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The map label for this gene is purQ

Identifier: 11498859

GI number: 11498859

Start: 1122849

End: 1123664

Strand: Reverse

Name: purQ

Synonym: AF1260

Alternate gene names: 11498859

Gene position: 1123664-1122849 (Counterclockwise)

Preceding gene: 11498860

Following gene: 11498858

Centisome position: 51.58

GC content: 50.74

Gene sequence:

>816_bases
ATGGACAGGGAGGAAATCAAGGTTGCAGTTCTGAGGATGGAGGGTACAAACTGCGAGGATGAGACGGTTAAAGCCTTCAG
AAGTCTCGGGGTTGAGGCAGAGGCCGTTCACATCAAGCAGTTTTACAGCGACATGATAAGGTTCGAGGAGCAAAGAAGCG
TATTCGACTACCAGTGCTTGGTCTTTCCCGGCGGGTTTTCGGCAGGGGATTACATCAGAGCCGGGGCAATCTTCTCGGCG
AGGGTAAAGAGCGTTCTGAGAAAGGACATTGAGGAGTTCATAAAAATGGGCTATCCAATCCTCGGTATCTGCAACGGCTT
TCAGGTTCTCGTCGAGCTTGGTGCTCTTCCGGGCTTTGATGAAGATAAGCCGCTTGCCGAAAAACCTGAGATGGCATTGG
CGATGAACGACTCAAGCAGGTTCGAGTGCAGGCCGACTCTGCTGAAAAAGGAGAGCGAGAAGTGCATCTTCGTGAAAAAT
CTAAAGAAAGACGTGGTGATGTTCCCTGTGGCGCATGCAGAGGGGAAGGTGGTTTTTCCCTCGGGAAAGGAGGATGAGTA
TCTGGAAAGGCTCACCTCCAACGACCAGATTGTTTTCAGATACGTTGATGAAAAGGGAGATTATGCAGGATACCCCTGGA
ATCCCAACGGAAGCTTCTACAACATCGCGGGCATTTGCAACGCAACACATACGGTCTTCGGCTTAATGCCCCACCCTGAA
AGGGCATTCTTCGGCTACCAGGTTGGGAGGAGAGAAGGTTACGGGGACGGCTACTGCATTTTCAGGAGCGTTGTTGATTA
TCTGGAAAAGCTTTAG

Upstream 100 bases:

>100_bases
ATTCTTTTCAAATTGATGCCGTTACTAGCACTAAAGAGTGCAGAACATCAACGCTGCCGACACGGAAAAAGCTTAAAAGA
TTGCGGTTGATTGCTTACCG

Downstream 100 bases:

>100_bases
CAAAAGTTTTTAGCTTGCCGTCATTTTTCTTCTGTAATGAGCATTAAGGTTAAGGACTACATGACGAAGAACGTTTACAC
GCTGAAGCCGGATAACACCG

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MDREEIKVAVLRMEGTNCEDETVKAFRSLGVEAEAVHIKQFYSDMIRFEEQRSVFDYQCLVFPGGFSAGDYIRAGAIFSA
RVKSVLRKDIEEFIKMGYPILGICNGFQVLVELGALPGFDEDKPLAEKPEMALAMNDSSRFECRPTLLKKESEKCIFVKN
LKKDVVMFPVAHAEGKVVFPSGKEDEYLERLTSNDQIVFRYVDEKGDYAGYPWNPNGSFYNIAGICNATHTVFGLMPHPE
RAFFGYQVGRREGYGDGYCIFRSVVDYLEKL

Sequences:

>Translated_271_residues
MDREEIKVAVLRMEGTNCEDETVKAFRSLGVEAEAVHIKQFYSDMIRFEEQRSVFDYQCLVFPGGFSAGDYIRAGAIFSA
RVKSVLRKDIEEFIKMGYPILGICNGFQVLVELGALPGFDEDKPLAEKPEMALAMNDSSRFECRPTLLKKESEKCIFVKN
LKKDVVMFPVAHAEGKVVFPSGKEDEYLERLTSNDQIVFRYVDEKGDYAGYPWNPNGSFYNIAGICNATHTVFGLMPHPE
RAFFGYQVGRREGYGDGYCIFRSVVDYLEKL
>Mature_271_residues
MDREEIKVAVLRMEGTNCEDETVKAFRSLGVEAEAVHIKQFYSDMIRFEEQRSVFDYQCLVFPGGFSAGDYIRAGAIFSA
RVKSVLRKDIEEFIKMGYPILGICNGFQVLVELGALPGFDEDKPLAEKPEMALAMNDSSRFECRPTLLKKESEKCIFVKN
LKKDVVMFPVAHAEGKVVFPSGKEDEYLERLTSNDQIVFRYVDEKGDYAGYPWNPNGSFYNIAGICNATHTVFGLMPHPE
RAFFGYQVGRREGYGDGYCIFRSVVDYLEKL

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI31657129, Length=261, Percent_Identity=31.0344827586207, Blast_Score=95, Evalue=7e-20,
Organism=Escherichia coli, GI48994899, Length=244, Percent_Identity=31.9672131147541, Blast_Score=101, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17553022, Length=252, Percent_Identity=27.7777777777778, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321498, Length=291, Percent_Identity=30.9278350515464, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24582111, Length=246, Percent_Identity=34.1463414634146, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24582109, Length=246, Percent_Identity=34.1463414634146, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI17137292, Length=246, Percent_Identity=34.1463414634146, Blast_Score=124, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_ARCFU (O29008)

Other databases:

- EMBL:   AE000782
- PIR:   C69407
- RefSeq:   NP_070088.1
- ProteinModelPortal:   O29008
- GeneID:   1484484
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF1260
- NMPDR:   fig|224325.1.peg.1248
- TIGR:   AF_1260
- HOGENOM:   HBG302712
- OMA:   FSYGDDT
- ProtClustDB:   PRK01175
- BioCyc:   AFUL224325:AF_1260-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF00117 GATase

EC number: =6.3.5.3

Molecular weight: Translated: 30787; Mature: 30787

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 104-104 ACT_SITE 238-238 ACT_SITE 240-240

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDREEIKVAVLRMEGTNCEDETVKAFRSLGVEAEAVHIKQFYSDMIRFEEQRSVFDYQCL
CCHHHEEEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEE
VFPGGFSAGDYIRAGAIFSARVKSVLRKDIEEFIKMGYPILGICNGFQVLVELGALPGFD
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCC
EDKPLAEKPEMALAMNDSSRFECRPTLLKKESEKCIFVKNLKKDVVMFPVAHAEGKVVFP
CCCCCCCCCCEEEEECCCCCCEECHHHHCCCCCCEEEEECCCCCEEEEEEECCCCEEECC
SGKEDEYLERLTSNDQIVFRYVDEKGDYAGYPWNPNGSFYNIAGICNATHTVFGLMPHPE
CCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEHHCCHHHEEECCCCCC
RAFFGYQVGRREGYGDGYCIFRSVVDYLEKL
HHHHCEECCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDREEIKVAVLRMEGTNCEDETVKAFRSLGVEAEAVHIKQFYSDMIRFEEQRSVFDYQCL
CCHHHEEEEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEE
VFPGGFSAGDYIRAGAIFSARVKSVLRKDIEEFIKMGYPILGICNGFQVLVELGALPGFD
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCC
EDKPLAEKPEMALAMNDSSRFECRPTLLKKESEKCIFVKNLKKDVVMFPVAHAEGKVVFP
CCCCCCCCCCEEEEECCCCCCEECHHHHCCCCCCEEEEECCCCCEEEEEEECCCCEEECC
SGKEDEYLERLTSNDQIVFRYVDEKGDYAGYPWNPNGSFYNIAGICNATHTVFGLMPHPE
CCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEHHCCHHHEEECCCCCC
RAFFGYQVGRREGYGDGYCIFRSVVDYLEKL
HHHHCEECCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475