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Identifier: 11498498

GI number: 11498498

Start: 796989

End: 797993

Strand: Reverse

Name: Not Available

Synonym: AF0893

Alternate gene names: 11498498

Gene position: 797993-796989 (Counterclockwise)

Preceding gene: 11498503

Following gene: 11498496

Centisome position: 36.63

GC content: 46.17

Gene sequence:

>1005_bases
ATGTTAGATCTTGATGTAGCCCTTCCCCTCGAAGTTTTGGAAAAGCTGAGAACGGGCATTTACGTGTATCAGGAAGGTAG
ATTCGTTTTTCTCAATAGAGAGGTTGAGCGGATTTCGGGCTACACCAGAGAGGAGCTATTGAGGAAAAGTCCTTACGATT
TGCTTGCTGACGAGACGGACAGAGAAAACATAAGGCTTTTTACCGAAATGTCTGAATCCGGTAAATTTGACAATCTTCCG
GAGAGGTACGTGGCGAAGATTAGGCGAAAGAACGGTTCCCCGGCCTGGGTTGAAATGAAGGCTTTTCCGGCCATTTTTAA
AGGAAAGGAAGCTATAGTTTGCAACGTCATCGACATTACCGAACTGGTGCTGGAGGAGGAGAGAAAAAAGAGCATCGAGA
GATACGTTGAACTTGTAGGGAAAATTATCCGTCACGACCTTGCTAACAAAATCTCCGCGGCGATGAATCTCCTTGAGCTT
TCAATGGAAAAGCGGGAGGATGAAATAGTCTCGAAAGCATACCAGATTTTGGCGGAGTCGGTAAAGACCCTCAGAAGGTT
GAGAAACCTGGAATTGCTGATGAAAACGGGAGGTGAGCTTAGAGTTGTGTCGGTAAAGGAGGTTTTTGAGGAGGTTAGCA
AGAACTACAGCATTAACGTCGTTGTGACGGGAGATGCAGCAGTAATGGCAGACGACGGTCTTTACTCGATCGCAGACAAC
CTGCTGAACAACGCCGTAAAGCATGGAAGATGCAAAAACGTGAGAGTTGCCACTGAATGGGAAAAAGACAAAGTCGTTGT
AAGGGTTGAGGATGATGGTATTGGCATTTCGGATGAGAACAAGAGCAGAATATTCAACGAAGGTTTTCATTCGGGAGAGG
GTCAGGGACTGGGTCTGTTCATCGTTGCAAGCCTTATGGAGAGATACGGAGGGAATGTGGAGGTTAAAGACAACGAGCCC
ACAGGGACAGTCTTCGTTTTGAAGTTTCCGTATAAGAAAGACTAG

Upstream 100 bases:

>100_bases
ACGCCGAACCCCCCGGCCTAGCCCACCAAATAAAGTATTGTCACAGTGAGTTATAAAGGTTATGGCAAACTATTTTAAGG
ATTTAATTCAAGATTAAATA

Downstream 100 bases:

>100_bases
AAGGCAAGAGTCAGAGGAACTTTATCCCTAGCTCCCCCATGCCGTTAAAGCGCATTATGTTCAATATTAAGGGCGTCAAG
GACTCGACAAGCCTCGAGTT

Product: signal-transducing histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MLDLDVALPLEVLEKLRTGIYVYQEGRFVFLNREVERISGYTREELLRKSPYDLLADETDRENIRLFTEMSESGKFDNLP
ERYVAKIRRKNGSPAWVEMKAFPAIFKGKEAIVCNVIDITELVLEEERKKSIERYVELVGKIIRHDLANKISAAMNLLEL
SMEKREDEIVSKAYQILAESVKTLRRLRNLELLMKTGGELRVVSVKEVFEEVSKNYSINVVVTGDAAVMADDGLYSIADN
LLNNAVKHGRCKNVRVATEWEKDKVVVRVEDDGIGISDENKSRIFNEGFHSGEGQGLGLFIVASLMERYGGNVEVKDNEP
TGTVFVLKFPYKKD

Sequences:

>Translated_334_residues
MLDLDVALPLEVLEKLRTGIYVYQEGRFVFLNREVERISGYTREELLRKSPYDLLADETDRENIRLFTEMSESGKFDNLP
ERYVAKIRRKNGSPAWVEMKAFPAIFKGKEAIVCNVIDITELVLEEERKKSIERYVELVGKIIRHDLANKISAAMNLLEL
SMEKREDEIVSKAYQILAESVKTLRRLRNLELLMKTGGELRVVSVKEVFEEVSKNYSINVVVTGDAAVMADDGLYSIADN
LLNNAVKHGRCKNVRVATEWEKDKVVVRVEDDGIGISDENKSRIFNEGFHSGEGQGLGLFIVASLMERYGGNVEVKDNEP
TGTVFVLKFPYKKD
>Mature_334_residues
MLDLDVALPLEVLEKLRTGIYVYQEGRFVFLNREVERISGYTREELLRKSPYDLLADETDRENIRLFTEMSESGKFDNLP
ERYVAKIRRKNGSPAWVEMKAFPAIFKGKEAIVCNVIDITELVLEEERKKSIERYVELVGKIIRHDLANKISAAMNLLEL
SMEKREDEIVSKAYQILAESVKTLRRLRNLELLMKTGGELRVVSVKEVFEEVSKNYSINVVVTGDAAVMADDGLYSIADN
LLNNAVKHGRCKNVRVATEWEKDKVVVRVEDDGIGISDENKSRIFNEGFHSGEGQGLGLFIVASLMERYGGNVEVKDNEP
TGTVFVLKFPYKKD

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates irlR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786837, Length=220, Percent_Identity=28.1818181818182, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38034; Mature: 38034

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLDVALPLEVLEKLRTGIYVYQEGRFVFLNREVERISGYTREELLRKSPYDLLADETD
CCCCCCCCHHHHHHHHHCCEEEEECCEEEEEECHHHHHCCCCHHHHHHCCCHHHHCCCCC
RENIRLFTEMSESGKFDNLPERYVAKIRRKNGSPAWVEMKAFPAIFKGKEAIVCNVIDIT
CCCEEEEEEHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHCCCCEEEEEHHHHH
ELVLEEERKKSIERYVELVGKIIRHDLANKISAAMNLLELSMEKREDEIVSKAYQILAES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKTLRRLRNLELLMKTGGELRVVSVKEVFEEVSKNYSINVVVTGDAAVMADDGLYSIADN
HHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCEEEEEEECCEEEEECCCHHHHHHH
LLNNAVKHGRCKNVRVATEWEKDKVVVRVEDDGIGISDENKSRIFNEGFHSGEGQGLGLF
HHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCHHHH
IVASLMERYGGNVEVKDNEPTGTVFVLKFPYKKD
HHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MLDLDVALPLEVLEKLRTGIYVYQEGRFVFLNREVERISGYTREELLRKSPYDLLADETD
CCCCCCCCHHHHHHHHHCCEEEEECCEEEEEECHHHHHCCCCHHHHHHCCCHHHHCCCCC
RENIRLFTEMSESGKFDNLPERYVAKIRRKNGSPAWVEMKAFPAIFKGKEAIVCNVIDIT
CCCEEEEEEHHCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCHHHHCCCCEEEEEHHHHH
ELVLEEERKKSIERYVELVGKIIRHDLANKISAAMNLLELSMEKREDEIVSKAYQILAES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKTLRRLRNLELLMKTGGELRVVSVKEVFEEVSKNYSINVVVTGDAAVMADDGLYSIADN
HHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCEEEEEEECCEEEEECCCHHHHHHH
LLNNAVKHGRCKNVRVATEWEKDKVVVRVEDDGIGISDENKSRIFNEGFHSGEGQGLGLF
HHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCHHHH
IVASLMERYGGNVEVKDNEPTGTVFVLKFPYKKD
HHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]