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The map label for this gene is cat2-2

Identifier: 11499439

GI number: 11499439

Start: 1663422

End: 1664846

Strand: Reverse

Name: cat2-2

Synonym: AF1854

Alternate gene names: 11499439

Gene position: 1664846-1663422 (Counterclockwise)

Preceding gene: 11499442

Following gene: 11499437

Centisome position: 76.43

GC content: 53.05

Gene sequence:

>1425_bases
ATGGACTACCAGAAAGAATATGAAAGAAAGCTCATCAGCCCCGAAGAGGCTGCAAACCTCGTAAAGGATGGAATGCACAT
CGAAATTGGCGGTTCTGCCAACACTGCCCTTATTATCGACAAGTACCTTGCAAAGAGGAAGGACGAGCTCAGCCATGTGG
AGGTCGGAACCTTCATCGACATCGCCCACTACGAGTTCTTGAAGGCTGACCCTGAGCAGGAGAAGATTAAGTGGGAAAGC
TGCTTCCTCTACGAACCAGTAAGGAAGTGCAGCAAGGAGCTTGGGCCCTGCGTGCACCGCCCCGGAGTTCTGTCGGATGC
GGGATACATAGCGAAGGAGCTTGGTGGAGTTTTGAAGGGAGGGAAGAAGTACACGGACATAGCTTTCCTCGTCACGACGC
CAATGGACAGGCACGGCTTCTTCAACTTCGGAGTCACCTGCACCTTCCTGAAATCCATAGCTGAGGGGGCAGAGAAGGTT
GTTGTGGTGGTTAAGAAGGACATGCCTTGGGTGAATGGAGGTTACGACGAGTGCATCCACATTTCGGAAGTTGATTACAT
TGTTGAGGACAATGAGTTCCCCACACCCTTCCTGCCCTTCTTACCCCCACCATCAAAGGAGGATGAGATGATAGCCGAGA
ACATCATGGAGGCAGGGCTGATTGAGAATGGCTCAACGCTTCAGGTTGGCATTGGTGGATTGCCCAACACGGTTGTCAGG
ATGCTGAAGGAAGCAGGACTGAAGGACTTGGGCATCCACACCGAGATGATGGGAGACGGACTGATGGAGCTGATGGAGGA
GGGGATAGTTACCAACCAGAACAAGAAGCTTGACAGGGGAAAGGCTGTGTTCTCCTTTGCCCTTGGAACAAGAAAGCTCT
ACGATTTCCTCGACAGGAATCCAGAGGTCGCAACCTATCCCGTTGAGTACACCAACAACCCCTTCGTTGTTGCCCAGCAG
CCGAAGATGTTCTCCCTCAATCAGGTTGCCCAGATAGACCTCATGGGACAGATAAACTCCGGGCAGATTGGTCTAACGTC
TCCAAGCGGCAAGATATTCCAGATCAGCGGTACAGGAGGGCAGCTTGACTTCGTGCTTGGCTGCTTCTACAGCTTCGACA
GGCAGGGGAAGAGCGTTCTGGCGACCTACTCAACCTACAACGGCACCTCAAGAATTATCCCCGCTCTACCAACAGGTGCT
GGGGTGACAGTTCCGAGGTCGGTTGTGCAGTATGTAGCTACAGAGTGGGGAATTGCCTATCTGCGAGGTCTGCCAATCTA
CAAGAGGGCAGCGGCAATGATTCAGCTTGCCCATCCAGACCACAGGGACTGGCTGGAGGAGGAGGCAAGGAAGCTCGGTA
TCCTGCCTCCAAAGTACTCCATCCCTGCAGGAAAGGCGGATGGGGTGATTTACAGGAGGGATTAG

Upstream 100 bases:

>100_bases
CTTTCAATATCTTTAATTTTAAAAAATTTCCTAAACTACCGCAAAATCTTTTTAGAAAAGGTTAAATTGTCAGCATAATT
TTTAAGGTAGAGGTGGTGAT

Downstream 100 bases:

>100_bases
TGAGCTCTTTCTTACTTTTTTATTCAGATTTTGTGGTATCTCCTGATGGCTCTGGACAGTTTAGAAAAATTATCCCCTCT
TTATCGTAAACGTACGTTTT

Product: 4-hydroxybutyrate CoA transferase (cat2-2)

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MDYQKEYERKLISPEEAANLVKDGMHIEIGGSANTALIIDKYLAKRKDELSHVEVGTFIDIAHYEFLKADPEQEKIKWES
CFLYEPVRKCSKELGPCVHRPGVLSDAGYIAKELGGVLKGGKKYTDIAFLVTTPMDRHGFFNFGVTCTFLKSIAEGAEKV
VVVVKKDMPWVNGGYDECIHISEVDYIVEDNEFPTPFLPFLPPPSKEDEMIAENIMEAGLIENGSTLQVGIGGLPNTVVR
MLKEAGLKDLGIHTEMMGDGLMELMEEGIVTNQNKKLDRGKAVFSFALGTRKLYDFLDRNPEVATYPVEYTNNPFVVAQQ
PKMFSLNQVAQIDLMGQINSGQIGLTSPSGKIFQISGTGGQLDFVLGCFYSFDRQGKSVLATYSTYNGTSRIIPALPTGA
GVTVPRSVVQYVATEWGIAYLRGLPIYKRAAAMIQLAHPDHRDWLEEEARKLGILPPKYSIPAGKADGVIYRRD

Sequences:

>Translated_474_residues
MDYQKEYERKLISPEEAANLVKDGMHIEIGGSANTALIIDKYLAKRKDELSHVEVGTFIDIAHYEFLKADPEQEKIKWES
CFLYEPVRKCSKELGPCVHRPGVLSDAGYIAKELGGVLKGGKKYTDIAFLVTTPMDRHGFFNFGVTCTFLKSIAEGAEKV
VVVVKKDMPWVNGGYDECIHISEVDYIVEDNEFPTPFLPFLPPPSKEDEMIAENIMEAGLIENGSTLQVGIGGLPNTVVR
MLKEAGLKDLGIHTEMMGDGLMELMEEGIVTNQNKKLDRGKAVFSFALGTRKLYDFLDRNPEVATYPVEYTNNPFVVAQQ
PKMFSLNQVAQIDLMGQINSGQIGLTSPSGKIFQISGTGGQLDFVLGCFYSFDRQGKSVLATYSTYNGTSRIIPALPTGA
GVTVPRSVVQYVATEWGIAYLRGLPIYKRAAAMIQLAHPDHRDWLEEEARKLGILPPKYSIPAGKADGVIYRRD
>Mature_474_residues
MDYQKEYERKLISPEEAANLVKDGMHIEIGGSANTALIIDKYLAKRKDELSHVEVGTFIDIAHYEFLKADPEQEKIKWES
CFLYEPVRKCSKELGPCVHRPGVLSDAGYIAKELGGVLKGGKKYTDIAFLVTTPMDRHGFFNFGVTCTFLKSIAEGAEKV
VVVVKKDMPWVNGGYDECIHISEVDYIVEDNEFPTPFLPFLPPPSKEDEMIAENIMEAGLIENGSTLQVGIGGLPNTVVR
MLKEAGLKDLGIHTEMMGDGLMELMEEGIVTNQNKKLDRGKAVFSFALGTRKLYDFLDRNPEVATYPVEYTNNPFVVAQQ
PKMFSLNQVAQIDLMGQINSGQIGLTSPSGKIFQISGTGGQLDFVLGCFYSFDRQGKSVLATYSTYNGTSRIIPALPTGA
GVTVPRSVVQYVATEWGIAYLRGLPIYKRAAAMIQLAHPDHRDWLEEEARKLGILPPKYSIPAGKADGVIYRRD

Specific function: Unknown

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=224, Percent_Identity=26.3392857142857, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538151, Length=452, Percent_Identity=33.4070796460177, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI32563853, Length=456, Percent_Identity=31.359649122807, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI21358615, Length=456, Percent_Identity=33.5526315789474, Blast_Score=227, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro [H]

EC number: NA

Molecular weight: Translated: 52525; Mature: 52525

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYQKEYERKLISPEEAANLVKDGMHIEIGGSANTALIIDKYLAKRKDELSHVEVGTFID
CCCHHHHHHHCCCHHHHHHHHHCCCEEEECCCCCEEEEHHHHHHHHHHHHCEEECCCEEE
IAHYEFLKADPEQEKIKWESCFLYEPVRKCSKELGPCVHRPGVLSDAGYIAKELGGVLKG
HHHHHHHCCCCHHHHEEHHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHCC
GKKYTDIAFLVTTPMDRHGFFNFGVTCTFLKSIAEGAEKVVVVVKKDMPWVNGGYDECIH
CCCEEEEEEEEECCCCCCCCEECCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHEEE
ISEVDYIVEDNEFPTPFLPFLPPPSKEDEMIAENIMEAGLIENGSTLQVGIGGLPNTVVR
EEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHH
MLKEAGLKDLGIHTEMMGDGLMELMEEGIVTNQNKKLDRGKAVFSFALGTRKLYDFLDRN
HHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
PEVATYPVEYTNNPFVVAQQPKMFSLNQVAQIDLMGQINSGQIGLTSPSGKIFQISGTGG
CCEEEEEEEECCCCEEEECCCCCCCCCHHEEEEEEEECCCCEEEEECCCCCEEEEECCCC
QLDFVLGCFYSFDRQGKSVLATYSTYNGTSRIIPALPTGAGVTVPRSVVQYVATEWGIAY
CHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LRGLPIYKRAAAMIQLAHPDHRDWLEEEARKLGILPPKYSIPAGKADGVIYRRD
HHCCCHHHHHHHHEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MDYQKEYERKLISPEEAANLVKDGMHIEIGGSANTALIIDKYLAKRKDELSHVEVGTFID
CCCHHHHHHHCCCHHHHHHHHHCCCEEEECCCCCEEEEHHHHHHHHHHHHCEEECCCEEE
IAHYEFLKADPEQEKIKWESCFLYEPVRKCSKELGPCVHRPGVLSDAGYIAKELGGVLKG
HHHHHHHCCCCHHHHEEHHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHCC
GKKYTDIAFLVTTPMDRHGFFNFGVTCTFLKSIAEGAEKVVVVVKKDMPWVNGGYDECIH
CCCEEEEEEEEECCCCCCCCEECCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHEEE
ISEVDYIVEDNEFPTPFLPFLPPPSKEDEMIAENIMEAGLIENGSTLQVGIGGLPNTVVR
EEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHH
MLKEAGLKDLGIHTEMMGDGLMELMEEGIVTNQNKKLDRGKAVFSFALGTRKLYDFLDRN
HHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
PEVATYPVEYTNNPFVVAQQPKMFSLNQVAQIDLMGQINSGQIGLTSPSGKIFQISGTGG
CCEEEEEEEECCCCEEEECCCCCCCCCHHEEEEEEEECCCCEEEEECCCCCEEEEECCCC
QLDFVLGCFYSFDRQGKSVLATYSTYNGTSRIIPALPTGAGVTVPRSVVQYVATEWGIAY
CHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHH
LRGLPIYKRAAAMIQLAHPDHRDWLEEEARKLGILPPKYSIPAGKADGVIYRRD
HHCCCHHHHHHHHEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]