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Identifier: 11499015

GI number: 11499015

Start: 1279005

End: 1279754

Strand: Reverse

Name: Not Available

Synonym: AF1420

Alternate gene names: 11499015

Gene position: 1279754-1279005 (Counterclockwise)

Preceding gene: 11499016

Following gene: 11499014

Centisome position: 58.75

GC content: 50.27

Gene sequence:

>750_bases
ATGGAGTGGTACTGGATAGGATTGCTTATAGTGGTGGTTCTGTTTCTCCTCTCCGCTGTAAGAATAGTCAAGGAGTACGA
GAGGGGAGTTATATTCAGGCTCGGAAGGCTTGTGGGGGCGAGGGGGCCGGGACTGTTCTTTATAATCCCGATTCTCGAAA
ACATGGTTGTCGTTGACCTCAGAACTGTAACGTACGATGTGCCATCGCAGGAGGTTGTTACAAAGGACAACGTGACGGTT
AAGGTTAATGCGGTGGTTTACTATAGAGTCGTTGATCCAGCAAAGGCCGTGACGGAGGTTTTTGACTACCAGTACGCCAC
CGCCCAGCTTGCCCAAACCACGCTCAGAAGCATAATTGGTCAGGCAGAGCTGGATGAGGTGCTTTCGGAGAGGGATAAGC
TCAACGTGAAGCTTCAGCAGATTATTGACGAGGAGACGAATCCGTGGGGCATTAAAGTGACCGCTGTGGAGATAAAGGAC
GTTGAACTGCCAGAGGAGATGCGCAGGATAATGGCGATGCAGGCTGAAGCTGAGAGAGAAAGGAGGTCGAAGATTATAAG
GGCTGAGGGTGAGTATCAGGCTGCAATGAAGCTGAGGGAAGCTGCTGACGTGCTTGCCCAGAGTGAAGGGGCGATTTTGC
TGAGGTATCTGCAAACTTTAAACGAGATTTCTGCGGAGCAGAACACGACCATCGTGATGCCCATTCCTGTGGAGCTTCTG
AAGTTCTTCGTGGAGAAAGCTAAAAGTTAA

Upstream 100 bases:

>100_bases
TCTGCTGGCAACGCTTCAAGACTTCGTGGATTCGTTTTCTGCAATATCTCAATATCAAACTCATGAAAAACCTTATTAGC
CTCTTGTTATTTATTTGCGT

Downstream 100 bases:

>100_bases
AAGCCCTTCCTCTTTTTTTGATTCATGAAAATAATTCCGTGTCCGTCTTCTCCGCTGCTGGCGAGGAGGGTTGCTGAAGC
CGCAGGAATTGAGATTGGAG

Product: membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MEWYWIGLLIVVVLFLLSAVRIVKEYERGVIFRLGRLVGARGPGLFFIIPILENMVVVDLRTVTYDVPSQEVVTKDNVTV
KVNAVVYYRVVDPAKAVTEVFDYQYATAQLAQTTLRSIIGQAELDEVLSERDKLNVKLQQIIDEETNPWGIKVTAVEIKD
VELPEEMRRIMAMQAEAERERRSKIIRAEGEYQAAMKLREAADVLAQSEGAILLRYLQTLNEISAEQNTTIVMPIPVELL
KFFVEKAKS

Sequences:

>Translated_249_residues
MEWYWIGLLIVVVLFLLSAVRIVKEYERGVIFRLGRLVGARGPGLFFIIPILENMVVVDLRTVTYDVPSQEVVTKDNVTV
KVNAVVYYRVVDPAKAVTEVFDYQYATAQLAQTTLRSIIGQAELDEVLSERDKLNVKLQQIIDEETNPWGIKVTAVEIKD
VELPEEMRRIMAMQAEAERERRSKIIRAEGEYQAAMKLREAADVLAQSEGAILLRYLQTLNEISAEQNTTIVMPIPVELL
KFFVEKAKS
>Mature_249_residues
MEWYWIGLLIVVVLFLLSAVRIVKEYERGVIFRLGRLVGARGPGLFFIIPILENMVVVDLRTVTYDVPSQEVVTKDNVTV
KVNAVVYYRVVDPAKAVTEVFDYQYATAQLAQTTLRSIIGQAELDEVLSERDKLNVKLQQIIDEETNPWGIKVTAVEIKD
VELPEEMRRIMAMQAEAERERRSKIIRAEGEYQAAMKLREAADVLAQSEGAILLRYLQTLNEISAEQNTTIVMPIPVELL
KFFVEKAKS

Specific function: Unknown

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family

Homologues:

Organism=Homo sapiens, GI38016911, Length=254, Percent_Identity=47.244094488189, Blast_Score=227, Evalue=7e-60,
Organism=Homo sapiens, GI21686995, Length=243, Percent_Identity=45.679012345679, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI221316744, Length=243, Percent_Identity=45.679012345679, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI7657615, Length=247, Percent_Identity=39.2712550607287, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI7305503, Length=192, Percent_Identity=39.0625, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI20149563, Length=157, Percent_Identity=34.3949044585987, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI38016907, Length=66, Percent_Identity=46.969696969697, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786697, Length=278, Percent_Identity=33.0935251798561, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17569493, Length=241, Percent_Identity=49.792531120332, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI193209764, Length=241, Percent_Identity=49.792531120332, Blast_Score=238, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71989948, Length=233, Percent_Identity=51.931330472103, Blast_Score=237, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17569499, Length=254, Percent_Identity=51.5748031496063, Blast_Score=237, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI71987612, Length=251, Percent_Identity=49.402390438247, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI25153583, Length=251, Percent_Identity=49.402390438247, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI71987621, Length=251, Percent_Identity=49.402390438247, Blast_Score=232, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17569497, Length=239, Percent_Identity=47.6987447698745, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17570459, Length=241, Percent_Identity=49.792531120332, Blast_Score=228, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI193210507, Length=244, Percent_Identity=49.1803278688525, Blast_Score=224, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17570161, Length=244, Percent_Identity=49.1803278688525, Blast_Score=224, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI32566490, Length=232, Percent_Identity=50.8620689655172, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71989955, Length=182, Percent_Identity=51.6483516483517, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71989963, Length=121, Percent_Identity=53.7190082644628, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32564147, Length=186, Percent_Identity=37.0967741935484, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17542664, Length=177, Percent_Identity=30.5084745762712, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6321571, Length=240, Percent_Identity=28.3333333333333, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45556022, Length=245, Percent_Identity=51.8367346938776, Blast_Score=250, Evalue=5e-67,
Organism=Drosophila melanogaster, GI18860517, Length=250, Percent_Identity=52.4, Blast_Score=243, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24657857, Length=246, Percent_Identity=52.4390243902439, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI281365664, Length=243, Percent_Identity=53.0864197530864, Blast_Score=237, Evalue=5e-63,
Organism=Drosophila melanogaster, GI62484448, Length=246, Percent_Identity=52.4390243902439, Blast_Score=237, Evalue=5e-63,
Organism=Drosophila melanogaster, GI62484274, Length=246, Percent_Identity=52.4390243902439, Blast_Score=236, Evalue=1e-62,
Organism=Drosophila melanogaster, GI28573263, Length=238, Percent_Identity=41.1764705882353, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI21356845, Length=241, Percent_Identity=39.4190871369295, Blast_Score=200, Evalue=8e-52,
Organism=Drosophila melanogaster, GI281361631, Length=241, Percent_Identity=41.49377593361, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI281361633, Length=241, Percent_Identity=41.49377593361, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI281361635, Length=185, Percent_Identity=41.0810810810811, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI45550506, Length=184, Percent_Identity=38.0434782608696, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1420_ARCFU (O28852)

Other databases:

- EMBL:   AE000782
- PIR:   C69427
- RefSeq:   NP_070249.1
- ProteinModelPortal:   O28852
- SMR:   O28852
- GeneID:   1484644
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1420
- NMPDR:   fig|224325.1.peg.1410
- TIGR:   AF_1420
- HOGENOM:   HBG714701
- OMA:   KERTEPQ
- ProtClustDB:   CLSK2746897
- BioCyc:   AFUL224325:AF_1420-MONOMER
- InterPro:   IPR001107
- InterPro:   IPR018080
- InterPro:   IPR001972
- PANTHER:   PTHR10264
- PRINTS:   PR00721
- SMART:   SM00244

Pfam domain/function: PF01145 Band_7

EC number: NA

Molecular weight: Translated: 28346; Mature: 28346

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS01270 BAND_7

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb3ceda0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWYWIGLLIVVVLFLLSAVRIVKEYERGVIFRLGRLVGARGPGLFFIIPILENMVVVDL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHCCEEEEEE
RTVTYDVPSQEVVTKDNVTVKVNAVVYYRVVDPAKAVTEVFDYQYATAQLAQTTLRSIIG
EEEEECCCCCCEEECCCEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QAELDEVLSERDKLNVKLQQIIDEETNPWGIKVTAVEIKDVELPEEMRRIMAMQAEAERE
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHH
RRSKIIRAEGEYQAAMKLREAADVLAQSEGAILLRYLQTLNEISAEQNTTIVMPIPVELL
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHH
KFFVEKAKS
HHHHHHHCH
>Mature Secondary Structure
MEWYWIGLLIVVVLFLLSAVRIVKEYERGVIFRLGRLVGARGPGLFFIIPILENMVVVDL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHCCEEEEEE
RTVTYDVPSQEVVTKDNVTVKVNAVVYYRVVDPAKAVTEVFDYQYATAQLAQTTLRSIIG
EEEEECCCCCCEEECCCEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QAELDEVLSERDKLNVKLQQIIDEETNPWGIKVTAVEIKDVELPEEMRRIMAMQAEAERE
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHH
RRSKIIRAEGEYQAAMKLREAADVLAQSEGAILLRYLQTLNEISAEQNTTIVMPIPVELL
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHH
KFFVEKAKS
HHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9389475