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Identifier: 11499342

GI number: 11499342

Start: 1574864

End: 1575664

Strand: Reverse

Name: Not Available

Synonym: AF1753

Alternate gene names: 11499342

Gene position: 1575664-1574864 (Counterclockwise)

Preceding gene: 11499343

Following gene: 11499341

Centisome position: 72.33

GC content: 49.44

Gene sequence:

>801_bases
ATGACTCTAAGAACGAAAGACGGGCTCACTCTCTACACTCGAAGGTGGGATGTTGAGTCTCCAAGAGCTGTAATCTGTCT
TGTTCATGGTCTGGGGGAGCACTCTGGAAGATACGAGCACGTTGCAAGGTTTTTCAATGAGAATGGCATCTCCTTTGCAG
CTTTTGATTTGAGGGGGCATGGAAGGTCGGAGGGGAAGAGGGGGCATGCTGAATATCAGCAGTTAATGGATGACATCACC
CTTTTCCTCCAAAGTTTGGATTACGACTGCCCGAAGATACTCTACGGCCACAGCATGGGCGGGAATCTCGCTCTGAACTA
CATCCTGAGATACGACCCCGACATTGCGGGAGGTATAATTTCCGCTCCCTTCCTTGCTCTGCCAAAGGAGCTACCAAAAC
ACCTGTTTTTCATTCTGAAGCTCCTCAACGTTGTTGCTCCTTCAATTCAGCTTTCAAATGGCATCGACCCAAACTTAATC
AGCAGAGATAGGGAAGTTGTTGAGGCCTATGTTTCTGACCCCCTCGTCCACGACAAAATCTCCCCTCGATTCATTCTGCA
ATCTCTTGAAGCGGGAAAATGGGCGCTGGAGAATGCAGACAGGCTGAGAAAGCCCATTCTTCTGATACACGGAACTGCTG
ACCAAATAACCTCCTACAGAGCAAGTCAGGAGTTTGCAAAAAGGGCTGGGGAGCTTTGCAAGTTTGTCAGCTACGAAGGC
TTTTATCACGAGCCCCACAACGAGCCCGAGAAGGAGAGGGTGCTTGCTGACATGCTGAAGTGGATAGAGGAGGTGATTTA
G

Upstream 100 bases:

>100_bases
CTTCGGTCTGTCAATCTTTGCAGCAGTGCTTTCTTACTACCTTCTGAGGCTTGCTGTGTGACTGCGAAAAATTTTAATCT
TTTTTCTGCCAAGACCAGAC

Downstream 100 bases:

>100_bases
TGCATTTTCTCGGCATCGATGCGGGAACGACAGGAGTGACTGTGGGAGTTTACGATGCCGATGGAAATCTGGTTGCAAAG
AGCTACTCCGAGTTTGAAAC

Product: lysophospholipase

Products: NA

Alternate protein names: Bacilysocin biosynthesis protein ytpA [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MTLRTKDGLTLYTRRWDVESPRAVICLVHGLGEHSGRYEHVARFFNENGISFAAFDLRGHGRSEGKRGHAEYQQLMDDIT
LFLQSLDYDCPKILYGHSMGGNLALNYILRYDPDIAGGIISAPFLALPKELPKHLFFILKLLNVVAPSIQLSNGIDPNLI
SRDREVVEAYVSDPLVHDKISPRFILQSLEAGKWALENADRLRKPILLIHGTADQITSYRASQEFAKRAGELCKFVSYEG
FYHEPHNEPEKERVLADMLKWIEEVI

Sequences:

>Translated_266_residues
MTLRTKDGLTLYTRRWDVESPRAVICLVHGLGEHSGRYEHVARFFNENGISFAAFDLRGHGRSEGKRGHAEYQQLMDDIT
LFLQSLDYDCPKILYGHSMGGNLALNYILRYDPDIAGGIISAPFLALPKELPKHLFFILKLLNVVAPSIQLSNGIDPNLI
SRDREVVEAYVSDPLVHDKISPRFILQSLEAGKWALENADRLRKPILLIHGTADQITSYRASQEFAKRAGELCKFVSYEG
FYHEPHNEPEKERVLADMLKWIEEVI
>Mature_265_residues
TLRTKDGLTLYTRRWDVESPRAVICLVHGLGEHSGRYEHVARFFNENGISFAAFDLRGHGRSEGKRGHAEYQQLMDDITL
FLQSLDYDCPKILYGHSMGGNLALNYILRYDPDIAGGIISAPFLALPKELPKHLFFILKLLNVVAPSIQLSNGIDPNLIS
RDREVVEAYVSDPLVHDKISPRFILQSLEAGKWALENADRLRKPILLIHGTADQITSYRASQEFAKRAGELCKFVSYEGF
YHEPHNEPEKERVLADMLKWIEEVI

Specific function: Phospholipase involved in the biosynthesis of the antibiotic bacilysocin. It probably catalyzes the hydrolysis of the 2-sn-acyl moiety of phosphatidylglycerol to produce bacilysocin (lysophosphatidylglycerol). Is also able to catalyze the hydrolysis react

COG id: COG2267

COG function: function code I; Lysophospholipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily [H]

Homologues:

Organism=Homo sapiens, GI51242953, Length=274, Percent_Identity=32.8467153284672, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI6005786, Length=274, Percent_Identity=32.8467153284672, Blast_Score=117, Evalue=9e-27,
Organism=Escherichia coli, GI1787678, Length=282, Percent_Identity=23.4042553191489, Blast_Score=74, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322756, Length=285, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR022742 [H]

Pfam domain/function: PF12146 Hydrolase_4 [H]

EC number: NA

Molecular weight: Translated: 30277; Mature: 30146

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRTKDGLTLYTRRWDVESPRAVICLVHGLGEHSGRYEHVARFFNENGISFAAFDLRGH
CCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCC
GRSEGKRGHAEYQQLMDDITLFLQSLDYDCPKILYGHSMGGNLALNYILRYDPDIAGGII
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCEEEEHEEECCCCCCHHH
SAPFLALPKELPKHLFFILKLLNVVAPSIQLSNGIDPNLISRDREVVEAYVSDPLVHDKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCCHHHCCC
SPRFILQSLEAGKWALENADRLRKPILLIHGTADQITSYRASQEFAKRAGELCKFVSYEG
CHHHHHHHHHCCCHHHHCHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FYHEPHNEPEKERVLADMLKWIEEVI
CCCCCCCCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TLRTKDGLTLYTRRWDVESPRAVICLVHGLGEHSGRYEHVARFFNENGISFAAFDLRGH
CCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCC
GRSEGKRGHAEYQQLMDDITLFLQSLDYDCPKILYGHSMGGNLALNYILRYDPDIAGGII
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCEEEEHEEECCCCCCHHH
SAPFLALPKELPKHLFFILKLLNVVAPSIQLSNGIDPNLISRDREVVEAYVSDPLVHDKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCCHHHCCC
SPRFILQSLEAGKWALENADRLRKPILLIHGTADQITSYRASQEFAKRAGELCKFVSYEG
CHHHHHHHHHCCCHHHHCHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FYHEPHNEPEKERVLADMLKWIEEVI
CCCCCCCCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]