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The map label for this gene is noxA-3

Identifier: 11498012

GI number: 11498012

Start: 363581

End: 365236

Strand: Reverse

Name: noxA-3

Synonym: AF0400

Alternate gene names: 11498012

Gene position: 365236-363581 (Counterclockwise)

Preceding gene: 11498018

Following gene: 11498008

Centisome position: 16.77

GC content: 50.6

Gene sequence:

>1656_bases
ATGAACGTTGTTGTAATCGGCGGAGGGGCTGCTGGACTGAAGGCTGCCTCCAGAATCAGAAGAAAGGATGGAGATGCAAG
CATCACCGTTGTTGAAGCTGGAAAATACGTCTCTTTAGGGAGATGCGGGCTGCCCTACTACGTTGGCGGACTTGTTCACG
AAGTTGACAATCTGAGGGAAACTACCTACGGGGCGGTGAGAGACGAGGCTTACTTCAAGAAGCTGAAAAACATCGACGTG
CTGACTGAAACGGTGGCAACCGAAATAGACAGGAGCAGGAAGACCGTGAAAATTGTGAGGAACGGCAGTGAGGACGAGCT
CAACTACGATTATCTGGTGATTGCCACAGGAGCCAGACCAGCTAAGCCGCCGATTGAGGGGATTGAGGCAGAGGGCGTTG
TAACACTTACGAGTGCCGAGGAAGCGGAGAAAATCATCGAAATGTGGGAAGAGGGGGCGGAGAAGGCTGTGGTCATCGGA
GCAGGGTTCATAGGGCTTGAATCCGCCGAGGCTCTGAAAAATCTGGACATGGAGGTTACCGTAATTGAGATGATGGATAG
AGTTGCGCCTGCTATGCTTGACAGAGAAATGGCAGTTCTTGTGGAGAACCACCTGAGGGAAAAGGGAGTGAACGTTGTAA
CGTCAACGAGAGTGGAGAAGATAGTTTCTCAAGACGATAAAGTCAGAGCAGTCATTGCGAACGGAAAGGAGTACCCTGCA
GACGTCGTTGTTGTCGCCACTGGTATCAAACCAAACAGCGAACTCGCTGAGAAGGCTGGGCTGAAAATAGGTGAAACGGG
GGCTATATGGGTTGACGAGTACATGAGAACGAGCGACGAAAGCATATACGCTGGTGGGGATTGTGTCGAGACCACGTGTC
TTGTTACGGGCAAGAAAATAATAGCTCCCTTTGGTGACGTGGCGAACAAGCAAGGAAGAGTTATAGGAGAGAACATAACG
GGAGGGAGGGCCGTTTTCCCGGGTGTGATTAGAACGGCCATTTTCAAAGTATTCGACTTCACAGCCGCTTCAGCCGGAGT
GAACGAGCAAATGGCAAAGGAGGCGGGCTTAGACTACTTTACCGTCATCGCCCCCTCTCCCGACAGAGCCCACTACTACC
CACAGGCCAACTACATCAGGTTAAAGCTCATCGTCGAAAAGGGCTCATGGAGAGTCATCGGTGCCCAGGGCGTTGGAATG
GGGGAGGTTGCAAAGAGAATTGACGTTTTAAGCACGGCAATTCAGGCCGGAATGACCATCGACCAGCTTGCAAACCTTGA
CCTTGCTTACGCCCCACCATACTCCCCCGCTCTCGACCCGGTGATTACTATCGCAAATGTCGCAATGAATAAGAGAGATG
GTCTATTCGAGGGGATTAACGTCTTCGAGCTGAAGGAGAAGCTTGAGAAAGAAGACATTGTGATTCTTGACGTAAGAAGT
GAGGAGGAGTTCAAAACCAGAAGAATAGAGTCGGAAAAGGTCATCCACATTCCCATCCTTGAGCTGAGGGAAAGGCTTGA
CGAGATACCCAGGGATAAAGAGATAGTTGTCGTCTGCGCCATTGGTCTCAGAAGCTTTGAGGCGTCAAGAATTCTCAAAC
ACGCTGGCTTCGAAAAGGTGAAAATTTTAGAGGGTGGAATGGCCTTCTGGTTTTGA

Upstream 100 bases:

>100_bases
CGTGTGCTGAGAACATGTGGGAAGTACGGCTCGAAAACTTAACATTTTTGGGTAAGCTGAAAATAGCAAGCCATATAATA
AGCGCTGCAGTCGGGGGTCC

Downstream 100 bases:

>100_bases
GTTTTAATTTTTTACTTTATATCTGAATAAAAGACCTCAACGCAATCATCGAACCTCCAAATCAACAGAGCTGCAGAAAA
CAACCGGCAGAGAGCCTATC

Product: NADH oxidase (noxA-3)

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MNVVVIGGGAAGLKAASRIRRKDGDASITVVEAGKYVSLGRCGLPYYVGGLVHEVDNLRETTYGAVRDEAYFKKLKNIDV
LTETVATEIDRSRKTVKIVRNGSEDELNYDYLVIATGARPAKPPIEGIEAEGVVTLTSAEEAEKIIEMWEEGAEKAVVIG
AGFIGLESAEALKNLDMEVTVIEMMDRVAPAMLDREMAVLVENHLREKGVNVVTSTRVEKIVSQDDKVRAVIANGKEYPA
DVVVVATGIKPNSELAEKAGLKIGETGAIWVDEYMRTSDESIYAGGDCVETTCLVTGKKIIAPFGDVANKQGRVIGENIT
GGRAVFPGVIRTAIFKVFDFTAASAGVNEQMAKEAGLDYFTVIAPSPDRAHYYPQANYIRLKLIVEKGSWRVIGAQGVGM
GEVAKRIDVLSTAIQAGMTIDQLANLDLAYAPPYSPALDPVITIANVAMNKRDGLFEGINVFELKEKLEKEDIVILDVRS
EEEFKTRRIESEKVIHIPILELRERLDEIPRDKEIVVVCAIGLRSFEASRILKHAGFEKVKILEGGMAFWF

Sequences:

>Translated_551_residues
MNVVVIGGGAAGLKAASRIRRKDGDASITVVEAGKYVSLGRCGLPYYVGGLVHEVDNLRETTYGAVRDEAYFKKLKNIDV
LTETVATEIDRSRKTVKIVRNGSEDELNYDYLVIATGARPAKPPIEGIEAEGVVTLTSAEEAEKIIEMWEEGAEKAVVIG
AGFIGLESAEALKNLDMEVTVIEMMDRVAPAMLDREMAVLVENHLREKGVNVVTSTRVEKIVSQDDKVRAVIANGKEYPA
DVVVVATGIKPNSELAEKAGLKIGETGAIWVDEYMRTSDESIYAGGDCVETTCLVTGKKIIAPFGDVANKQGRVIGENIT
GGRAVFPGVIRTAIFKVFDFTAASAGVNEQMAKEAGLDYFTVIAPSPDRAHYYPQANYIRLKLIVEKGSWRVIGAQGVGM
GEVAKRIDVLSTAIQAGMTIDQLANLDLAYAPPYSPALDPVITIANVAMNKRDGLFEGINVFELKEKLEKEDIVILDVRS
EEEFKTRRIESEKVIHIPILELRERLDEIPRDKEIVVVCAIGLRSFEASRILKHAGFEKVKILEGGMAFWF
>Mature_551_residues
MNVVVIGGGAAGLKAASRIRRKDGDASITVVEAGKYVSLGRCGLPYYVGGLVHEVDNLRETTYGAVRDEAYFKKLKNIDV
LTETVATEIDRSRKTVKIVRNGSEDELNYDYLVIATGARPAKPPIEGIEAEGVVTLTSAEEAEKIIEMWEEGAEKAVVIG
AGFIGLESAEALKNLDMEVTVIEMMDRVAPAMLDREMAVLVENHLREKGVNVVTSTRVEKIVSQDDKVRAVIANGKEYPA
DVVVVATGIKPNSELAEKAGLKIGETGAIWVDEYMRTSDESIYAGGDCVETTCLVTGKKIIAPFGDVANKQGRVIGENIT
GGRAVFPGVIRTAIFKVFDFTAASAGVNEQMAKEAGLDYFTVIAPSPDRAHYYPQANYIRLKLIVEKGSWRVIGAQGVGM
GEVAKRIDVLSTAIQAGMTIDQLANLDLAYAPPYSPALDPVITIANVAMNKRDGLFEGINVFELKEKLEKEDIVILDVRS
EEEFKTRRIESEKVIHIPILELRERLDEIPRDKEIVVVCAIGLRSFEASRILKHAGFEKVKILEGGMAFWF

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI226437568, Length=338, Percent_Identity=27.5147928994083, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI65787454, Length=338, Percent_Identity=27.5147928994083, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI21389617, Length=338, Percent_Identity=27.5147928994083, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI91199540, Length=366, Percent_Identity=25.6830601092896, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI22035672, Length=289, Percent_Identity=26.643598615917, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1789065, Length=320, Percent_Identity=27.1875, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786307, Length=470, Percent_Identity=29.7872340425532, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789765, Length=382, Percent_Identity=28.0104712041885, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788892, Length=289, Percent_Identity=28.0276816608997, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI87082354, Length=371, Percent_Identity=26.1455525606469, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87081717, Length=398, Percent_Identity=24.3718592964824, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI1789915, Length=330, Percent_Identity=24.5454545454545, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559934, Length=291, Percent_Identity=27.1477663230241, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI32564386, Length=386, Percent_Identity=26.9430051813472, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17557007, Length=349, Percent_Identity=24.6418338108883, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639257, Length=323, Percent_Identity=25.3869969040248, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281359715, Length=323, Percent_Identity=25.3869969040248, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI281359713, Length=323, Percent_Identity=25.3869969040248, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24639250, Length=323, Percent_Identity=25.3869969040248, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI18543267, Length=323, Percent_Identity=25.3869969040248, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24639252, Length=323, Percent_Identity=25.3869969040248, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24585130, Length=324, Percent_Identity=22.2222222222222, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24640553, Length=431, Percent_Identity=28.0742459396752, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640549, Length=431, Percent_Identity=28.0742459396752, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640551, Length=399, Percent_Identity=28.8220551378446, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21358499, Length=354, Percent_Identity=26.271186440678, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17737741, Length=482, Percent_Identity=25.3112033195021, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 60181; Mature: 60181

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVVVIGGGAAGLKAASRIRRKDGDASITVVEAGKYVSLGRCGLPYYVGGLVHEVDNLRE
CEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHH
TTYGAVRDEAYFKKLKNIDVLTETVATEIDRSRKTVKIVRNGSEDELNYDYLVIATGARP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCC
AKPPIEGIEAEGVVTLTSAEEAEKIIEMWEEGAEKAVVIGAGFIGLESAEALKNLDMEVT
CCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCEEEEEEECEECCCHHHHHHCCCCEEH
VIEMMDRVAPAMLDREMAVLVENHLREKGVNVVTSTRVEKIVSQDDKVRAVIANGKEYPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCEEEEEECCCCCCC
DVVVVATGIKPNSELAEKAGLKIGETGAIWVDEYMRTSDESIYAGGDCVETTCLVTGKKI
CEEEEEECCCCCHHHHHHCCCEECCCCCEEHHHHHCCCCCCEEECCCHHEEEEEEECCHH
IAPFGDVANKQGRVIGENITGGRAVFPGVIRTAIFKVFDFTAASAGVNEQMAKEAGLDYF
CCCCHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEE
TVIAPSPDRAHYYPQANYIRLKLIVEKGSWRVIGAQGVGMGEVAKRIDVLSTAIQAGMTI
EEEECCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCH
DQLANLDLAYAPPYSPALDPVITIANVAMNKRDGLFEGINVFELKEKLEKEDIVILDVRS
HHHHCCCEEECCCCCCCCCHHHHHHHHHHCCCCCHHHCCHHHHHHHHCCCCCEEEEEECC
EEEFKTRRIESEKVIHIPILELRERLDEIPRDKEIVVVCAIGLRSFEASRILKHAGFEKV
CHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEE
KILEGGMAFWF
EEEECCCHHCC
>Mature Secondary Structure
MNVVVIGGGAAGLKAASRIRRKDGDASITVVEAGKYVSLGRCGLPYYVGGLVHEVDNLRE
CEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHH
TTYGAVRDEAYFKKLKNIDVLTETVATEIDRSRKTVKIVRNGSEDELNYDYLVIATGARP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCC
AKPPIEGIEAEGVVTLTSAEEAEKIIEMWEEGAEKAVVIGAGFIGLESAEALKNLDMEVT
CCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCEEEEEEECEECCCHHHHHHCCCCEEH
VIEMMDRVAPAMLDREMAVLVENHLREKGVNVVTSTRVEKIVSQDDKVRAVIANGKEYPA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCEEEEEECCCCCCC
DVVVVATGIKPNSELAEKAGLKIGETGAIWVDEYMRTSDESIYAGGDCVETTCLVTGKKI
CEEEEEECCCCCHHHHHHCCCEECCCCCEEHHHHHCCCCCCEEECCCHHEEEEEEECCHH
IAPFGDVANKQGRVIGENITGGRAVFPGVIRTAIFKVFDFTAASAGVNEQMAKEAGLDYF
CCCCHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEE
TVIAPSPDRAHYYPQANYIRLKLIVEKGSWRVIGAQGVGMGEVAKRIDVLSTAIQAGMTI
EEEECCCCCCCCCCCCCEEEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCH
DQLANLDLAYAPPYSPALDPVITIANVAMNKRDGLFEGINVFELKEKLEKEDIVILDVRS
HHHHCCCEEECCCCCCCCCHHHHHHHHHHCCCCCHHHCCHHHHHHHHCCCCCEEEEEECC
EEEFKTRRIESEKVIHIPILELRERLDEIPRDKEIVVVCAIGLRSFEASRILKHAGFEKV
CHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEE
KILEGGMAFWF
EEEECCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]