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The map label for this gene is hisD

Identifier: 11497828

GI number: 11497828

Start: 188172

End: 189386

Strand: Reverse

Name: hisD

Synonym: AF0212

Alternate gene names: 11497828

Gene position: 189386-188172 (Counterclockwise)

Preceding gene: 11497829

Following gene: 11497824

Centisome position: 8.69

GC content: 51.11

Gene sequence:

>1215_bases
ATGGAGGAAATTCTGAGGCTCAGAAGGAGTGTCAGCATTGACGATTACATTGAAAAGGTAAAGCCAATCGTTGAGGCCGT
CAAAAGGGAGGGAGATAAAGCTGTAATCCGATTTACGAGGGATTTGGACGGAGTCGAGCTTGACAGCCTGAGAGTTACGG
AGGATGAGTTTGAGAAGGCTTATGATGCGGTGGATGACGGCCTCATTGACGCTCTTGAAGTGGCGAAGGAGAACATCTAC
AGGTTCCACTACGTCACATCAGTTGAGAGGGATATGAAGGTTGAGTTCGAGGACTGCGTTATGGGGAAAATCTACACCCC
CATAGAGAAGGTTGGCGCTTACATTCCAGGCGGGAGAGCAAGCTATCCATCAACGGCCTTAATGATAGGCGTTCCGGCAA
AGATTGCGGGAGTTGAGAAACTGGTCGCCTGCACCCCTCCCAACAAGGATGGTAAAGTAAACCCACTAACCCTCGTTGCC
CTCGATATTGCCGAATTTGATGAGGTTTACAAGGCAGGCGGAGCGCAGGCGATAGCGGCCATGGCATACGGAACCGAAAC
TGTTGAGAAGGTTTACAAGATTGTGGGGCCTGGAAACATCTACGTCACAGCGGCCAAGCTTCTTGTGGCAAAGGATGTGG
CAATAGACATGCCTGCAGGCCCTTCGGAAATTCTCGTTATAGCGGACGAAACTGCTAATGCGGACTTCATAGCCTGCGAC
TGCCTCGCTCAGCTTGAGCACGACCCGATGGCAGTGGCTGTGGTTCTCACAACCTCCCGGAAAGTTGCCGACGAGGTGGA
AAAAAAGGTCAAATCGGAAGGAGATTTCAGCAACTTCGCCGTTTTCGTTGTTGAGGACTTGGCGGAGGCCTTTGAAATTT
CGAACGAATTTGCTCCGGAGCACCTCACGGTAGCGGTTAAAAATCCGGAGGAATGGCTCGGGAAAGTCAGAAATGCTGGC
AGCGTTTTTCTCGGAAACTTCTCTCCCGTCGCAGCAGGAGACTACGCCTCTGGAACGAACCACGTTTTACCCACTGCAGG
CTACGCCAAGATTTACGGCGGCCTGAGCGTTGAGAGCTTTCTGAAGCACTTCACCTTCCAGATGCTGAGCGAGGAGAGCA
TGAGGAGAATTGGAGGGGATGTAGTAAAAATTGCAGAAGCTGAAGGGTTGAGGTGGCATGCGGAGAGTGTGAGAAAAAGG
TTGGAAAAAATTTAG

Upstream 100 bases:

>100_bases
CTTGGCGTGAGCATAAGCCTTCCGATAATCATACTCTTTCAGAGGATGATCTTCCTCGGACTTCTGGCAAAGTGATTTAT
TCCACCCGCCTACTTAAAGC

Downstream 100 bases:

>100_bases
TATTCGAGAACTTCTTCGTAGAACCTTTTTATCATTCTTTTGTCTTCCAGCAGCTCTTTCTCCTTCAGTATCTCTCTTTC
GAGCTTCTTCAGCGCCACAT

Product: histidinol dehydrogenase (hisD)

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MEEILRLRRSVSIDDYIEKVKPIVEAVKREGDKAVIRFTRDLDGVELDSLRVTEDEFEKAYDAVDDGLIDALEVAKENIY
RFHYVTSVERDMKVEFEDCVMGKIYTPIEKVGAYIPGGRASYPSTALMIGVPAKIAGVEKLVACTPPNKDGKVNPLTLVA
LDIAEFDEVYKAGGAQAIAAMAYGTETVEKVYKIVGPGNIYVTAAKLLVAKDVAIDMPAGPSEILVIADETANADFIACD
CLAQLEHDPMAVAVVLTTSRKVADEVEKKVKSEGDFSNFAVFVVEDLAEAFEISNEFAPEHLTVAVKNPEEWLGKVRNAG
SVFLGNFSPVAAGDYASGTNHVLPTAGYAKIYGGLSVESFLKHFTFQMLSEESMRRIGGDVVKIAEAEGLRWHAESVRKR
LEKI

Sequences:

>Translated_404_residues
MEEILRLRRSVSIDDYIEKVKPIVEAVKREGDKAVIRFTRDLDGVELDSLRVTEDEFEKAYDAVDDGLIDALEVAKENIY
RFHYVTSVERDMKVEFEDCVMGKIYTPIEKVGAYIPGGRASYPSTALMIGVPAKIAGVEKLVACTPPNKDGKVNPLTLVA
LDIAEFDEVYKAGGAQAIAAMAYGTETVEKVYKIVGPGNIYVTAAKLLVAKDVAIDMPAGPSEILVIADETANADFIACD
CLAQLEHDPMAVAVVLTTSRKVADEVEKKVKSEGDFSNFAVFVVEDLAEAFEISNEFAPEHLTVAVKNPEEWLGKVRNAG
SVFLGNFSPVAAGDYASGTNHVLPTAGYAKIYGGLSVESFLKHFTFQMLSEESMRRIGGDVVKIAEAEGLRWHAESVRKR
LEKI
>Mature_404_residues
MEEILRLRRSVSIDDYIEKVKPIVEAVKREGDKAVIRFTRDLDGVELDSLRVTEDEFEKAYDAVDDGLIDALEVAKENIY
RFHYVTSVERDMKVEFEDCVMGKIYTPIEKVGAYIPGGRASYPSTALMIGVPAKIAGVEKLVACTPPNKDGKVNPLTLVA
LDIAEFDEVYKAGGAQAIAAMAYGTETVEKVYKIVGPGNIYVTAAKLLVAKDVAIDMPAGPSEILVIADETANADFIACD
CLAQLEHDPMAVAVVLTTSRKVADEVEKKVKSEGDFSNFAVFVVEDLAEAFEISNEFAPEHLTVAVKNPEEWLGKVRNAG
SVFLGNFSPVAAGDYASGTNHVLPTAGYAKIYGGLSVESFLKHFTFQMLSEESMRRIGGDVVKIAEAEGLRWHAESVRKR
LEKI

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=416, Percent_Identity=40.1442307692308, Blast_Score=286, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6319819, Length=418, Percent_Identity=40.4306220095694, Blast_Score=308, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_ARCFU (O30027)

Other databases:

- EMBL:   AE000782
- PIR:   D69276
- RefSeq:   NP_069050.1
- ProteinModelPortal:   O30027
- SMR:   O30027
- GeneID:   1483423
- GenomeReviews:   AE000782_GR
- KEGG:   afu:AF0212
- NMPDR:   fig|224325.1.peg.209
- TIGR:   AF_0212
- HOGENOM:   HBG329596
- OMA:   TEWEVEK
- ProtClustDB:   CLSK2746336
- BioCyc:   AFUL224325:AF_0212-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 44153; Mature: 44153

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 300-300 ACT_SITE 301-301 BINDING 114-114 BINDING 176-176 BINDING 199-199 BINDING 222-222 BINDING 244-244 BINDING 247-247 BINDING 301-301 BINDING 334-334 BINDING 388-388 BINDING 393-393

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEILRLRRSVSIDDYIEKVKPIVEAVKREGDKAVIRFTRDLDGVELDSLRVTEDEFEKA
CHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEECCEECCHHHHHHH
YDAVDDGLIDALEVAKENIYRFHYVTSVERDMKVEFEDCVMGKIYTPIEKVGAYIPGGRA
HHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEHHHHHHHHHCCCHHHHCCCCCCCCC
SYPSTALMIGVPAKIAGVEKLVACTPPNKDGKVNPLTLVALDIAEFDEVYKAGGAQAIAA
CCCCCEEEEECCHHHHCHHHEEEECCCCCCCCCCCEEEEEEEHHHHHHHHHCCCHHHHHH
MAYGTETVEKVYKIVGPGNIYVTAAKLLVAKDVAIDMPAGPSEILVIADETANADFIACD
HHHCHHHHHHHHHHCCCCCEEEEHHHHHHHHCCEEECCCCCCCEEEEEECCCCCCEEEHH
CLAQLEHDPMAVAVVLTTSRKVADEVEKKVKSEGDFSNFAVFVVEDLAEAFEISNEFAPE
HHHHCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
HLTVAVKNPEEWLGKVRNAGSVFLGNFSPVAAGDYASGTNHVLPTAGYAKIYGGLSVESF
EEEEEECCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHH
LKHFTFQMLSEESMRRIGGDVVKIAEAEGLRWHAESVRKRLEKI
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEHHHHHHHHHHCC
>Mature Secondary Structure
MEEILRLRRSVSIDDYIEKVKPIVEAVKREGDKAVIRFTRDLDGVELDSLRVTEDEFEKA
CHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEECCEECCHHHHHHH
YDAVDDGLIDALEVAKENIYRFHYVTSVERDMKVEFEDCVMGKIYTPIEKVGAYIPGGRA
HHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEHHHHHHHHHCCCHHHHCCCCCCCCC
SYPSTALMIGVPAKIAGVEKLVACTPPNKDGKVNPLTLVALDIAEFDEVYKAGGAQAIAA
CCCCCEEEEECCHHHHCHHHEEEECCCCCCCCCCCEEEEEEEHHHHHHHHHCCCHHHHHH
MAYGTETVEKVYKIVGPGNIYVTAAKLLVAKDVAIDMPAGPSEILVIADETANADFIACD
HHHCHHHHHHHHHHCCCCCEEEEHHHHHHHHCCEEECCCCCCCEEEEEECCCCCCEEEHH
CLAQLEHDPMAVAVVLTTSRKVADEVEKKVKSEGDFSNFAVFVVEDLAEAFEISNEFAPE
HHHHCCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
HLTVAVKNPEEWLGKVRNAGSVFLGNFSPVAAGDYASGTNHVLPTAGYAKIYGGLSVESF
EEEEEECCHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHH
LKHFTFQMLSEESMRRIGGDVVKIAEAEGLRWHAESVRKRLEKI
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475