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The map label for this gene is noxA-5

Identifier: 11499442

GI number: 11499442

Start: 1669875

End: 1671221

Strand: Reverse

Name: noxA-5

Synonym: AF1858

Alternate gene names: 11499442

Gene position: 1671221-1669875 (Counterclockwise)

Preceding gene: 11499443

Following gene: 11499439

Centisome position: 76.72

GC content: 48.26

Gene sequence:

>1347_bases
ATGTGTATTATGAAGTACGACGTTTTGATTATCGGAGGTGGACCAGCAGGAATAGTCACAGCAACGACGGCTAAAAAGTT
TTACCCTGCCAAGAGCGTGGCGATAATAAAGAAAGAGGAAACAAGTTTGGTGCCTTGCGGTATACCGTACATCTTCAAAA
CTCTCGGCTCTGTAGAGGCTGACGTGATGCCAACGAAGCCTGCAGAGAACCTTGGGATTGAGTTCATCATCGATGAGGTC
GAAGATGTTGACGTAAAAGCCAAGGTCGTGAGAACGAAGGGTGGAAAGAGCATTTCATACGAGAAGCTTGTTTTTGCAAC
GGGTTCAACACCGGTGATGCCGAGAATAGAGGGGGTTGAGAAGAAAGGAGTTTTCACGGTCTCGAAGAACATAGAAGAGC
TCAGAAAACTGCATGAGGCAGTAAAAAAGGCTGAAAAGGTTGTCATAGTCGGAGGCGGGTTCATAGGTGTCGAGGTAGGA
GAGCAGATTGCTAAAGCTGGGAAAAAGTTTACGATGGTGGAAATGATGGATCAGCTGCTTCCAGCCGCTTTTGACAAGGA
ATTCGCAAGAATTGCTGAGGAAGAGCTCAAGAAGCTTGGAGTAGAAGTTTATCTGAACTCGACAGTTAAGAGGATTACGG
GCAATTCCAGCGTAGAAGCTGTTGAACTCGCGGATGGCAGGAAGATTGAGGCAGATGTGGTCATAATGTCGGTGGGATAC
CGTCCGAACATAGAGCTTGCTAAGAAGGCAGGACTTAGAATAAGCATAGGAAATAGAATATGGACGGATGAGTACGGAAG
GACGAGCGAGAAAGACGTTTTCGCCGTTGGGGACTGTTCGGAAGAAAAGGACTTTTTCACCAGGGAAACGAGCAGGGTAA
TGTTAGCTTCAACTGCCACCTTCGAAGCGAGAATTGTTGGGGCAAATCTGTACTCTCTCAAGGTTGTGAGAGTGAACAAG
GGAACGGTGGGTGTTTTCTCAACCTTCGTTGGGGATGTTGCACTCGGCGCTGCAGGCCTTACTGAGGAGATGGCGAAGAA
AGAAGGTTTTGAGGTCGTTGCAGGCTACGGAGAGAGCTTAAACAGACATCTGGCAAGTATCCCCGGGGCGGCAAAGACGA
AGGTGAAGCTGATCTTTGCCAAGGAGAGTGGTGTAATCCTTGGAGGTCAGGTTACTGGGAGATATGAGGTTGGAGAAATG
GTAAATCAGATAGCAATGGCAATCCAGAACAACCTGACCGCCTCAGAGATAGACACGCTTCAGATAGGCACGCATCCGCT
TTTAACTTCAGCTCCCACCACCCCACCAGTAATACTTGCAGCAGAGGATGCGCTCAGGAAGATGTGA

Upstream 100 bases:

>100_bases
ATTAATCTATCGAAACAGAAAAAGAAATATTCACAAAAGGTTTATAACTGAAAGATTTTATTTATTAATATTCTTATAAG
TTTAAATATTCATCGAGAGC

Downstream 100 bases:

>100_bases
GTATTTTTTCCACCTTTTTTGCGACCTCTCTTAGTGGCAGATTAAGCTCCCTCGCCACCCTCTTTAAATCCTCGTACTCC
GGCTTTGCGTTGATAACTTT

Product: NADH oxidase (noxA-5)

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MCIMKYDVLIIGGGPAGIVTATTAKKFYPAKSVAIIKKEETSLVPCGIPYIFKTLGSVEADVMPTKPAENLGIEFIIDEV
EDVDVKAKVVRTKGGKSISYEKLVFATGSTPVMPRIEGVEKKGVFTVSKNIEELRKLHEAVKKAEKVVIVGGGFIGVEVG
EQIAKAGKKFTMVEMMDQLLPAAFDKEFARIAEEELKKLGVEVYLNSTVKRITGNSSVEAVELADGRKIEADVVIMSVGY
RPNIELAKKAGLRISIGNRIWTDEYGRTSEKDVFAVGDCSEEKDFFTRETSRVMLASTATFEARIVGANLYSLKVVRVNK
GTVGVFSTFVGDVALGAAGLTEEMAKKEGFEVVAGYGESLNRHLASIPGAAKTKVKLIFAKESGVILGGQVTGRYEVGEM
VNQIAMAIQNNLTASEIDTLQIGTHPLLTSAPTTPPVILAAEDALRKM

Sequences:

>Translated_448_residues
MCIMKYDVLIIGGGPAGIVTATTAKKFYPAKSVAIIKKEETSLVPCGIPYIFKTLGSVEADVMPTKPAENLGIEFIIDEV
EDVDVKAKVVRTKGGKSISYEKLVFATGSTPVMPRIEGVEKKGVFTVSKNIEELRKLHEAVKKAEKVVIVGGGFIGVEVG
EQIAKAGKKFTMVEMMDQLLPAAFDKEFARIAEEELKKLGVEVYLNSTVKRITGNSSVEAVELADGRKIEADVVIMSVGY
RPNIELAKKAGLRISIGNRIWTDEYGRTSEKDVFAVGDCSEEKDFFTRETSRVMLASTATFEARIVGANLYSLKVVRVNK
GTVGVFSTFVGDVALGAAGLTEEMAKKEGFEVVAGYGESLNRHLASIPGAAKTKVKLIFAKESGVILGGQVTGRYEVGEM
VNQIAMAIQNNLTASEIDTLQIGTHPLLTSAPTTPPVILAAEDALRKM
>Mature_448_residues
MCIMKYDVLIIGGGPAGIVTATTAKKFYPAKSVAIIKKEETSLVPCGIPYIFKTLGSVEADVMPTKPAENLGIEFIIDEV
EDVDVKAKVVRTKGGKSISYEKLVFATGSTPVMPRIEGVEKKGVFTVSKNIEELRKLHEAVKKAEKVVIVGGGFIGVEVG
EQIAKAGKKFTMVEMMDQLLPAAFDKEFARIAEEELKKLGVEVYLNSTVKRITGNSSVEAVELADGRKIEADVVIMSVGY
RPNIELAKKAGLRISIGNRIWTDEYGRTSEKDVFAVGDCSEEKDFFTRETSRVMLASTATFEARIVGANLYSLKVVRVNK
GTVGVFSTFVGDVALGAAGLTEEMAKKEGFEVVAGYGESLNRHLASIPGAAKTKVKLIFAKESGVILGGQVTGRYEVGEM
VNQIAMAIQNNLTASEIDTLQIGTHPLLTSAPTTPPVILAAEDALRKM

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI22202629, Length=259, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4757732, Length=259, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI65787454, Length=277, Percent_Identity=25.9927797833935, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI226437568, Length=277, Percent_Identity=25.9927797833935, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI21389617, Length=277, Percent_Identity=25.9927797833935, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI50301238, Length=348, Percent_Identity=25.8620689655172, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI91199540, Length=299, Percent_Identity=26.7558528428094, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789065, Length=202, Percent_Identity=33.1683168316832, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789765, Length=215, Percent_Identity=26.9767441860465, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786307, Length=369, Percent_Identity=28.9972899728997, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788892, Length=185, Percent_Identity=28.1081081081081, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787352, Length=253, Percent_Identity=26.4822134387352, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789915, Length=356, Percent_Identity=26.123595505618, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17559934, Length=203, Percent_Identity=27.5862068965517, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=299, Percent_Identity=26.4214046822742, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17557007, Length=347, Percent_Identity=25.6484149855908, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324402, Length=240, Percent_Identity=25.4166666666667, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24585130, Length=279, Percent_Identity=24.3727598566308, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28573993, Length=250, Percent_Identity=26.4, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24581020, Length=250, Percent_Identity=26.4, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281359715, Length=289, Percent_Identity=22.8373702422145, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281359713, Length=289, Percent_Identity=22.8373702422145, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639250, Length=289, Percent_Identity=22.8373702422145, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI18543267, Length=289, Percent_Identity=22.8373702422145, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639252, Length=289, Percent_Identity=22.8373702422145, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639257, Length=289, Percent_Identity=22.8373702422145, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21358499, Length=367, Percent_Identity=25.8855585831063, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 48222; Mature: 48222

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCIMKYDVLIIGGGPAGIVTATTAKKFYPAKSVAIIKKEETSLVPCGIPYIFKTLGSVEA
CEEEEEEEEEECCCCCCEEEECCHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCC
DVMPTKPAENLGIEFIIDEVEDVDVKAKVVRTKGGKSISYEKLVFATGSTPVMPRIEGVE
CCCCCCCHHHCCEEEEEECCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCC
KKGVFTVSKNIEELRKLHEAVKKAEKVVIVGGGFIGVEVGEQIAKAGKKFTMVEMMDQLL
CCCEEEECCCHHHHHHHHHHHHHCCEEEEECCCEEEEHHHHHHHHCCCCEEHHHHHHHHH
PAAFDKEFARIAEEELKKLGVEVYLNSTVKRITGNSSVEAVELADGRKIEADVVIMSVGY
HHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHCCCCCEEEEEECCCCEEEEEEEEEEECC
RPNIELAKKAGLRISIGNRIWTDEYGRTSEKDVFAVGDCSEEKDFFTRETSRVMLASTAT
CCCCHHHHHCCCEEEECCEEECCCCCCCCCCCEEEECCCCCCHHHHHHCCCEEEEEEECE
FEARIVGANLYSLKVVRVNKGTVGVFSTFVGDVALGAAGLTEEMAKKEGFEVVAGYGESL
EEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECCCHHH
NRHLASIPGAAKTKVKLIFAKESGVILGGQVTGRYEVGEMVNQIAMAIQNNLTASEIDTL
HHHHHHCCCCCCEEEEEEEEECCCEEECCEECCCCHHHHHHHHHHHHHHCCCCHHHCCEE
QIGTHPLLTSAPTTPPVILAAEDALRKM
EECCCCCCCCCCCCCCEEEEECHHHHCC
>Mature Secondary Structure
MCIMKYDVLIIGGGPAGIVTATTAKKFYPAKSVAIIKKEETSLVPCGIPYIFKTLGSVEA
CEEEEEEEEEECCCCCCEEEECCHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCC
DVMPTKPAENLGIEFIIDEVEDVDVKAKVVRTKGGKSISYEKLVFATGSTPVMPRIEGVE
CCCCCCCHHHCCEEEEEECCCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCC
KKGVFTVSKNIEELRKLHEAVKKAEKVVIVGGGFIGVEVGEQIAKAGKKFTMVEMMDQLL
CCCEEEECCCHHHHHHHHHHHHHCCEEEEECCCEEEEHHHHHHHHCCCCEEHHHHHHHHH
PAAFDKEFARIAEEELKKLGVEVYLNSTVKRITGNSSVEAVELADGRKIEADVVIMSVGY
HHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHCCCCCEEEEEECCCCEEEEEEEEEEECC
RPNIELAKKAGLRISIGNRIWTDEYGRTSEKDVFAVGDCSEEKDFFTRETSRVMLASTAT
CCCCHHHHHCCCEEEECCEEECCCCCCCCCCCEEEECCCCCCHHHHHHCCCEEEEEEECE
FEARIVGANLYSLKVVRVNKGTVGVFSTFVGDVALGAAGLTEEMAKKEGFEVVAGYGESL
EEEEEEECCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECCCHHH
NRHLASIPGAAKTKVKLIFAKESGVILGGQVTGRYEVGEMVNQIAMAIQNNLTASEIDTL
HHHHHHCCCCCCEEEEEEEEECCCEEECCEECCCCHHHHHHHHHHHHHHCCCCHHHCCEE
QIGTHPLLTSAPTTPPVILAAEDALRKM
EECCCCCCCCCCCCCCEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]