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Identifier: 15679808

GI number: 15679808

Start: 1661627

End: 1662586

Strand: Direct

Name: Not Available

Synonym: MTH1820

Alternate gene names: NA

Gene position: 1661627-1662586 (Clockwise)

Preceding gene: 15679807

Following gene: 15679809

Centisome position: 94.88

GC content: 50.0

Gene sequence:

>960_bases
TTGATGGAGGAGATTCCAGCATCCTATTTCAAAATCGAAGAATTCCAGTTTGAATCAGGAGAAAAAATCCAGGAGGCTCC
CGTTGAGTACAGAACAACAGGGAAACCATCCCTTGATGATATGGGAGTAATAGATAATGCTGTTATATACATACATGGCT
GGAGCGGGGACTGTTCATCAGTCAGGAGGATAGCTGCCCTTACAGAGCCGGGAGGGGCCCTTGAGAACTTCTTCGTAATC
TCTATAAGCTCCCTTGGATCACCGGGATCAGCATCACCATCCACAACAGCGATGGGAAAGGATTTCCCGGAATACACCAT
CCTCGACATGGTCAACTTCCAGAGGCAGTTCTTAGATGAAAAATTCGGGATAAGAAAGGTTAGGGGAGTTATAGGCACAT
CCATGGGCGGTTTCCAGGCCCTTCAGTGGGCTGCGGAGTACCCTGATGAAATGGAGTTCCTCATACCCCTTGTGACATCA
TGGCAGGTGCGCGGTATAAACTATGCACTCTTCAGCTACATGAACCACCTCATCGAGGGGGACCCGGAATTCAGGGCAGG
CACGAGGCCTGAGAGGGCACTTTCGCTGGCCTCAATGCTCATGTACCTCCACGGACTTTCAAGGGAATACTACCAGGGCC
TCGAAAATGCTGAACTGGAGTCCTCAATGATGGATATGGGTTCTGAGGGGGCCCTCATGGACCCCTATGACGTTATCTGG
AGAAACAGGGCCGCCATGAAACATGACCTCAGCGGGAAACTGGAGAGTATCAGGGCCCGCACCCTCATATTCGGGGTGAA
CCAGGACCGCTACTTCCCACCTGAACTTGATACAATCCCGATGGCTCAACTAATACCGAAAGCAGAACTTGTCCTATTCG
ATTCAGAGTGCGGACACCTCGGGGTGAATGAGATAGGAAAATACAATGAGATCATAGTGTCCTTTATTGGTGGTGATTGA

Upstream 100 bases:

>100_bases
CCATCCTGCAGTGAAAAGGCTGCAGGTAACTGCCCGGTAATGTGCATAAAGCTTTACAGGGATGGAGAGGAGGTTCTGTA
ACAATGAGACGGGAGGCAAA

Downstream 100 bases:

>100_bases
GGAGCTACTGAGCTGATCTCAGGATCAGTGGGCATGGTGTTCTGTGGGGCTTATTGATGATGATCTCAATCTACATAAAT
GATGGGTGGTGTTTTATTTG

Product: homoserine O-acetyltransferase

Products: NA

Alternate protein names: Homoserine O-trans-acetylase; HTA; Homoserine transacetylase

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MMEEIPASYFKIEEFQFESGEKIQEAPVEYRTTGKPSLDDMGVIDNAVIYIHGWSGDCSSVRRIAALTEPGGALENFFVI
SISSLGSPGSASPSTTAMGKDFPEYTILDMVNFQRQFLDEKFGIRKVRGVIGTSMGGFQALQWAAEYPDEMEFLIPLVTS
WQVRGINYALFSYMNHLIEGDPEFRAGTRPERALSLASMLMYLHGLSREYYQGLENAELESSMMDMGSEGALMDPYDVIW
RNRAAMKHDLSGKLESIRARTLIFGVNQDRYFPPELDTIPMAQLIPKAELVLFDSECGHLGVNEIGKYNEIIVSFIGGD

Sequences:

>Translated_319_residues
MMEEIPASYFKIEEFQFESGEKIQEAPVEYRTTGKPSLDDMGVIDNAVIYIHGWSGDCSSVRRIAALTEPGGALENFFVI
SISSLGSPGSASPSTTAMGKDFPEYTILDMVNFQRQFLDEKFGIRKVRGVIGTSMGGFQALQWAAEYPDEMEFLIPLVTS
WQVRGINYALFSYMNHLIEGDPEFRAGTRPERALSLASMLMYLHGLSREYYQGLENAELESSMMDMGSEGALMDPYDVIW
RNRAAMKHDLSGKLESIRARTLIFGVNQDRYFPPELDTIPMAQLIPKAELVLFDSECGHLGVNEIGKYNEIIVSFIGGD
>Mature_319_residues
MMEEIPASYFKIEEFQFESGEKIQEAPVEYRTTGKPSLDDMGVIDNAVIYIHGWSGDCSSVRRIAALTEPGGALENFFVI
SISSLGSPGSASPSTTAMGKDFPEYTILDMVNFQRQFLDEKFGIRKVRGVIGTSMGGFQALQWAAEYPDEMEFLIPLVTS
WQVRGINYALFSYMNHLIEGDPEFRAGTRPERALSLASMLMYLHGLSREYYQGLENAELESSMMDMGSEGALMDPYDVIW
RNRAAMKHDLSGKLESIRARTLIFGVNQDRYFPPELDTIPMAQLIPKAELVLFDSECGHLGVNEIGKYNEIIVSFIGGD

Specific function: Unknown

COG id: COG2021

COG function: function code E; Homoserine acetyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. HTA family

Homologues:

Organism=Saccharomyces cerevisiae, GI6324052, Length=218, Percent_Identity=30.2752293577982, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): METX_METTH (O27848)

Other databases:

- EMBL:   AE000666
- PIR:   D69110
- RefSeq:   NP_276926.1
- ProteinModelPortal:   O27848
- SMR:   O27848
- STRING:   O27848
- GeneID:   1470905
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1820
- NMPDR:   fig|187420.1.peg.1781
- eggNOG:   arNOG07775
- HOGENOM:   HBG551746
- OMA:   FVISISS
- ProtClustDB:   CLSK798279
- BioCyc:   MTHE187420:MTH1820-MONOMER
- BRENDA:   2.3.1.31
- GO:   GO:0005737
- HAMAP:   MF_00296
- InterPro:   IPR000073
- InterPro:   IPR008220
- PIRSF:   PIRSF000443

Pfam domain/function: PF00561 Abhydrolase_1

EC number: =2.3.1.31

Molecular weight: Translated: 35688; Mature: 35688

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: ACT_SITE 134-134 ACT_SITE 299-299

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEEIPASYFKIEEFQFESGEKIQEAPVEYRTTGKPSLDDMGVIDNAVIYIHGWSGDCSS
CCCCCCCHHHEEEEEECCCCCHHHHCCCCEECCCCCCCCCCCCCCCEEEEEECCCCCHHH
VRRIAALTEPGGALENFFVISISSLGSPGSASPSTTAMGKDFPEYTILDMVNFQRQFLDE
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KFGIRKVRGVIGTSMGGFQALQWAAEYPDEMEFLIPLVTSWQVRGINYALFSYMNHLIEG
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCEEECCCHHHHHHHHHHHHCC
DPEFRAGTRPERALSLASMLMYLHGLSREYYQGLENAELESSMMDMGSEGALMDPYDVIW
CCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHH
RNRAAMKHDLSGKLESIRARTLIFGVNQDRYFPPELDTIPMAQLIPKAELVLFDSECGHL
CCCHHHHHHHCHHHHHHHEEEEEEECCCCCCCCCCCCCCCHHHHCCCCEEEEEECCCCCC
GVNEIGKYNEIIVSFIGGD
CHHHHCCHHHEEEEEECCC
>Mature Secondary Structure
MMEEIPASYFKIEEFQFESGEKIQEAPVEYRTTGKPSLDDMGVIDNAVIYIHGWSGDCSS
CCCCCCCHHHEEEEEECCCCCHHHHCCCCEECCCCCCCCCCCCCCCEEEEEECCCCCHHH
VRRIAALTEPGGALENFFVISISSLGSPGSASPSTTAMGKDFPEYTILDMVNFQRQFLDE
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
KFGIRKVRGVIGTSMGGFQALQWAAEYPDEMEFLIPLVTSWQVRGINYALFSYMNHLIEG
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCEEECCCHHHHHHHHHHHHCC
DPEFRAGTRPERALSLASMLMYLHGLSREYYQGLENAELESSMMDMGSEGALMDPYDVIW
CCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHH
RNRAAMKHDLSGKLESIRARTLIFGVNQDRYFPPELDTIPMAQLIPKAELVLFDSECGHL
CCCHHHHHHHCHHHHHHHEEEEEEECCCCCCCCCCCCCCCHHHHCCCCEEEEEECCCCCC
GVNEIGKYNEIIVSFIGGD
CHHHHCCHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463