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The map label for this gene is eif2G

Identifier: 11498200

GI number: 11498200

Start: 533652

End: 534926

Strand: Reverse

Name: eif2G

Synonym: AF0592

Alternate gene names: 11498200

Gene position: 534926-533652 (Counterclockwise)

Preceding gene: 11498207

Following gene: 11498199

Centisome position: 24.56

GC content: 51.29

Gene sequence:

>1275_bases
ATGAGGCGAAATCCCTCAACATTTAAATACATTCCCCTAAGGATTGATTTCATGAGTGAAGTTCCGCTTCCTGAAGTTAA
TATCGGACTTGTCGGTCACGTTGATCACGGTAAAACCACTCTTGTTGCAGCGTTGAGTGGTGTCTGGACTGACAGACATA
GTGAGGAGTTGAAAAGAGGTATCTCAATCAAGCTCGGTTATGCAGATGCGACATTCAGAAAATGTCCGGAATGTGAACCT
CCCGAAGCGTACACGGTTGAAGAAATCTGCCCGATTCATGGCGTTGAAACTGAAATTTTGAGGACGGTAAGCTTTGTTGA
CAGCCCGGGCCACGAGATGCTGATGGCAACGATGCTCAGCGGTGCGGCAATCATGGATGGGGCCGTGCTGGTCATCGCCG
CTAATGAGAAGTGTCCCCGTCCCCAAACAAAGGAGCACCTGATGGCTCTGCAGATCATCGGTATCGACAAAATAGTCATT
GCCCAGAACAAGATAGATATCGTAAGCAGAGAGAGGGTGCTGGAAAACTATCAGGAAATAAAGGAGTTTGTTAAGGGAAC
AGTGGCAGAAAACGCTCCGATAATCCCAATCTCAGCGCAGCAGAAGGTGAACATGGACGCACTCATCGAGGCTATCGAGG
AAACCATCCCAACACCTGAAAGGGACCTTGACTCCCCGCCGCTAATGCATGTGGCAAGAAGCTTCGATGTCAACAAGCCA
GGCACTCCGCCCGAGAAGCTGCTCGGAGGTGTGCTCGGAGGGAGCCTTTCGAGAGGCAGGATAAGAGTTGGCGATGAGAT
CGAAATCAGGCCCGGGGTGAAGGATGAAAGGGGGAACTGGAATCCTCTCTTTACCGAGGTTCAGAGCATTGTGGCATCGG
GAAGATTTGTTGATGAGGCAACACCGGGAGGGCTTGTGGGTATAGCAACGAAGCTCGACCCTACCCTTACGAAGAGCGAC
GCCCTCGTGGGAAATGTAGTAGGCCACCCGGGCAATTTGCCAGACGTGCTGACGAGCTTTACGATGGAAGTGAACCTCCT
TGAAAGGGTTGTGGGGCTTGATGAAGAAATGGAGGTCGAGAAGATAAAGATGAACGAGCCCCTCATGCTCGCAGTGGGGA
CTGCAATAACTCTGGGAGTTGTGACATCAGCGAGGGATGACATCGTTGAGGTGAAGCTCAGAAGGCCAGTGTGTGCTGAT
AAGGGTTCGAGAGTTGCCATCAGCAGGAGAGTAGGGAGCAGATGGAGGCTGATAGGGGCAGGAATAATAAGGTGA

Upstream 100 bases:

>100_bases
TCCATGAATCCCATCGCCCTTCTCCGAAGCTTTTCCGCAACATCTTTTCTGGGCATTGACGACAAACTGTCAGAAAAGTT
AAAAATGTTGCCCAAAGCTC

Downstream 100 bases:

>100_bases
GGTGCGCGGTAGTAGACACCAACGTTCTGATGTACGTATACCTCAATAAGGCCGACGTAGTTGGGCAGCTAAGGGAGTTC
GGCTTCAGCAGGTTTCTGAT

Product: translation initiation factor IF-2 subunit gamma

Products: NA

Alternate protein names: aIF2-gamma; eIF-2-gamma

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MRRNPSTFKYIPLRIDFMSEVPLPEVNIGLVGHVDHGKTTLVAALSGVWTDRHSEELKRGISIKLGYADATFRKCPECEP
PEAYTVEEICPIHGVETEILRTVSFVDSPGHEMLMATMLSGAAIMDGAVLVIAANEKCPRPQTKEHLMALQIIGIDKIVI
AQNKIDIVSRERVLENYQEIKEFVKGTVAENAPIIPISAQQKVNMDALIEAIEETIPTPERDLDSPPLMHVARSFDVNKP
GTPPEKLLGGVLGGSLSRGRIRVGDEIEIRPGVKDERGNWNPLFTEVQSIVASGRFVDEATPGGLVGIATKLDPTLTKSD
ALVGNVVGHPGNLPDVLTSFTMEVNLLERVVGLDEEMEVEKIKMNEPLMLAVGTAITLGVVTSARDDIVEVKLRRPVCAD
KGSRVAISRRVGSRWRLIGAGIIR

Sequences:

>Translated_424_residues
MRRNPSTFKYIPLRIDFMSEVPLPEVNIGLVGHVDHGKTTLVAALSGVWTDRHSEELKRGISIKLGYADATFRKCPECEP
PEAYTVEEICPIHGVETEILRTVSFVDSPGHEMLMATMLSGAAIMDGAVLVIAANEKCPRPQTKEHLMALQIIGIDKIVI
AQNKIDIVSRERVLENYQEIKEFVKGTVAENAPIIPISAQQKVNMDALIEAIEETIPTPERDLDSPPLMHVARSFDVNKP
GTPPEKLLGGVLGGSLSRGRIRVGDEIEIRPGVKDERGNWNPLFTEVQSIVASGRFVDEATPGGLVGIATKLDPTLTKSD
ALVGNVVGHPGNLPDVLTSFTMEVNLLERVVGLDEEMEVEKIKMNEPLMLAVGTAITLGVVTSARDDIVEVKLRRPVCAD
KGSRVAISRRVGSRWRLIGAGIIR
>Mature_424_residues
MRRNPSTFKYIPLRIDFMSEVPLPEVNIGLVGHVDHGKTTLVAALSGVWTDRHSEELKRGISIKLGYADATFRKCPECEP
PEAYTVEEICPIHGVETEILRTVSFVDSPGHEMLMATMLSGAAIMDGAVLVIAANEKCPRPQTKEHLMALQIIGIDKIVI
AQNKIDIVSRERVLENYQEIKEFVKGTVAENAPIIPISAQQKVNMDALIEAIEETIPTPERDLDSPPLMHVARSFDVNKP
GTPPEKLLGGVLGGSLSRGRIRVGDEIEIRPGVKDERGNWNPLFTEVQSIVASGRFVDEATPGGLVGIATKLDPTLTKSD
ALVGNVVGHPGNLPDVLTSFTMEVNLLERVVGLDEEMEVEKIKMNEPLMLAVGTAITLGVVTSARDDIVEVKLRRPVCAD
KGSRVAISRRVGSRWRLIGAGIIR

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA

COG id: COG5257

COG function: function code J; Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)

Gene ontology:

Cell location: Cytoplasmic, and membrane-associated [C]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily

Homologues:

Organism=Homo sapiens, GI4503507, Length=419, Percent_Identity=47.4940334128878, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI34147630, Length=269, Percent_Identity=33.0855018587361, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI54607086, Length=317, Percent_Identity=29.6529968454259, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4503475, Length=375, Percent_Identity=24.8, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI4503471, Length=375, Percent_Identity=24.8, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI46094014, Length=357, Percent_Identity=24.3697478991597, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1790412, Length=437, Percent_Identity=29.2906178489703, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1789737, Length=437, Percent_Identity=29.2906178489703, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI2367247, Length=401, Percent_Identity=27.431421446384, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17509919, Length=419, Percent_Identity=46.0620525059666, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17556456, Length=350, Percent_Identity=29.1428571428571, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25141371, Length=335, Percent_Identity=29.8507462686567, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17506081, Length=266, Percent_Identity=25.5639097744361, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17552884, Length=336, Percent_Identity=25.8928571428571, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17569207, Length=336, Percent_Identity=25.8928571428571, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6320863, Length=440, Percent_Identity=45, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324761, Length=299, Percent_Identity=37.123745819398, Blast_Score=136, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6325337, Length=354, Percent_Identity=24.0112994350282, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319594, Length=354, Percent_Identity=24.0112994350282, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24647046, Length=418, Percent_Identity=47.6076555023923, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24647048, Length=418, Percent_Identity=47.6076555023923, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI19921738, Length=252, Percent_Identity=36.1111111111111, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI281363316, Length=338, Percent_Identity=30.4733727810651, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI17864358, Length=338, Percent_Identity=30.4733727810651, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI19922690, Length=373, Percent_Identity=27.8820375335121, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45553807, Length=377, Percent_Identity=24.6684350132626, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45553816, Length=377, Percent_Identity=24.6684350132626, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24651721, Length=377, Percent_Identity=24.6684350132626, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17864154, Length=377, Percent_Identity=24.6684350132626, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: 20568 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): IF2G_ARCFU (O29663)

Other databases:

- EMBL:   AE000782
- PIR:   H69323
- RefSeq:   NP_069426.1
- ProteinModelPortal:   O29663
- SMR:   O29663
- GeneID:   1483809
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0592
- NMPDR:   fig|224325.1.peg.585
- TIGR:   AF_0592
- HOGENOM:   HBG307581
- OMA:   IAANEPC
- ProtClustDB:   PRK04000
- BioCyc:   AFUL224325:AF_0592-MONOMER
- HAMAP:   MF_00119
- InterPro:   IPR000795
- InterPro:   IPR022424
- InterPro:   IPR015256
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- PRINTS:   PR00315
- TIGRFAMs:   TIGR03680

Pfam domain/function: PF09173 eIF2_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; SSF50465 Elong_init_C; SSF50447 Translat_factor

EC number: NA

Molecular weight: Translated: 46271; Mature: 46271

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRNPSTFKYIPLRIDFMSEVPLPEVNIGLVGHVDHGKTTLVAALSGVWTDRHSEELKRG
CCCCCCCEEEEEEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHCC
ISIKLGYADATFRKCPECEPPEAYTVEEICPIHGVETEILRTVSFVDSPGHEMLMATMLS
CEEEEECCCHHHHCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHC
GAAIMDGAVLVIAANEKCPRPQTKEHLMALQIIGIDKIVIAQNKIDIVSRERVLENYQEI
CCCEECCEEEEEECCCCCCCCCCHHHEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHH
KEFVKGTVAENAPIIPISAQQKVNMDALIEAIEETIPTPERDLDSPPLMHVARSFDVNKP
HHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCC
GTPPEKLLGGVLGGSLSRGRIRVGDEIEIRPGVKDERGNWNPLFTEVQSIVASGRFVDEA
CCCHHHHHHHHHCCCCCCCEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEECCC
TPGGLVGIATKLDPTLTKSDALVGNVVGHPGNLPDVLTSFTMEVNLLERVVGLDEEMEVE
CCCCEEEEEECCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHH
KIKMNEPLMLAVGTAITLGVVTSARDDIVEVKLRRPVCADKGSRVAISRRVGSRWRLIGA
EEECCCCEEEEECHHHEEHHHHCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCEEEECC
GIIR
CCCC
>Mature Secondary Structure
MRRNPSTFKYIPLRIDFMSEVPLPEVNIGLVGHVDHGKTTLVAALSGVWTDRHSEELKRG
CCCCCCCEEEEEEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHCC
ISIKLGYADATFRKCPECEPPEAYTVEEICPIHGVETEILRTVSFVDSPGHEMLMATMLS
CEEEEECCCHHHHCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHC
GAAIMDGAVLVIAANEKCPRPQTKEHLMALQIIGIDKIVIAQNKIDIVSRERVLENYQEI
CCCEECCEEEEEECCCCCCCCCCHHHEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHH
KEFVKGTVAENAPIIPISAQQKVNMDALIEAIEETIPTPERDLDSPPLMHVARSFDVNKP
HHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCC
GTPPEKLLGGVLGGSLSRGRIRVGDEIEIRPGVKDERGNWNPLFTEVQSIVASGRFVDEA
CCCHHHHHHHHHCCCCCCCEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEECCC
TPGGLVGIATKLDPTLTKSDALVGNVVGHPGNLPDVLTSFTMEVNLLERVVGLDEEMEVE
CCCCEEEEEECCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHH
KIKMNEPLMLAVGTAITLGVVTSARDDIVEVKLRRPVCADKGSRVAISRRVGSRWRLIGA
EEECCCCEEEEECHHHEEHHHHCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCEEEECC
GIIR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9389475