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Identifier: 11499391

GI number: 11499391

Start: 1618684

End: 1619616

Strand: Reverse

Name: Not Available

Synonym: AF1803

Alternate gene names: NA

Gene position: 1619616-1618684 (Counterclockwise)

Preceding gene: 11499395

Following gene: 11499390

Centisome position: 74.35

GC content: 49.3

Gene sequence:

>933_bases
ATGAATAATATCTCCATCCCGTTTGAAAAGCTTGGAAATGCCAAAAAAGTCGGAATACAGCTTCCCGATGGACTTAAGAG
AAGAGCCATAGAAATAGCTCAGCTCATTGAGGATAGGGGGTACGATGTTGTAATCTCCGGCGAGACAAGCTTTGGAGCGT
GCGACATCGACCTCTCTATCCTCGAAGTAGTTGACGTTCTCCTGCATTTCGCCCATACACCCATCCTGAAAGATGAAAGG
GTCGTTTACGTGCCGTACTTTATCGAATACAACCCAAAAATTGACCTGAAAGTTGATGAAAGGAGAATCGCTCTCATCGC
AACGGCTCAGTACGTGCACAAGCTCCCCGAGGTTGCAGAGTGGCTAAGAGGCAAAGGCTACGAGGTTGAAATCGGCAGTC
CAAGGGGGAGGGTTGTCTATCCGGGACAGGTTCTTGGTTGCAACTACTCGGTTTTGAGAGGCAGTAACGCCGATGCGGTT
GTTTTCATTGGCGATGGGCTTTTCCATGCCACGGGAGCGGCGATGTACACCAAGAAAAAGGTTTACGCCTACAATCCCCT
TTCGGGTGAACTTAAGGAGGTTGATGCCAGGAACTTTGAGAAAAAGAGGTACCTAGAGGTCTCGAAGTGCGTGGGGAAGA
GTAAAGCAGGTATTCTGGTGTCTTCAAAGCCCGGCCAGAGAAGGCTCAGGCTTGCTGAAAAACTAAAGAAAATCGGAAGG
GAAAATGGGCTGTTCTGCAGCATAATCTACCTTAACAACGTAAGGGCCGAGGAGCTATACAACCTGCCCTTTGACTTCTA
CGTCAACACCGCCTGTCCCCGGATAGCCTACGATGACGGGGCGAGGTTTGAGAAGCCGGTAATAAGCCCCCAGGAATTCG
AGCTTTTGCTCGGCCTTAGAGAGTCAATCGCAATGGACGAGATAGAGTTTTAA

Upstream 100 bases:

>100_bases
TTTATCCTGAGCTTATCGAGGTAGCTTTCGATTTTCTTCAAATCCTTCACAAAGTACAACTTCGGGCCGTATTTTATAAA
TCTAATGACAGAGTGTGTTC

Downstream 100 bases:

>100_bases
ATAGTTGATAATTAGTTTGGGTGTGGACAGAGAGAAAGCTGAAAAGCTAATCGCGATGAACAGGGCTTTCAAAATTCTGA
GGGAGAGGCAGAGGGCTAAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MNNISIPFEKLGNAKKVGIQLPDGLKRRAIEIAQLIEDRGYDVVISGETSFGACDIDLSILEVVDVLLHFAHTPILKDER
VVYVPYFIEYNPKIDLKVDERRIALIATAQYVHKLPEVAEWLRGKGYEVEIGSPRGRVVYPGQVLGCNYSVLRGSNADAV
VFIGDGLFHATGAAMYTKKKVYAYNPLSGELKEVDARNFEKKRYLEVSKCVGKSKAGILVSSKPGQRRLRLAEKLKKIGR
ENGLFCSIIYLNNVRAEELYNLPFDFYVNTACPRIAYDDGARFEKPVISPQEFELLLGLRESIAMDEIEF

Sequences:

>Translated_310_residues
MNNISIPFEKLGNAKKVGIQLPDGLKRRAIEIAQLIEDRGYDVVISGETSFGACDIDLSILEVVDVLLHFAHTPILKDER
VVYVPYFIEYNPKIDLKVDERRIALIATAQYVHKLPEVAEWLRGKGYEVEIGSPRGRVVYPGQVLGCNYSVLRGSNADAV
VFIGDGLFHATGAAMYTKKKVYAYNPLSGELKEVDARNFEKKRYLEVSKCVGKSKAGILVSSKPGQRRLRLAEKLKKIGR
ENGLFCSIIYLNNVRAEELYNLPFDFYVNTACPRIAYDDGARFEKPVISPQEFELLLGLRESIAMDEIEF
>Mature_310_residues
MNNISIPFEKLGNAKKVGIQLPDGLKRRAIEIAQLIEDRGYDVVISGETSFGACDIDLSILEVVDVLLHFAHTPILKDER
VVYVPYFIEYNPKIDLKVDERRIALIATAQYVHKLPEVAEWLRGKGYEVEIGSPRGRVVYPGQVLGCNYSVLRGSNADAV
VFIGDGLFHATGAAMYTKKKVYAYNPLSGELKEVDARNFEKKRYLEVSKCVGKSKAGILVSSKPGQRRLRLAEKLKKIGR
ENGLFCSIIYLNNVRAEELYNLPFDFYVNTACPRIAYDDGARFEKPVISPQEFELLLGLRESIAMDEIEF

Specific function: Unknown

COG id: COG1736

COG function: function code J; Diphthamide synthase subunit DPH2

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI116686106, Length=311, Percent_Identity=27.6527331189711, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17552166, Length=304, Percent_Identity=27.3026315789474, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322088, Length=310, Percent_Identity=28.0645161290323, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24662841, Length=304, Percent_Identity=26.9736842105263, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21356957, Length=304, Percent_Identity=26.9736842105263, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016435
- InterPro:   IPR002728
- InterPro:   IPR022428 [H]

Pfam domain/function: PF01866 Diphthamide_syn [H]

EC number: NA

Molecular weight: Translated: 34886; Mature: 34886

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNISIPFEKLGNAKKVGIQLPDGLKRRAIEIAQLIEDRGYDVVISGETSFGACDIDLSI
CCCCCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCHHH
LEVVDVLLHFAHTPILKDERVVYVPYFIEYNPKIDLKVDERRIALIATAQYVHKLPEVAE
HHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCEEEEEECCCEEEEEEEHHHHHHHHHHHH
WLRGKGYEVEIGSPRGRVVYPGQVLGCNYSVLRGSNADAVVFIGDGLFHATGAAMYTKKK
HHCCCCEEEEECCCCCCEEECCEEECCCEEEEECCCCCEEEEEECCHHHHCCCHHEEECE
VYAYNPLSGELKEVDARNFEKKRYLEVSKCVGKSKAGILVSSKPGQRRLRLAEKLKKIGR
EEEECCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCC
ENGLFCSIIYLNNVRAEELYNLPFDFYVNTACPRIAYDDGARFEKPVISPQEFELLLGLR
CCCCEEEEEEECCCCHHHHHCCCCEEEECCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
ESIAMDEIEF
HHHHHHCCCC
>Mature Secondary Structure
MNNISIPFEKLGNAKKVGIQLPDGLKRRAIEIAQLIEDRGYDVVISGETSFGACDIDLSI
CCCCCCCHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCHHH
LEVVDVLLHFAHTPILKDERVVYVPYFIEYNPKIDLKVDERRIALIATAQYVHKLPEVAE
HHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCEEEEEECCCEEEEEEEHHHHHHHHHHHH
WLRGKGYEVEIGSPRGRVVYPGQVLGCNYSVLRGSNADAVVFIGDGLFHATGAAMYTKKK
HHCCCCEEEEECCCCCCEEECCEEECCCEEEEECCCCCEEEEEECCHHHHCCCHHEEECE
VYAYNPLSGELKEVDARNFEKKRYLEVSKCVGKSKAGILVSSKPGQRRLRLAEKLKKIGR
EEEECCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCC
ENGLFCSIIYLNNVRAEELYNLPFDFYVNTACPRIAYDDGARFEKPVISPQEFELLLGLR
CCCCEEEEEEECCCCHHHHHCCCCEEEECCCCCEEEECCCCCCCCCCCCHHHHHHHHHHH
ESIAMDEIEF
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]