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The map label for this gene is deoA-2

Identifier: 11498940

GI number: 11498940

Start: 1200362

End: 1201879

Strand: Reverse

Name: deoA-2

Synonym: AF1342

Alternate gene names: 11498940

Gene position: 1201879-1200362 (Counterclockwise)

Preceding gene: 11498943

Following gene: 11498939

Centisome position: 55.17

GC content: 52.11

Gene sequence:

>1518_bases
ATGAAGTTCAGGATAAAGACCTTGCCCCTCAGAACCGAAAGGATTGCTGTTGTTCTGAGTCAGGATGACGCGGCTGAACT
CGGTCTCCTTCCGGGAGACAGAGTGAAGGTTAGCTATGACGGCAAATCATTCGTAGCGGAGGTTGAGATCTCTCAGGAGT
TCATTAGCAGTGGGGAAGCTGGAGTTTGCACCTTCACCGCCGAGACGTGCAGCCTTTCCGAGGAGTGCGTGGTTGAGATT
GTTCCCTTCGCCAGGCCGAAGTCGGTCGAATACATAAGAAAGAAGCTTAACGGAGCTAAATACGAAAGAGAGGAGATTAA
GGACATAATTGGCAGCATCTCATCTGACGTACTCTCGGACATTGAAATCTCTGCATTCATACTTGCAAACGAGATTGTAG
GGATGCAGAACGACGAGATTCAGTGGATGATCGAGGCGATGGTCGAAGTCGGAGAAAGGGTAGTTTTCGAAAGGGGAACG
GTTGTGGACATGCACAGCATTGGAGGGTTGCCCGGAAACAGGTTTTCGCTGATTGCCGTCCCCACGGTTGCTGCGGCGGG
GCTCTTAATTCCGAAGACAGCAAGCAGAGCCATAACCACTGCAAGCGGAACGGCAGACACTATGGAGGTTCTCGCAAACG
TCAATCTGAGCGTTGACGAGATAAAGGAGATTACCGAGGAAGTTGGAGGGGTTATAGCATGGAACGCCCCCACGGGAATT
GCCCCGGCTGATGAGAAAATAATAAGGGTCGAATACCAGCTGGAGCTAAGCCCAAAACCGCATCTAATGGCCAGTGTGCT
GTCCAAAAAGCTGGGAAGCGGTGCAAGATTCGTCGCCATCGACATTCCGGTTGGAAAGAAGGCCAAGGTCGAGAACGTTG
ACGTCGGAAGAGGCTTCGCAAATGCTATGATGGAAATTGGGAGGAACTTGAACCTCAAGGTTGCAACGGCTCTGACAGAT
GGCTCTCAACCCCTTGGAAGGGCTATTGGCCCCGCGCTGGAGGCGAGAGAGGTTCTCGAAGTTATGGAGAGGAAGGTTGA
AGGGGACTTGCTTGAGAAGTCCCTTGGCATAGCGGGAATACTCTTCGAGATGACCGGTATAGCCACAAACGGCTATCAGC
ATGCCAGGAAGATATTCGAGAGCGGAAAAACGCTTGAGAAGTTCAGGGAGATTGTTGCGGCTCAGGGAGGAGATGAGAGC
GTTAAGGCCGAGGACGTGGCGGTGGGGGATAAGACCTACACTCTCCACGCTGCGAAGGAGGGTTACGTTAGGGAAATAGA
CATAGCAGCCCTTAACGAAATAGCAAGGACAGCAGGAGCCCCCAAGGACAAGGGAGCGGGAGTTTATGTCCACAAGAAGA
GGGGTGAGGTTGTAAAGGTCGGAGACCCGCTTCTCACCATCTATGCTGAGAAGGAGTGGAAGCTCGACAACGCAATAGAG
GTTGCGAACACCAAGCAGGCCTTCGAGATTTCAGGGGTTATTATAGAGAGGTACACGATGGGAAGGTGGTGGTCATGA

Upstream 100 bases:

>100_bases
ACCTTTTCAGGTGAGAATTTTTAAACATAAACAACATTATCTATAACTTCTTCACGATAGCGAGAAAAAGTTAATATTCT
TTCAGAGTTTTTGAAGTTCA

Downstream 100 bases:

>100_bases
TTTTCAAGGCGGTTAGAGTTCCATTCAAGTCGGGAAGGTTTGCCGTGATTCTTAACGAAGAGGATGCAAGCGAGCTTGGC
GTCAGAGAGGGGGATAGAGT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase 2

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MKFRIKTLPLRTERIAVVLSQDDAAELGLLPGDRVKVSYDGKSFVAEVEISQEFISSGEAGVCTFTAETCSLSEECVVEI
VPFARPKSVEYIRKKLNGAKYEREEIKDIIGSISSDVLSDIEISAFILANEIVGMQNDEIQWMIEAMVEVGERVVFERGT
VVDMHSIGGLPGNRFSLIAVPTVAAAGLLIPKTASRAITTASGTADTMEVLANVNLSVDEIKEITEEVGGVIAWNAPTGI
APADEKIIRVEYQLELSPKPHLMASVLSKKLGSGARFVAIDIPVGKKAKVENVDVGRGFANAMMEIGRNLNLKVATALTD
GSQPLGRAIGPALEAREVLEVMERKVEGDLLEKSLGIAGILFEMTGIATNGYQHARKIFESGKTLEKFREIVAAQGGDES
VKAEDVAVGDKTYTLHAAKEGYVREIDIAALNEIARTAGAPKDKGAGVYVHKKRGEVVKVGDPLLTIYAEKEWKLDNAIE
VANTKQAFEISGVIIERYTMGRWWS

Sequences:

>Translated_505_residues
MKFRIKTLPLRTERIAVVLSQDDAAELGLLPGDRVKVSYDGKSFVAEVEISQEFISSGEAGVCTFTAETCSLSEECVVEI
VPFARPKSVEYIRKKLNGAKYEREEIKDIIGSISSDVLSDIEISAFILANEIVGMQNDEIQWMIEAMVEVGERVVFERGT
VVDMHSIGGLPGNRFSLIAVPTVAAAGLLIPKTASRAITTASGTADTMEVLANVNLSVDEIKEITEEVGGVIAWNAPTGI
APADEKIIRVEYQLELSPKPHLMASVLSKKLGSGARFVAIDIPVGKKAKVENVDVGRGFANAMMEIGRNLNLKVATALTD
GSQPLGRAIGPALEAREVLEVMERKVEGDLLEKSLGIAGILFEMTGIATNGYQHARKIFESGKTLEKFREIVAAQGGDES
VKAEDVAVGDKTYTLHAAKEGYVREIDIAALNEIARTAGAPKDKGAGVYVHKKRGEVVKVGDPLLTIYAEKEWKLDNAIE
VANTKQAFEISGVIIERYTMGRWWS
>Mature_505_residues
MKFRIKTLPLRTERIAVVLSQDDAAELGLLPGDRVKVSYDGKSFVAEVEISQEFISSGEAGVCTFTAETCSLSEECVVEI
VPFARPKSVEYIRKKLNGAKYEREEIKDIIGSISSDVLSDIEISAFILANEIVGMQNDEIQWMIEAMVEVGERVVFERGT
VVDMHSIGGLPGNRFSLIAVPTVAAAGLLIPKTASRAITTASGTADTMEVLANVNLSVDEIKEITEEVGGVIAWNAPTGI
APADEKIIRVEYQLELSPKPHLMASVLSKKLGSGARFVAIDIPVGKKAKVENVDVGRGFANAMMEIGRNLNLKVATALTD
GSQPLGRAIGPALEAREVLEVMERKVEGDLLEKSLGIAGILFEMTGIATNGYQHARKIFESGKTLEKFREIVAAQGGDES
VKAEDVAVGDKTYTLHAAKEGYVREIDIAALNEIARTAGAPKDKGAGVYVHKKRGEVVKVGDPLLTIYAEKEWKLDNAIE
VANTKQAFEISGVIIERYTMGRWWS

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI166158925, Length=418, Percent_Identity=27.0334928229665, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4503445, Length=418, Percent_Identity=27.0334928229665, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI166158922, Length=418, Percent_Identity=27.0334928229665, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1790842, Length=408, Percent_Identity=26.7156862745098, Blast_Score=111, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH2_ARCFU (O28927)

Other databases:

- EMBL:   AE000782
- PIR:   E69417
- RefSeq:   NP_070171.1
- ProteinModelPortal:   O28927
- SMR:   O28927
- GeneID:   1484568
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1342
- NMPDR:   fig|224325.1.peg.1332
- TIGR:   AF_1342
- HOGENOM:   HBG460532
- OMA:   ILANEIV
- ProtClustDB:   PRK04350
- BioCyc:   AFUL224325:AF_1342-MONOMER
- BRENDA:   2.4.2.4
- GO:   GO:0005488
- HAMAP:   MF_00703
- InterPro:   IPR017713
- InterPro:   IPR009010
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466
- Gene3D:   G3DSA:2.40.40.20
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR03327
- TIGRFAMs:   TIGR02645

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 54693; Mature: 54693

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRIKTLPLRTERIAVVLSQDDAAELGLLPGDRVKVSYDGKSFVAEVEISQEFISSGEA
CCEEEEECCCCCEEEEEEEECCCCHHCCCCCCCEEEEEECCCEEEEEEEEHHHHHCCCCC
GVCTFTAETCSLSEECVVEIVPFARPKSVEYIRKKLNGAKYEREEIKDIIGSISSDVLSD
CEEEEEHHHHCCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IEISAFILANEIVGMQNDEIQWMIEAMVEVGERVVFERGTVVDMHSIGGLPGNRFSLIAV
CCHHEEEEEHHHCCCCCCHHHHHHHHHHHHHHHEEECCCCEEEHHHCCCCCCCCEEEEEE
PTVAAAGLLIPKTASRAITTASGTADTMEVLANVNLSVDEIKEITEEVGGVIAWNAPTGI
CHHHHCCEECCCCCCCEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCC
APADEKIIRVEYQLELSPKPHLMASVLSKKLGSGARFVAIDIPVGKKAKVENVDVGRGFA
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHH
NAMMEIGRNLNLKVATALTDGSQPLGRAIGPALEAREVLEVMERKVEGDLLEKSLGIAGI
HHHHHHCCCCCEEEEEEECCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEE
LFEMTGIATNGYQHARKIFESGKTLEKFREIVAAQGGDESVKAEDVAVGDKTYTLHAAKE
EEHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCC
GYVREIDIAALNEIARTAGAPKDKGAGVYVHKKRGEVVKVGDPLLTIYAEKEWKLDNAIE
CCEEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEECCCEEEEEECCCCCCCCCEE
VANTKQAFEISGVIIERYTMGRWWS
ECCCCCEEEECCEEEEEEECCCCCC
>Mature Secondary Structure
MKFRIKTLPLRTERIAVVLSQDDAAELGLLPGDRVKVSYDGKSFVAEVEISQEFISSGEA
CCEEEEECCCCCEEEEEEEECCCCHHCCCCCCCEEEEEECCCEEEEEEEEHHHHHCCCCC
GVCTFTAETCSLSEECVVEIVPFARPKSVEYIRKKLNGAKYEREEIKDIIGSISSDVLSD
CEEEEEHHHHCCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IEISAFILANEIVGMQNDEIQWMIEAMVEVGERVVFERGTVVDMHSIGGLPGNRFSLIAV
CCHHEEEEEHHHCCCCCCHHHHHHHHHHHHHHHEEECCCCEEEHHHCCCCCCCCEEEEEE
PTVAAAGLLIPKTASRAITTASGTADTMEVLANVNLSVDEIKEITEEVGGVIAWNAPTGI
CHHHHCCEECCCCCCCEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCC
APADEKIIRVEYQLELSPKPHLMASVLSKKLGSGARFVAIDIPVGKKAKVENVDVGRGFA
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCHHH
NAMMEIGRNLNLKVATALTDGSQPLGRAIGPALEAREVLEVMERKVEGDLLEKSLGIAGI
HHHHHHCCCCCEEEEEEECCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEE
LFEMTGIATNGYQHARKIFESGKTLEKFREIVAAQGGDESVKAEDVAVGDKTYTLHAAKE
EEHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEEECCC
GYVREIDIAALNEIARTAGAPKDKGAGVYVHKKRGEVVKVGDPLLTIYAEKEWKLDNAIE
CCEEEEHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEECCCEEEEEECCCCCCCCCEE
VANTKQAFEISGVIIERYTMGRWWS
ECCCCCEEEECCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475