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The map label for this gene is merP

Identifier: 11497958

GI number: 11497958

Start: 315997

End: 316611

Strand: Reverse

Name: merP

Synonym: AF0346

Alternate gene names: 11497958

Gene position: 316611-315997 (Counterclockwise)

Preceding gene: 11497963

Following gene: 11497957

Centisome position: 14.53

GC content: 51.87

Gene sequence:

>615_bases
ATGATGCGATGCCCAGAATGCAGCACGGAAGGATGGAGAGTTTTGCCGCTGACCGTCGGCGCACACGTTAAGGAGGGACT
CTGGAGTAAAATCAAAGGGGATTTTTACTTCTGCTCTTTGGAGAGCTGCGAGGTTGTTTACTTCAACGAGCAAACGGTCT
TTAGGAAGGGTGAGCTGAAGACGAGAGTGGGTGTTAAGGAACGGGAAGAACCAAAGCCGGTTTGCTACTGCAACAGGGTT
ACAGAGAAGATGCTGTTGGAAGCTGCCGAAAAGTTCGGAAAGGAGAAAGCTGTCGAGATCACGGGAGCAGGAAAAGGAAA
ATGGTGCGTCGTTACCAACCCATCCGGGAGATGCTGCCACTGGCATCTGGAGAGGCTGGGATTTCCCGTTGGAGGTGAGA
AGAAAGCGGCTAAAAGAGTGGAAATTAAGCTTGACGGTCTCACATGCATGGGGTGTGTTAGCGCTGTAAAGGCGGCTCTT
GAAGAGGCCGGAGCGAATGTTGTTGAAATTGGGCTGGACAGGGCTGTTGTTGAGGTTGACGAGGAAGCGGAGCTGCAGAA
ACTCGTTGAGGCTGTTGAGGGAGCAGGTTACTCTGCACGGCTTGAAAAGAGATGA

Upstream 100 bases:

>100_bases
AAAGAAAAATGGCGTGTGGTAAAGTTGTAGTGAAGTCAATCTGTAAGACTGTTGAACTCTTTGAGTGAAAAAGCTTTTCA
GGAGAATGTGGTGAAGAAAA

Downstream 100 bases:

>100_bases
AAGGCAGGCTTAAGGTTTGACAAGATAGACGCTAATAATCACCGGGATGCATTTCTGTCTCTGATGAAGCCATCATGCTT
AGACGGGAAAAGCTAATTTA

Product: mercuric transport protein periplasmic component (merP)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MMRCPECSTEGWRVLPLTVGAHVKEGLWSKIKGDFYFCSLESCEVVYFNEQTVFRKGELKTRVGVKEREEPKPVCYCNRV
TEKMLLEAAEKFGKEKAVEITGAGKGKWCVVTNPSGRCCHWHLERLGFPVGGEKKAAKRVEIKLDGLTCMGCVSAVKAAL
EEAGANVVEIGLDRAVVEVDEEAELQKLVEAVEGAGYSARLEKR

Sequences:

>Translated_204_residues
MMRCPECSTEGWRVLPLTVGAHVKEGLWSKIKGDFYFCSLESCEVVYFNEQTVFRKGELKTRVGVKEREEPKPVCYCNRV
TEKMLLEAAEKFGKEKAVEITGAGKGKWCVVTNPSGRCCHWHLERLGFPVGGEKKAAKRVEIKLDGLTCMGCVSAVKAAL
EEAGANVVEIGLDRAVVEVDEEAELQKLVEAVEGAGYSARLEKR
>Mature_204_residues
MMRCPECSTEGWRVLPLTVGAHVKEGLWSKIKGDFYFCSLESCEVVYFNEQTVFRKGELKTRVGVKEREEPKPVCYCNRV
TEKMLLEAAEKFGKEKAVEITGAGKGKWCVVTNPSGRCCHWHLERLGFPVGGEKKAAKRVEIKLDGLTCMGCVSAVKAAL
EEAGANVVEIGLDRAVVEVDEEAELQKLVEAVEGAGYSARLEKR

Specific function: Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) directly to the transmembrane transport sites of copper-exporting P-type ATPase A (CopA). Probably has a redox function due to the presence of a 2Fe-2S cluste

COG id: COG2608

COG function: function code P; Copper chaperone

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COPZ_ARCFU (O29901)

Other databases:

- EMBL:   AE000782
- PIR:   B69293
- RefSeq:   NP_069182.1
- PDB:   2HU9
- PDBsum:   2HU9
- ProteinModelPortal:   O29901
- SMR:   O29901
- GeneID:   1483560
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0346
- NMPDR:   fig|224325.1.peg.341
- TIGR:   AF_0346
- BioCyc:   AFUL224325:AF_0346-MONOMER
- GO:   GO:0005737
- InterPro:   IPR007419
- InterPro:   IPR017969
- InterPro:   IPR006121

Pfam domain/function: PF04324 Fer2_BFD; PF00403 HMA; SSF55008 HeavyMe_transpt

EC number: NA

Molecular weight: Translated: 22588; Mature: 22588

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS01047 HMA_1; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
5.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRCPECSTEGWRVLPLTVGAHVKEGLWSKIKGDFYFCSLESCEVVYFNEQTVFRKGELK
CCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCEEEEEECCEEEEEECCCEEEECCCCC
TRVGVKEREEPKPVCYCNRVTEKMLLEAAEKFGKEKAVEITGAGKGKWCVVTNPSGRCCH
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCEEE
WHLERLGFPVGGEKKAAKRVEIKLDGLTCMGCVSAVKAALEEAGANVVEIGLDRAVVEVD
EEHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECC
EEAELQKLVEAVEGAGYSARLEKR
CHHHHHHHHHHHHCCCCCEEECCC
>Mature Secondary Structure
MMRCPECSTEGWRVLPLTVGAHVKEGLWSKIKGDFYFCSLESCEVVYFNEQTVFRKGELK
CCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCEEEEEECCEEEEEECCCEEEECCCCC
TRVGVKEREEPKPVCYCNRVTEKMLLEAAEKFGKEKAVEITGAGKGKWCVVTNPSGRCCH
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCEEE
WHLERLGFPVGGEKKAAKRVEIKLDGLTCMGCVSAVKAALEEAGANVVEIGLDRAVVEVD
EEHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECC
EEAELQKLVEAVEGAGYSARLEKR
CHHHHHHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475