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The map label for this gene is hbd-7

Identifier: 11498790

GI number: 11498790

Start: 1060943

End: 1061830

Strand: Reverse

Name: hbd-7

Synonym: AF1190

Alternate gene names: 11498790

Gene position: 1061830-1060943 (Counterclockwise)

Preceding gene: 11498791

Following gene: 11498789

Centisome position: 48.74

GC content: 50.0

Gene sequence:

>888_bases
ATGAAGCTGGAGGATATTAAGGTTATTGGAGTTGTTGGCGCTGGAGTTATGGGGCATGGAATTGCTCAGGTGGCTGCGAG
AACCGGCTATGATGTGGTAATGGTTGACGTGAGTGAAGAAGTGCTTAAAAAGGCGATGGAGCTGATAGAATCAGGCCCCT
TTGGCCTGAGAAGGCTTGTGGAGAAGGGAAAGATGAGCGAGGATGAGGCAAAGGCGGTGATGGCGAGGATAAGGACATCA
ACGTCTCTCGAAGCTTTAAAGGATGCGGACTTCATAATTGAGGCTGTAACCGAGAAAGCTGACCTAAAGAAGAAGATTTT
TGCCGAGCTGGACAGAATATGCAAGCCAGAAACCATCATAGCCTCAAACACCTCCGCAATAATGATTTCTGATCTGGCTA
CGGCTGTGGAGAGGAAGGACAAGTTCATCGGGATGCACTGGTTCAATCCTGCTCCGGTTATGAGGCTGATCGAGGTTATA
AGAGGGGCATTAACGAGCGATGAAACCTTCAACATCACCGTTGAGCTTTCCAAGAAGATGGGCAAGATTCCCATCGAGGC
AGGAGATGGTCCGGGCTTCTTCACAACCAGATTCATAAACTCGTGGCTCGTTGAGGCGGTAAGACTCTTCGAGATTGGAA
TTGCAGGAATTAAGGAGATTGACGAGATGTGCAAGCTGGCTTTCGGCTTCCCAATGGGTCCCTTTGAGCTCATGGACCTC
ATTGGCTTGGATACTGCGCTGCACATTGCCGAGTATCTGTACAACGAAACGAAGGAGCCGCACTACGCTGCACCAAACAC
GTTGAAGAAGCTCGTCCTTTCAGGTTACGTGGGAAGGAAGCCCGGAAGCAGAGGAGGGTGGTACGACTACTACGGGATAG
AGCGCTAA

Upstream 100 bases:

>100_bases
AAGCCTCTACTACGGCACTGAGGAGTCGCTTGAGGGCAGAAACGCCTTCATGGAGAAGAGGAAGCCCGACTTCTGGAAGT
TTGTTGAAGGAGGTGATTGA

Downstream 100 bases:

>100_bases
TCATCTAAAATTTTCAATACTTTTTTCATACGACTAATAAAAAAATATTCTGAGAAAAAAGATATTCAGCATTTTATCAT
CGAAAAAATCCCGCTTGGAC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKLEDIKVIGVVGAGVMGHGIAQVAARTGYDVVMVDVSEEVLKKAMELIESGPFGLRRLVEKGKMSEDEAKAVMARIRTS
TSLEALKDADFIIEAVTEKADLKKKIFAELDRICKPETIIASNTSAIMISDLATAVERKDKFIGMHWFNPAPVMRLIEVI
RGALTSDETFNITVELSKKMGKIPIEAGDGPGFFTTRFINSWLVEAVRLFEIGIAGIKEIDEMCKLAFGFPMGPFELMDL
IGLDTALHIAEYLYNETKEPHYAAPNTLKKLVLSGYVGRKPGSRGGWYDYYGIER

Sequences:

>Translated_295_residues
MKLEDIKVIGVVGAGVMGHGIAQVAARTGYDVVMVDVSEEVLKKAMELIESGPFGLRRLVEKGKMSEDEAKAVMARIRTS
TSLEALKDADFIIEAVTEKADLKKKIFAELDRICKPETIIASNTSAIMISDLATAVERKDKFIGMHWFNPAPVMRLIEVI
RGALTSDETFNITVELSKKMGKIPIEAGDGPGFFTTRFINSWLVEAVRLFEIGIAGIKEIDEMCKLAFGFPMGPFELMDL
IGLDTALHIAEYLYNETKEPHYAAPNTLKKLVLSGYVGRKPGSRGGWYDYYGIER
>Mature_295_residues
MKLEDIKVIGVVGAGVMGHGIAQVAARTGYDVVMVDVSEEVLKKAMELIESGPFGLRRLVEKGKMSEDEAKAVMARIRTS
TSLEALKDADFIIEAVTEKADLKKKIFAELDRICKPETIIASNTSAIMISDLATAVERKDKFIGMHWFNPAPVMRLIEVI
RGALTSDETFNITVELSKKMGKIPIEAGDGPGFFTTRFINSWLVEAVRLFEIGIAGIKEIDEMCKLAFGFPMGPFELMDL
IGLDTALHIAEYLYNETKEPHYAAPNTLKKLVLSGYVGRKPGSRGGWYDYYGIER

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=39.7923875432526, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=37.5816993464052, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI20127408, Length=294, Percent_Identity=34.3537414965986, Blast_Score=168, Evalue=5e-42,
Organism=Homo sapiens, GI68989263, Length=300, Percent_Identity=35.3333333333333, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI261878539, Length=300, Percent_Identity=35.3333333333333, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI115430219, Length=240, Percent_Identity=31.25, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1787661, Length=287, Percent_Identity=35.5400696864112, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1790281, Length=224, Percent_Identity=38.3928571428571, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1788682, Length=267, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17549919, Length=297, Percent_Identity=40.4040404040404, Blast_Score=220, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17553560, Length=292, Percent_Identity=40.0684931506849, Blast_Score=220, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17558304, Length=275, Percent_Identity=38.1818181818182, Blast_Score=174, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17563036, Length=294, Percent_Identity=34.3537414965986, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI25144276, Length=276, Percent_Identity=36.9565217391304, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17508953, Length=276, Percent_Identity=36.9565217391304, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17508951, Length=276, Percent_Identity=36.9565217391304, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71985923, Length=289, Percent_Identity=31.1418685121107, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71985930, Length=289, Percent_Identity=28.0276816608997, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI115533614, Length=202, Percent_Identity=29.2079207920792, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193203623, Length=202, Percent_Identity=29.2079207920792, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921000, Length=292, Percent_Identity=38.3561643835616, Blast_Score=190, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24583077, Length=292, Percent_Identity=38.3561643835616, Blast_Score=190, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24583079, Length=292, Percent_Identity=38.3561643835616, Blast_Score=190, Evalue=9e-49,
Organism=Drosophila melanogaster, GI45549573, Length=254, Percent_Identity=29.1338582677165, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20129993, Length=248, Percent_Identity=27.8225806451613, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 32631; Mature: 32631

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLEDIKVIGVVGAGVMGHGIAQVAARTGYDVVMVDVSEEVLKKAMELIESGPFGLRRLV
CCCCCEEEEEEHHCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHH
EKGKMSEDEAKAVMARIRTSTSLEALKDADFIIEAVTEKADLKKKIFAELDRICKPETII
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ASNTSAIMISDLATAVERKDKFIGMHWFNPAPVMRLIEVIRGALTSDETFNITVELSKKM
ECCCCEEHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEEECHHH
GKIPIEAGDGPGFFTTRFINSWLVEAVRLFEIGIAGIKEIDEMCKLAFGFPMGPFELMDL
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IGLDTALHIAEYLYNETKEPHYAAPNTLKKLVLSGYVGRKPGSRGGWYDYYGIER
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLEDIKVIGVVGAGVMGHGIAQVAARTGYDVVMVDVSEEVLKKAMELIESGPFGLRRLV
CCCCCEEEEEEHHCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHH
EKGKMSEDEAKAVMARIRTSTSLEALKDADFIIEAVTEKADLKKKIFAELDRICKPETII
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ASNTSAIMISDLATAVERKDKFIGMHWFNPAPVMRLIEVIRGALTSDETFNITVELSKKM
ECCCCEEHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEEECHHH
GKIPIEAGDGPGFFTTRFINSWLVEAVRLFEIGIAGIKEIDEMCKLAFGFPMGPFELMDL
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
IGLDTALHIAEYLYNETKEPHYAAPNTLKKLVLSGYVGRKPGSRGGWYDYYGIER
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]