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The map label for this gene is nrd

Identifier: 11499254

GI number: 11499254

Start: 1492471

End: 1494729

Strand: Reverse

Name: nrd

Synonym: AF1664

Alternate gene names: 11499254

Gene position: 1494729-1492471 (Counterclockwise)

Preceding gene: 11499264

Following gene: 11499253

Centisome position: 68.62

GC content: 52.1

Gene sequence:

>2259_bases
ATGAAGCTCAATCGTACTGCTGAAACTGTGCTCAGAAAGAGGTATCTTCTCAAGGATGATGAAGGTAACGTAATTGAGAC
TCCAGAAGAGATGTGCTGGAGGGTTGCCAGGGCAATTGCAAAGGCTGAGGAGAATTACGGAAACAATGCTGAAGAGTGGG
CTGAAAAGTTCTTCAAGCTCCTCTGGGAGCAGAAGTTCATGCCCAACTCCCCAACGCTGATGAATGCGGGGACGGAGCTG
AATCAGCTTTCTGCATGCTTCGTCATCCCCGTTGAGGACTCCATTGACGGCATTTTCAAGGCCCTCTGGGATATGGCGAA
GGTTCAAAAGAGCGGGGGAGGGACGGGATTCAGCTTTTCAAGGCTGAGACCGAAGGGAGATATAGTAAAATCCACAATGG
GCGTTGCAAGCGGACCGGTAAGCTTCATGAAAATATTTGATGCTGCGACGGAGCAGATAAAGCAGGGAGGGAGGAGAAGA
GGGGCAAACATGGGCGTTCTGAACGTCCACCACCCGGACATTGAGGAATTCATAAAGGCGAAATGGGAGGAGGGGGTGCT
GAGAAACTTCAACATCAGCGTTGCCGCAACCGACGCCTTCATGGAAGCTTTGAAGAAAGATGATGATTACGACCTCATCA
ACCCCAGAACGGGGGAGGTTGTAAGGAGAGTTCCCGCCAGAAAGATATTCAATTTGATTGTGGAGGGAGCATGGCGCAAC
GGAGAGCCGGGAATGATTTTCATCGACACCATAAACCGCTTCAACCCCACTCCGCACGTGGGACAGATTGAAGCAACAAA
CCCCTGCGGAGAGCAACCGCTCCTGCCCTACGAATCCTGCAACCTTGGCAGCATAAACCTCGCAAAGTTCGTTAAAGATG
GGGAAATCGACTGGGATGGGCTCAGGGAGGTTGTCTGGATTGCCGTGAGGTTTTTGGATGACGTTATCGATGTCAACAGC
TACCCCATTCCCGAAATCGAGCAGATGACCAAAGCCAACCGCAAAATAGGTCTCGGAGTTATGGGCTGGGCTGACATGCT
CTTTCTGCTCAACATCCCCTACGACAGCGATGAAGCCATCCAGCTTGCTGAGAAGGTGATGAAGTTCATTCAGGAGGAAA
GTCACAGGGCTTCGCAGCAGCTGGCGGAGGAGAGGGGTGTTTTCCCCAACTGGAAGGGCAGCGTGTGGGAGAAGAAGGGA
ATAAAGATGAGGAACGCAACGACAACAACAATCGCACCAACGGGAACGATAAGCATTATCGCTGGCTGTTCAAGCGGAAT
AGAGCCGATTTTCGCTTTAGCATACAAGAGAACGAACATTCTTGACGGAGAAGAGTTCTTCGAGATAAATGAGATATTCG
AGGAAGTTTTAAGGAGAAGAGGGCTGTACACAGATGAGCTGATTGAGAAAGTTGCCGAAAAAGGCAGCATTCAGGAAATA
GAGGAGATTCCCGAGGACATAAGGAGGGTCTTCAAGTGCGCTCTCGACATCTCTCCAGAGTGGCATGTGAGAATGCAGGC
GGCCTTCCAGAAGTACACGGACAATGCGGTCAGCAAAACCATAAATATGCCGAACTCTGCTACGCGGAAAGACGTTGAGA
AGGCTTTCCTGCTGGCATACGAGCTTGGATGTAAGGGCATAACCGTTTACAGAGATGGCAGCAGAGAGGAGCAGGTTCTC
AGAATAAAGAAGGCTGAGGAGGAGAAGAAGGAGGCGAAGCCGAGACCCCCTGCCAAGTACATCGAGCCGAGGCCGAGGCC
GAGGATAACCACCGGCAGAACGATTGAGACCAGAACAGGCTGCGGTTCCCTGTATGTGACCATCAACGAGGACGAGTACG
GGATTGCCGAAGTCTTCGTGCAGCTTGGAAAAAGCGGAGGCTGCGCTGCGTCGCAGACAGAGGCAATGGGGAGGCTGCTT
TCAGTCGCGCTTAGGAGTTGGATTGACCCTGAGGTGCTGATAAGGCAGCTCAAGAACATACGCTGTCCCTCGCCAGGATT
CGACAACGGAGAGGTCATAACATCCTGCGCGGATGGAGTGGCAAAGGTTCTCGAAAAGCACCTAAAGGGAGAGTACAAGA
AAATAAAGTTCGAAGTTGAGGGAATCAAGCCCCTCACGGCCTTCACCGGCGAGGCTGAGGAGAGAGAGGAGCCGAGGACG
AAGCAGATTGGCGGAGTGTGTCCTGAATGCGGGAATGTTCTTGAGTACGGGGAGGGTTGCGCAACCTGCAGGTTCTGCGG
GTTTACGAGGTGCGGTTGA

Upstream 100 bases:

>100_bases
TGAGATGCTGTAAGAAAAATTTTTCTATTCAATTTTTCCTTCAATAGATGCTCTCGAAGGGCAGGCAAAATTGTTTTATC
TTTCTTATCTACCATAACTG

Downstream 100 bases:

>100_bases
GGGCTTATAAAAATAATTTTTATACAATTAATTTAAGGCTCTCATCATTATGGTAGTTACAATTCAACAAAATCTATAAA
TATCATTAAAAACATAAACA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 752; Mature: 752

Protein sequence:

>752_residues
MKLNRTAETVLRKRYLLKDDEGNVIETPEEMCWRVARAIAKAEENYGNNAEEWAEKFFKLLWEQKFMPNSPTLMNAGTEL
NQLSACFVIPVEDSIDGIFKALWDMAKVQKSGGGTGFSFSRLRPKGDIVKSTMGVASGPVSFMKIFDAATEQIKQGGRRR
GANMGVLNVHHPDIEEFIKAKWEEGVLRNFNISVAATDAFMEALKKDDDYDLINPRTGEVVRRVPARKIFNLIVEGAWRN
GEPGMIFIDTINRFNPTPHVGQIEATNPCGEQPLLPYESCNLGSINLAKFVKDGEIDWDGLREVVWIAVRFLDDVIDVNS
YPIPEIEQMTKANRKIGLGVMGWADMLFLLNIPYDSDEAIQLAEKVMKFIQEESHRASQQLAEERGVFPNWKGSVWEKKG
IKMRNATTTTIAPTGTISIIAGCSSGIEPIFALAYKRTNILDGEEFFEINEIFEEVLRRRGLYTDELIEKVAEKGSIQEI
EEIPEDIRRVFKCALDISPEWHVRMQAAFQKYTDNAVSKTINMPNSATRKDVEKAFLLAYELGCKGITVYRDGSREEQVL
RIKKAEEEKKEAKPRPPAKYIEPRPRPRITTGRTIETRTGCGSLYVTINEDEYGIAEVFVQLGKSGGCAASQTEAMGRLL
SVALRSWIDPEVLIRQLKNIRCPSPGFDNGEVITSCADGVAKVLEKHLKGEYKKIKFEVEGIKPLTAFTGEAEEREEPRT
KQIGGVCPECGNVLEYGEGCATCRFCGFTRCG

Sequences:

>Translated_752_residues
MKLNRTAETVLRKRYLLKDDEGNVIETPEEMCWRVARAIAKAEENYGNNAEEWAEKFFKLLWEQKFMPNSPTLMNAGTEL
NQLSACFVIPVEDSIDGIFKALWDMAKVQKSGGGTGFSFSRLRPKGDIVKSTMGVASGPVSFMKIFDAATEQIKQGGRRR
GANMGVLNVHHPDIEEFIKAKWEEGVLRNFNISVAATDAFMEALKKDDDYDLINPRTGEVVRRVPARKIFNLIVEGAWRN
GEPGMIFIDTINRFNPTPHVGQIEATNPCGEQPLLPYESCNLGSINLAKFVKDGEIDWDGLREVVWIAVRFLDDVIDVNS
YPIPEIEQMTKANRKIGLGVMGWADMLFLLNIPYDSDEAIQLAEKVMKFIQEESHRASQQLAEERGVFPNWKGSVWEKKG
IKMRNATTTTIAPTGTISIIAGCSSGIEPIFALAYKRTNILDGEEFFEINEIFEEVLRRRGLYTDELIEKVAEKGSIQEI
EEIPEDIRRVFKCALDISPEWHVRMQAAFQKYTDNAVSKTINMPNSATRKDVEKAFLLAYELGCKGITVYRDGSREEQVL
RIKKAEEEKKEAKPRPPAKYIEPRPRPRITTGRTIETRTGCGSLYVTINEDEYGIAEVFVQLGKSGGCAASQTEAMGRLL
SVALRSWIDPEVLIRQLKNIRCPSPGFDNGEVITSCADGVAKVLEKHLKGEYKKIKFEVEGIKPLTAFTGEAEEREEPRT
KQIGGVCPECGNVLEYGEGCATCRFCGFTRCG
>Mature_752_residues
MKLNRTAETVLRKRYLLKDDEGNVIETPEEMCWRVARAIAKAEENYGNNAEEWAEKFFKLLWEQKFMPNSPTLMNAGTEL
NQLSACFVIPVEDSIDGIFKALWDMAKVQKSGGGTGFSFSRLRPKGDIVKSTMGVASGPVSFMKIFDAATEQIKQGGRRR
GANMGVLNVHHPDIEEFIKAKWEEGVLRNFNISVAATDAFMEALKKDDDYDLINPRTGEVVRRVPARKIFNLIVEGAWRN
GEPGMIFIDTINRFNPTPHVGQIEATNPCGEQPLLPYESCNLGSINLAKFVKDGEIDWDGLREVVWIAVRFLDDVIDVNS
YPIPEIEQMTKANRKIGLGVMGWADMLFLLNIPYDSDEAIQLAEKVMKFIQEESHRASQQLAEERGVFPNWKGSVWEKKG
IKMRNATTTTIAPTGTISIIAGCSSGIEPIFALAYKRTNILDGEEFFEINEIFEEVLRRRGLYTDELIEKVAEKGSIQEI
EEIPEDIRRVFKCALDISPEWHVRMQAAFQKYTDNAVSKTINMPNSATRKDVEKAFLLAYELGCKGITVYRDGSREEQVL
RIKKAEEEKKEAKPRPPAKYIEPRPRPRITTGRTIETRTGCGSLYVTINEDEYGIAEVFVQLGKSGGCAASQTEAMGRLL
SVALRSWIDPEVLIRQLKNIRCPSPGFDNGEVITSCADGVAKVLEKHLKGEYKKIKFEVEGIKPLTAFTGEAEEREEPRT
KQIGGVCPECGNVLEYGEGCATCRFCGFTRCG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=579, Percent_Identity=31.0880829015544, Blast_Score=239, Evalue=5e-63,
Organism=Escherichia coli, GI1789030, Length=578, Percent_Identity=25.7785467128028, Blast_Score=152, Evalue=7e-38,
Organism=Escherichia coli, GI2367133, Length=651, Percent_Identity=21.9662058371736, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17555242, Length=577, Percent_Identity=30.155979202773, Blast_Score=230, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322123, Length=574, Percent_Identity=28.2229965156794, Blast_Score=219, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320914, Length=580, Percent_Identity=27.9310344827586, Blast_Score=212, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17352481, Length=579, Percent_Identity=30.3972366148532, Blast_Score=233, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 84457; Mature: 84457

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNRTAETVLRKRYLLKDDEGNVIETPEEMCWRVARAIAKAEENYGNNAEEWAEKFFKL
CCCCHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LWEQKFMPNSPTLMNAGTELNQLSACFVIPVEDSIDGIFKALWDMAKVQKSGGGTGFSFS
HHHHHCCCCCCCEEECCCCHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
RLRPKGDIVKSTMGVASGPVSFMKIFDAATEQIKQGGRRRGANMGVLNVHHPDIEEFIKA
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHCCCCCCEEECCCCCHHHHHHH
KWEEGVLRNFNISVAATDAFMEALKKDDDYDLINPRTGEVVRRVPARKIFNLIVEGAWRN
HHHCCCHHCCCEEEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GEPGMIFIDTINRFNPTPHVGQIEATNPCGEQPLLPYESCNLGSINLAKFVKDGEIDWDG
CCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHH
LREVVWIAVRFLDDVIDVNSYPIPEIEQMTKANRKIGLGVMGWADMLFLLNIPYDSDEAI
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHEECCCCCHHHH
QLAEKVMKFIQEESHRASQQLAEERGVFPNWKGSVWEKKGIKMRNATTTTIAPTGTISII
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEECCCEEEECCCCCEEEE
AGCSSGIEPIFALAYKRTNILDGEEFFEINEIFEEVLRRRGLYTDELIEKVAEKGSIQEI
ECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHH
EEIPEDIRRVFKCALDISPEWHVRMQAAFQKYTDNAVSKTINMPNSATRKDVEKAFLLAY
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ELGCKGITVYRDGSREEQVLRIKKAEEEKKEAKPRPPAKYIEPRPRPRITTGRTIETRTG
HHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCEEEECCC
CGSLYVTINEDEYGIAEVFVQLGKSGGCAASQTEAMGRLLSVALRSWIDPEVLIRQLKNI
CCEEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
RCPSPGFDNGEVITSCADGVAKVLEKHLKGEYKKIKFEVEGIKPLTAFTGEAEEREEPRT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCCCHHHCCCCH
KQIGGVCPECGNVLEYGEGCATCRFCGFTRCG
HHHCCCCHHHCCHHHHCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MKLNRTAETVLRKRYLLKDDEGNVIETPEEMCWRVARAIAKAEENYGNNAEEWAEKFFKL
CCCCHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LWEQKFMPNSPTLMNAGTELNQLSACFVIPVEDSIDGIFKALWDMAKVQKSGGGTGFSFS
HHHHHCCCCCCCEEECCCCHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
RLRPKGDIVKSTMGVASGPVSFMKIFDAATEQIKQGGRRRGANMGVLNVHHPDIEEFIKA
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHCCCCCCEEECCCCCHHHHHHH
KWEEGVLRNFNISVAATDAFMEALKKDDDYDLINPRTGEVVRRVPARKIFNLIVEGAWRN
HHHCCCHHCCCEEEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GEPGMIFIDTINRFNPTPHVGQIEATNPCGEQPLLPYESCNLGSINLAKFVKDGEIDWDG
CCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHH
LREVVWIAVRFLDDVIDVNSYPIPEIEQMTKANRKIGLGVMGWADMLFLLNIPYDSDEAI
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHEECCCCCHHHH
QLAEKVMKFIQEESHRASQQLAEERGVFPNWKGSVWEKKGIKMRNATTTTIAPTGTISII
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEECCCEEEECCCCCEEEE
AGCSSGIEPIFALAYKRTNILDGEEFFEINEIFEEVLRRRGLYTDELIEKVAEKGSIQEI
ECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHH
EEIPEDIRRVFKCALDISPEWHVRMQAAFQKYTDNAVSKTINMPNSATRKDVEKAFLLAY
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ELGCKGITVYRDGSREEQVLRIKKAEEEKKEAKPRPPAKYIEPRPRPRITTGRTIETRTG
HHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCEEEECCC
CGSLYVTINEDEYGIAEVFVQLGKSGGCAASQTEAMGRLLSVALRSWIDPEVLIRQLKNI
CCEEEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
RCPSPGFDNGEVITSCADGVAKVLEKHLKGEYKKIKFEVEGIKPLTAFTGEAEEREEPRT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHCCCCHHHCCCCH
KQIGGVCPECGNVLEYGEGCATCRFCGFTRCG
HHHCCCCHHHCCHHHHCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]