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Identifier: 11499341

GI number: 11499341

Start: 1573404

End: 1574885

Strand: Reverse

Name: Not Available

Synonym: AF1752

Alternate gene names: 11499341

Gene position: 1574885-1573404 (Counterclockwise)

Preceding gene: 11499342

Following gene: 11499340

Centisome position: 72.3

GC content: 53.78

Gene sequence:

>1482_bases
GTGGATAGAGGAGGTGATTTAGTGCATTTTCTCGGCATCGATGCGGGAACGACAGGAGTGACTGTGGGAGTTTACGATGC
CGATGGAAATCTGGTTGCAAAGAGCTACTCCGAGTTTGAAACCTACTACCCCCAGCCGGGATGGGTCGAGCAGGATGCCG
AGCACTGGTGGAACAGCATCATCGATGCCTGCAGGCAGGCGGTGAAGATTGCCAAAGCCTCTGACAGCATAGCAGCTATA
GCTGTTGCAAATCAGAGGGAAACAATCGTCCCCGTTGGCAGAGACGGTGAGCCTGTAAGCAGAGCGATAGTCTGGCAGGA
CAGGAGGTGCAGGGAGGAGGTTGAGCTGATAAAGGAGAGAATCGGGGAGGAAAGGGTTGCAAAAATTACCGGACTAAAGC
CGGACCCCTACTTCTCCCTGCCGAAAATTCTCTGGTGGATGAGGAACAGGCCTGAAGTCATAGAGAAAAGCTGGAAGCTG
ATGCTCGTCCACGACTACATCGTTTACAGGCTAACCGGAGAGGTTGTGACGGACTACTCAAACGCCTCAAGGACGATGCT
CCTCGACCTGAATTCGAGGAAGTGGTGCGATGAAATCGCTGCCGAATTCAACCTTGACCTGTCTCTGATGCCTGATCTCG
TCAATTCGGGAGAGGTTGTGGGGGAGATCAGGGGGAACGTGGCGGAGAAGCTTGGCATAAGTTCGAATCCGGTAGTGGTT
GCAGGTGGGGGAGACCAGCAGTGCTCCGCCCTCGCTCAGGGTGTTGTTGAGGAGGGGAGCGTGAAGTCCACGACGGGAAC
GGGGACCTTCATGGTTGCACCTGTGGAGAAAGTCAGAGGCCACGGAGACATCATATACTCCGCCCACGTTCTGCCCGGCA
TCAATGTGGGCGAGGTGAGCATCTTCACCACGGGCAGCCTGCTATCGTGGGTTAAGAAAGCCTTCTATCACGGTGAGGGC
TATGATGTGATTAACGAGGAGGCTGAGAAGTCAGGAGTGGGGGCGAGAGGTGTGTTCATCCTGCCCTTCTTTTCCGGAGC
TGGCTGTCCCCACTGGAATCCGGAGGCGAAGGGGGTTATATTCGGCTTAACTCTTGCCCACAACAGAGGAGACATTGCGA
GGGCTGTGATGGAGGCAGTAGCTTTCGAGGTGAGAAGCAACATTGAGGTGATGGAGAATAAGGGAATCAGCATTGAGGAG
CTTCGCCTTGATGGCGGAGCAGCGAACAGCAGGCTTTGGAACCAGATTTTTGCTGACGTTACCGGCAGAAAATGCCTCGT
TTCATCTGATGTGGAAGCGACTGCGAGGGGGGCGGCAATTCTTGCAGCTTCCGGATCTGACAGCTTCAATGGTATTGACG
ACGCTCTTACAACCTTCCTACCCGATTTCACAGAGGTTATGCCGTCCGAGGATGGGATGGGAAAATACGAGGAGATTTAT
AGCAAATATGTCCAGATTAGGGATGCATACTTGAAAGGCTGA

Upstream 100 bases:

>100_bases
AAAGGGCTGGGGAGCTTTGCAAGTTTGTCAGCTACGAAGGCTTTTATCACGAGCCCCACAACGAGCCCGAGAAGGAGAGG
GTGCTTGCTGACATGCTGAA

Downstream 100 bases:

>100_bases
GGTGATAGAGTGCCTGTACTGCTGATTGTTGTTGACGGCCTATCAGACAGGCCCATCGACGGTAAAACCCCGCTGAGTGT
TGCGAGAAAGCCAAACCTCG

Product: carbohydrate kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MDRGGDLVHFLGIDAGTTGVTVGVYDADGNLVAKSYSEFETYYPQPGWVEQDAEHWWNSIIDACRQAVKIAKASDSIAAI
AVANQRETIVPVGRDGEPVSRAIVWQDRRCREEVELIKERIGEERVAKITGLKPDPYFSLPKILWWMRNRPEVIEKSWKL
MLVHDYIVYRLTGEVVTDYSNASRTMLLDLNSRKWCDEIAAEFNLDLSLMPDLVNSGEVVGEIRGNVAEKLGISSNPVVV
AGGGDQQCSALAQGVVEEGSVKSTTGTGTFMVAPVEKVRGHGDIIYSAHVLPGINVGEVSIFTTGSLLSWVKKAFYHGEG
YDVINEEAEKSGVGARGVFILPFFSGAGCPHWNPEAKGVIFGLTLAHNRGDIARAVMEAVAFEVRSNIEVMENKGISIEE
LRLDGGAANSRLWNQIFADVTGRKCLVSSDVEATARGAAILAASGSDSFNGIDDALTTFLPDFTEVMPSEDGMGKYEEIY
SKYVQIRDAYLKG

Sequences:

>Translated_493_residues
MDRGGDLVHFLGIDAGTTGVTVGVYDADGNLVAKSYSEFETYYPQPGWVEQDAEHWWNSIIDACRQAVKIAKASDSIAAI
AVANQRETIVPVGRDGEPVSRAIVWQDRRCREEVELIKERIGEERVAKITGLKPDPYFSLPKILWWMRNRPEVIEKSWKL
MLVHDYIVYRLTGEVVTDYSNASRTMLLDLNSRKWCDEIAAEFNLDLSLMPDLVNSGEVVGEIRGNVAEKLGISSNPVVV
AGGGDQQCSALAQGVVEEGSVKSTTGTGTFMVAPVEKVRGHGDIIYSAHVLPGINVGEVSIFTTGSLLSWVKKAFYHGEG
YDVINEEAEKSGVGARGVFILPFFSGAGCPHWNPEAKGVIFGLTLAHNRGDIARAVMEAVAFEVRSNIEVMENKGISIEE
LRLDGGAANSRLWNQIFADVTGRKCLVSSDVEATARGAAILAASGSDSFNGIDDALTTFLPDFTEVMPSEDGMGKYEEIY
SKYVQIRDAYLKG
>Mature_493_residues
MDRGGDLVHFLGIDAGTTGVTVGVYDADGNLVAKSYSEFETYYPQPGWVEQDAEHWWNSIIDACRQAVKIAKASDSIAAI
AVANQRETIVPVGRDGEPVSRAIVWQDRRCREEVELIKERIGEERVAKITGLKPDPYFSLPKILWWMRNRPEVIEKSWKL
MLVHDYIVYRLTGEVVTDYSNASRTMLLDLNSRKWCDEIAAEFNLDLSLMPDLVNSGEVVGEIRGNVAEKLGISSNPVVV
AGGGDQQCSALAQGVVEEGSVKSTTGTGTFMVAPVEKVRGHGDIIYSAHVLPGINVGEVSIFTTGSLLSWVKKAFYHGEG
YDVINEEAEKSGVGARGVFILPFFSGAGCPHWNPEAKGVIFGLTLAHNRGDIARAVMEAVAFEVRSNIEVMENKGISIEE
LRLDGGAANSRLWNQIFADVTGRKCLVSSDVEATARGAAILAASGSDSFNGIDDALTTFLPDFTEVMPSEDGMGKYEEIY
SKYVQIRDAYLKG

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI41393575, Length=431, Percent_Identity=31.0904872389791, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI42794763, Length=434, Percent_Identity=29.4930875576037, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI189409120, Length=434, Percent_Identity=29.7235023041475, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI4504007, Length=434, Percent_Identity=29.7235023041475, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI88196792, Length=465, Percent_Identity=26.2365591397849, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI164663828, Length=533, Percent_Identity=24.390243902439, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1790361, Length=462, Percent_Identity=33.7662337662338, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1789987, Length=487, Percent_Identity=30.3901437371663, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1787789, Length=513, Percent_Identity=27.4853801169591, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1790005, Length=489, Percent_Identity=24.9488752556237, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1789168, Length=466, Percent_Identity=25.3218884120172, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790338, Length=436, Percent_Identity=20.6422018348624, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17535599, Length=447, Percent_Identity=32.4384787472036, Blast_Score=199, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6321755, Length=491, Percent_Identity=26.4765784114053, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI17864214, Length=467, Percent_Identity=30.1927194860814, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24655555, Length=474, Percent_Identity=30.379746835443, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24655560, Length=474, Percent_Identity=30.379746835443, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24655570, Length=474, Percent_Identity=30.379746835443, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24655574, Length=474, Percent_Identity=30.379746835443, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24655565, Length=474, Percent_Identity=30.379746835443, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24654573, Length=411, Percent_Identity=30.4136253041363, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24657106, Length=528, Percent_Identity=22.3484848484848, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24657102, Length=528, Percent_Identity=22.3484848484848, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24656367, Length=460, Percent_Identity=23.2608695652174, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19922058, Length=494, Percent_Identity=23.6842105263158, Blast_Score=89, Evalue=8e-18,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 53828; Mature: 53828

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRGGDLVHFLGIDAGTTGVTVGVYDADGNLVAKSYSEFETYYPQPGWVEQDAEHWWNSI
CCCCCCEEEEEECCCCCCCEEEEEEECCCCEEECCHHHHHHCCCCCCCCCHHHHHHHHHH
IDACRQAVKIAKASDSIAAIAVANQRETIVPVGRDGEPVSRAIVWQDRRCREEVELIKER
HHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHEEECHHHHHHHHHHHHHH
IGEERVAKITGLKPDPYFSLPKILWWMRNRPEVIEKSWKLMLVHDYIVYRLTGEVVTDYS
HCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHCCCCEEEEEEEEEEEEECHHHCCCC
NASRTMLLDLNSRKWCDEIAAEFNLDLSLMPDLVNSGEVVGEIRGNVAEKLGISSNPVVV
CCCCEEEEECCCCHHHHHHHHHHCCCCEECCHHCCCCCEEHHHHHHHHHHCCCCCCCEEE
AGGGDQQCSALAQGVVEEGSVKSTTGTGTFMVAPVEKVRGHGDIIYSAHVLPGINVGEVS
ECCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHCCCCCEEEEEEECCCCCCCEEE
IFTTGSLLSWVKKAFYHGEGYDVINEEAEKSGVGARGVFILPFFSGAGCPHWNPEAKGVI
EEECHHHHHHHHHHHHCCCCCCHHCCHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCEEE
FGLTLAHNRGDIARAVMEAVAFEVRSNIEVMENKGISIEELRLDGGAANSRLWNQIFADV
EEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHHHC
TGRKCLVSSDVEATARGAAILAASGSDSFNGIDDALTTFLPDFTEVMPSEDGMGKYEEIY
CCCEEEEECCCCHHCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHCCCCCCCCHHHHHH
SKYVQIRDAYLKG
HHHHHHHHHHCCC
>Mature Secondary Structure
MDRGGDLVHFLGIDAGTTGVTVGVYDADGNLVAKSYSEFETYYPQPGWVEQDAEHWWNSI
CCCCCCEEEEEECCCCCCCEEEEEEECCCCEEECCHHHHHHCCCCCCCCCHHHHHHHHHH
IDACRQAVKIAKASDSIAAIAVANQRETIVPVGRDGEPVSRAIVWQDRRCREEVELIKER
HHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCHHHHEEECHHHHHHHHHHHHHH
IGEERVAKITGLKPDPYFSLPKILWWMRNRPEVIEKSWKLMLVHDYIVYRLTGEVVTDYS
HCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHCCCCEEEEEEEEEEEEECHHHCCCC
NASRTMLLDLNSRKWCDEIAAEFNLDLSLMPDLVNSGEVVGEIRGNVAEKLGISSNPVVV
CCCCEEEEECCCCHHHHHHHHHHCCCCEECCHHCCCCCEEHHHHHHHHHHCCCCCCCEEE
AGGGDQQCSALAQGVVEEGSVKSTTGTGTFMVAPVEKVRGHGDIIYSAHVLPGINVGEVS
ECCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHCCCCCEEEEEEECCCCCCCEEE
IFTTGSLLSWVKKAFYHGEGYDVINEEAEKSGVGARGVFILPFFSGAGCPHWNPEAKGVI
EEECHHHHHHHHHHHHCCCCCCHHCCHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCEEE
FGLTLAHNRGDIARAVMEAVAFEVRSNIEVMENKGISIEELRLDGGAANSRLWNQIFADV
EEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHHHC
TGRKCLVSSDVEATARGAAILAASGSDSFNGIDDALTTFLPDFTEVMPSEDGMGKYEEIY
CCCEEEEECCCCHHCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHCCCCCCCCHHHHHH
SKYVQIRDAYLKG
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA