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Identifier: 15679652

GI number: 15679652

Start: 1520984

End: 1521802

Strand: Direct

Name: Not Available

Synonym: MTH1657

Alternate gene names: 15679652

Gene position: 1520984-1521802 (Clockwise)

Preceding gene: 15679651

Following gene: 15679653

Centisome position: 86.85

GC content: 51.89

Gene sequence:

>819_bases
ATGCTCAGGGATATTATAAGGTCAAAGAAACTCGAAGTTAAGGAACTCATGAAAAAAACACCCCTCAGCATCCTAAGGGA
TGATATAACAGTCATGGACGAGCCAGTGAGCTTCCCAGCTGCAGTGGGAGGAGGCAAAGTATCTCTCATATGCGAATACA
AGAGGGCATCACCATCAATGGGCAGAATATCAGAGAGAGGCCTTGAAGAGATGATGGAGGTATACCAGGACCTCGCCGAT
GCAGTATCCATAGTAACCGACGGCAAATACTTCAAAGGCTCCCTGGATCTGCTGAGCGGGGCCACAGATTACGGTAAACC
ACTGCTCATGAAGGACTTCCTGGTCGACGAGTACAAGATCTACCAGGCAAGGGCATCGGGGGCATCCTCGGTTCTCCTAA
TCACAGGCGTATTCCCTGACCTTGAGGCAGGGATTCAAAAATGCAGGGAGCTCTCAATGGAGCCACTGGTGGAGTGTCAC
ACATCGCTTGACATCTTCAGGGCCCTTGAAGCAGGTGCAGAGATAATAGGTGTGAACAACAGGGACCTTGAAACCTTCGA
GGTGGACCTTGAAAGAACCCATGCACTGGCACCCCTCGTACCCGATGAACTCATACTCGTATCAGAGAGTGGTGTCAGGG
GCCCCGAGGATGCTGAGATACTGGCAGGTTACGGTGCAGATGCTCTGCTCATCGGCACAGCACCCATGTCAGCCCAGAAC
CCACGGGAACTCCTTGAGGAGATAGTAGATGCGGTGAGCCAGTGCAGGGACCGGAGAAGAAGGTACACGGGGGATGAATT
CTTTGAACAGTTCGCATGA

Upstream 100 bases:

>100_bases
CACAGAGAATATCCAGTCTACGGGCTGCAGTTTCACCCGGAGTCAGCCGGAACCCCAAGCGGAAGAACCGTCATTAGAAA
TTTCCTCAGGATGTGAACAC

Downstream 100 bases:

>100_bases
GTCCCTGGCAGATGTACTCGTAAAGATCTGCGGTATAAAAAGGCCAGAGGACGCAATACTGGCAGATAAACTTGGTGCTG
ACCTCCTTGGCCTCATACAC

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MLRDIIRSKKLEVKELMKKTPLSILRDDITVMDEPVSFPAAVGGGKVSLICEYKRASPSMGRISERGLEEMMEVYQDLAD
AVSIVTDGKYFKGSLDLLSGATDYGKPLLMKDFLVDEYKIYQARASGASSVLLITGVFPDLEAGIQKCRELSMEPLVECH
TSLDIFRALEAGAEIIGVNNRDLETFEVDLERTHALAPLVPDELILVSESGVRGPEDAEILAGYGADALLIGTAPMSAQN
PRELLEEIVDAVSQCRDRRRRYTGDEFFEQFA

Sequences:

>Translated_272_residues
MLRDIIRSKKLEVKELMKKTPLSILRDDITVMDEPVSFPAAVGGGKVSLICEYKRASPSMGRISERGLEEMMEVYQDLAD
AVSIVTDGKYFKGSLDLLSGATDYGKPLLMKDFLVDEYKIYQARASGASSVLLITGVFPDLEAGIQKCRELSMEPLVECH
TSLDIFRALEAGAEIIGVNNRDLETFEVDLERTHALAPLVPDELILVSESGVRGPEDAEILAGYGADALLIGTAPMSAQN
PRELLEEIVDAVSQCRDRRRRYTGDEFFEQFA
>Mature_272_residues
MLRDIIRSKKLEVKELMKKTPLSILRDDITVMDEPVSFPAAVGGGKVSLICEYKRASPSMGRISERGLEEMMEVYQDLAD
AVSIVTDGKYFKGSLDLLSGATDYGKPLLMKDFLVDEYKIYQARASGASSVLLITGVFPDLEAGIQKCRELSMEPLVECH
TSLDIFRALEAGAEIIGVNNRDLETFEVDLERTHALAPLVPDELILVSESGVRGPEDAEILAGYGADALLIGTAPMSAQN
PRELLEEIVDAVSQCRDRRRRYTGDEFFEQFA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=243, Percent_Identity=32.9218106995885, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6322638, Length=215, Percent_Identity=35.3488372093023, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_METTH (O27694)

Other databases:

- EMBL:   AE000666
- PIR:   E69088
- RefSeq:   NP_276769.1
- ProteinModelPortal:   O27694
- SMR:   O27694
- STRING:   O27694
- GeneID:   1470742
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1657
- NMPDR:   fig|187420.1.peg.1624
- eggNOG:   arNOG04622
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- PhylomeDB:   O27694
- ProtClustDB:   CLSK2750637
- BioCyc:   MTHE187420:MTH1657-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_A
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 30043; Mature: 30043

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRDIIRSKKLEVKELMKKTPLSILRDDITVMDEPVSFPAAVGGGKVSLICEYKRASPSM
CCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCC
GRISERGLEEMMEVYQDLADAVSIVTDGKYFKGSLDLLSGATDYGKPLLMKDFLVDEYKI
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHH
YQARASGASSVLLITGVFPDLEAGIQKCRELSMEPLVECHTSLDIFRALEAGAEIIGVNN
HHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCC
RDLETFEVDLERTHALAPLVPDELILVSESGVRGPEDAEILAGYGADALLIGTAPMSAQN
CCCCCEEEHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHEECCCCCEEEEECCCCCCCC
PRELLEEIVDAVSQCRDRRRRYTGDEFFEQFA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure
MLRDIIRSKKLEVKELMKKTPLSILRDDITVMDEPVSFPAAVGGGKVSLICEYKRASPSM
CCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCCC
GRISERGLEEMMEVYQDLADAVSIVTDGKYFKGSLDLLSGATDYGKPLLMKDFLVDEYKI
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHH
YQARASGASSVLLITGVFPDLEAGIQKCRELSMEPLVECHTSLDIFRALEAGAEIIGVNN
HHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCC
RDLETFEVDLERTHALAPLVPDELILVSESGVRGPEDAEILAGYGADALLIGTAPMSAQN
CCCCCEEEHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHEECCCCCEEEEECCCCCCCC
PRELLEEIVDAVSQCRDRRRRYTGDEFFEQFA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463