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The map label for this gene is argC

Identifier: 161484929

GI number: 161484929

Start: 768694

End: 769698

Strand: Direct

Name: argC

Synonym: MTH846

Alternate gene names: 161484929

Gene position: 768694-769698 (Clockwise)

Preceding gene: 15678864

Following gene: 15678867

Centisome position: 43.89

GC content: 52.74

Gene sequence:

>1005_bases
ATGATAAGTGTGGGTATTATCGGAGCCAGTGGATACACTGGAGGTGAACTGCTGCGACTCCTCGAGAACCACAGGGAGGT
GGAGGTGGTCTCAGCCACATCGAGGCAGTACAGTGGTGTTCCCGTGTCGAGGGTGCATCCACACCTCCAGGACACTGACC
TGAAGTTTGAAGACGTCGGTGCCGGTGAAATAGACGCGGACCTTGTCTTCACAGCCACCCCCCACGGGGCCTCAATGAAG
ATCGTCCCCCAGCTTATAGAGAGGGGTATAAGGGTGGTGGACCTCAGCGGTGACTACCGCTTTGATGACACTGAAACCTA
TGAGGAATGGTATGGAATCAAACACGAAAGCCCCCTCGAAGCGGTTTATGGTCTTCCTGAGATACACAGGGAGGAAATAG
CCTCCGCAGATCTTGTGGCAAATCCTGGCTGTTTCCCGACGGGTGCAATACTTGCATGTCTCCCCCTGGTATATGAGAAG
ATTGCAGATACATTCATAATCGATTCGAAGACAGGGGTGAGTGGTGCGGGTGTTAAGCCAACAGCCCTGACCCATTACCC
TCACTGCAGTGATAATGTAATTCCCTACAATGTAACAGGCCACAGGCATACACCGGAGATAAGGCAGGAACTCTCAAGGC
TGAATCCTGTGAGGCTCAGCTTCACACCACACCTCGTCCCGGTGACAAGGGGCATCCTTACAACAGCCCACACCTTCCTC
CTTGAGGACCTGGAGCAGGGCGAAATCGCAGACATATTCATGGGATTCTATGATGGAGAACCCTTTGTAAGGGTTGTTGA
GGGTATCCCTGGGCTCAGTGCAGTCAGGGGCTCCAACTTCTGCCAGATCGGATGCTTTGAGGTTGATGATAATCAGAGGG
CTGTTATAGTATCAGCCATAGACAACCTTGTGAAGGGCGCATCCGGTCAGGCCATCCAGAACATGAACATAATGTTCGGG
TTCAGGGAGGTCGAGGGTCTTGATTTCCCCGGGATGTACCCATAG

Upstream 100 bases:

>100_bases
GCACGGATTATCATATCAGTTAAGGCATCTAAACCATAACACCTTATTAAATCAGTTCACCAAAGTAATTATCACAGTCA
AGTCAATTAAGGTGATCAAG

Downstream 100 bases:

>100_bases
CACAGGACCGTTATTAAATGGGCAGAAATATATATGATGCCATCAAATCTCATCCCTAGGTGAATAAGCTGAGTGATATG
ATGAAAACGTGTGTAATTTA

Product: N-acetyl-gamma-glutamyl-phosphate reductase

Products: NA

Alternate protein names: AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MISVGIIGASGYTGGELLRLLENHREVEVVSATSRQYSGVPVSRVHPHLQDTDLKFEDVGAGEIDADLVFTATPHGASMK
IVPQLIERGIRVVDLSGDYRFDDTETYEEWYGIKHESPLEAVYGLPEIHREEIASADLVANPGCFPTGAILACLPLVYEK
IADTFIIDSKTGVSGAGVKPTALTHYPHCSDNVIPYNVTGHRHTPEIRQELSRLNPVRLSFTPHLVPVTRGILTTAHTFL
LEDLEQGEIADIFMGFYDGEPFVRVVEGIPGLSAVRGSNFCQIGCFEVDDNQRAVIVSAIDNLVKGASGQAIQNMNIMFG
FREVEGLDFPGMYP

Sequences:

>Translated_334_residues
MISVGIIGASGYTGGELLRLLENHREVEVVSATSRQYSGVPVSRVHPHLQDTDLKFEDVGAGEIDADLVFTATPHGASMK
IVPQLIERGIRVVDLSGDYRFDDTETYEEWYGIKHESPLEAVYGLPEIHREEIASADLVANPGCFPTGAILACLPLVYEK
IADTFIIDSKTGVSGAGVKPTALTHYPHCSDNVIPYNVTGHRHTPEIRQELSRLNPVRLSFTPHLVPVTRGILTTAHTFL
LEDLEQGEIADIFMGFYDGEPFVRVVEGIPGLSAVRGSNFCQIGCFEVDDNQRAVIVSAIDNLVKGASGQAIQNMNIMFG
FREVEGLDFPGMYP
>Mature_334_residues
MISVGIIGASGYTGGELLRLLENHREVEVVSATSRQYSGVPVSRVHPHLQDTDLKFEDVGAGEIDADLVFTATPHGASMK
IVPQLIERGIRVVDLSGDYRFDDTETYEEWYGIKHESPLEAVYGLPEIHREEIASADLVANPGCFPTGAILACLPLVYEK
IADTFIIDSKTGVSGAGVKPTALTHYPHCSDNVIPYNVTGHRHTPEIRQELSRLNPVRLSFTPHLVPVTRGILTTAHTFL
LEDLEQGEIADIFMGFYDGEPFVRVVEGIPGLSAVRGSNFCQIGCFEVDDNQRAVIVSAIDNLVKGASGQAIQNMNIMFG
FREVEGLDFPGMYP

Specific function: Arginine biosynthesis; third step. [C]

COG id: COG0002

COG function: function code E; Acetylglutamate semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1790396, Length=341, Percent_Identity=37.5366568914956, Blast_Score=190, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6320913, Length=336, Percent_Identity=31.8452380952381, Blast_Score=137, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGC_METTH (O26934)

Other databases:

- EMBL:   AE000666
- PIR:   H69212
- RefSeq:   NP_275983.2
- ProteinModelPortal:   O26934
- SMR:   O26934
- STRING:   O26934
- GeneID:   1471254
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH846
- NMPDR:   fig|187420.1.peg.838
- eggNOG:   arNOG05044
- HOGENOM:   HBG294213
- OMA:   VCRIAVH
- PhylomeDB:   O26934
- ProtClustDB:   PRK00436
- BioCyc:   MTHE187420:MTH846-MONOMER
- BRENDA:   1.2.1.38
- GO:   GO:0005737
- HAMAP:   MF_00150
- InterPro:   IPR023013
- InterPro:   IPR000706
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280
- Gene3D:   G3DSA:3.40.50.720
- SMART:   SM00859
- TIGRFAMs:   TIGR01850

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC

EC number: =1.2.1.38

Molecular weight: Translated: 36526; Mature: 36526

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS01224 ARGC

Important sites: ACT_SITE 144-144

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVGIIGASGYTGGELLRLLENHREVEVVSATSRQYSGVPVSRVHPHLQDTDLKFEDVG
CEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHCCCCCCCCCEEECCC
AGEIDADLVFTATPHGASMKIVPQLIERGIRVVDLSGDYRFDDTETYEEWYGIKHESPLE
CCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHCCCCCCCHHH
AVYGLPEIHREEIASADLVANPGCFPTGAILACLPLVYEKIADTFIIDSKTGVSGAGVKP
HHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCC
TALTHYPHCSDNVIPYNVTGHRHTPEIRQELSRLNPVRLSFTPHLVPVTRGILTTAHTFL
CEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHH
LEDLEQGEIADIFMGFYDGEPFVRVVEGIPGLSAVRGSNFCQIGCFEVDDNQRAVIVSAI
HHHCCCCCEEEHEEEHCCCCHHHHHHHCCCCCHHHCCCCEEEEEEEEECCCCCEEEHHHH
DNLVKGASGQAIQNMNIMFGFREVEGLDFPGMYP
HHHHCCCCCCEEECCEEEEEEEHHCCCCCCCCCC
>Mature Secondary Structure
MISVGIIGASGYTGGELLRLLENHREVEVVSATSRQYSGVPVSRVHPHLQDTDLKFEDVG
CEEEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHCCCCCCCCCEEECCC
AGEIDADLVFTATPHGASMKIVPQLIERGIRVVDLSGDYRFDDTETYEEWYGIKHESPLE
CCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHCCCCCCCHHH
AVYGLPEIHREEIASADLVANPGCFPTGAILACLPLVYEKIADTFIIDSKTGVSGAGVKP
HHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCC
TALTHYPHCSDNVIPYNVTGHRHTPEIRQELSRLNPVRLSFTPHLVPVTRGILTTAHTFL
CEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHH
LEDLEQGEIADIFMGFYDGEPFVRVVEGIPGLSAVRGSNFCQIGCFEVDDNQRAVIVSAI
HHHCCCCCEEEHEEEHCCCCHHHHHHHCCCCCHHHCCCCEEEEEEEEECCCCCEEEHHHH
DNLVKGASGQAIQNMNIMFGFREVEGLDFPGMYP
HHHHCCCCCCEEECCEEEEEEEHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463