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Identifier: 15679840

GI number: 15679840

Start: 1688503

End: 1690359

Strand: Direct

Name: Not Available

Synonym: MTH1852

Alternate gene names: 15679840

Gene position: 1688503-1690359 (Clockwise)

Preceding gene: 15679839

Following gene: 15679841

Centisome position: 96.41

GC content: 52.72

Gene sequence:

>1857_bases
ATGGAACTGGAGGATATACTTAACGCCAGAGAGGGCGATAAACTGTTCTTACTTGGAAACGAGGCTACTGTGAGGGCAGC
GATAGAGTCAGGGGTGGGGGTTGCAAGCACCTACCCTGGAACACCATCATCGGAGATAGGCAATGTGCTCTCAGGGATCG
CAAAGAGGGCAGGAATGTACTTTGAATTCTCTGTGAATGAAAAGGTGGCCCTGGAGGTTGCTGCAGCTGCAGCTGCCTCA
GGTGTCAGATCATTCACCTTCATGAAACACGTCGGCCTTAACGTGGCCTCTGACTCCTTCATGAGCACAGCCTACACAGG
TGTGAGGGCTGGCATGGTGGTTCTCACAGCCGACGACCCATCCATGTTCTCTTCCCAGAACGAGCAGGACAACAGACACT
ACGCCCGCCTCGCATGCCTCCCTCTCCTGGAACCATCAGATCCCCAGGAGGTACTGGAATTCATGAACCATGCCTTTGAA
CTATCAGAGGATTACGGCCTGCCGGTCCTCCTGAGGACAACAACTAGGGTATCCCACATGAGGGGAGTGGTTGAGGTGGG
CAGCAGGATGCGTGAACCTTCAGAGGGGTTCTTCAGGAAGGACCCGGAACGATTTGTACCGGTACCTGCCACCGCGAGGG
TGATGCACAGGAAACTTGTTGATAAGATGAAGGAACTGAGGATACGTGCAGATGAATCAGAACTCAACAGAGTATTCAAT
GGGGGCAGTGATTCAGAACTCGGGGTAGTGGCCTCAGGCGGGGCCTTCAACTATGTATACGATGCTCTTGAATCCCTTGG
TCTTGAATTACCAGTACTCAAACTTGGATTCACGTATCCATTCCCTGCAGGACTCGTGGAGGAGTTCCTCTCAGGCCTTA
AACGTGTTCTGGTTGTTGAGGAGGTTGACCCCATAATGGAGAGGGAGGTCCTTGCAGTAGCGGGATCCGCCCGCCTGGAC
CTTGATGTCCATGGAAAACTTGATGGCACACTCCCTGAGATATACGAGTACAATGAGGACATACTCAGAAAAGCAATATC
AGGGCTTACAGGCGCACCATCAGTTGAAAGGGAATGTGATGTCCCGGATATACCTGAAAGACCTCCTTCACTCTGTCCGG
GATGTCCGCACAGGGCTGTCTATTACGCCGTGAGGAGGGCTGCTGATGAACTGGAACTCTCAGGGGATGAGATAATATTC
CCGACAGATATAGGTTGTTACACCCTTGGAATAGAGCCTCCATACTCTGCAGCCGATTACCTCCTGAGCATGGGATCCAG
CATAGGAACCTCCTGTGGATTCTCAGCCGCGACCACCCAGAGGATAGTCTCCTTCATAGGTGACTCCACATTCTTCCATG
CAGGCATACCCCCACTCATAAATGCTGTGCACAACAAGCAGAGATTTGTGCTGGTTGTCCTCGATAACAGGACAACGGCC
ATGACGGGTGGTCAGCCACACCCGGGCCTGCCTGTAGATGGGATGGGTGATGAGGCCCCTGAGATCTCCATTGAGGAAAT
AGTGAGGGCCTCTGGAGTTGAATTTGTGGAGACGGTGAACCCCATGAACATAAAAAGAACATCAGAAACAGTTAAACGGG
CCCTGGAACATGAATCCGTGGCTGTGGTGATCTCAAAGTATCCGTGCATGCTCTCCTCTGGAGCGGTCCGGGGGAGGCCA
ATGGCTGTTGATGGGGAGAAATGTGATCTCTGTCTGGAATGCATCAGGGACCTTGCCTGCCCTGCGATGGTGACCCGTGA
GGGGGAGGTGTTCATAGACCCTCTAAAGTGCAGGGGATGCAGTGTATGCCTCCAGATATGTCCCGCAGGAGCAATAAAAC
CGGAGGGAAAAGGATGA

Upstream 100 bases:

>100_bases
ACACCGGAGTCCATCAACAGTTAAAGAGATTTTGTGAAGAATATCATATGGGTTCCTCAGATTGGCGGGATCAGGTTTAT
ACCATCATTAAGGTGATTTA

Downstream 100 bases:

>100_bases
ACTACAATATTTACGTCTGTGGCGTGGGCGGCCAGGGCATAATAAAGACCTCGGTCATAATCGGCGAGGCTGCAATGAAA
AAGGACATCAACGTCGTTAT

Product: indolepyruvate oxidoreductase, alpha subunit

Products: NA

Alternate protein names: IOR; Indolepyruvate ferredoxin oxidoreductase subunit alpha

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MELEDILNAREGDKLFLLGNEATVRAAIESGVGVASTYPGTPSSEIGNVLSGIAKRAGMYFEFSVNEKVALEVAAAAAAS
GVRSFTFMKHVGLNVASDSFMSTAYTGVRAGMVVLTADDPSMFSSQNEQDNRHYARLACLPLLEPSDPQEVLEFMNHAFE
LSEDYGLPVLLRTTTRVSHMRGVVEVGSRMREPSEGFFRKDPERFVPVPATARVMHRKLVDKMKELRIRADESELNRVFN
GGSDSELGVVASGGAFNYVYDALESLGLELPVLKLGFTYPFPAGLVEEFLSGLKRVLVVEEVDPIMEREVLAVAGSARLD
LDVHGKLDGTLPEIYEYNEDILRKAISGLTGAPSVERECDVPDIPERPPSLCPGCPHRAVYYAVRRAADELELSGDEIIF
PTDIGCYTLGIEPPYSAADYLLSMGSSIGTSCGFSAATTQRIVSFIGDSTFFHAGIPPLINAVHNKQRFVLVVLDNRTTA
MTGGQPHPGLPVDGMGDEAPEISIEEIVRASGVEFVETVNPMNIKRTSETVKRALEHESVAVVISKYPCMLSSGAVRGRP
MAVDGEKCDLCLECIRDLACPAMVTREGEVFIDPLKCRGCSVCLQICPAGAIKPEGKG

Sequences:

>Translated_618_residues
MELEDILNAREGDKLFLLGNEATVRAAIESGVGVASTYPGTPSSEIGNVLSGIAKRAGMYFEFSVNEKVALEVAAAAAAS
GVRSFTFMKHVGLNVASDSFMSTAYTGVRAGMVVLTADDPSMFSSQNEQDNRHYARLACLPLLEPSDPQEVLEFMNHAFE
LSEDYGLPVLLRTTTRVSHMRGVVEVGSRMREPSEGFFRKDPERFVPVPATARVMHRKLVDKMKELRIRADESELNRVFN
GGSDSELGVVASGGAFNYVYDALESLGLELPVLKLGFTYPFPAGLVEEFLSGLKRVLVVEEVDPIMEREVLAVAGSARLD
LDVHGKLDGTLPEIYEYNEDILRKAISGLTGAPSVERECDVPDIPERPPSLCPGCPHRAVYYAVRRAADELELSGDEIIF
PTDIGCYTLGIEPPYSAADYLLSMGSSIGTSCGFSAATTQRIVSFIGDSTFFHAGIPPLINAVHNKQRFVLVVLDNRTTA
MTGGQPHPGLPVDGMGDEAPEISIEEIVRASGVEFVETVNPMNIKRTSETVKRALEHESVAVVISKYPCMLSSGAVRGRP
MAVDGEKCDLCLECIRDLACPAMVTREGEVFIDPLKCRGCSVCLQICPAGAIKPEGKG
>Mature_618_residues
MELEDILNAREGDKLFLLGNEATVRAAIESGVGVASTYPGTPSSEIGNVLSGIAKRAGMYFEFSVNEKVALEVAAAAAAS
GVRSFTFMKHVGLNVASDSFMSTAYTGVRAGMVVLTADDPSMFSSQNEQDNRHYARLACLPLLEPSDPQEVLEFMNHAFE
LSEDYGLPVLLRTTTRVSHMRGVVEVGSRMREPSEGFFRKDPERFVPVPATARVMHRKLVDKMKELRIRADESELNRVFN
GGSDSELGVVASGGAFNYVYDALESLGLELPVLKLGFTYPFPAGLVEEFLSGLKRVLVVEEVDPIMEREVLAVAGSARLD
LDVHGKLDGTLPEIYEYNEDILRKAISGLTGAPSVERECDVPDIPERPPSLCPGCPHRAVYYAVRRAADELELSGDEIIF
PTDIGCYTLGIEPPYSAADYLLSMGSSIGTSCGFSAATTQRIVSFIGDSTFFHAGIPPLINAVHNKQRFVLVVLDNRTTA
MTGGQPHPGLPVDGMGDEAPEISIEEIVRASGVEFVETVNPMNIKRTSETVKRALEHESVAVVISKYPCMLSSGAVRGRP
MAVDGEKCDLCLECIRDLACPAMVTREGEVFIDPLKCRGCSVCLQICPAGAIKPEGKG

Specific function: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates

COG id: COG4231

COG function: function code C; Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IORA_METTH (O27880)

Other databases:

- EMBL:   AE000666
- PIR:   G69114
- RefSeq:   NP_276958.1
- ProteinModelPortal:   O27880
- STRING:   O27880
- GeneID:   1470937
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1852
- NMPDR:   fig|187420.1.peg.1813
- eggNOG:   arNOG04233
- HOGENOM:   HBG733885
- OMA:   VADDPSM
- ProtClustDB:   CLSK798288
- BioCyc:   MTHE187420:MTH1852-MONOMER
- BRENDA:   1.2.7.8
- GO:   GO:0006810
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR017721
- InterPro:   IPR002880
- InterPro:   IPR011766
- InterPro:   IPR009014
- TIGRFAMs:   TIGR03336

Pfam domain/function: PF01855 POR_N; PF02775 TPP_enzyme_C; SSF52922 Transketo_C_like

EC number: =1.2.7.8

Molecular weight: Translated: 66872; Mature: 66872

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELEDILNAREGDKLFLLGNEATVRAAIESGVGVASTYPGTPSSEIGNVLSGIAKRAGMY
CCCHHHHCCCCCCEEEEECCCHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHCCEE
FEFSVNEKVALEVAAAAAASGVRSFTFMKHVGLNVASDSFMSTAYTGVRAGMVVLTADDP
EEEECCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCC
SMFSSQNEQDNRHYARLACLPLLEPSDPQEVLEFMNHAFELSEDYGLPVLLRTTTRVSHM
HHHCCCCCCCCHHEEHEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHH
RGVVEVGSRMREPSEGFFRKDPERFVPVPATARVMHRKLVDKMKELRIRADESELNRVFN
HHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHHC
GGSDSELGVVASGGAFNYVYDALESLGLELPVLKLGFTYPFPAGLVEEFLSGLKRVLVVE
CCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
EVDPIMEREVLAVAGSARLDLDVHGKLDGTLPEIYEYNEDILRKAISGLTGAPSVERECD
HHCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCCC
VPDIPERPPSLCPGCPHRAVYYAVRRAADELELSGDEIIFPTDIGCYTLGIEPPYSAADY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCHHHHH
LLSMGSSIGTSCGFSAATTQRIVSFIGDSTFFHAGIPPLINAVHNKQRFVLVVLDNRTTA
HHHHCCHHCCCCCCCHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCEEEEEEECCCEEE
MTGGQPHPGLPVDGMGDEAPEISIEEIVRASGVEFVETVNPMNIKRTSETVKRALEHESV
ECCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCCE
AVVISKYPCMLSSGAVRGRPMAVDGEKCDLCLECIRDLACPAMVTREGEVFIDPLKCRGC
EEEEECCCCHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEECCCCEEECCHHCCHH
SVCLQICPAGAIKPEGKG
HHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MELEDILNAREGDKLFLLGNEATVRAAIESGVGVASTYPGTPSSEIGNVLSGIAKRAGMY
CCCHHHHCCCCCCEEEEECCCHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHCCEE
FEFSVNEKVALEVAAAAAASGVRSFTFMKHVGLNVASDSFMSTAYTGVRAGMVVLTADDP
EEEECCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCC
SMFSSQNEQDNRHYARLACLPLLEPSDPQEVLEFMNHAFELSEDYGLPVLLRTTTRVSHM
HHHCCCCCCCCHHEEHEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHH
RGVVEVGSRMREPSEGFFRKDPERFVPVPATARVMHRKLVDKMKELRIRADESELNRVFN
HHHHHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHHC
GGSDSELGVVASGGAFNYVYDALESLGLELPVLKLGFTYPFPAGLVEEFLSGLKRVLVVE
CCCCCCCEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
EVDPIMEREVLAVAGSARLDLDVHGKLDGTLPEIYEYNEDILRKAISGLTGAPSVERECD
HHCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCCC
VPDIPERPPSLCPGCPHRAVYYAVRRAADELELSGDEIIFPTDIGCYTLGIEPPYSAADY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCCCHHHHH
LLSMGSSIGTSCGFSAATTQRIVSFIGDSTFFHAGIPPLINAVHNKQRFVLVVLDNRTTA
HHHHCCHHCCCCCCCHHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCEEEEEEECCCEEE
MTGGQPHPGLPVDGMGDEAPEISIEEIVRASGVEFVETVNPMNIKRTSETVKRALEHESV
ECCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHCCCCE
AVVISKYPCMLSSGAVRGRPMAVDGEKCDLCLECIRDLACPAMVTREGEVFIDPLKCRGC
EEEEECCCCHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCEEECCCCEEECCHHCCHH
SVCLQICPAGAIKPEGKG
HHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463