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The map label for this gene is htpX

Identifier: 11497851

GI number: 11497851

Start: 210600

End: 211607

Strand: Reverse

Name: htpX

Synonym: AF0235

Alternate gene names: 11497851

Gene position: 211607-210600 (Counterclockwise)

Preceding gene: 11497854

Following gene: 11497850

Centisome position: 9.71

GC content: 52.78

Gene sequence:

>1008_bases
ATGATGCTGTACTTCTTCGACCCCGTGTACATGATGCTGGCCGTGCTGGGCTACTTCGTAATGCTGCTCTTAGCCTCCAC
CATCGCCCCCAAGGTGGCCAGCAGAGTTTCAGGGAAGTTCTCGCTCTTCACCTCAATGGTACTTCTCGCCGGAATGATTC
TCGCCATTTCGGCAGCAATAATCTACCTCATACTGGCCTACGCTGGAGTTTACATCAGCTTCTACGGGCTTATAATCTTC
CTGTTGATAATCAACCTGCTGATGTACCTGCTTTCCCCCTACATCATCAACCTCAGCTACGGAGCGCAGAGAGACGAGAG
GCTGCAGATGGTTGTGAACAGCGTTGCGAGGAGGCTGAACGTAAAGCCGCCAAAGGCGGTGGTTGTGAGAAGTCCCCCGA
ACGCCTTCGCCTACGGAAACTTTTTGACGGGAAAGTTCGTGGCGGTTTCAGAGTCGCTGATGAGGATGCTCAGCCAGGAG
GAGCTTGAGGCAGTCATTGGTCATGAAATCGGCCACCACAAGCACAGGGACAATGCCGTGATGCTCCTCTTCGGCCTGCT
GCCCTCAGTAATCTTCTACCTCGGTTACGCCTTGCTCCACTCCTCAATGAGGGACGACAGGAGGGGAGCGCAGCTCGCAG
CAATTGGCATTGCAGCAGTTATAGTTTCATTTATAGTCCAGATTCTCGTTCTCGCCTTCAGCAGGCTCAGAGAGTACTAT
GCGGACTTCGAGGGAGTTAGGGCGACAAACAAGGATGCAATGCAGAGGAGTCTGGCGAAGATACACCTCTTCTACCACCG
CTACCCCGACTACCTCGCCCCCATCCAGGACAGCAAGTTCAGAACTCTCTTCATCTACGCCTTCACCAATGCGGTGGCTG
AGCCAATAACGAGAGCTGACATTGAAGCGCTGAAGAACATGAAAGTCAGCCCCATTCAGGAGTTCCTTTCAACACACCCG
CCACTGCCGAAAAGGCTGAGGTTTATCGAGAGTATAAGAGTTTTTTAG

Upstream 100 bases:

>100_bases
GTTTTTATTGTTTTTGGTTGTGCTGTTTATGGGAGACTGGGGATTTGAAATTAGCGGACACCTTTTAAACTATAAATACC
GCAGCAGCCTATAAACCAAC

Downstream 100 bases:

>100_bases
CTGTAAAATTTTTTAACTTCAAACATAACACTCTTTTGTGAAGCTTAAGTCAAAGGGCTGCAATGTTTATCTCATAAAAG
ATGGAGATTCCACATACCTG

Product: heat shock protein (htpX)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MMLYFFDPVYMMLAVLGYFVMLLLASTIAPKVASRVSGKFSLFTSMVLLAGMILAISAAIIYLILAYAGVYISFYGLIIF
LLIINLLMYLLSPYIINLSYGAQRDERLQMVVNSVARRLNVKPPKAVVVRSPPNAFAYGNFLTGKFVAVSESLMRMLSQE
ELEAVIGHEIGHHKHRDNAVMLLFGLLPSVIFYLGYALLHSSMRDDRRGAQLAAIGIAAVIVSFIVQILVLAFSRLREYY
ADFEGVRATNKDAMQRSLAKIHLFYHRYPDYLAPIQDSKFRTLFIYAFTNAVAEPITRADIEALKNMKVSPIQEFLSTHP
PLPKRLRFIESIRVF

Sequences:

>Translated_335_residues
MMLYFFDPVYMMLAVLGYFVMLLLASTIAPKVASRVSGKFSLFTSMVLLAGMILAISAAIIYLILAYAGVYISFYGLIIF
LLIINLLMYLLSPYIINLSYGAQRDERLQMVVNSVARRLNVKPPKAVVVRSPPNAFAYGNFLTGKFVAVSESLMRMLSQE
ELEAVIGHEIGHHKHRDNAVMLLFGLLPSVIFYLGYALLHSSMRDDRRGAQLAAIGIAAVIVSFIVQILVLAFSRLREYY
ADFEGVRATNKDAMQRSLAKIHLFYHRYPDYLAPIQDSKFRTLFIYAFTNAVAEPITRADIEALKNMKVSPIQEFLSTHP
PLPKRLRFIESIRVF
>Mature_335_residues
MMLYFFDPVYMMLAVLGYFVMLLLASTIAPKVASRVSGKFSLFTSMVLLAGMILAISAAIIYLILAYAGVYISFYGLIIF
LLIINLLMYLLSPYIINLSYGAQRDERLQMVVNSVARRLNVKPPKAVVVRSPPNAFAYGNFLTGKFVAVSESLMRMLSQE
ELEAVIGHEIGHHKHRDNAVMLLFGLLPSVIFYLGYALLHSSMRDDRRGAQLAAIGIAAVIVSFIVQILVLAFSRLREYY
ADFEGVRATNKDAMQRSLAKIHLFYHRYPDYLAPIQDSKFRTLFIYAFTNAVAEPITRADIEALKNMKVSPIQEFLSTHP
PLPKRLRFIESIRVF

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=299, Percent_Identity=26.0869565217391, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_ARCFU (O30004)

Other databases:

- EMBL:   AE000782
- PIR:   C69279
- RefSeq:   NP_069073.1
- ProteinModelPortal:   O30004
- SMR:   O30004
- GeneID:   1483446
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0235
- NMPDR:   fig|224325.1.peg.232
- TIGR:   AF_0235
- HOGENOM:   HBG739460
- OMA:   EYYADAH
- ProtClustDB:   CLSK2746351
- BioCyc:   AFUL224325:AF_0235-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.- [C]

Molecular weight: Translated: 37856; Mature: 37856

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 169-169

Signals:

None

Transmembrane regions:

HASH(0xbfa077c)-; HASH(0xc7da734)-; HASH(0xc6ccc50)-; HASH(0xc760128)-; HASH(0xc3e63f8)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLYFFDPVYMMLAVLGYFVMLLLASTIAPKVASRVSGKFSLFTSMVLLAGMILAISAAI
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IYLILAYAGVYISFYGLIIFLLIINLLMYLLSPYIINLSYGAQRDERLQMVVNSVARRLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCC
VKPPKAVVVRSPPNAFAYGNFLTGKFVAVSESLMRMLSQEELEAVIGHEIGHHKHRDNAV
CCCCCEEEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
MLLFGLLPSVIFYLGYALLHSSMRDDRRGAQLAAIGIAAVIVSFIVQILVLAFSRLREYY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADFEGVRATNKDAMQRSLAKIHLFYHRYPDYLAPIQDSKFRTLFIYAFTNAVAEPITRAD
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHH
IEALKNMKVSPIQEFLSTHPPLPKRLRFIESIRVF
HHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHCH
>Mature Secondary Structure
MMLYFFDPVYMMLAVLGYFVMLLLASTIAPKVASRVSGKFSLFTSMVLLAGMILAISAAI
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IYLILAYAGVYISFYGLIIFLLIINLLMYLLSPYIINLSYGAQRDERLQMVVNSVARRLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCC
VKPPKAVVVRSPPNAFAYGNFLTGKFVAVSESLMRMLSQEELEAVIGHEIGHHKHRDNAV
CCCCCEEEEECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
MLLFGLLPSVIFYLGYALLHSSMRDDRRGAQLAAIGIAAVIVSFIVQILVLAFSRLREYY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADFEGVRATNKDAMQRSLAKIHLFYHRYPDYLAPIQDSKFRTLFIYAFTNAVAEPITRAD
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHH
IEALKNMKVSPIQEFLSTHPPLPKRLRFIESIRVF
HHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9389475