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Identifier: 15679829

GI number: 15679829

Start: 1679126

End: 1679962

Strand: Direct

Name: Not Available

Synonym: MTH1841

Alternate gene names: 15679829

Gene position: 1679126-1679962 (Clockwise)

Preceding gene: 15679828

Following gene: 15679831

Centisome position: 95.87

GC content: 50.9

Gene sequence:

>837_bases
TTGATGCGTGTTGTCAGTGTCGGGACCTGTAACATGGACTTTATCTTCAGGGTGCAGGAGTTTGTTGAACCTGACTCTGA
GATGTACATAGATGATATCCACATCCTTCCAGGGGGTTCCGCCCTCAACTTCGCTGTCTGGATCTCAGCCCTTGGTTTCA
GTTCAGACATCGTGGCTGCCACCGGCGGAGACATGTATGGGGAAATAATAAGATCCAGACTGGAATCAGAGGGTGTATCC
ACAGGGTGTCTTTCTGTGGTTGAAAAACCTACAGGCATGGCCTTCATATCAGTTGATGGCTCAGGCAGAAGGTCAATATA
TTCATATATGGGGGCCAATGCAGAACTTGAGATCGGAACACCTGAGGGGCGGTGTATCAGGGCTGCAGATGCTGTTCATC
TTAGCGGCTGCTACGTTGAAGTTGCACAGAGGGTTGCTGAAATCAGGGAGGTTTACTTCAGTCCAGGCCGCCTTCTGGCA
GGCTATGGCCTCGATGTCCTTGAACCGGTACTCAGGAAAACGGAGGTCCTCTTTCTGAATGATGATGAACTTGAGATTCT
CACGGGGTCCCGTAAATCAGGGATTTCCAGGTTACTGGGTGTCGGTGTTGATTATGTTGTTGTAACCCATGGACCAGGGG
GCGCGTCCTTCTTCTCAGCTGACCATTCCCTGGAGATGAAGGTTGAGGATGCTGGAGCCATCGACACAACCGGTGCAGGC
GATGCCTTTGCAGCGGGTTTCATGTCAGAATGGCTCAGGGGATATGAGCCATTAGAATGTCTCAGGGGAGGTCACAGGGC
AGCCCTTAAGGTGATTTCAAGGTTTGGGGCTTTTTAA

Upstream 100 bases:

>100_bases
GCGAGGAATACCAGCCAATTGAGCCTGACAAGCAGGGAGTTATTGCGAAACTCATAAGCGGTTTAATGGGGCGGAGATGA
TCACCCCCCGGTGATTTATT

Downstream 100 bases:

>100_bases
TGTCTTTTGAGTTTCGGATTAGTTAATTTTGATGAGGTCTCTGATGTTATCCCGGGACACCCTCCTTATCTCTCTTCTCC
CGAAGCCCTCCATCCTCATC

Product: ribokinase

Products: ADP; D-ribose 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MMRVVSVGTCNMDFIFRVQEFVEPDSEMYIDDIHILPGGSALNFAVWISALGFSSDIVAATGGDMYGEIIRSRLESEGVS
TGCLSVVEKPTGMAFISVDGSGRRSIYSYMGANAELEIGTPEGRCIRAADAVHLSGCYVEVAQRVAEIREVYFSPGRLLA
GYGLDVLEPVLRKTEVLFLNDDELEILTGSRKSGISRLLGVGVDYVVVTHGPGGASFFSADHSLEMKVEDAGAIDTTGAG
DAFAAGFMSEWLRGYEPLECLRGGHRAALKVISRFGAF

Sequences:

>Translated_278_residues
MMRVVSVGTCNMDFIFRVQEFVEPDSEMYIDDIHILPGGSALNFAVWISALGFSSDIVAATGGDMYGEIIRSRLESEGVS
TGCLSVVEKPTGMAFISVDGSGRRSIYSYMGANAELEIGTPEGRCIRAADAVHLSGCYVEVAQRVAEIREVYFSPGRLLA
GYGLDVLEPVLRKTEVLFLNDDELEILTGSRKSGISRLLGVGVDYVVVTHGPGGASFFSADHSLEMKVEDAGAIDTTGAG
DAFAAGFMSEWLRGYEPLECLRGGHRAALKVISRFGAF
>Mature_278_residues
MMRVVSVGTCNMDFIFRVQEFVEPDSEMYIDDIHILPGGSALNFAVWISALGFSSDIVAATGGDMYGEIIRSRLESEGVS
TGCLSVVEKPTGMAFISVDGSGRRSIYSYMGANAELEIGTPEGRCIRAADAVHLSGCYVEVAQRVAEIREVYFSPGRLLA
GYGLDVLEPVLRKTEVLFLNDDELEILTGSRKSGISRLLGVGVDYVVVTHGPGGASFFSADHSLEMKVEDAGAIDTTGAG
DAFAAGFMSEWLRGYEPLECLRGGHRAALKVISRFGAF

Specific function: Ribose metabolism; first step. [C]

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family [H]

Homologues:

Organism=Escherichia coli, GI1790193, Length=276, Percent_Identity=26.8115942028986, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87081971, Length=261, Percent_Identity=25.6704980842912, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532905, Length=298, Percent_Identity=24.1610738255034, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR002139 [H]

Pfam domain/function: PF00294 PfkB [H]

EC number: 2.7.1.15

Molecular weight: Translated: 29847; Mature: 29847

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00583 PFKB_KINASES_1 ; PS00584 PFKB_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRVVSVGTCNMDFIFRVQEFVEPDSEMYIDDIHILPGGSALNFAVWISALGFSSDIVAA
CEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEE
TGGDMYGEIIRSRLESEGVSTGCLSVVEKPTGMAFISVDGSGRRSIYSYMGANAELEIGT
CCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCEEEEEC
PEGRCIRAADAVHLSGCYVEVAQRVAEIREVYFSPGRLLAGYGLDVLEPVLRKTEVLFLN
CCCCEEEECCCEEECHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCEEEEEC
DDELEILTGSRKSGISRLLGVGVDYVVVTHGPGGASFFSADHSLEMKVEDAGAIDTTGAG
CCCEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCEECCCCEEEEEECCCCCCCCCCCC
DAFAAGFMSEWLRGYEPLECLRGGHRAALKVISRFGAF
HHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MMRVVSVGTCNMDFIFRVQEFVEPDSEMYIDDIHILPGGSALNFAVWISALGFSSDIVAA
CEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEE
TGGDMYGEIIRSRLESEGVSTGCLSVVEKPTGMAFISVDGSGRRSIYSYMGANAELEIGT
CCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCEEEEEC
PEGRCIRAADAVHLSGCYVEVAQRVAEIREVYFSPGRLLAGYGLDVLEPVLRKTEVLFLN
CCCCEEEECCCEEECHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCEEEEEC
DDELEILTGSRKSGISRLLGVGVDYVVVTHGPGGASFFSADHSLEMKVEDAGAIDTTGAG
CCCEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCCEECCCCEEEEEECCCCCCCCCCCC
DAFAAGFMSEWLRGYEPLECLRGGHRAALKVISRFGAF
HHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; D-ribose

Specific reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate

General reaction: Phospho group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]