Click here to switch to the map view.

The map label for this gene is panF-1

Identifier: 11498674

GI number: 11498674

Start: 972726

End: 974201

Strand: Reverse

Name: panF-1

Synonym: AF1069

Alternate gene names: 11498674

Gene position: 974201-972726 (Counterclockwise)

Preceding gene: 11498675

Following gene: 11498669

Centisome position: 44.72

GC content: 49.53

Gene sequence:

>1476_bases
ATGATTATTGAAGCTGTGCTGATTGGCTACCTTGCCGTAGTCCTTCTTATTGGGATTTACGAATACCGCAAAACGAGGGG
ATTGCTGGATTACTACCTTGCAGGTAAAAAGCTTGGAACGCTGGTCGTTAGCTTCTCCTTCTTCGCCACTTACTTCAGCA
CGGCCGCCTTTCTGGGAGGAGGGGGGACGGGTTTCCTGCTGGGCTTTCAGTGGTCCGCGTTCCTAACCTTTTTCCACGTT
CTCTTCGCAATTCTTGCGTGGATGGTGATAGCCCCACCGATGAAGAGAATTGCTGATGAGTATGGGGCTCTAACGATTCC
TGAGCTTTTCAGAAAAAGAGCAGGTGTTTTCAGCCAGATTGTGGCGGCGGTGGTTATCATATTTTTCTTTGAGCTCTACA
TGGTCTCGATTTACAAAGGTGCCGGAAATCTCCTGCAGGTGATGCTTTCAATGGATTACACCACCGGTTTGGTGATAACG
GCTGTAATCGTGATGGTTTACACTGCGATCGGCGGATTCAGAGCTGTTGTGATGACCGACCTCATTCAGGGGGTAATCGT
TCTAATTGGTGGCGTTGCTCTGTTCCTTACCTTAATTTACTCACTTGGAGGTTTCAGCTCCGCAATTGAGGCTCTGAGCA
ATGCAAAGATTTTCGGAGAGATGGTCGGAAAAGCCTTATTTGAAATCGGAAAAGTTGGCCCACCGCCAATAGTTAAGGCA
GGGATGATTGTGCCCTTTGTCCTCAGCCTGACCTTCGCCATTAGCGTCGCCCAGCTCGCAAGTCCCCAGCTTGTTGTAAG
GTTTGTGGCAGCGAGAGACAGCAGAGTAATCGCGAACGGGATGATTTTGACACCTCTGATTATTGGTATTTTTGCCATCT
GCGTTTTCAGCATCGGCCCCTTCGGCTGGTTGGTTATACCAAAGTACACCGATGATGTCACTCAATTTCTCAAAGACGTC
GATCTGGTGGTGCCCTTCATAGCGATGAAGCTGTTTCCAGCAGGCATCAACGCACTGCTCCTCACGGCGATAATTGCTGC
CGCGATGTCCACGATAAACTCCTTGATCCACTTGGTTGCCACCGCGTTTGTCAGGGACTTGGTTCAGAATGTCAAAAAGA
TAGAGGAGAGAACCGCGTTAAACCTGACGAGGTTTGCGGTATTCATCTTCGCAACCATCCCTGTAATCTTTGCAATCAAC
CCCATGGGGGTTATTGTCGAGATTGTAGGTGTGAGCTTTTCCGTTATCACCTCAGCTTTCCTCGTTCCGCTGATTGCCTG
CCTTTACAGCGAAAAGCCCAATTCAGCTGCAATCTCAGCCTCTATGGTTGCTGCTGTGCTTGCAAGCGTTCTATGGTACT
TCTACTACTACAAGGTTTACTGGATTTACCCCGTTGTGCCCGGGCTGCTGGTCTCGATTGCGGTGTTTGCAGCCTTCAGT
CTCGCATTTCCGCAGCCTTCAAAGGCCGAAGCGTGA

Upstream 100 bases:

>100_bases
CAGGGGGTGAAAAAATGGTTATTGCAACTGTTTATGCGGCCTCTATTGGCCTGATGGTGTTTGGATTTGCCGTGGCACTG
TTCAAGGCGAGGAGGATGGC

Downstream 100 bases:

>100_bases
AAACGAGCTCAGTATTTTTTTCCTTTAAGTATTCAACCATTTCTCTGCTTAAGTCTGCAGCAGCCTTGTTTGCCTTAACG
AGAAGAGTTCTGGGGCATGT

Product: pantothenate permease (panF-1)

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MIIEAVLIGYLAVVLLIGIYEYRKTRGLLDYYLAGKKLGTLVVSFSFFATYFSTAAFLGGGGTGFLLGFQWSAFLTFFHV
LFAILAWMVIAPPMKRIADEYGALTIPELFRKRAGVFSQIVAAVVIIFFFELYMVSIYKGAGNLLQVMLSMDYTTGLVIT
AVIVMVYTAIGGFRAVVMTDLIQGVIVLIGGVALFLTLIYSLGGFSSAIEALSNAKIFGEMVGKALFEIGKVGPPPIVKA
GMIVPFVLSLTFAISVAQLASPQLVVRFVAARDSRVIANGMILTPLIIGIFAICVFSIGPFGWLVIPKYTDDVTQFLKDV
DLVVPFIAMKLFPAGINALLLTAIIAAAMSTINSLIHLVATAFVRDLVQNVKKIEERTALNLTRFAVFIFATIPVIFAIN
PMGVIVEIVGVSFSVITSAFLVPLIACLYSEKPNSAAISASMVAAVLASVLWYFYYYKVYWIYPVVPGLLVSIAVFAAFS
LAFPQPSKAEA

Sequences:

>Translated_491_residues
MIIEAVLIGYLAVVLLIGIYEYRKTRGLLDYYLAGKKLGTLVVSFSFFATYFSTAAFLGGGGTGFLLGFQWSAFLTFFHV
LFAILAWMVIAPPMKRIADEYGALTIPELFRKRAGVFSQIVAAVVIIFFFELYMVSIYKGAGNLLQVMLSMDYTTGLVIT
AVIVMVYTAIGGFRAVVMTDLIQGVIVLIGGVALFLTLIYSLGGFSSAIEALSNAKIFGEMVGKALFEIGKVGPPPIVKA
GMIVPFVLSLTFAISVAQLASPQLVVRFVAARDSRVIANGMILTPLIIGIFAICVFSIGPFGWLVIPKYTDDVTQFLKDV
DLVVPFIAMKLFPAGINALLLTAIIAAAMSTINSLIHLVATAFVRDLVQNVKKIEERTALNLTRFAVFIFATIPVIFAIN
PMGVIVEIVGVSFSVITSAFLVPLIACLYSEKPNSAAISASMVAAVLASVLWYFYYYKVYWIYPVVPGLLVSIAVFAAFS
LAFPQPSKAEA
>Mature_491_residues
MIIEAVLIGYLAVVLLIGIYEYRKTRGLLDYYLAGKKLGTLVVSFSFFATYFSTAAFLGGGGTGFLLGFQWSAFLTFFHV
LFAILAWMVIAPPMKRIADEYGALTIPELFRKRAGVFSQIVAAVVIIFFFELYMVSIYKGAGNLLQVMLSMDYTTGLVIT
AVIVMVYTAIGGFRAVVMTDLIQGVIVLIGGVALFLTLIYSLGGFSSAIEALSNAKIFGEMVGKALFEIGKVGPPPIVKA
GMIVPFVLSLTFAISVAQLASPQLVVRFVAARDSRVIANGMILTPLIIGIFAICVFSIGPFGWLVIPKYTDDVTQFLKDV
DLVVPFIAMKLFPAGINALLLTAIIAAAMSTINSLIHLVATAFVRDLVQNVKKIEERTALNLTRFAVFIFATIPVIFAIN
PMGVIVEIVGVSFSVITSAFLVPLIACLYSEKPNSAAISASMVAAVLASVLWYFYYYKVYWIYPVVPGLLVSIAVFAAFS
LAFPQPSKAEA

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=497, Percent_Identity=25.9557344064386, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI17941285, Length=397, Percent_Identity=27.455919395466, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI14140236, Length=435, Percent_Identity=23.9080459770115, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4507033, Length=424, Percent_Identity=24.5283018867925, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI110835708, Length=438, Percent_Identity=24.8858447488584, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4507031, Length=410, Percent_Identity=23.6585365853659, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI109659836, Length=431, Percent_Identity=23.8979118329466, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082237, Length=453, Percent_Identity=27.5938189845475, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1787251, Length=496, Percent_Identity=28.0241935483871, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790503, Length=470, Percent_Identity=23.1914893617021, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221459584, Length=392, Percent_Identity=22.4489795918367, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53097; Mature: 53097

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCCCCCCC
>Mature Secondary Structure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HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]