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Identifier: 11499009

GI number: 11499009

Start: 1272726

End: 1274156

Strand: Reverse

Name: Not Available

Synonym: AF1414

Alternate gene names: NA

Gene position: 1274156-1272726 (Counterclockwise)

Preceding gene: 11499010

Following gene: 11499008

Centisome position: 58.49

GC content: 49.34

Gene sequence:

>1431_bases
ATGAGGGTCTTGCTCGTCACGGGGAAGCTGGCTGAGGAAATGGTGAGGAAATATGGCAAGGGTGCTGACGTTAAAGTGTA
CAACATAGACATTGCGGCCTTCATAACCCCCTCTATGCTTGAAAATGAGGATTTCAGCGGTTACGACCTCGTCCTCGTTC
CCGGTTTAACCTACAGCCACAACTGGGAGGATTTTGAGAGGAGAAAGGGTGTTAAGGTCAGGCTCGGCCCTATTCACGCT
TACGATTTGCAGCACGTTTTAAAGCTAATTGGAAAGGTCGAGTTCTCCCACAAAATTCCCGCGTGCAGGCTCGTGGAGTC
TTTGAGGGCTGAGGAAACGCTCAGGGAAATTGACGCTCTTGATGAAGACTGCGCATTTGAAATAGGCGGTGTAAAGGTTG
GCGGTAGCAGCAGAATGAAGGTTGTTGCTGAAATAGCGAGCTTCTGCGATTTTGATGATTTGAGGGCGAAAATTGACCAT
TACACGGAGAGCGGAGCGGACATAATCGACATTGGTGTGCCGCTGGAATTCGATAAGGAGTGGCTGCACAAAACGCTGAA
GATTGCCGTTGACCATTCCAAGCTTCCGCTCAGCATCGACACCTTCAGCAGTAAGGCGATAGAGATTGCAGTAAAACACG
GAGTTGACATGGTTATGAGCATTTCGATGGACAACCTGAAGGCTCTGGACTTAATTGAAAATCAGGCGGTTGTTGTTGTT
GAAAGGGACATTGATGGACTGCTGAATCTCGTTGAGAGGGTCGGGGAGAAGGTGGAGAGGGTCATTGCAGACCCCATCCT
TGATCCACCACTGAAAGTTGCTGAATCAATAGGAAGGTATGCGGAGTTCAGAAGGCGTGATGAAAAAACTCCGCTTCTCT
TTGGAGCTGGAAATGTTACGGAGCTAAGCGATGCCGATTCCATTGGAATTAACGCCTTGCTGGCGTTCATCGCGGAGGAG
CTTAAATGCAACCTGCTGTTCACGACAGAGGCAAGTCCAAAGACTTTTGGCAGTGTTAGGGAGCTCAATATCGCATCCTA
TCTCGCCAAGGCCGCAAAAATCAGGAACTCCCCACCAAAGGACGCTGGTGTCAGCCTTCTGGCTCTCAAGGAGAAGGTGA
GGTACGAGGAAAGGGTGGAGCTTGACGACTTTGTGAGGGCCGAAGAGACAAGAGAGTTCGTGAGAGACCCGCTCGGAGAC
TTCATAATTCAGGTGGTTGATGGCAAAATCGTTTGCAAGCACGACAGGATGACAATTGTTGGAGAGAAAGCCAAGGAAGT
TGCTGACACCGCAATAAAAAACAACCTTCTCTCAAGGCTTGACCACGCAGCCTACCTCGGCAGGGAGCTGATGAAGGCCG
AGATTGCAGCTTTGCTTAAAAAGAGCTACATTCAGGACAGGGAGTTGAATTTTGGGTTTTACCAGAAATAG

Upstream 100 bases:

>100_bases
TCCCGGTAGTTGACCGCAACGACGAGAAAAAGCTTTTAGGAATTATAACAAGAAGCGACATAATGAAAGCCCACGCAAGA
GAGGTTAAGAGGATAGTTTC

Downstream 100 bases:

>100_bases
CTTTTTTTGCCATTATAACATTATTGTTAAATAGGAAAATTTATATTGATTAAAGTTGAATTGGCGAAACCAAGCTACGG
GCTATTTTTTGCCTATTGCT

Product: dihydropteroate synthase

Products: diphosphate; dihydropteroate

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MRVLLVTGKLAEEMVRKYGKGADVKVYNIDIAAFITPSMLENEDFSGYDLVLVPGLTYSHNWEDFERRKGVKVRLGPIHA
YDLQHVLKLIGKVEFSHKIPACRLVESLRAEETLREIDALDEDCAFEIGGVKVGGSSRMKVVAEIASFCDFDDLRAKIDH
YTESGADIIDIGVPLEFDKEWLHKTLKIAVDHSKLPLSIDTFSSKAIEIAVKHGVDMVMSISMDNLKALDLIENQAVVVV
ERDIDGLLNLVERVGEKVERVIADPILDPPLKVAESIGRYAEFRRRDEKTPLLFGAGNVTELSDADSIGINALLAFIAEE
LKCNLLFTTEASPKTFGSVRELNIASYLAKAAKIRNSPPKDAGVSLLALKEKVRYEERVELDDFVRAEETREFVRDPLGD
FIIQVVDGKIVCKHDRMTIVGEKAKEVADTAIKNNLLSRLDHAAYLGRELMKAEIAALLKKSYIQDRELNFGFYQK

Sequences:

>Translated_476_residues
MRVLLVTGKLAEEMVRKYGKGADVKVYNIDIAAFITPSMLENEDFSGYDLVLVPGLTYSHNWEDFERRKGVKVRLGPIHA
YDLQHVLKLIGKVEFSHKIPACRLVESLRAEETLREIDALDEDCAFEIGGVKVGGSSRMKVVAEIASFCDFDDLRAKIDH
YTESGADIIDIGVPLEFDKEWLHKTLKIAVDHSKLPLSIDTFSSKAIEIAVKHGVDMVMSISMDNLKALDLIENQAVVVV
ERDIDGLLNLVERVGEKVERVIADPILDPPLKVAESIGRYAEFRRRDEKTPLLFGAGNVTELSDADSIGINALLAFIAEE
LKCNLLFTTEASPKTFGSVRELNIASYLAKAAKIRNSPPKDAGVSLLALKEKVRYEERVELDDFVRAEETREFVRDPLGD
FIIQVVDGKIVCKHDRMTIVGEKAKEVADTAIKNNLLSRLDHAAYLGRELMKAEIAALLKKSYIQDRELNFGFYQK
>Mature_476_residues
MRVLLVTGKLAEEMVRKYGKGADVKVYNIDIAAFITPSMLENEDFSGYDLVLVPGLTYSHNWEDFERRKGVKVRLGPIHA
YDLQHVLKLIGKVEFSHKIPACRLVESLRAEETLREIDALDEDCAFEIGGVKVGGSSRMKVVAEIASFCDFDDLRAKIDH
YTESGADIIDIGVPLEFDKEWLHKTLKIAVDHSKLPLSIDTFSSKAIEIAVKHGVDMVMSISMDNLKALDLIENQAVVVV
ERDIDGLLNLVERVGEKVERVIADPILDPPLKVAESIGRYAEFRRRDEKTPLLFGAGNVTELSDADSIGINALLAFIAEE
LKCNLLFTTEASPKTFGSVRELNIASYLAKAAKIRNSPPKDAGVSLLALKEKVRYEERVELDDFVRAEETREFVRDPLGD
FIIQVVDGKIVCKHDRMTIVGEKAKEVADTAIKNNLLSRLDHAAYLGRELMKAEIAALLKKSYIQDRELNFGFYQK

Specific function: Unknown. Does not possess dihydropteroate synthase (DHPS) activity since it does not catalyze the condensation of 6- hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) and 4- aminobenzoate to form 7,8-dihydropteroate [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005236
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: 2.5.1.15

Molecular weight: Translated: 53265; Mature: 53265

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLVTGKLAEEMVRKYGKGADVKVYNIDIAAFITPSMLENEDFSGYDLVLVPGLTYSH
CEEEEEECHHHHHHHHHHCCCCCEEEEEEEEEEEECHHHHCCCCCCCEEEEEECCCCCCC
NWEDFERRKGVKVRLGPIHAYDLQHVLKLIGKVEFSHKIPACRLVESLRAEETLREIDAL
CCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
DEDCAFEIGGVKVGGSSRMKVVAEIASFCDFDDLRAKIDHYTESGADIIDIGVPLEFDKE
CCCCCEEECCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCCCHH
WLHKTLKIAVDHSKLPLSIDTFSSKAIEIAVKHGVDMVMSISMDNLKALDLIENQAVVVV
HHHHHHHHEECCCCCCEEEECCCCCCEEEEECCCCCEEEEECCCCCHHHHHHCCCEEEEE
ERDIDGLLNLVERVGEKVERVIADPILDPPLKVAESIGRYAEFRRRDEKTPLLFGAGNVT
ECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
ELSDADSIGINALLAFIAEELKCNLLFTTEASPKTFGSVRELNIASYLAKAAKIRNSPPK
CCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHCCCCCC
DAGVSLLALKEKVRYEERVELDDFVRAEETREFVRDPLGDFIIQVVDGKIVCKHDRMTIV
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEECCCEEEE
GEKAKEVADTAIKNNLLSRLDHAAYLGRELMKAEIAALLKKSYIQDRELNFGFYQK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRVLLVTGKLAEEMVRKYGKGADVKVYNIDIAAFITPSMLENEDFSGYDLVLVPGLTYSH
CEEEEEECHHHHHHHHHHCCCCCEEEEEEEEEEEECHHHHCCCCCCCEEEEEECCCCCCC
NWEDFERRKGVKVRLGPIHAYDLQHVLKLIGKVEFSHKIPACRLVESLRAEETLREIDAL
CCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
DEDCAFEIGGVKVGGSSRMKVVAEIASFCDFDDLRAKIDHYTESGADIIDIGVPLEFDKE
CCCCCEEECCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCCCHH
WLHKTLKIAVDHSKLPLSIDTFSSKAIEIAVKHGVDMVMSISMDNLKALDLIENQAVVVV
HHHHHHHHEECCCCCCEEEECCCCCCEEEEECCCCCEEEEECCCCCHHHHHHCCCEEEEE
ERDIDGLLNLVERVGEKVERVIADPILDPPLKVAESIGRYAEFRRRDEKTPLLFGAGNVT
ECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
ELSDADSIGINALLAFIAEELKCNLLFTTEASPKTFGSVRELNIASYLAKAAKIRNSPPK
CCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHCCCCCC
DAGVSLLALKEKVRYEERVELDDFVRAEETREFVRDPLGDFIIQVVDGKIVCKHDRMTIV
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEEECCCEEEE
GEKAKEVADTAIKNNLLSRLDHAAYLGRELMKAEIAALLKKSYIQDRELNFGFYQK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate; 4-aminobenzoate

Specific reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]