Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15679733

GI number: 15679733

Start: 1592087

End: 1593661

Strand: Direct

Name: Not Available

Synonym: MTH1741

Alternate gene names: NA

Gene position: 1592087-1593661 (Clockwise)

Preceding gene: 15679726

Following gene: 15679734

Centisome position: 90.9

GC content: 52.25

Gene sequence:

>1575_bases
ATGAAAGTCCTCATAATCACAGGAAAACTTGCATCAGAGACTGTAAGGGAAGCATCATCCACTTCCGAGCATGAAGTTCA
TGTTCACGTTGCTGACACTCCCATAGCAGCCTTTTTAACACCTCGAAGGATAATATCTGAGATCGGGAAGATTAACTTTT
CGGATGATGGGGAACCTGACATCCTAATCGTGCCGGGACTCATACCCAAGGATGTGGGGATTATCGGGGAGAGGACAGGC
ATACCCGCATACAAGGGACCAACAGATGCGGCCGACCTTCCCATAGTTCTGGACCTCCTGGGGGAACTTGAACTCTCAAC
AGAAAAACCCGCCGACAAACTGATAGAGGAGGAACAGAGGAAGAGGGCCCTGCAGTTCATAGAGGACTTTGAGAACGATC
AAAGAAGGATAAGCACCCTCCTTGAGAGGGATGAAAACATACTCGTCGGGGGCTTACCGACCGGGAGGGACTTCCCCATG
AGGGTCCTCGCCGAGGTGGCCAATGCACCCATCCTGCTGGAGCAGGGCAGGCTCAGGGAACGCATCGATTACTTCATAAG
AAGCGGTGCAGACATGATAGACCTTGGAATGCTTGCCGGTGAGGACAACTCTCACCTCATACCTGAGATAATAAGGACAG
CACGCTCCGCAGCAGGGGAGGTGCCTGTAAGCGTGGATAGTCTGAACCCGCCTGAGATTGAGGCTGCAGTGGAGTGTGGT
GCAGACATGATACTGAGCCTCGACCTGGGGAACTACAGGGAGGTTCTGCCGCTCCTCAGGAAACATGGGGTGCCTGCGGT
GATCCTTCCAACGGATTACAGTGAGGGATGGGTCCCGGAGACAGTTGAGGAGAGGGTTGAAGCCCTGGATGAGCTTAAAA
GGAAGTGCAGCGGCATAGATGTCATAGCTGACCCTGTACTGGACCCTGTAAACAGCAGGAGCATAGTTGACTCGGTTATG
GCCTGCAGGATGTACGCAGAGAGAAACCCGGACCCCATATTCTTTGGTGTGGGTAACGTGACGGAGCTACTGGACACCGA
CTCCACCGGCGTAAACGCCCTCCTGGCAGGTTTCGGGATGGAACTTGGTGTCAGCATACTGTTCACGCCCGAGGAGAGTG
GGAAGGCCCGTGGAAGTGTTTATGAATTATCGGTGGCATCACAGATGATGTTCCTTGCCAGACACCGTGGCTCGGTTCCA
AAGGACCTCGGTATCAACCTGGTGCTGTTCAAGGACAAGAGGAGGTCAGGAGGGGTTGTAGAGAAGGTTGATGTCCCGGT
CATTGAGGCAGAGGGAGGAATGAAGTTCGTTAGGGACAAAATGGGAAGCTTCAAGATTATGGTGGAGGATGGGCAAATAA
AGGCAGTACTCTACCAGGGAATGGAGCCCAGAACTGCCCTGACATCAGACAGCGCCAAAAAATTATATGAGGAGATCATA
AATAGAAACCTTGTAAGCAGACTCGAACATGCAGCCTACCTCGGGGCAGAACTTCAGAAGGCAGAGATAGCCCTCAGGAC
AGGCAAAGATTATGTCCAGGATTTTGAACTATTTGAGAGGTCATTCCCGCTTTGA

Upstream 100 bases:

>100_bases
CGAATTTCGATCATAGTTTACCTCCATTTCTCATTGTTAATCATTATAAATTTTTAATATATATACATGTTGGTCAACTA
AAATTAATGGGGGTAACGAA

Downstream 100 bases:

>100_bases
GGGGATTTAGGAGACAGAGTTGGTGAAAGGGCCTTGATACAAACTTTGAGGGGATTCAGGAGAAGTTTGTGTTGAAGGGA
CCCTCATACAACTTCATTAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MKVLIITGKLASETVREASSTSEHEVHVHVADTPIAAFLTPRRIISEIGKINFSDDGEPDILIVPGLIPKDVGIIGERTG
IPAYKGPTDAADLPIVLDLLGELELSTEKPADKLIEEEQRKRALQFIEDFENDQRRISTLLERDENILVGGLPTGRDFPM
RVLAEVANAPILLEQGRLRERIDYFIRSGADMIDLGMLAGEDNSHLIPEIIRTARSAAGEVPVSVDSLNPPEIEAAVECG
ADMILSLDLGNYREVLPLLRKHGVPAVILPTDYSEGWVPETVEERVEALDELKRKCSGIDVIADPVLDPVNSRSIVDSVM
ACRMYAERNPDPIFFGVGNVTELLDTDSTGVNALLAGFGMELGVSILFTPEESGKARGSVYELSVASQMMFLARHRGSVP
KDLGINLVLFKDKRRSGGVVEKVDVPVIEAEGGMKFVRDKMGSFKIMVEDGQIKAVLYQGMEPRTALTSDSAKKLYEEII
NRNLVSRLEHAAYLGAELQKAEIALRTGKDYVQDFELFERSFPL

Sequences:

>Translated_524_residues
MKVLIITGKLASETVREASSTSEHEVHVHVADTPIAAFLTPRRIISEIGKINFSDDGEPDILIVPGLIPKDVGIIGERTG
IPAYKGPTDAADLPIVLDLLGELELSTEKPADKLIEEEQRKRALQFIEDFENDQRRISTLLERDENILVGGLPTGRDFPM
RVLAEVANAPILLEQGRLRERIDYFIRSGADMIDLGMLAGEDNSHLIPEIIRTARSAAGEVPVSVDSLNPPEIEAAVECG
ADMILSLDLGNYREVLPLLRKHGVPAVILPTDYSEGWVPETVEERVEALDELKRKCSGIDVIADPVLDPVNSRSIVDSVM
ACRMYAERNPDPIFFGVGNVTELLDTDSTGVNALLAGFGMELGVSILFTPEESGKARGSVYELSVASQMMFLARHRGSVP
KDLGINLVLFKDKRRSGGVVEKVDVPVIEAEGGMKFVRDKMGSFKIMVEDGQIKAVLYQGMEPRTALTSDSAKKLYEEII
NRNLVSRLEHAAYLGAELQKAEIALRTGKDYVQDFELFERSFPL
>Mature_524_residues
MKVLIITGKLASETVREASSTSEHEVHVHVADTPIAAFLTPRRIISEIGKINFSDDGEPDILIVPGLIPKDVGIIGERTG
IPAYKGPTDAADLPIVLDLLGELELSTEKPADKLIEEEQRKRALQFIEDFENDQRRISTLLERDENILVGGLPTGRDFPM
RVLAEVANAPILLEQGRLRERIDYFIRSGADMIDLGMLAGEDNSHLIPEIIRTARSAAGEVPVSVDSLNPPEIEAAVECG
ADMILSLDLGNYREVLPLLRKHGVPAVILPTDYSEGWVPETVEERVEALDELKRKCSGIDVIADPVLDPVNSRSIVDSVM
ACRMYAERNPDPIFFGVGNVTELLDTDSTGVNALLAGFGMELGVSILFTPEESGKARGSVYELSVASQMMFLARHRGSVP
KDLGINLVLFKDKRRSGGVVEKVDVPVIEAEGGMKFVRDKMGSFKIMVEDGQIKAVLYQGMEPRTALTSDSAKKLYEEII
NRNLVSRLEHAAYLGAELQKAEIALRTGKDYVQDFELFERSFPL

Specific function: Unknown. Does not possess dihydropteroate synthase (DHPS) activity since it does not catalyze the condensation of 6- hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) and 4- aminobenzoate to form 7,8-dihydropteroate [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005236
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: NA

Molecular weight: Translated: 57614; Mature: 57614

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLIITGKLASETVREASSTSEHEVHVHVADTPIAAFLTPRRIISEIGKINFSDDGEPD
CEEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCHHHHHHHHHCCCCCCCCCCC
ILIVPGLIPKDVGIIGERTGIPAYKGPTDAADLPIVLDLLGELELSTEKPADKLIEEEQR
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHH
KRALQFIEDFENDQRRISTLLERDENILVGGLPTGRDFPMRVLAEVANAPILLEQGRLRE
HHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCCEEECCCHHHH
RIDYFIRSGADMIDLGMLAGEDNSHLIPEIIRTARSAAGEVPVSVDSLNPPEIEAAVECG
HHHHHHHCCCCEEEHHEEECCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHCC
ADMILSLDLGNYREVLPLLRKHGVPAVILPTDYSEGWVPETVEERVEALDELKRKCSGID
CCEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
VIADPVLDPVNSRSIVDSVMACRMYAERNPDPIFFGVGNVTELLDTDSTGVNALLAGFGM
EEHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCCCCCCHHHHHHHCCH
ELGVSILFTPEESGKARGSVYELSVASQMMFLARHRGSVPKDLGINLVLFKDKRRSGGVV
HHCEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHCCEEEEEECCCCCCCCE
EKVDVPVIEAEGGMKFVRDKMGSFKIMVEDGQIKAVLYQGMEPRTALTSDSAKKLYEEII
EEECCCEEECCCCHHHHHHCCCCEEEEEECCCEEEEEECCCCCCHHHCCHHHHHHHHHHH
NRNLVSRLEHAAYLGAELQKAEIALRTGKDYVQDFELFERSFPL
HHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVLIITGKLASETVREASSTSEHEVHVHVADTPIAAFLTPRRIISEIGKINFSDDGEPD
CEEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCHHHHHHHHHCCCCCCCCCCC
ILIVPGLIPKDVGIIGERTGIPAYKGPTDAADLPIVLDLLGELELSTEKPADKLIEEEQR
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHH
KRALQFIEDFENDQRRISTLLERDENILVGGLPTGRDFPMRVLAEVANAPILLEQGRLRE
HHHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCCEEECCCHHHH
RIDYFIRSGADMIDLGMLAGEDNSHLIPEIIRTARSAAGEVPVSVDSLNPPEIEAAVECG
HHHHHHHCCCCEEEHHEEECCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHCC
ADMILSLDLGNYREVLPLLRKHGVPAVILPTDYSEGWVPETVEERVEALDELKRKCSGID
CCEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
VIADPVLDPVNSRSIVDSVMACRMYAERNPDPIFFGVGNVTELLDTDSTGVNALLAGFGM
EEHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCCCCCCHHHHHHHCCH
ELGVSILFTPEESGKARGSVYELSVASQMMFLARHRGSVPKDLGINLVLFKDKRRSGGVV
HHCEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHCCEEEEEECCCCCCCCE
EKVDVPVIEAEGGMKFVRDKMGSFKIMVEDGQIKAVLYQGMEPRTALTSDSAKKLYEEII
EEECCCEEECCCCHHHHHHCCCCEEEEEECCCEEEEEECCCCCCHHHCCHHHHHHHHHHH
NRNLVSRLEHAAYLGAELQKAEIALRTGKDYVQDFELFERSFPL
HHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]