Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15679628

GI number: 15679628

Start: 1497550

End: 1498536

Strand: Direct

Name: Not Available

Synonym: MTH1633

Alternate gene names: 15679628

Gene position: 1497550-1498536 (Clockwise)

Preceding gene: 15679627

Following gene: 15679632

Centisome position: 85.51

GC content: 53.39

Gene sequence:

>987_bases
ATGGGAGTTAAACTCAGGGATGTTGTATCACCCCGCAGGATACGCCTTGAGGACCTTAGGGGAAGAACGGTCGCAGTCGA
TGCAGCCAACACACTCTACCAGTTCCTATCAAGCATAAGGCAGAGGGATGGAACACCCCTCATGGATTCCAGGGGTAGAG
TAACATCACACCTCAGCGGCATACTCTACAGGACGGCCGCGGTCATGGAGAGGGAGATAAGGGTCATATATGTCTTCGAT
GGAAGGTCCCACCACCTCAAGGGCGAGACCGTGAGCAGGAGGGCTGATATCCGGAAGAAATCTGAGGTTGAGTGGAAGAG
GGCCCTTGAGGAGGGGGACATTGACAGGGCGAAAAAATATGCTGTAAGGTCCTCAAGGATGTCCTCAGAAATACTGGAGA
GTTCAAAGAGGCTCCTGGAACTTCTGGGAATACCCTATGTACAGGCACCCGGTGAGGGGGAGGCTCAGGCATCATACATG
GTTAAGATGGGCGATGCATGGGCCGTGGCATCCCAGGACTATGACTGTCTCCTCTTTGGCGCCCCAAGGGTTGTAAGGAA
CCTCACCCTCAGCGGAAAACTTGAGGACCCCGAGATCATTGAACTGGAGTCCACCCTCAGGGAACTCTCAATCAGCCACA
CACAGCTCGTGGATATGGCACTACTCGTCGGGACTGACTTCAATGAGGGTGTAAAGGGGATAGGCGCAAGGAGGGGACTC
AAACTCATCAGGGAGAAGGGCGACATTTTCAAAGTCATCAGGGACCTTGAAGCTGACATAGGTGGCGACCCCCAGGTTCT
CAGGAGGATCTTTCTGGAGCCAGAGGTTTCAGAGGACTATGAGATCAGGTGGAGAAAACCTGACGTGGAAGGTGTTATCG
AGTTCCTGTGCACTGAACACGGCTTTTCAGAGGACCGTGTGAGGGCTGCACTTAAAAAATTTGAGGGTGCATCCTCCACC
CAGAAGAGCCTGGAGGACTGGTTCTGA

Upstream 100 bases:

>100_bases
TACAATATCATCCATGAAGGTGAGGTTCTCATAAGGATAAAGGAGACCTTCCCCTTCGAATGGTTCAGGGAGGAGTTTTA
GAGATTCACCGGGTGTTCAT

Downstream 100 bases:

>100_bases
AAGCATTAATTTTTATGAAGCACCCCACTTCCTGACATCATCGAGGCCGGCTTCATCAAGGAATCCCCTTTTTCTGCAGA
ATTCAGTGAGCCGCCTGTAG

Product: flap endonuclease-1

Products: NA

Alternate protein names: FEN-1; Flap structure-specific endonuclease 1

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MGVKLRDVVSPRRIRLEDLRGRTVAVDAANTLYQFLSSIRQRDGTPLMDSRGRVTSHLSGILYRTAAVMEREIRVIYVFD
GRSHHLKGETVSRRADIRKKSEVEWKRALEEGDIDRAKKYAVRSSRMSSEILESSKRLLELLGIPYVQAPGEGEAQASYM
VKMGDAWAVASQDYDCLLFGAPRVVRNLTLSGKLEDPEIIELESTLRELSISHTQLVDMALLVGTDFNEGVKGIGARRGL
KLIREKGDIFKVIRDLEADIGGDPQVLRRIFLEPEVSEDYEIRWRKPDVEGVIEFLCTEHGFSEDRVRAALKKFEGASST
QKSLEDWF

Sequences:

>Translated_328_residues
MGVKLRDVVSPRRIRLEDLRGRTVAVDAANTLYQFLSSIRQRDGTPLMDSRGRVTSHLSGILYRTAAVMEREIRVIYVFD
GRSHHLKGETVSRRADIRKKSEVEWKRALEEGDIDRAKKYAVRSSRMSSEILESSKRLLELLGIPYVQAPGEGEAQASYM
VKMGDAWAVASQDYDCLLFGAPRVVRNLTLSGKLEDPEIIELESTLRELSISHTQLVDMALLVGTDFNEGVKGIGARRGL
KLIREKGDIFKVIRDLEADIGGDPQVLRRIFLEPEVSEDYEIRWRKPDVEGVIEFLCTEHGFSEDRVRAALKKFEGASST
QKSLEDWF
>Mature_327_residues
GVKLRDVVSPRRIRLEDLRGRTVAVDAANTLYQFLSSIRQRDGTPLMDSRGRVTSHLSGILYRTAAVMEREIRVIYVFDG
RSHHLKGETVSRRADIRKKSEVEWKRALEEGDIDRAKKYAVRSSRMSSEILESSKRLLELLGIPYVQAPGEGEAQASYMV
KMGDAWAVASQDYDCLLFGAPRVVRNLTLSGKLEDPEIIELESTLRELSISHTQLVDMALLVGTDFNEGVKGIGARRGLK
LIREKGDIFKVIRDLEADIGGDPQVLRRIFLEPEVSEDYEIRWRKPDVEGVIEFLCTEHGFSEDRVRAALKKFEGASSTQ
KSLEDWF

Specific function: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymeras

COG id: COG0258

COG function: function code L; 5'-3' exonuclease (including N-terminal domain of PolI)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily

Homologues:

Organism=Homo sapiens, GI4758356, Length=339, Percent_Identity=36.8731563421829, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI194018535, Length=281, Percent_Identity=27.7580071174377, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI194018531, Length=281, Percent_Identity=27.7580071174377, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI51988900, Length=240, Percent_Identity=23.3333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510005, Length=346, Percent_Identity=35.2601156069364, Blast_Score=221, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6322736, Length=351, Percent_Identity=35.6125356125356, Blast_Score=204, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320469, Length=249, Percent_Identity=23.2931726907631, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324607, Length=204, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321697, Length=213, Percent_Identity=23.4741784037559, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17647423, Length=345, Percent_Identity=35.9420289855072, Blast_Score=214, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24658219, Length=236, Percent_Identity=27.9661016949153, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17137168, Length=234, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FEN_METTH (O27670)

Other databases:

- EMBL:   AE000666
- PIR:   C69085
- RefSeq:   NP_276745.1
- ProteinModelPortal:   O27670
- SMR:   O27670
- STRING:   O27670
- GeneID:   1470718
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1633
- NMPDR:   fig|187420.1.peg.1600
- eggNOG:   arNOG04505
- HOGENOM:   HBG316651
- OMA:   DYDSLLF
- PhylomeDB:   O27670
- ProtClustDB:   PRK03980
- BioCyc:   MTHE187420:MTH1633-MONOMER
- HAMAP:   MF_00614
- InterPro:   IPR020045
- InterPro:   IPR019973
- InterPro:   IPR008918
- InterPro:   IPR006086
- InterPro:   IPR019974
- InterPro:   IPR006085
- InterPro:   IPR006084
- PANTHER:   PTHR11081
- PRINTS:   PR00853
- SMART:   SM00279
- SMART:   SM00484
- SMART:   SM00485
- TIGRFAMs:   TIGR03674

Pfam domain/function: PF00867 XPG_I; PF00752 XPG_N; SSF47807 5_3_exo_C

EC number: 3.-.-.-

Molecular weight: Translated: 37171; Mature: 37040

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00841 XPG_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVKLRDVVSPRRIRLEDLRGRTVAVDAANTLYQFLSSIRQRDGTPLMDSRGRVTSHLSG
CCCCCHHHCCCCHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
ILYRTAAVMEREIRVIYVFDGRSHHLKGETVSRRADIRKKSEVEWKRALEEGDIDRAKKY
HHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AVRSSRMSSEILESSKRLLELLGIPYVQAPGEGEAQASYMVKMGDAWAVASQDYDCLLFG
HHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEECCEEEECCCCCCEEEEC
APRVVRNLTLSGKLEDPEIIELESTLRELSISHTQLVDMALLVGTDFNEGVKGIGARRGL
CHHHHHHCCCCCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
KLIREKGDIFKVIRDLEADIGGDPQVLRRIFLEPEVSEDYEIRWRKPDVEGVIEFLCTEH
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHC
GFSEDRVRAALKKFEGASSTQKSLEDWF
CCCHHHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
GVKLRDVVSPRRIRLEDLRGRTVAVDAANTLYQFLSSIRQRDGTPLMDSRGRVTSHLSG
CCCCHHHCCCCHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
ILYRTAAVMEREIRVIYVFDGRSHHLKGETVSRRADIRKKSEVEWKRALEEGDIDRAKKY
HHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AVRSSRMSSEILESSKRLLELLGIPYVQAPGEGEAQASYMVKMGDAWAVASQDYDCLLFG
HHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEECCEEEECCCCCCEEEEC
APRVVRNLTLSGKLEDPEIIELESTLRELSISHTQLVDMALLVGTDFNEGVKGIGARRGL
CHHHHHHCCCCCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
KLIREKGDIFKVIRDLEADIGGDPQVLRRIFLEPEVSEDYEIRWRKPDVEGVIEFLCTEH
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHC
GFSEDRVRAALKKFEGASSTQKSLEDWF
CCCHHHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463