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The map label for this gene is gyrA

Identifier: 11498076

GI number: 11498076

Start: 422440

End: 424800

Strand: Reverse

Name: gyrA

Synonym: AF0465

Alternate gene names: 11498076

Gene position: 424800-422440 (Counterclockwise)

Preceding gene: 11498077

Following gene: 11498074

Centisome position: 19.5

GC content: 49.64

Gene sequence:

>2361_bases
ATGGAGCTGCTCAGAGACATCAGCGAGGAGTTGAAAAGCTCGTACATTGACTATGCCATGAGCGTTATTGTTGGCAGGGC
ATTGCCAGACGTCAGGGACGGCCTTAAACCCGTTCAGCGACGCATTCTCTATGCCATGTACGAAATGGGGCTGTTCAGCA
ACCGCCCCTACAGGAAGTCAGCGAGAATAGTCGGAGAGGTTCTCGGTAAGTACCATCCTCACGGCGACTCGGCGGTTTAC
GATGCTCTCGTCAGAATGGCTCAGGACTTCGTCATGCGCTATCCTCTTGTGGATGGACAGGGCAACTTCGGAAGCATAGA
CGGCGATTCCCCAGCAGCGATGAGGTACACCGAGGCGAGGCTCACCAAGATTGCGGAGGAGATGCTGGCCGACATAGGCA
AAAACACCGTTGATTTCATGCCGAACTTTGATGCCACTCTCAAAGAGCCTGTAGTTCTGCCCTCAAAAATCCCAAACCTT
CTCATTAATGGATCAAGCGGTATCGCGGTGGGAATGGCCACGAACATGCCGCCCCACAATTTGGCTGAGGTGTGTGAGGG
CATTATTGCCTACATCCAGAATCCCGAAATTTCCGTTGAGGAGCTGATGAAATACGTCAAAGGTCCCGACTTTCCGACTG
GCGGCGTGATTGTTGGCGTGGATGGGATTAAAGAAGCCTACCTCACCGGCAGGGGAAAGATAACGGTGAGAGGGAAGGTT
GAGGTTGAAAAGAACGCAATCATAATCAGAGAGGTTCCCTACATGGTCAACAAGGCCAAGCTGGTGGAAAGCATAGCTGA
GCTTGCGAAGGACAGAATAGATGAGATAAGGACGATAAGGGATGAATCGGATAGGGAGGGAATCAGAGTTGTAATCGAGC
TCAAATCCGGCTCAAATCCGGAAACGGTGATAAAGAAGCTGTATGCCTACTCAAACCTCCAGACTACATTCGGAATCATA
AACCTCGCCCTTGTTGATAACGAGCCGAGAATTCTCAACCTGAAGGAGCTCATAGCACTGTTCGTTGACCACAGAAGGGA
GATTATTAGGAGAAGAACGACCTATGACCTCGAAAAGGCACAGGAGAGGCTCCACATTGTTGAGGGTTTGAAGGTTGTTG
TTGAAGACATTGACAACGCCATAAACCTGATTAAATCCTCATCTTCACCATCCGAGGCGAAAGGAAAGCTGATTGAGACA
TACTCCCTCTCCGAAAAGCAGGCGGATGCCGTGCTGCAAATGCGCCTGCAGAAGTTGACGGCAATGGAAATTGACGCTCT
CCTTAAAGAGTACGAGAGCTTGAAAGAGAAAATCGCGGAGTACGAGTCAATTCTTGCCAGTCCCGAGAAAATAGATGCCA
TAATTGCAGACGAGGTTAGGGAAATCAGGGAAAAGTACGGGGATGAGAGAAGAACTGAGATTATCGGCCAGGTGGATGAA
ATATCAACGACCGACCTCATAGAGGAGGAAGAGAACGCTGTGCTGATTACAGCAGAAGGCTACGCGAAGCGCATGTCTCT
GGAAGAGTTCAGGGTGCAGTCCAGAGGTGGAGTTGGCGTTATTGGAGCGAGCGTCTCTCCTGGAGATGAAATAGCCGTCT
TTAGAATATGCAACTCAACCGACAGGCTCCTGATTTTCACCAACACCGGCAGGGCATTCTGGATTAACGCCTACGAAATT
CCTAAAATGGACAGAACGGCCAGAGGCACCACCTTAAAGAGGTTGATAAGGCTCGAAAACGGTGAGAAGGTTGTATCCGC
CTTAGGTGTTAAAGATTTCAACGGCAAGATTGCAGTTATCCTCTCACCTGATGGCTACATTAAGAAGGTCCCGCTGATTG
AGTTCGAGAACGCCAAGAGGGCAGGAGTTAAGGCTTCAGCCGGGGAAATCCAGCAGGTCGAGCTTCTTGAGGGGGACAGC
ATTTTCATCGCCACAGCCAACGGGAATGTTGTGAGGCTGAGAGAGACTGACGTGCCCGAGTATGGAAGAAATGCAAAGGG
CGTTATTGCGGTCAGGCTCAGAGATGGGGATAGGATAGCGTGGATGAGCGCTTCTGAAGGAGAGTACTTGCTGATGCTGA
CAGAAAGAGGATACGGAAAGAGATGCGATGTTAACGAGTTCAGGTTCATCGGCAGAGGCTCTATGGGAATGATTGGTTAC
AGAATTTCGGAAAAAACCGGTAAATTGGCGTTCATTTCTGCATGCAATGGTGAGGAAGTGTTTATCATGAGTGAGGACGG
CTACTGCATAAGAATTGACTCCTCCACAATTCCAGTGCAGGGCAGATACTCCTCAGGAGTCGTGGTTGCGAGAAAGGGTG
TGAAGAGAGTTGCATTAAAAAAGGTTAGAAAAGGTCCTTGA

Upstream 100 bases:

>100_bases
GCTACCTCGGCTCAATGCCATTTAGCCCAACTTGAATTAAAACTCTTTCGCTCAAAGCTCAAGTGCTCAAAGTTTTAAAC
ACTCCCTCAGACTGTTAAAA

Downstream 100 bases:

>100_bases
GGTCCCAGAGGAGCTTCGGATGCGCCTTTAGAAGCTCCTTGACTATCGCGGCAACGCTCATCTCCCTTAAATTTTTGCCC
GCAATCGCCCCTGCAAGCTT

Product: DNA gyrase, subunit A (gyrA)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 786

Protein sequence:

>786_residues
MELLRDISEELKSSYIDYAMSVIVGRALPDVRDGLKPVQRRILYAMYEMGLFSNRPYRKSARIVGEVLGKYHPHGDSAVY
DALVRMAQDFVMRYPLVDGQGNFGSIDGDSPAAMRYTEARLTKIAEEMLADIGKNTVDFMPNFDATLKEPVVLPSKIPNL
LINGSSGIAVGMATNMPPHNLAEVCEGIIAYIQNPEISVEELMKYVKGPDFPTGGVIVGVDGIKEAYLTGRGKITVRGKV
EVEKNAIIIREVPYMVNKAKLVESIAELAKDRIDEIRTIRDESDREGIRVVIELKSGSNPETVIKKLYAYSNLQTTFGII
NLALVDNEPRILNLKELIALFVDHRREIIRRRTTYDLEKAQERLHIVEGLKVVVEDIDNAINLIKSSSSPSEAKGKLIET
YSLSEKQADAVLQMRLQKLTAMEIDALLKEYESLKEKIAEYESILASPEKIDAIIADEVREIREKYGDERRTEIIGQVDE
ISTTDLIEEEENAVLITAEGYAKRMSLEEFRVQSRGGVGVIGASVSPGDEIAVFRICNSTDRLLIFTNTGRAFWINAYEI
PKMDRTARGTTLKRLIRLENGEKVVSALGVKDFNGKIAVILSPDGYIKKVPLIEFENAKRAGVKASAGEIQQVELLEGDS
IFIATANGNVVRLRETDVPEYGRNAKGVIAVRLRDGDRIAWMSASEGEYLLMLTERGYGKRCDVNEFRFIGRGSMGMIGY
RISEKTGKLAFISACNGEEVFIMSEDGYCIRIDSSTIPVQGRYSSGVVVARKGVKRVALKKVRKGP

Sequences:

>Translated_786_residues
MELLRDISEELKSSYIDYAMSVIVGRALPDVRDGLKPVQRRILYAMYEMGLFSNRPYRKSARIVGEVLGKYHPHGDSAVY
DALVRMAQDFVMRYPLVDGQGNFGSIDGDSPAAMRYTEARLTKIAEEMLADIGKNTVDFMPNFDATLKEPVVLPSKIPNL
LINGSSGIAVGMATNMPPHNLAEVCEGIIAYIQNPEISVEELMKYVKGPDFPTGGVIVGVDGIKEAYLTGRGKITVRGKV
EVEKNAIIIREVPYMVNKAKLVESIAELAKDRIDEIRTIRDESDREGIRVVIELKSGSNPETVIKKLYAYSNLQTTFGII
NLALVDNEPRILNLKELIALFVDHRREIIRRRTTYDLEKAQERLHIVEGLKVVVEDIDNAINLIKSSSSPSEAKGKLIET
YSLSEKQADAVLQMRLQKLTAMEIDALLKEYESLKEKIAEYESILASPEKIDAIIADEVREIREKYGDERRTEIIGQVDE
ISTTDLIEEEENAVLITAEGYAKRMSLEEFRVQSRGGVGVIGASVSPGDEIAVFRICNSTDRLLIFTNTGRAFWINAYEI
PKMDRTARGTTLKRLIRLENGEKVVSALGVKDFNGKIAVILSPDGYIKKVPLIEFENAKRAGVKASAGEIQQVELLEGDS
IFIATANGNVVRLRETDVPEYGRNAKGVIAVRLRDGDRIAWMSASEGEYLLMLTERGYGKRCDVNEFRFIGRGSMGMIGY
RISEKTGKLAFISACNGEEVFIMSEDGYCIRIDSSTIPVQGRYSSGVVVARKGVKRVALKKVRKGP
>Mature_786_residues
MELLRDISEELKSSYIDYAMSVIVGRALPDVRDGLKPVQRRILYAMYEMGLFSNRPYRKSARIVGEVLGKYHPHGDSAVY
DALVRMAQDFVMRYPLVDGQGNFGSIDGDSPAAMRYTEARLTKIAEEMLADIGKNTVDFMPNFDATLKEPVVLPSKIPNL
LINGSSGIAVGMATNMPPHNLAEVCEGIIAYIQNPEISVEELMKYVKGPDFPTGGVIVGVDGIKEAYLTGRGKITVRGKV
EVEKNAIIIREVPYMVNKAKLVESIAELAKDRIDEIRTIRDESDREGIRVVIELKSGSNPETVIKKLYAYSNLQTTFGII
NLALVDNEPRILNLKELIALFVDHRREIIRRRTTYDLEKAQERLHIVEGLKVVVEDIDNAINLIKSSSSPSEAKGKLIET
YSLSEKQADAVLQMRLQKLTAMEIDALLKEYESLKEKIAEYESILASPEKIDAIIADEVREIREKYGDERRTEIIGQVDE
ISTTDLIEEEENAVLITAEGYAKRMSLEEFRVQSRGGVGVIGASVSPGDEIAVFRICNSTDRLLIFTNTGRAFWINAYEI
PKMDRTARGTTLKRLIRLENGEKVVSALGVKDFNGKIAVILSPDGYIKKVPLIEFENAKRAGVKASAGEIQQVELLEGDS
IFIATANGNVVRLRETDVPEYGRNAKGVIAVRLRDGDRIAWMSASEGEYLLMLTERGYGKRCDVNEFRFIGRGSMGMIGY
RISEKTGKLAFISACNGEEVFIMSEDGYCIRIDSSTIPVQGRYSSGVVVARKGVKRVALKKVRKGP

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=315, Percent_Identity=24.1269841269841, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1788562, Length=829, Percent_Identity=45.1145958986731, Blast_Score=701, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=573, Percent_Identity=38.7434554973822, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI212645657, Length=375, Percent_Identity=25.0666666666667, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17535065, Length=349, Percent_Identity=24.9283667621776, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=483, Percent_Identity=24.223602484472, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=370, Percent_Identity=23.5135135135135, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=180, Percent_Identity=27.2222222222222, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 87463; Mature: 87463

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLRDISEELKSSYIDYAMSVIVGRALPDVRDGLKPVQRRILYAMYEMGLFSNRPYRKS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
ARIVGEVLGKYHPHGDSAVYDALVRMAQDFVMRYPLVDGQGNFGSIDGDSPAAMRYTEAR
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
LTKIAEEMLADIGKNTVDFMPNFDATLKEPVVLPSKIPNLLINGSSGIAVGMATNMPPHN
HHHHHHHHHHHCCCCCEECCCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEECCCCCHH
LAEVCEGIIAYIQNPEISVEELMKYVKGPDFPTGGVIVGVDGIKEAYLTGRGKITVRGKV
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCHHHHCCCCCEEEEEEEE
EVEKNAIIIREVPYMVNKAKLVESIAELAKDRIDEIRTIRDESDREGIRVVIELKSGSNP
EEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCH
ETVIKKLYAYSNLQTTFGIINLALVDNEPRILNLKELIALFVDHRREIIRRRTTYDLEKA
HHHHHHHHHHCCCCHHEEEEEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHCCCCHHHH
QERLHIVEGLKVVVEDIDNAINLIKSSSSPSEAKGKLIETYSLSEKQADAVLQMRLQKLT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
AMEIDALLKEYESLKEKIAEYESILASPEKIDAIIADEVREIREKYGDERRTEIIGQVDE
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHC
ISTTDLIEEEENAVLITAEGYAKRMSLEEFRVQSRGGVGVIGASVSPGDEIAVFRICNST
CCHHHHHCCCCCEEEEEECCHHHHCCHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCC
DRLLIFTNTGRAFWINAYEIPKMDRTARGTTLKRLIRLENGEKVVSALGVKDFNGKIAVI
CEEEEEEECCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCEECCCEEEEE
LSPDGYIKKVPLIEFENAKRAGVKASAGEIQQVELLEGDSIFIATANGNVVRLRETDVPE
ECCCCCEEECCEEEECCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCEEEEECCCCCC
YGRNAKGVIAVRLRDGDRIAWMSASEGEYLLMLTERGYGKRCDVNEFRFIGRGSMGMIGY
CCCCCCCEEEEEEECCCEEEEEECCCCCEEEEEECCCCCCCCCCHHHEEECCCCCCEEEE
RISEKTGKLAFISACNGEEVFIMSEDGYCIRIDSSTIPVQGRYSSGVVVARKGVKRVALK
EEECCCCCEEEEEECCCCEEEEECCCCEEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHH
KVRKGP
HHHCCC
>Mature Secondary Structure
MELLRDISEELKSSYIDYAMSVIVGRALPDVRDGLKPVQRRILYAMYEMGLFSNRPYRKS
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
ARIVGEVLGKYHPHGDSAVYDALVRMAQDFVMRYPLVDGQGNFGSIDGDSPAAMRYTEAR
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
LTKIAEEMLADIGKNTVDFMPNFDATLKEPVVLPSKIPNLLINGSSGIAVGMATNMPPHN
HHHHHHHHHHHCCCCCEECCCCCCCCCCCCEECCCCCCCEEEECCCCEEEEEECCCCCHH
LAEVCEGIIAYIQNPEISVEELMKYVKGPDFPTGGVIVGVDGIKEAYLTGRGKITVRGKV
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEECCCCHHHHCCCCCEEEEEEEE
EVEKNAIIIREVPYMVNKAKLVESIAELAKDRIDEIRTIRDESDREGIRVVIELKSGSNP
EEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCH
ETVIKKLYAYSNLQTTFGIINLALVDNEPRILNLKELIALFVDHRREIIRRRTTYDLEKA
HHHHHHHHHHCCCCHHEEEEEEEEECCCCCEECHHHHHHHHHHHHHHHHHHHCCCCHHHH
QERLHIVEGLKVVVEDIDNAINLIKSSSSPSEAKGKLIETYSLSEKQADAVLQMRLQKLT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
AMEIDALLKEYESLKEKIAEYESILASPEKIDAIIADEVREIREKYGDERRTEIIGQVDE
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHC
ISTTDLIEEEENAVLITAEGYAKRMSLEEFRVQSRGGVGVIGASVSPGDEIAVFRICNST
CCHHHHHCCCCCEEEEEECCHHHHCCHHHHHHHCCCCEEEEECCCCCCCCEEEEEEECCC
DRLLIFTNTGRAFWINAYEIPKMDRTARGTTLKRLIRLENGEKVVSALGVKDFNGKIAVI
CEEEEEEECCCEEEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCEECCCEEEEE
LSPDGYIKKVPLIEFENAKRAGVKASAGEIQQVELLEGDSIFIATANGNVVRLRETDVPE
ECCCCCEEECCEEEECCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCEEEEECCCCCC
YGRNAKGVIAVRLRDGDRIAWMSASEGEYLLMLTERGYGKRCDVNEFRFIGRGSMGMIGY
CCCCCCCEEEEEEECCCEEEEEECCCCCEEEEEECCCCCCCCCCHHHEEECCCCCCEEEE
RISEKTGKLAFISACNGEEVFIMSEDGYCIRIDSSTIPVQGRYSSGVVVARKGVKRVALK
EEECCCCCEEEEEECCCCEEEEECCCCEEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHH
KVRKGP
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]