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Identifier: 11498376

GI number: 11498376

Start: 687349

End: 688944

Strand: Reverse

Name: Not Available

Synonym: AF0770

Alternate gene names: 11498376

Gene position: 688944-687349 (Counterclockwise)

Preceding gene: 11498378

Following gene: 11498369

Centisome position: 31.63

GC content: 48.81

Gene sequence:

>1596_bases
GTGACCTTTCTCGACCGCACCCCTGACATCATTCTAACGATGAACGAAGAGGGGGTTATAGTAAGCCAGAATGAGACAGC
CCGCAGAGTTTTTGGGGATGTGGGGGGAAAAATCTACTCTGAGATTTGTAAAGATGACACCTGCTCCGTCGGTGACAGAT
ACTACAGCATGGTTGCCATTAAGGGATTCAGGAGGACCATAGTTGTGGGGAGGGACATCACTGAGAGAATCAGGCTTGAA
AAAGAGCTTGAGGACAGGGAGAGGAAGTTCAAAGCCCTTGCAGAGCTCTCACCAGCAGGAATCCTCGTGCATCACCAGGG
CACAATTCTCTTCGTGAATGAGGCTCTCTGCCAAATTCACGGCTACACCAGAGAGGAACTTCTGAATAGGAAGGTCTGGG
ATTTGATTCATCCAGATTACCACGACTTGGCAAGGGCTATGATGCAAAAGAGGCTTGAGGGAGAAAAGCCGGTTTACGAG
CTCAAAACCATCAGAAAAGACGGAAGCGAAAGGTGGGTGCTCGTTGCCGGAGGGGCGATTGATTGGGATGGGAAGAAGTC
CGTCATGGCCTTCGCAATAGACATAACCGACAAGAAAATGATAGAACAAAGGCTTGCAGAAAGGGAGGAGCTTTTCAGGA
GCATATTCAACATCTCTCCTGCTGGGCTTTACATACTCGTAGGGGGTAAGTTTAAGCTCGTCAATCCAGCATTTGAGCGA
ATTACGGGCTATTCTGCTGAGGAGCTTGTTGGAATGAAAAGCCTTGAGATCGTTGCTGAAGAAGACAGGGAGTTTGTGAG
GCGGAAAGCCATTGAGATGCTGAAAGGGCGTGAGACAGAGCCCTACAAGTACAGAGTAGTGAGGAAAGACGGTAAAATCA
GGTGGGTTTACGAGAACGTGGCTTCTATCGCTTATGAAGGAGAGAGGGCGGCACTCGGCAGCGTTATCGACATCACAGAA
ATTGAGGAGGAGAGAAAAAGGCTGGAAGAGCTGACATCCATGCTCGAGCTGATAAACAAGACGCTAAGGCATGACGTTCT
CAACGCCCTGACTTCGGCAATGGCCCTCCTTGAGATGGGTATTGAGGAGAGCAACAAGGACTACCTGAACAAGGCTTTGA
CGTCAATTAACAGAGCTGTAAGCATAGTCCGGAACATGAGGGCGTTTGAGGATGCCGTGAAGTCTGGAGAGTTGAGATGC
ATAGATGTTGGAGAGCTGGTTTCCGAGGTTGCAAAGTCCTTTGAGAACGTTTCGGTTAAAGGAGAGGGCAGGGCTCTTGC
CGACGAGGGTCTGAGGTCTGTGGTAGAGAACATCGTGAACAACGCATTCATCCACAGCGGTACGGACAGAGTGGAAATCA
CAGTTTCTGAAGGCAAGGAATGGTGTGAGATAAGGATTGCCGATTTTGGAATCGGTATTCCGGATGAGATAAAACAGAGA
ATTTTTGAGGAGGGGTTCAAGTACGGGAAGGCTGCGCAGACAGGACTGGGGCTTTTCATCGCAAGAAAAATAGTCGAGAG
ATATGCTGGAGAAATCTGGGTTGAGGATAACGAACCAAAAGGCTCAGTTTTTGTAATCAGGCTTAAGAAATGCTGA

Upstream 100 bases:

>100_bases
AGATGCCACGATAAGGCTCTGCGGGGATGATGAGGTAATAAAGCTTCTGATTCCCTTGCTGAGCAAGCTGCTGGACAGGT
TGCTGCTCTTCCAAGAAGTC

Downstream 100 bases:

>100_bases
AATCTGCTCCAATATGGCTTCTCGGGCTGTTTTGTAGTCGGCAAAGCCCATGAAGCCTCCCAAAACCTCATCTCCATCTG
CAAGAACCAAGGTGGGGAGC

Product: signal-transducing histidine kinase

Products: NA

Alternate protein names: Stage II sporulation protein F; Stage II sporulation protein J [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTFLDRTPDIILTMNEEGVIVSQNETARRVFGDVGGKIYSEICKDDTCSVGDRYYSMVAIKGFRRTIVVGRDITERIRLE
KELEDRERKFKALAELSPAGILVHHQGTILFVNEALCQIHGYTREELLNRKVWDLIHPDYHDLARAMMQKRLEGEKPVYE
LKTIRKDGSERWVLVAGGAIDWDGKKSVMAFAIDITDKKMIEQRLAEREELFRSIFNISPAGLYILVGGKFKLVNPAFER
ITGYSAEELVGMKSLEIVAEEDREFVRRKAIEMLKGRETEPYKYRVVRKDGKIRWVYENVASIAYEGERAALGSVIDITE
IEEERKRLEELTSMLELINKTLRHDVLNALTSAMALLEMGIEESNKDYLNKALTSINRAVSIVRNMRAFEDAVKSGELRC
IDVGELVSEVAKSFENVSVKGEGRALADEGLRSVVENIVNNAFIHSGTDRVEITVSEGKEWCEIRIADFGIGIPDEIKQR
IFEEGFKYGKAAQTGLGLFIARKIVERYAGEIWVEDNEPKGSVFVIRLKKC

Sequences:

>Translated_531_residues
MTFLDRTPDIILTMNEEGVIVSQNETARRVFGDVGGKIYSEICKDDTCSVGDRYYSMVAIKGFRRTIVVGRDITERIRLE
KELEDRERKFKALAELSPAGILVHHQGTILFVNEALCQIHGYTREELLNRKVWDLIHPDYHDLARAMMQKRLEGEKPVYE
LKTIRKDGSERWVLVAGGAIDWDGKKSVMAFAIDITDKKMIEQRLAEREELFRSIFNISPAGLYILVGGKFKLVNPAFER
ITGYSAEELVGMKSLEIVAEEDREFVRRKAIEMLKGRETEPYKYRVVRKDGKIRWVYENVASIAYEGERAALGSVIDITE
IEEERKRLEELTSMLELINKTLRHDVLNALTSAMALLEMGIEESNKDYLNKALTSINRAVSIVRNMRAFEDAVKSGELRC
IDVGELVSEVAKSFENVSVKGEGRALADEGLRSVVENIVNNAFIHSGTDRVEITVSEGKEWCEIRIADFGIGIPDEIKQR
IFEEGFKYGKAAQTGLGLFIARKIVERYAGEIWVEDNEPKGSVFVIRLKKC
>Mature_530_residues
TFLDRTPDIILTMNEEGVIVSQNETARRVFGDVGGKIYSEICKDDTCSVGDRYYSMVAIKGFRRTIVVGRDITERIRLEK
ELEDRERKFKALAELSPAGILVHHQGTILFVNEALCQIHGYTREELLNRKVWDLIHPDYHDLARAMMQKRLEGEKPVYEL
KTIRKDGSERWVLVAGGAIDWDGKKSVMAFAIDITDKKMIEQRLAEREELFRSIFNISPAGLYILVGGKFKLVNPAFERI
TGYSAEELVGMKSLEIVAEEDREFVRRKAIEMLKGRETEPYKYRVVRKDGKIRWVYENVASIAYEGERAALGSVIDITEI
EEERKRLEELTSMLELINKTLRHDVLNALTSAMALLEMGIEESNKDYLNKALTSINRAVSIVRNMRAFEDAVKSGELRCI
DVGELVSEVAKSFENVSVKGEGRALADEGLRSVVENIVNNAFIHSGTDRVEITVSEGKEWCEIRIADFGIGIPDEIKQRI
FEEGFKYGKAAQTGLGLFIARKIVERYAGEIWVEDNEPKGSVFVIRLKKC

Specific function: Phosphorylates the sporulation-regulatory proteins spo0A and spo0F. It also autophosphorylates in the presence of ATP [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1786837, Length=365, Percent_Identity=24.3835616438356, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR013655
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF08447 PAS_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 60406; Mature: 60275

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLDRTPDIILTMNEEGVIVSQNETARRVFGDVGGKIYSEICKDDTCSVGDRYYSMVAI
CCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
KGFRRTIVVGRDITERIRLEKELEDRERKFKALAELSPAGILVHHQGTILFVNEALCQIH
HCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEHHHHHHC
GYTREELLNRKVWDLIHPDYHDLARAMMQKRLEGEKPVYELKTIRKDGSERWVLVAGGAI
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEECCEE
DWDGKKSVMAFAIDITDKKMIEQRLAEREELFRSIFNISPAGLYILVGGKFKLVNPAFER
CCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEECCHHHHH
ITGYSAEELVGMKSLEIVAEEDREFVRRKAIEMLKGRETEPYKYRVVRKDGKIRWVYENV
HCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEHHHH
ASIAYEGERAALGSVIDITEIEEERKRLEELTSMLELINKTLRHDVLNALTSAMALLEMG
HHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IEESNKDYLNKALTSINRAVSIVRNMRAFEDAVKSGELRCIDVGELVSEVAKSFENVSVK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCEEC
GEGRALADEGLRSVVENIVNNAFIHSGTDRVEITVSEGKEWCEIRIADFGIGIPDEIKQR
CCCCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHHH
IFEEGFKYGKAAQTGLGLFIARKIVERYAGEIWVEDNEPKGSVFVIRLKKC
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEECC
>Mature Secondary Structure 
TFLDRTPDIILTMNEEGVIVSQNETARRVFGDVGGKIYSEICKDDTCSVGDRYYSMVAI
CCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
KGFRRTIVVGRDITERIRLEKELEDRERKFKALAELSPAGILVHHQGTILFVNEALCQIH
HCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEEHHHHHHC
GYTREELLNRKVWDLIHPDYHDLARAMMQKRLEGEKPVYELKTIRKDGSERWVLVAGGAI
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEEECCEE
DWDGKKSVMAFAIDITDKKMIEQRLAEREELFRSIFNISPAGLYILVGGKFKLVNPAFER
CCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEECCHHHHH
ITGYSAEELVGMKSLEIVAEEDREFVRRKAIEMLKGRETEPYKYRVVRKDGKIRWVYENV
HCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEHHHH
ASIAYEGERAALGSVIDITEIEEERKRLEELTSMLELINKTLRHDVLNALTSAMALLEMG
HHHHCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IEESNKDYLNKALTSINRAVSIVRNMRAFEDAVKSGELRCIDVGELVSEVAKSFENVSVK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCEEC
GEGRALADEGLRSVVENIVNNAFIHSGTDRVEITVSEGKEWCEIRIADFGIGIPDEIKQR
CCCCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHHH
IFEEGFKYGKAAQTGLGLFIARKIVERYAGEIWVEDNEPKGSVFVIRLKKC
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2104615; 2509430; 9384377 [H]