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The map label for this gene is drrB

Identifier: 11499467

GI number: 11499467

Start: 1694464

End: 1695219

Strand: Reverse

Name: drrB

Synonym: AF1883

Alternate gene names: 11499467

Gene position: 1695219-1694464 (Counterclockwise)

Preceding gene: 11499468

Following gene: 11499466

Centisome position: 77.82

GC content: 51.32

Gene sequence:

>756_bases
ATGAGAGCGTTTGAAATCATGGTTTACAGGCAGATAAAGCGATTTTTGAGGGCGAGGTCGAGGGTGGCTGGGATGATTAT
AAACCCCCTTGTCTGGCTAACGTTCTTCGGCATCGGGTGGAGCCGAGCTTTCAGAGACCCGAGCATTTTCGGAGGCGTTG
ACTACCTCACCTACCTTTCTCCTGGCATATTTGCCATGACCGTTTTCAACCAGAGCTTCGTTAGCGGAATAAGCGTGATA
TGGGATAGAGAGTTTGGGTTTCTCAAGGAGGTGCTTGTAGCTCCCGCATCGAGAAAGGAGACGATAGCAGGCAGAATTTT
TGGCGATTCGGCGGTCGCCACACTTCAGGGAGCGATAATACTAGCTCTCACCTTTTTCATTGCAAGGATAAACATATTCG
GTGTGATTCCCGCTCTCGGAGTAGGTTTTGTTCTTGCGGTAGCGTTCTCCAGCTTCGGGGTCAGCATCGCAGCCAGGATG
AGGAGCATGGAGGGATTTCAGATGATAATGGCTCTCGTGATGCTCCCCCTGATATTCCTCAGTGGGGCGATTTACCCCAT
CGCCTTCATGCCCGCCTGGATGAAGGTCTTGGCTCTCCTAAATCCTCTAACGTACGCCGTAGAATCTTCGAGAGTTCTGC
TTACGGGAGTCAGCGGGATTTTCCCCTTAGACCAAAGCCTGCTGATACTTCTGTCACTCACAGCGTTGATGCTGTACGTG
GCGATGGTCTCATTCGAGAGGAGCACCGTGGAGTAA

Upstream 100 bases:

>100_bases
CGCTCAACGATGTGTTTCTCCACCTCACGGGAAGGGAAATAAGGGATGAGGGTGGTGAGCTGAGAAAAGCGATTATCAGG
GCTAGAATGAGGAGATAAAG

Downstream 100 bases:

>100_bases
AATTAATTAACTCTTCGCCTCAATCACCCCATGCTGCCGCCGTGGCTCAGCTGGCAGAGCGGGTGACTTGTAATCACCAG
GTCGCGGGTTCAAATCCCGC

Product: daunorubicin resistance membrane protein (drrB)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MRAFEIMVYRQIKRFLRARSRVAGMIINPLVWLTFFGIGWSRAFRDPSIFGGVDYLTYLSPGIFAMTVFNQSFVSGISVI
WDREFGFLKEVLVAPASRKETIAGRIFGDSAVATLQGAIILALTFFIARINIFGVIPALGVGFVLAVAFSSFGVSIAARM
RSMEGFQMIMALVMLPLIFLSGAIYPIAFMPAWMKVLALLNPLTYAVESSRVLLTGVSGIFPLDQSLLILLSLTALMLYV
AMVSFERSTVE

Sequences:

>Translated_251_residues
MRAFEIMVYRQIKRFLRARSRVAGMIINPLVWLTFFGIGWSRAFRDPSIFGGVDYLTYLSPGIFAMTVFNQSFVSGISVI
WDREFGFLKEVLVAPASRKETIAGRIFGDSAVATLQGAIILALTFFIARINIFGVIPALGVGFVLAVAFSSFGVSIAARM
RSMEGFQMIMALVMLPLIFLSGAIYPIAFMPAWMKVLALLNPLTYAVESSRVLLTGVSGIFPLDQSLLILLSLTALMLYV
AMVSFERSTVE
>Mature_251_residues
MRAFEIMVYRQIKRFLRARSRVAGMIINPLVWLTFFGIGWSRAFRDPSIFGGVDYLTYLSPGIFAMTVFNQSFVSGISVI
WDREFGFLKEVLVAPASRKETIAGRIFGDSAVATLQGAIILALTFFIARINIFGVIPALGVGFVLAVAFSSFGVSIAARM
RSMEGFQMIMALVMLPLIFLSGAIYPIAFMPAWMKVLALLNPLTYAVESSRVLLTGVSGIFPLDQSLLILLSLTALMLYV
AMVSFERSTVE

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1787010, Length=209, Percent_Identity=25.8373205741627, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 27684; Mature: 27684

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAFEIMVYRQIKRFLRARSRVAGMIINPLVWLTFFGIGWSRAFRDPSIFGGVDYLTYLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHCHHHHHHHHC
PGIFAMTVFNQSFVSGISVIWDREFGFLKEVLVAPASRKETIAGRIFGDSAVATLQGAII
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHEECCHHHHHHHHHHH
LALTFFIARINIFGVIPALGVGFVLAVAFSSFGVSIAARMRSMEGFQMIMALVMLPLIFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGAIYPIAFMPAWMKVLALLNPLTYAVESSRVLLTGVSGIFPLDQSLLILLSLTALMLYV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
AMVSFERSTVE
HHHHHHHHCCC
>Mature Secondary Structure
MRAFEIMVYRQIKRFLRARSRVAGMIINPLVWLTFFGIGWSRAFRDPSIFGGVDYLTYLS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHCHHHHHHHHC
PGIFAMTVFNQSFVSGISVIWDREFGFLKEVLVAPASRKETIAGRIFGDSAVATLQGAII
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHEECCHHHHHHHHHHH
LALTFFIARINIFGVIPALGVGFVLAVAFSSFGVSIAARMRSMEGFQMIMALVMLPLIFL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGAIYPIAFMPAWMKVLALLNPLTYAVESSRVLLTGVSGIFPLDQSLLILLSLTALMLYV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
AMVSFERSTVE
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]