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The map label for this gene is deoA-1

Identifier: 11498939

GI number: 11498939

Start: 1198851

End: 1200365

Strand: Reverse

Name: deoA-1

Synonym: AF1341

Alternate gene names: 11498939

Gene position: 1200365-1198851 (Counterclockwise)

Preceding gene: 11498940

Following gene: 11498938

Centisome position: 55.1

GC content: 53.27

Gene sequence:

>1515_bases
ATGATTTTCAAGGCGGTTAGAGTTCCATTCAAGTCGGGAAGGTTTGCCGTGATTCTTAACGAAGAGGATGCAAGCGAGCT
TGGCGTCAGAGAGGGGGATAGAGTCAGGGTGAGGTACGGCAAGGCGGGGGTTGTCGCCACAGTACAGATAACGAGGGAAA
TCGTTGAGAAGGGCTTTGTCGGATTAACAGACCTCGCTTCAATGGAGCTTGGAATATCGGACGGTGCTGAGGTTGATGTG
TTTCCATCTCCGAAACCAAAAAGCGTTGAGCTGATAAAGAAGAAGACGAGGGGCGAGAAGCTGAGCCAGGATGAAATCAG
GAGGATAGTTGAGGACATAACCAACAACGCTCTGAGCGAGGTTGAGCTCACAGCCTTTGTCATTTCTTCGATGCTTCGCG
GGATGGATTTTGACGAAATAGAGTGGTTAACGAGGTCGATGATTGAAACCGGAGAGAGGATTGAGTTTGACAGGGGAACG
GTTGTGGACAAGCACAGCATTGGCGGTGTGCCGGGCAACAAGATATCCCTGCTCATCGTTCCGACTGTTGCTGCGGCGGG
GCTCTTAATTCCGAAGACAGCAAGCAGAGCGATAACGTCAGCCAGCGGAACGGCAGACACTATGGAGGTTCTCGCAAACG
TCAATCTGAGCGTTGACGAGATAAAGGAGATTACGGAGAGAGTGGGGGGAGTCATTGCCTGGGGAGGGGCGACGAACATA
GCTCCGGCAGATGATAAAATAATAAGGGTCGAACATCCCCTCTCCATCGATCCCAGACCGCAGCTTCTTGCCAGCGTTAT
GGCCAAGAAGGGCTCGGTTGGAGCGAAGCATGTCGTAATCGACATTCCCGTTGGGGAGGGGGCAAAGATTGAGAAGGTGG
AGGTCGGCAGGTCTCTGGCAAACGACTTCATTGAGCTCGGCAGAAGGCTCGGGCTTAACGTCATGGCGGCAATAACCTAC
GGAGGTCAGCCCGTGGGAAGGGCTATTGGCCCCGCGCTGGAAGCAAGGGAAGCGCTTAAGACGATGGAGGACAGACGAGG
TCCTTCGAGTCTGGTTGAGAAGTCCCTTGGCATAGCGGGAATACTCTTCGAGATGACCGGCATAGCCACAAACGGCTATC
AGCATGCCAGGAAGATATTCGAGAGCGGAAAAACGCTTGAGAAGTTCAGGGAGATTGTTGCGGCTCAGGGAGGAGATGAG
AGCGTTAAGGCCGAGGACGTGGCGGTGGGAGATAAGACCTACACACTCACCTCTCAGGTGGAAGGGGCGGTGGTTTCGGT
AAACAATAAAAGCATCGTGAAAATAGCGAGAACAGCAGGCGCTCCCAAGGACAAGGGAGCGGGAGTTTATGTCCACAAGA
AGAGGGGTGAGGTTGTAAAGGTCGGAGACCCGCTTCTCACCATCTACGCCGAGAAGGAGTGGAAGCTCGACAACGCAATA
GAGGTTGCGAACACCGAGAGGCCAATTGTGGTTTCGGGAATGGTGCTGGAAGTTTACGGAAGAAGAGGTGTGTAA

Upstream 100 bases:

>100_bases
AGTGGAAGCTCGACAACGCAATAGAGGTTGCGAACACCAAGCAGGCCTTCGAGATTTCAGGGGTTATTATAGAGAGGTAC
ACGATGGGAAGGTGGTGGTC

Downstream 100 bases:

>100_bases
AATGAAGGACGGATTGGAAGATGTGATTGCCTGCAAAACCACGATTTCGAGGATTGCCCTTGAAAACGGGAGGGCAATTC
TTGAGTACAGGGGTTACGAC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase 1

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MIFKAVRVPFKSGRFAVILNEEDASELGVREGDRVRVRYGKAGVVATVQITREIVEKGFVGLTDLASMELGISDGAEVDV
FPSPKPKSVELIKKKTRGEKLSQDEIRRIVEDITNNALSEVELTAFVISSMLRGMDFDEIEWLTRSMIETGERIEFDRGT
VVDKHSIGGVPGNKISLLIVPTVAAAGLLIPKTASRAITSASGTADTMEVLANVNLSVDEIKEITERVGGVIAWGGATNI
APADDKIIRVEHPLSIDPRPQLLASVMAKKGSVGAKHVVIDIPVGEGAKIEKVEVGRSLANDFIELGRRLGLNVMAAITY
GGQPVGRAIGPALEAREALKTMEDRRGPSSLVEKSLGIAGILFEMTGIATNGYQHARKIFESGKTLEKFREIVAAQGGDE
SVKAEDVAVGDKTYTLTSQVEGAVVSVNNKSIVKIARTAGAPKDKGAGVYVHKKRGEVVKVGDPLLTIYAEKEWKLDNAI
EVANTERPIVVSGMVLEVYGRRGV

Sequences:

>Translated_504_residues
MIFKAVRVPFKSGRFAVILNEEDASELGVREGDRVRVRYGKAGVVATVQITREIVEKGFVGLTDLASMELGISDGAEVDV
FPSPKPKSVELIKKKTRGEKLSQDEIRRIVEDITNNALSEVELTAFVISSMLRGMDFDEIEWLTRSMIETGERIEFDRGT
VVDKHSIGGVPGNKISLLIVPTVAAAGLLIPKTASRAITSASGTADTMEVLANVNLSVDEIKEITERVGGVIAWGGATNI
APADDKIIRVEHPLSIDPRPQLLASVMAKKGSVGAKHVVIDIPVGEGAKIEKVEVGRSLANDFIELGRRLGLNVMAAITY
GGQPVGRAIGPALEAREALKTMEDRRGPSSLVEKSLGIAGILFEMTGIATNGYQHARKIFESGKTLEKFREIVAAQGGDE
SVKAEDVAVGDKTYTLTSQVEGAVVSVNNKSIVKIARTAGAPKDKGAGVYVHKKRGEVVKVGDPLLTIYAEKEWKLDNAI
EVANTERPIVVSGMVLEVYGRRGV
>Mature_504_residues
MIFKAVRVPFKSGRFAVILNEEDASELGVREGDRVRVRYGKAGVVATVQITREIVEKGFVGLTDLASMELGISDGAEVDV
FPSPKPKSVELIKKKTRGEKLSQDEIRRIVEDITNNALSEVELTAFVISSMLRGMDFDEIEWLTRSMIETGERIEFDRGT
VVDKHSIGGVPGNKISLLIVPTVAAAGLLIPKTASRAITSASGTADTMEVLANVNLSVDEIKEITERVGGVIAWGGATNI
APADDKIIRVEHPLSIDPRPQLLASVMAKKGSVGAKHVVIDIPVGEGAKIEKVEVGRSLANDFIELGRRLGLNVMAAITY
GGQPVGRAIGPALEAREALKTMEDRRGPSSLVEKSLGIAGILFEMTGIATNGYQHARKIFESGKTLEKFREIVAAQGGDE
SVKAEDVAVGDKTYTLTSQVEGAVVSVNNKSIVKIARTAGAPKDKGAGVYVHKKRGEVVKVGDPLLTIYAEKEWKLDNAI
EVANTERPIVVSGMVLEVYGRRGV

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI166158925, Length=333, Percent_Identity=33.033033033033, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI4503445, Length=333, Percent_Identity=33.033033033033, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI166158922, Length=333, Percent_Identity=33.033033033033, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1790842, Length=409, Percent_Identity=28.6063569682152, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYPH1_ARCFU (O28928)

Other databases:

- EMBL:   AE000782
- PIR:   D69417
- RefSeq:   NP_070170.1
- ProteinModelPortal:   O28928
- SMR:   O28928
- GeneID:   1484567
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1341
- NMPDR:   fig|224325.1.peg.1331
- TIGR:   AF_1341
- HOGENOM:   HBG460532
- OMA:   GGTADLM
- ProtClustDB:   PRK04350
- BioCyc:   AFUL224325:AF_1341-MONOMER
- BRENDA:   2.4.2.4
- HAMAP:   MF_00703
- InterPro:   IPR017713
- InterPro:   IPR009010
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR006657
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466
- Gene3D:   G3DSA:2.40.40.20
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- PANTHER:   PTHR10515
- PIRSF:   PIRSF000478
- SMART:   SM00941
- TIGRFAMs:   TIGR03327
- TIGRFAMs:   TIGR02645

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF01568 Molydop_binding; PF07831 PYNP_C; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3; SSF54680 PYNP_C

EC number: =2.4.2.4

Molecular weight: Translated: 54099; Mature: 54099

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFKAVRVPFKSGRFAVILNEEDASELGVREGDRVRVRYGKAGVVATVQITREIVEKGFV
CCCCEEECCCCCCCEEEEECCCCHHHCCCCCCCEEEEEECCCCEEEEHHHHHHHHHCCCC
GLTDLASMELGISDGAEVDVFPSPKPKSVELIKKKTRGEKLSQDEIRRIVEDITNNALSE
CHHHHHHEEECCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VELTAFVISSMLRGMDFDEIEWLTRSMIETGERIEFDRGTVVDKHSIGGVPGNKISLLIV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCCEEECCCCCCCCCCEEEEEEE
PTVAAAGLLIPKTASRAITSASGTADTMEVLANVNLSVDEIKEITERVGGVIAWGGATNI
ECHHHCCEECCCCHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCC
APADDKIIRVEHPLSIDPRPQLLASVMAKKGSVGAKHVVIDIPVGEGAKIEKVEVGRSLA
CCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEHHHHHHHHH
NDFIELGRRLGLNVMAAITYGGQPVGRAIGPALEAREALKTMEDRRGPSSLVEKSLGIAG
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHE
ILFEMTGIATNGYQHARKIFESGKTLEKFREIVAAQGGDESVKAEDVAVGDKTYTLTSQV
EEHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEECCC
EGAVVSVNNKSIVKIARTAGAPKDKGAGVYVHKKRGEVVKVGDPLLTIYAEKEWKLDNAI
CCEEEEECCCCEEEEEHHCCCCCCCCCEEEEECCCCCEEEECCCEEEEEECCCCCCCCCE
EVANTERPIVVSGMVLEVYGRRGV
EECCCCCCEEEECEEEEECCCCCC
>Mature Secondary Structure
MIFKAVRVPFKSGRFAVILNEEDASELGVREGDRVRVRYGKAGVVATVQITREIVEKGFV
CCCCEEECCCCCCCEEEEECCCCHHHCCCCCCCEEEEEECCCCEEEEHHHHHHHHHCCCC
GLTDLASMELGISDGAEVDVFPSPKPKSVELIKKKTRGEKLSQDEIRRIVEDITNNALSE
CHHHHHHEEECCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VELTAFVISSMLRGMDFDEIEWLTRSMIETGERIEFDRGTVVDKHSIGGVPGNKISLLIV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEECCCCCEEECCCCCCCCCCEEEEEEE
PTVAAAGLLIPKTASRAITSASGTADTMEVLANVNLSVDEIKEITERVGGVIAWGGATNI
ECHHHCCEECCCCHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCEEEECCCCCC
APADDKIIRVEHPLSIDPRPQLLASVMAKKGSVGAKHVVIDIPVGEGAKIEKVEVGRSLA
CCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEHHHHHHHHH
NDFIELGRRLGLNVMAAITYGGQPVGRAIGPALEAREALKTMEDRRGPSSLVEKSLGIAG
HHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHE
ILFEMTGIATNGYQHARKIFESGKTLEKFREIVAAQGGDESVKAEDVAVGDKTYTLTSQV
EEHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEEECCC
EGAVVSVNNKSIVKIARTAGAPKDKGAGVYVHKKRGEVVKVGDPLLTIYAEKEWKLDNAI
CCEEEEECCCCEEEEEHHCCCCCCCCCEEEEECCCCCEEEECCCEEEEEECCCCCCCCCE
EVANTERPIVVSGMVLEVYGRRGV
EECCCCCCEEEECEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475