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The map label for this gene is menB

Identifier: 11498791

GI number: 11498791

Start: 1061831

End: 1062664

Strand: Reverse

Name: menB

Synonym: AF1191

Alternate gene names: 11498791

Gene position: 1062664-1061831 (Counterclockwise)

Preceding gene: 11498792

Following gene: 11498790

Centisome position: 48.78

GC content: 53.72

Gene sequence:

>834_bases
GTGGGCTTTTTGAAGTTTCAGGACATAATCTACGAGAAAGAGGGAAGAGTGGCGAAAATAACCATCAACCGCCCCGAAAA
GCTGAACGCCTGCACGCCCGTGACGGTTTACGAGATTAGCAAGGCCTTCATTGACGCATGGACGGACAGGAAGATTGGTG
TTGTCGTTTTCACGGGGGCAGGGGATAAAGCCTTCTGCGTCGGTGGGGACCAGTCCATCAGGGATCTGGGTGGGTACAGC
TACAGCAGCGAGGAGCTTGAGGGGACTATTGCCGCTTTACCGCTTGAGGTGGGATGGCAGATAGTCACCTTTCTCATCAG
GCACATTCCCAAGCCAGTCATTGCGAGAGTGAATGGCTATGCTGTCGGTGGGGGGCATGTTTGGCAGGTGAACTGTGATC
TCTCAATAGCCTCTGAAAAAGCAAAGTTCGGTCAGGCGGGGCCGAGGGTTGGCAGCTTCGACCCAGGTTTTGGCACTGGA
GAGCTTTGGAGAAACGTTGGAATGAAGAGGGCGAAGGAAATCTGGTTCCTCTGCAGGCTCTACACCGCTGAAGAGGCCCT
GAAAATGGGCCTTGTCAATGCTGTTGTCCCCCACGAGAAGCTTGACGAAGAGGTGGAGAAGTGGTGCAGCGAGCTGCTTG
AAAAAAGCCCTACAGCATTGAAAATGCTAAAATACGCCTTTCTGGCTGACACTGAAGGCCTTGCGGGCATAACGGAGCTT
GGCGTGGGAGGGCTAAGCCTCTACTACGGCACTGAGGAGTCGCTTGAGGGCAGAAACGCCTTCATGGAGAAGAGGAAGCC
CGACTTCTGGAAGTTTGTTGAAGGAGGTGATTGA

Upstream 100 bases:

>100_bases
ACCCCACTCCAGAAAGGGCTGTAAGGGCACTGAGACACATGGTTACGGTTGCAAAGAGGAAATCTTAAGTATTTTCCAGT
ACATTTTTCCCTGCCCGGAG

Downstream 100 bases:

>100_bases
ATGAAGCTGGAGGATATTAAGGTTATTGGAGTTGTTGGCGCTGGAGTTATGGGGCATGGAATTGCTCAGGTGGCTGCGAG
AACCGGCTATGATGTGGTAA

Product: dihydroxynaphthoic acid synthase (menB)

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MGFLKFQDIIYEKEGRVAKITINRPEKLNACTPVTVYEISKAFIDAWTDRKIGVVVFTGAGDKAFCVGGDQSIRDLGGYS
YSSEELEGTIAALPLEVGWQIVTFLIRHIPKPVIARVNGYAVGGGHVWQVNCDLSIASEKAKFGQAGPRVGSFDPGFGTG
ELWRNVGMKRAKEIWFLCRLYTAEEALKMGLVNAVVPHEKLDEEVEKWCSELLEKSPTALKMLKYAFLADTEGLAGITEL
GVGGLSLYYGTEESLEGRNAFMEKRKPDFWKFVEGGD

Sequences:

>Translated_277_residues
MGFLKFQDIIYEKEGRVAKITINRPEKLNACTPVTVYEISKAFIDAWTDRKIGVVVFTGAGDKAFCVGGDQSIRDLGGYS
YSSEELEGTIAALPLEVGWQIVTFLIRHIPKPVIARVNGYAVGGGHVWQVNCDLSIASEKAKFGQAGPRVGSFDPGFGTG
ELWRNVGMKRAKEIWFLCRLYTAEEALKMGLVNAVVPHEKLDEEVEKWCSELLEKSPTALKMLKYAFLADTEGLAGITEL
GVGGLSLYYGTEESLEGRNAFMEKRKPDFWKFVEGGD
>Mature_276_residues
GFLKFQDIIYEKEGRVAKITINRPEKLNACTPVTVYEISKAFIDAWTDRKIGVVVFTGAGDKAFCVGGDQSIRDLGGYSY
SSEELEGTIAALPLEVGWQIVTFLIRHIPKPVIARVNGYAVGGGHVWQVNCDLSIASEKAKFGQAGPRVGSFDPGFGTGE
LWRNVGMKRAKEIWFLCRLYTAEEALKMGLVNAVVPHEKLDEEVEKWCSELLEKSPTALKMLKYAFLADTEGLAGITELG
VGGLSLYYGTEESLEGRNAFMEKRKPDFWKFVEGGD

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=274, Percent_Identity=34.6715328467153, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI31542718, Length=264, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4502327, Length=266, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI45643119, Length=222, Percent_Identity=30.1801801801802, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI260275230, Length=222, Percent_Identity=30.1801801801802, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI260274832, Length=222, Percent_Identity=30.1801801801802, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788597, Length=269, Percent_Identity=53.5315985130111, Blast_Score=272, Evalue=2e-74,
Organism=Escherichia coli, GI1787659, Length=269, Percent_Identity=30.4832713754647, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082183, Length=258, Percent_Identity=28.2945736434109, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI221142681, Length=264, Percent_Identity=29.5454545454545, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1787660, Length=262, Percent_Identity=28.2442748091603, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=258, Percent_Identity=32.5581395348837, Blast_Score=113, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI25145438, Length=254, Percent_Identity=32.2834645669291, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17540714, Length=208, Percent_Identity=28.3653846153846, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17549921, Length=216, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17535521, Length=253, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=264, Percent_Identity=30.3030303030303, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=243, Percent_Identity=27.5720164609054, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20129971, Length=263, Percent_Identity=33.8403041825095, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24653477, Length=263, Percent_Identity=33.8403041825095, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24653139, Length=264, Percent_Identity=29.5454545454545, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19922422, Length=277, Percent_Identity=26.7148014440433, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357171, Length=192, Percent_Identity=31.7708333333333, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24654903, Length=205, Percent_Identity=24.390243902439, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30604; Mature: 30473

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFLKFQDIIYEKEGRVAKITINRPEKLNACTPVTVYEISKAFIDAWTDRKIGVVVFTGA
CCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECC
GDKAFCVGGDQSIRDLGGYSYSSEELEGTIAALPLEVGWQIVTFLIRHIPKPVIARVNGY
CCEEEEECCCCHHHHHCCCCCCCHHHCCEEEEECHHHHHHHHHHHHHHCCCHHHEEECCE
AVGGGHVWQVNCDLSIASEKAKFGQAGPRVGSFDPGFGTGELWRNVGMKRAKEIWFLCRL
EECCCEEEEEEECEEECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YTAEEALKMGLVNAVVPHEKLDEEVEKWCSELLEKSPTALKMLKYAFLADTEGLAGITEL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHH
GVGGLSLYYGTEESLEGRNAFMEKRKPDFWKFVEGGD
CCCCEEEEECCHHHCCHHHHHHHCCCCCHHHHCCCCC
>Mature Secondary Structure 
GFLKFQDIIYEKEGRVAKITINRPEKLNACTPVTVYEISKAFIDAWTDRKIGVVVFTGA
CCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECC
GDKAFCVGGDQSIRDLGGYSYSSEELEGTIAALPLEVGWQIVTFLIRHIPKPVIARVNGY
CCEEEEECCCCHHHHHCCCCCCCHHHCCEEEEECHHHHHHHHHHHHHHCCCHHHEEECCE
AVGGGHVWQVNCDLSIASEKAKFGQAGPRVGSFDPGFGTGELWRNVGMKRAKEIWFLCRL
EECCCEEEEEEECEEECCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YTAEEALKMGLVNAVVPHEKLDEEVEKWCSELLEKSPTALKMLKYAFLADTEGLAGITEL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHH
GVGGLSLYYGTEESLEGRNAFMEKRKPDFWKFVEGGD
CCCCEEEEECCHHHCCHHHHHHHCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]