIVLGG
HHHHHHHHCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IMEVLAEAIAIGEKAGIDKETLINVLNDGAGKSYILDVKKKKLLEEDFSTHFSVNLIYKD
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCEEEEHHHHH
LHYAQDLIKDLGLFSFTTAAVKETYGLARKEGFGNLDFSAVYKLFKED
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]