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Identifier: 15679753

GI number: 15679753

Start: 1619573

End: 1620157

Strand: Direct

Name: Not Available

Synonym: MTH1765

Alternate gene names: 15679753

Gene position: 1619573-1620157 (Clockwise)

Preceding gene: 15679740

Following gene: 15679760

Centisome position: 92.47

GC content: 51.62

Gene sequence:

>585_bases
ATGTACATATGCTTTGAAGGAATCGATGGTTCCGGTAAGACAACCCATGCCGCCCTGACGGCCAGCTGGCTTAGGGAAAA
CGGTTACATGGTCCATGAGGTGAGGGAACCAACCGATTCTAATATCGGCAGCCTTATAAGGAGCATGCTTTCAAGTCCAG
ATGCCCGGACACCTGATGTTCAGAGGATGCTTGCCCTCCTCTTTGCAGCGGACCGTCTGACCTTGAGGAGCAAAATTGAG
GGTGACTGGGCAGAGGATGTGGTTGTAAGTGACAGGTGCTACTACTCCAGCATGGTGTATCAGGGACCCGAGGAATGGGT
CTGTGAGATAAACAGGTTCGCTCCACGACCGGATGTTGTCATACTTCTCGACATTGACGTGGAGGTGGCCATGGAGCGCT
GCGGCGGGACCGATGAGTTTGAGGACCCATTATACCTTGCAGGAGTCCGTGAAAGGTACCTTGAACTTGCAGATAAAAAC
GGGTTCTACACTGTGAATGCTGAAAGGGGGGTTAACCTGATCCAGAGGGATATAAGGAGGATACTGGCCCCCCATTTTGG
CATATGTTCAGGGGGTATAATGTAG

Upstream 100 bases:

>100_bases
TCCTCCAGCGGAGGAGAAGATCTTTTCCCGGCTCCTGATGGATTAACCACGATCCTCGGTAGGGGAAGATTTTTTTACTC
TTCCTGATAGATTAACCATC

Downstream 100 bases:

>100_bases
AAGGCGGCCCCGGATCCTTTTCAGGAAAAATAGAAACTTATTATGTGAAATCAGCTCTCTGAGCCGGGGTTTTCGAGTTC
CTCTATTCTCTCCCTGAGGG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MYICFEGIDGSGKTTHAALTASWLRENGYMVHEVREPTDSNIGSLIRSMLSSPDARTPDVQRMLALLFAADRLTLRSKIE
GDWAEDVVVSDRCYYSSMVYQGPEEWVCEINRFAPRPDVVILLDIDVEVAMERCGGTDEFEDPLYLAGVRERYLELADKN
GFYTVNAERGVNLIQRDIRRILAPHFGICSGGIM

Sequences:

>Translated_194_residues
MYICFEGIDGSGKTTHAALTASWLRENGYMVHEVREPTDSNIGSLIRSMLSSPDARTPDVQRMLALLFAADRLTLRSKIE
GDWAEDVVVSDRCYYSSMVYQGPEEWVCEINRFAPRPDVVILLDIDVEVAMERCGGTDEFEDPLYLAGVRERYLELADKN
GFYTVNAERGVNLIQRDIRRILAPHFGICSGGIM
>Mature_194_residues
MYICFEGIDGSGKTTHAALTASWLRENGYMVHEVREPTDSNIGSLIRSMLSSPDARTPDVQRMLALLFAADRLTLRSKIE
GDWAEDVVVSDRCYYSSMVYQGPEEWVCEINRFAPRPDVVILLDIDVEVAMERCGGTDEFEDPLYLAGVRERYLELADKN
GFYTVNAERGVNLIQRDIRRILAPHFGICSGGIM

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Caenorhabditis elegans, GI17535647, Length=198, Percent_Identity=30.8080808080808, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_METTH (O27793)

Other databases:

- EMBL:   AE000666
- PIR:   F69102
- RefSeq:   NP_276871.1
- ProteinModelPortal:   O27793
- STRING:   O27793
- GeneID:   1470850
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1765
- NMPDR:   fig|187420.1.peg.1726
- eggNOG:   arNOG06813
- HOGENOM:   HBG626009
- OMA:   ETAIARI
- PhylomeDB:   O27793
- ProtClustDB:   CLSK798266
- BioCyc:   MTHE187420:MTH1765-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 21875; Mature: 21875

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYICFEGIDGSGKTTHAALTASWLRENGYMVHEVREPTDSNIGSLIRSMLSSPDARTPDV
CEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHH
QRMLALLFAADRLTLRSKIEGDWAEDVVVSDRCYYSSMVYQGPEEWVCEINRFAPRPDVV
HHHHHHHHHHHHHHHHHHCCCCCHHHEEECCHHHHHHHHHCCHHHHHHHHHCCCCCCCEE
ILLDIDVEVAMERCGGTDEFEDPLYLAGVRERYLELADKNGFYTVNAERGVNLIQRDIRR
EEEECCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHCHHHHHHHHHH
ILAPHFGICSGGIM
HHCCCCCCCCCCCC
>Mature Secondary Structure
MYICFEGIDGSGKTTHAALTASWLRENGYMVHEVREPTDSNIGSLIRSMLSSPDARTPDV
CEEEEECCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHH
QRMLALLFAADRLTLRSKIEGDWAEDVVVSDRCYYSSMVYQGPEEWVCEINRFAPRPDVV
HHHHHHHHHHHHHHHHHHCCCCCHHHEEECCHHHHHHHHHCCHHHHHHHHHCCCCCCCEE
ILLDIDVEVAMERCGGTDEFEDPLYLAGVRERYLELADKNGFYTVNAERGVNLIQRDIRR
EEEECCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHCHHHHHHHHHH
ILAPHFGICSGGIM
HHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463