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Identifier: 11497824

GI number: 11497824

Start: 182491

End: 183936

Strand: Reverse

Name: Not Available

Synonym: AF0208

Alternate gene names: 11497824

Gene position: 183936-182491 (Counterclockwise)

Preceding gene: 11497828

Following gene: 11497809

Centisome position: 8.44

GC content: 45.85

Gene sequence:

>1446_bases
ATGAGTATCTACGCAGTTGGATTGCTGCTATCACTGTTTGAGCTTACTCTGTTCACCGTAAATTACTATTACGGTCTGCC
CCCCTATGTATTTCTGCCAAGTATATACCTATTTAATATTATTTTGGTAATGGTTGCATTTATCGCTTCAGTCTACTTAG
CAAGAGCATCCAAGAGCGAAAGGAGAACGCTCTTCTCCACCCTCGCATTTTTTTCGGGATTATTGCTGCTCTCGATTCTC
AGCGTTGGTCAGATGGTTTGGGTGAGGAGCGACTTTCAACTGAAGGTTGAGCACTTTGAGTACTTTATACCGATATACCT
TCTGGCAGAAACGCCGATTCTCGGATTCTTCCTCTGGAAGATTTTGAGGGAGATGAGGTATTTCGATGTAAAGCACTTTC
TGCCCGCAATCCTCGCAATACCCATCCTTGTTTTTTCCAGTTATGAGCTGGTAGGTCTTGAGTACTCCAATCTGTCAACG
TTTATACATCTGGAAACTCTGATATGCGACTCTGTGATAATTCTTTCTCTGTTAACGCTCACAGCTGCTTACTTCAAAAC
GGAGTCTGCGGCTTACTACAAATCCTTTCTGCTTTACTTCATACTGAAGTACATCAGCGATGTGGCCCTCCTGAGGTCTT
TCAGGGGGTGGCTGGACTTCGACCTCTCTACAGCCATTTTCACATTCTCAAACATAGTGCTACTGACAGTTCTCTACAAA
TTCTACAGGACAGAAATCACGCTTCTCAGCTACTACGACCTCGACGCGGAGAGGAAGAAATATGCAGAACTCTACGCTCA
AGTAAACGAGTTGCAGGAAATTCTCAAGCTGATAAACAGGATGCTGAGACACGATATTTTGAACAAGCTGCAGATCATAT
CGGGATACGTCGAGACGTACCGAATGACGAAAAGGGAGGAGCTTCTCGACAAGGTCATGAAAGCTGTTGAGGAAAGCAGC
TCCTACATAGACAAGATAAGGGAGCTCGAAAAAATTGTTCTCACGATGAGCGAGAAGCTGAAGCCCATCAACATGCGAGA
GGTTGCAGAGGAGGTGGCAAAGTCTTTCAATATCGAGATAAACATAAAGGGAAGCTGTGTTGCAATGGCGGACGGTGCAA
TATACTCCGTCCTTGAAAATCTCATTTCAAACGCAATCAAGCACGGAAGGACGAACAGGGTGGACATAATCCTCAGTGAG
TTTGAGGATGACTGCGAGATTAGGGTTGTGGACTACGGAGTAGGAATCCCCTTGGAAATCAGGAGGCAGATTTTCAAGGA
GAGCTTCAAGTACGGTGAGACTGGCGGGACGGGACTGGGGCTTTACATCGTCAAGAGGGTCGTGGAGAGGTATGGGGGTA
AAGTGTGGGTTGAAGATACAAAGCCCCACGGAGCGACCTTTGTGATAAGGTTAAAAGCTGCGAGGGTAAAGCTGAGTGAG
CGATGA

Upstream 100 bases:

>100_bases
CCCCAAGGTAAAAAAGTTTTATTGGTTTATACAAAGACATAAATTTTTTTGAAAAGAATTGGCAGTTAGGTTTATTAATT
ACCTCAACGTAATAACAATA

Downstream 100 bases:

>100_bases
TGAAAGGGCCCCTCTGAACGGTGATGAGGGTTTTGAGTTCTGAGCTCAGAGCTGCTCTAAAAGTGTGTTGCAAGCTGCTA
TAATCTTCTCATTGGCTCTT

Product: signal-transducing histidine kinase

Products: NA

Alternate protein names: Sensor histidine kinase CitA [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MSIYAVGLLLSLFELTLFTVNYYYGLPPYVFLPSIYLFNIILVMVAFIASVYLARASKSERRTLFSTLAFFSGLLLLSIL
SVGQMVWVRSDFQLKVEHFEYFIPIYLLAETPILGFFLWKILREMRYFDVKHFLPAILAIPILVFSSYELVGLEYSNLST
FIHLETLICDSVIILSLLTLTAAYFKTESAAYYKSFLLYFILKYISDVALLRSFRGWLDFDLSTAIFTFSNIVLLTVLYK
FYRTEITLLSYYDLDAERKKYAELYAQVNELQEILKLINRMLRHDILNKLQIISGYVETYRMTKREELLDKVMKAVEESS
SYIDKIRELEKIVLTMSEKLKPINMREVAEEVAKSFNIEINIKGSCVAMADGAIYSVLENLISNAIKHGRTNRVDIILSE
FEDDCEIRVVDYGVGIPLEIRRQIFKESFKYGETGGTGLGLYIVKRVVERYGGKVWVEDTKPHGATFVIRLKAARVKLSE
R

Sequences:

>Translated_481_residues
MSIYAVGLLLSLFELTLFTVNYYYGLPPYVFLPSIYLFNIILVMVAFIASVYLARASKSERRTLFSTLAFFSGLLLLSIL
SVGQMVWVRSDFQLKVEHFEYFIPIYLLAETPILGFFLWKILREMRYFDVKHFLPAILAIPILVFSSYELVGLEYSNLST
FIHLETLICDSVIILSLLTLTAAYFKTESAAYYKSFLLYFILKYISDVALLRSFRGWLDFDLSTAIFTFSNIVLLTVLYK
FYRTEITLLSYYDLDAERKKYAELYAQVNELQEILKLINRMLRHDILNKLQIISGYVETYRMTKREELLDKVMKAVEESS
SYIDKIRELEKIVLTMSEKLKPINMREVAEEVAKSFNIEINIKGSCVAMADGAIYSVLENLISNAIKHGRTNRVDIILSE
FEDDCEIRVVDYGVGIPLEIRRQIFKESFKYGETGGTGLGLYIVKRVVERYGGKVWVEDTKPHGATFVIRLKAARVKLSE
R
>Mature_480_residues
SIYAVGLLLSLFELTLFTVNYYYGLPPYVFLPSIYLFNIILVMVAFIASVYLARASKSERRTLFSTLAFFSGLLLLSILS
VGQMVWVRSDFQLKVEHFEYFIPIYLLAETPILGFFLWKILREMRYFDVKHFLPAILAIPILVFSSYELVGLEYSNLSTF
IHLETLICDSVIILSLLTLTAAYFKTESAAYYKSFLLYFILKYISDVALLRSFRGWLDFDLSTAIFTFSNIVLLTVLYKF
YRTEITLLSYYDLDAERKKYAELYAQVNELQEILKLINRMLRHDILNKLQIISGYVETYRMTKREELLDKVMKAVEESSS
YIDKIRELEKIVLTMSEKLKPINMREVAEEVAKSFNIEINIKGSCVAMADGAIYSVLENLISNAIKHGRTNRVDIILSEF
EDDCEIRVVDYGVGIPLEIRRQIFKESFKYGETGGTGLGLYIVKRVVERYGGKVWVEDTKPHGATFVIRLKAARVKLSER

Specific function: Member of the two-component regulatory system DpiA/DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox c

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786837, Length=221, Percent_Identity=23.9819004524887, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR016120
- InterPro:   IPR005467
- InterPro:   IPR016121 [H]

Pfam domain/function: PF02518 HATPase_c; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55633; Mature: 55502

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYAVGLLLSLFELTLFTVNYYYGLPPYVFLPSIYLFNIILVMVAFIASVYLARASKSE
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
RRTLFSTLAFFSGLLLLSILSVGQMVWVRSDFQLKVEHFEYFIPIYLLAETPILGFFLWK
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEHHHHHHHHHHHHHHCCHHHHHHHHH
ILREMRYFDVKHFLPAILAIPILVFSSYELVGLEYSNLSTFIHLETLICDSVIILSLLTL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
TAAYFKTESAAYYKSFLLYFILKYISDVALLRSFRGWLDFDLSTAIFTFSNIVLLTVLYK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHH
FYRTEITLLSYYDLDAERKKYAELYAQVNELQEILKLINRMLRHDILNKLQIISGYVETY
HHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMTKREELLDKVMKAVEESSSYIDKIRELEKIVLTMSEKLKPINMREVAEEVAKSFNIEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEE
NIKGSCVAMADGAIYSVLENLISNAIKHGRTNRVDIILSEFEDDCEIRVVDYGVGIPLEI
EECCCEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCHHH
RRQIFKESFKYGETGGTGLGLYIVKRVVERYGGKVWVEDTKPHGATFVIRLKAARVKLSE
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEHHHCCCC
R
C
>Mature Secondary Structure 
SIYAVGLLLSLFELTLFTVNYYYGLPPYVFLPSIYLFNIILVMVAFIASVYLARASKSE
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
RRTLFSTLAFFSGLLLLSILSVGQMVWVRSDFQLKVEHFEYFIPIYLLAETPILGFFLWK
HHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEHHHHHHHHHHHHHHCCHHHHHHHHH
ILREMRYFDVKHFLPAILAIPILVFSSYELVGLEYSNLSTFIHLETLICDSVIILSLLTL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
TAAYFKTESAAYYKSFLLYFILKYISDVALLRSFRGWLDFDLSTAIFTFSNIVLLTVLYK
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHH
FYRTEITLLSYYDLDAERKKYAELYAQVNELQEILKLINRMLRHDILNKLQIISGYVETY
HHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMTKREELLDKVMKAVEESSSYIDKIRELEKIVLTMSEKLKPINMREVAEEVAKSFNIEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEE
NIKGSCVAMADGAIYSVLENLISNAIKHGRTNRVDIILSEFEDDCEIRVVDYGVGIPLEI
EECCCEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCCCCHHH
RRQIFKESFKYGETGGTGLGLYIVKRVVERYGGKVWVEDTKPHGATFVIRLKAARVKLSE
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEHHHCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9701802; 8905232; 9278503 [H]