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Identifier: 11499379

GI number: 11499379

Start: 1607374

End: 1608840

Strand: Reverse

Name: Not Available

Synonym: AF1790

Alternate gene names: 11499379

Gene position: 1608840-1607374 (Counterclockwise)

Preceding gene: 11499383

Following gene: 11499378

Centisome position: 73.85

GC content: 50.1

Gene sequence:

>1467_bases
ATGGTAATTAAAAATATCGATGCCGCAACAGTGGCGAAGAAGTTTCTGGTAAGGGGGTACAACATAGACCCCAAAGCTGC
TGAGCTAATTTGCAAATCCGGCCTCTTTAGCGATGAACTCGTTGACAAGATTTGCCGCATAGCCAATGGGGGTTTCATCA
TAGAAAAGAGCGTTGTTGAGGAGTTCTTACGAAACCTATCAAATCTGAAGCCAGCAACCCTAACGCCCAGGCCGGAGGAA
AGGAAGGTGGAAGAGGTAAAGGCCTCCTGCATCGCTCTCAAGGTCATAAAGGACATAACGGGGAAGTCCAGCTGTCAGGG
AAACGTGGAGGACTTCCTTATGTACTTCAACTCCAGACTTGAGAAGCTTTCAAGGATAATAAGGAGCAGGGTAAACACCA
CCCCCATAGCCCACGCCGGGAAGGTTAGGGGGAACGTTAGCGTTGTGGGGATGGTGAATGAAGTCTACGAGAGGGGAGAC
AAATGCTACATACGCCTTGAAGACACAACAGGAACCATAACCTGCGTTGCAACCGGAAAAAACGCTGAGGTTGCAAGAGA
GCTTCTTGGTGACGAGGTCATCGGCGTAACAGGATTGCTGAAGGGCTCCTCACTCTACGCAAACAGAATAGTTTTTCCCG
ACGTTCCGATTAACGGGAACGGAGAGAAGAAGAGGGATTTTTACATCGTTTTCCTCTCGGACACGCACTTCGGAAGCAAG
GAATTCCTCGAGAAGGAGTGGGAAATGTTCGTCAGGTGGCTTAAGGGGGAGGTTGGAGGAAAGAAAAGCCAGAATCTCGC
TGAGAAGGTTAAGTACATTGTAATTGCGGGCGATATCGTTGACGGTATCGGTGTTTATCCCGGTCAGGAGGATGATTTAG
CGATAAGCGACATCTACGGCCAGTACGAGTTTGCAGCCTCCCATCTTGACGAGATTCCGAAAGAGATCAAAATAATAGTC
TCTCCCGGAAACCATGATGCGGTCAGGCAGGCCGAACCTCAACCAGCGTTTGAAGGCGAGATCAGGAGCCTGTTTCCTAA
AAACGTTGAGCATGTTGGAAATCCCGCATACGTCGATATAGAGGGTGTGAAGGTTCTGATTTACCACGGGAGGAGCATAG
ACGACATAATTTCGAAAATTCCGCGCCTGAGCTACGATGAGCCTCAGAAGGTCATGGAGGAGCTGCTGAAGAGGAGGCAC
CTCAGCCCGATTTACGGTGGAAGAACACCTTTGGCTCCGGAAAGGGAGGATTACCTCGTTATTGAGGACGTTCCCGATAT
TCTTCACTGCGGACACATCCACACCTACGGAACGGGGTTTTACAGAGGCGTTTTCATGGTCAACTCCTCCACCTGGCAGG
CGCAGACCGAGTTTCAGAAAAAGGTCAATCTCAACCCGATGCCCGGCAACGTTGCGGTTTACAGGCCGGGAGGAGAGGTT
ATAAGGCTGAGGTTCTACGGTGAGTAA

Upstream 100 bases:

>100_bases
TCCACCCACCACAACCGCAACGATAATTAACGTTGAGACGACATCTTTCAGAAACTGGTAGGTCTTGGATTCAGTGTCCA
TGCTTTAAGGAGGAGATGGG

Downstream 100 bases:

>100_bases
AATGTACCTCGTTCTGAGCTGGAGATACGTGGAAAGCCTCTGCAGGAAAATTGCGTTTGAGATCGTGGAAGACAAGTTCA
TCCCCGAAAGAATTGTCGCG

Product: DNA polymerase II small subunit

Products: NA

Alternate protein names: Pol II

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MVIKNIDAATVAKKFLVRGYNIDPKAAELICKSGLFSDELVDKICRIANGGFIIEKSVVEEFLRNLSNLKPATLTPRPEE
RKVEEVKASCIALKVIKDITGKSSCQGNVEDFLMYFNSRLEKLSRIIRSRVNTTPIAHAGKVRGNVSVVGMVNEVYERGD
KCYIRLEDTTGTITCVATGKNAEVARELLGDEVIGVTGLLKGSSLYANRIVFPDVPINGNGEKKRDFYIVFLSDTHFGSK
EFLEKEWEMFVRWLKGEVGGKKSQNLAEKVKYIVIAGDIVDGIGVYPGQEDDLAISDIYGQYEFAASHLDEIPKEIKIIV
SPGNHDAVRQAEPQPAFEGEIRSLFPKNVEHVGNPAYVDIEGVKVLIYHGRSIDDIISKIPRLSYDEPQKVMEELLKRRH
LSPIYGGRTPLAPEREDYLVIEDVPDILHCGHIHTYGTGFYRGVFMVNSSTWQAQTEFQKKVNLNPMPGNVAVYRPGGEV
IRLRFYGE

Sequences:

>Translated_488_residues
MVIKNIDAATVAKKFLVRGYNIDPKAAELICKSGLFSDELVDKICRIANGGFIIEKSVVEEFLRNLSNLKPATLTPRPEE
RKVEEVKASCIALKVIKDITGKSSCQGNVEDFLMYFNSRLEKLSRIIRSRVNTTPIAHAGKVRGNVSVVGMVNEVYERGD
KCYIRLEDTTGTITCVATGKNAEVARELLGDEVIGVTGLLKGSSLYANRIVFPDVPINGNGEKKRDFYIVFLSDTHFGSK
EFLEKEWEMFVRWLKGEVGGKKSQNLAEKVKYIVIAGDIVDGIGVYPGQEDDLAISDIYGQYEFAASHLDEIPKEIKIIV
SPGNHDAVRQAEPQPAFEGEIRSLFPKNVEHVGNPAYVDIEGVKVLIYHGRSIDDIISKIPRLSYDEPQKVMEELLKRRH
LSPIYGGRTPLAPEREDYLVIEDVPDILHCGHIHTYGTGFYRGVFMVNSSTWQAQTEFQKKVNLNPMPGNVAVYRPGGEV
IRLRFYGE
>Mature_488_residues
MVIKNIDAATVAKKFLVRGYNIDPKAAELICKSGLFSDELVDKICRIANGGFIIEKSVVEEFLRNLSNLKPATLTPRPEE
RKVEEVKASCIALKVIKDITGKSSCQGNVEDFLMYFNSRLEKLSRIIRSRVNTTPIAHAGKVRGNVSVVGMVNEVYERGD
KCYIRLEDTTGTITCVATGKNAEVARELLGDEVIGVTGLLKGSSLYANRIVFPDVPINGNGEKKRDFYIVFLSDTHFGSK
EFLEKEWEMFVRWLKGEVGGKKSQNLAEKVKYIVIAGDIVDGIGVYPGQEDDLAISDIYGQYEFAASHLDEIPKEIKIIV
SPGNHDAVRQAEPQPAFEGEIRSLFPKNVEHVGNPAYVDIEGVKVLIYHGRSIDDIISKIPRLSYDEPQKVMEELLKRRH
LSPIYGGRTPLAPEREDYLVIEDVPDILHCGHIHTYGTGFYRGVFMVNSSTWQAQTEFQKKVNLNPMPGNVAVYRPGGEV
IRLRFYGE

Specific function: Possesses two activities:a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase

COG id: COG1311

COG function: function code L; Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA polymerase delta/II small subunit family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DP2S_ARCFU (O28484)

Other databases:

- EMBL:   AE000782
- PIR:   E69473
- RefSeq:   NP_070618.1
- ProteinModelPortal:   O28484
- GeneID:   1485013
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1790
- NMPDR:   fig|224325.1.peg.1779
- TIGR:   AF_1790
- HOGENOM:   HBG512811
- OMA:   CPIAPEH
- ProtClustDB:   PRK04036
- BioCyc:   AFUL224325:AF_1790-MONOMER
- BRENDA:   2.7.7.7
- HAMAP:   MF_00325
- InterPro:   IPR004843
- InterPro:   IPR012340
- InterPro:   IPR004365
- InterPro:   IPR011149
- Gene3D:   G3DSA:2.40.50.140
- PIRSF:   PIRSF000803

Pfam domain/function: PF00149 Metallophos; PF01336 tRNA_anti

EC number: =2.7.7.7

Molecular weight: Translated: 54586; Mature: 54586

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIKNIDAATVAKKFLVRGYNIDPKAAELICKSGLFSDELVDKICRIANGGFIIEKSVVE
CEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEHHHHH
EFLRNLSNLKPATLTPRPEERKVEEVKASCIALKVIKDITGKSSCQGNVEDFLMYFNSRL
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
EKLSRIIRSRVNTTPIAHAGKVRGNVSVVGMVNEVYERGDKCYIRLEDTTGTITCVATGK
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHCCCEEEEEEECCCCEEEEEEECC
NAEVARELLGDEVIGVTGLLKGSSLYANRIVFPDVPINGNGEKKRDFYIVFLSDTHFGSK
CHHHHHHHHCCCCEEHHHEECCCCEEECEEECCCCCCCCCCCCCCEEEEEEEECCCCCHH
EFLEKEWEMFVRWLKGEVGGKKSQNLAEKVKYIVIAGDIVDGIGVYPGQEDDLAISDIYG
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHCEEEEEECCHHCCCCCCCCCCCCEEHHHHHC
QYEFAASHLDEIPKEIKIIVSPGNHDAVRQAEPQPAFEGEIRSLFPKNVEHVGNPAYVDI
HHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCCCCCCCCHHHHHCCCCHHHCCCCCEEEE
EGVKVLIYHGRSIDDIISKIPRLSYDEPQKVMEELLKRRHLSPIYGGRTPLAPEREDYLV
CCEEEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
IEDVPDILHCGHIHTYGTGFYRGVFMVNSSTWQAQTEFQKKVNLNPMPGNVAVYRPGGEV
EECCCHHHHCCCEEECCCCEEEEEEEEECCCCCHHHHHHHHCCCCCCCCCEEEECCCCCE
IRLRFYGE
EEEEEECC
>Mature Secondary Structure
MVIKNIDAATVAKKFLVRGYNIDPKAAELICKSGLFSDELVDKICRIANGGFIIEKSVVE
CEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEHHHHH
EFLRNLSNLKPATLTPRPEERKVEEVKASCIALKVIKDITGKSSCQGNVEDFLMYFNSRL
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
EKLSRIIRSRVNTTPIAHAGKVRGNVSVVGMVNEVYERGDKCYIRLEDTTGTITCVATGK
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHCCCEEEEEEECCCCEEEEEEECC
NAEVARELLGDEVIGVTGLLKGSSLYANRIVFPDVPINGNGEKKRDFYIVFLSDTHFGSK
CHHHHHHHHCCCCEEHHHEECCCCEEECEEECCCCCCCCCCCCCCEEEEEEEECCCCCHH
EFLEKEWEMFVRWLKGEVGGKKSQNLAEKVKYIVIAGDIVDGIGVYPGQEDDLAISDIYG
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHCEEEEEECCHHCCCCCCCCCCCCEEHHHHHC
QYEFAASHLDEIPKEIKIIVSPGNHDAVRQAEPQPAFEGEIRSLFPKNVEHVGNPAYVDI
HHHHHHHHHHHCCCEEEEEECCCCCCHHHCCCCCCCCCCHHHHHCCCCHHHCCCCCEEEE
EGVKVLIYHGRSIDDIISKIPRLSYDEPQKVMEELLKRRHLSPIYGGRTPLAPEREDYLV
CCEEEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEE
IEDVPDILHCGHIHTYGTGFYRGVFMVNSSTWQAQTEFQKKVNLNPMPGNVAVYRPGGEV
EECCCHHHHCCCEEECCCCEEEEEEEEECCCCCHHHHHHHHCCCCCCCCCEEEECCCCCE
IRLRFYGE
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475