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Identifier: 15679575

GI number: 15679575

Start: 1446239

End: 1447924

Strand: Direct

Name: Not Available

Synonym: MTH1580

Alternate gene names: 15679575

Gene position: 1446239-1447924 (Clockwise)

Preceding gene: 15679574

Following gene: 15679576

Centisome position: 82.58

GC content: 50.24

Gene sequence:

>1686_bases
ATGAAGGAATTGCTCTATATGGAACTTGCAGAGGTATACCACAGACTTGAATCAACCACAAAACGCCTTGAAAAGACTGA
AATACTTGCGGAACTCCTGAGGAGTGTTGATAAGGAACTTCTGCCCGATGTAACAATACTGATGCTTGGCAGGGTGTTTC
CAATCTGGAGTGAGGAGGAACTTGGGGTTGGCATAAAGCTGCTCATGAAGGCAATATCCCTGGTTGTGGGGGTTTCGATG
GATGAAATCGAGGACGAAATAAGGGAACAGGGTGATATAGGCCTTGCAAGTGAAAAACTATTCTCCAGAAAAACTCAAAC
AACCTTTTTTTCACAACCCCTGACAGTGGAATTTGTTTACAGCAGACTGAAGGCCCTGGCATCAGCTTCTGGTGATAGGG
CACAGTCAAAGAAGATAAACATACTTGTTGAGGTCCTGTCCCAGGCAAAGCCACTGGAGGCACGCTATATAACAAGGACG
GTCCTTGAGGAACTGAGGGTTGGTGTTGCAGAGGGAATCATAAGGGACGCCATTGCCCGGGCCTTTGAGGTTGACCCGGC
ACTCGTTGAAAGGGCCCACATGCTCACAAATGACCTGGGAATGGTGGCCGCAGTTGCAAGGGAGGAGGGCGAGCCTGGAC
TTGGAAGACTCAACCTTGAACCGGGAAGACCCGTGAAACCAATGCTGGCACAGCTTGCCAGCAGCATAGAATCTGCCATA
ACGGAGCTTGGAAGGGCCTTCTGTGAAACCAAATATGATGGTATACGTGTTCAGATACACAGATGCGGGGATGAGATATC
CATCTTCACCAGGAGACTTGAGAACATCACCGCGGCGGTCCCCGAGATACTTGAGGGTGTTGAGGAGGCCCTTCCAGCCG
ATGACTACATAGTTGAGGGGGAAATAATAGTCACCATGGATGGGAGGCCAGCCTCCTTCCAGTACATACTCCAGCGTGTC
AGAAGAAAATATGATGTGGAGAGACTTACAAGGGAGGTTCCCCTCTCACTGTTCCTCTTTGATGTCCTCTACCACAGAGA
ACCCCTCATCGATGAACCCCTCCGGCACAGAAGGGAGGTCCTTGAGTCAATACTCTCAGAAATACCTGGAAGGGTTGAGG
CGAGTCGCATGGTTGATGTGGGCCCGGATAACCTGAATGATGCTCTATGGCTCTTCGAGGAGTCAATAAGAGAGGGACAT
GAGGGTATAATGATAAAGGATACGGAGGCGCCGTATATACCGGGTATAAGGGGTAAAAAGATGCTTAAGTTTAAGGCAGA
ACCAGAGACCCTGGACCTCATTGTGGTCGGTGGCACCTATGGCAGGGGTAAAAGGGCACATCTGGTGGGATCCTATCTCC
TGGCAGCCAGGGATGAGGATAGCGGGGACCTTGTTACGGTTGCACATGTTGCAACGGGGCTTGACGATGAGACGCTCCAG
CAACTCTCAGAGAGGATGGAAAAACTTGCCATTGAGAGGAAGGGACGGAAACTCTTGGTCAGGCCAGAAATAATACTTGA
GGTCGCCTACAGTGAGATAGTGAAGAGTCCTGAGTATGAAAGCGGTTACTCCCTGCGTTTTCCAGTGGTGAAACGTATAA
GGGACGATCTGTGCCTGGACGATGTTGATACAGTTGGACGTATAGAGTCCCTCTTCCAGTCCGGACAGCCAGACCAACCA
GGTTAG

Upstream 100 bases:

>100_bases
CATGGCGGAAGCGCCAGCAGACAAGGATGACTGTGAATTGTAGGTGCTGAAGAATGGTTTTAAGGTCGATGGGAGTTTAA
CGGTTCAGATTACTTAGGGG

Downstream 100 bases:

>100_bases
TAATATTTAAATAGTACAAAGTAATAATTACTTTTATGGGAACCCTTCTGGATGACAGGAAACTGCTCATAATATCAGCC
ATGCTGGGACTCGCCGGCTT

Product: DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MKELLYMELAEVYHRLESTTKRLEKTEILAELLRSVDKELLPDVTILMLGRVFPIWSEEELGVGIKLLMKAISLVVGVSM
DEIEDEIREQGDIGLASEKLFSRKTQTTFFSQPLTVEFVYSRLKALASASGDRAQSKKINILVEVLSQAKPLEARYITRT
VLEELRVGVAEGIIRDAIARAFEVDPALVERAHMLTNDLGMVAAVAREEGEPGLGRLNLEPGRPVKPMLAQLASSIESAI
TELGRAFCETKYDGIRVQIHRCGDEISIFTRRLENITAAVPEILEGVEEALPADDYIVEGEIIVTMDGRPASFQYILQRV
RRKYDVERLTREVPLSLFLFDVLYHREPLIDEPLRHRREVLESILSEIPGRVEASRMVDVGPDNLNDALWLFEESIREGH
EGIMIKDTEAPYIPGIRGKKMLKFKAEPETLDLIVVGGTYGRGKRAHLVGSYLLAARDEDSGDLVTVAHVATGLDDETLQ
QLSERMEKLAIERKGRKLLVRPEIILEVAYSEIVKSPEYESGYSLRFPVVKRIRDDLCLDDVDTVGRIESLFQSGQPDQP
G

Sequences:

>Translated_561_residues
MKELLYMELAEVYHRLESTTKRLEKTEILAELLRSVDKELLPDVTILMLGRVFPIWSEEELGVGIKLLMKAISLVVGVSM
DEIEDEIREQGDIGLASEKLFSRKTQTTFFSQPLTVEFVYSRLKALASASGDRAQSKKINILVEVLSQAKPLEARYITRT
VLEELRVGVAEGIIRDAIARAFEVDPALVERAHMLTNDLGMVAAVAREEGEPGLGRLNLEPGRPVKPMLAQLASSIESAI
TELGRAFCETKYDGIRVQIHRCGDEISIFTRRLENITAAVPEILEGVEEALPADDYIVEGEIIVTMDGRPASFQYILQRV
RRKYDVERLTREVPLSLFLFDVLYHREPLIDEPLRHRREVLESILSEIPGRVEASRMVDVGPDNLNDALWLFEESIREGH
EGIMIKDTEAPYIPGIRGKKMLKFKAEPETLDLIVVGGTYGRGKRAHLVGSYLLAARDEDSGDLVTVAHVATGLDDETLQ
QLSERMEKLAIERKGRKLLVRPEIILEVAYSEIVKSPEYESGYSLRFPVVKRIRDDLCLDDVDTVGRIESLFQSGQPDQP
G
>Mature_561_residues
MKELLYMELAEVYHRLESTTKRLEKTEILAELLRSVDKELLPDVTILMLGRVFPIWSEEELGVGIKLLMKAISLVVGVSM
DEIEDEIREQGDIGLASEKLFSRKTQTTFFSQPLTVEFVYSRLKALASASGDRAQSKKINILVEVLSQAKPLEARYITRT
VLEELRVGVAEGIIRDAIARAFEVDPALVERAHMLTNDLGMVAAVAREEGEPGLGRLNLEPGRPVKPMLAQLASSIESAI
TELGRAFCETKYDGIRVQIHRCGDEISIFTRRLENITAAVPEILEGVEEALPADDYIVEGEIIVTMDGRPASFQYILQRV
RRKYDVERLTREVPLSLFLFDVLYHREPLIDEPLRHRREVLESILSEIPGRVEASRMVDVGPDNLNDALWLFEESIREGH
EGIMIKDTEAPYIPGIRGKKMLKFKAEPETLDLIVVGGTYGRGKRAHLVGSYLLAARDEDSGDLVTVAHVATGLDDETLQ
QLSERMEKLAIERKGRKLLVRPEIILEVAYSEIVKSPEYESGYSLRFPVVKRIRDDLCLDDVDTVGRIESLFQSGQPDQP
G

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family

Homologues:

Organism=Homo sapiens, GI4557719, Length=623, Percent_Identity=30.1765650080257, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI73747829, Length=596, Percent_Identity=26.1744966442953, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI73747844, Length=596, Percent_Identity=26.1744966442953, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI46255052, Length=479, Percent_Identity=29.6450939457203, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI23199993, Length=479, Percent_Identity=29.6450939457203, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI148539894, Length=479, Percent_Identity=29.6450939457203, Blast_Score=150, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71985269, Length=612, Percent_Identity=28.7581699346405, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71985278, Length=185, Percent_Identity=26.4864864864865, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320038, Length=611, Percent_Identity=30.6055646481178, Blast_Score=232, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24762424, Length=611, Percent_Identity=28.4779050736498, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI85815841, Length=557, Percent_Identity=25.3141831238779, Blast_Score=126, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNLI_METTH (Q50566)

Other databases:

- EMBL:   U51624
- EMBL:   AE000666
- PIR:   H69077
- RefSeq:   NP_276692.1
- ProteinModelPortal:   Q50566
- SMR:   Q50566
- STRING:   Q50566
- GeneID:   1471849
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1580
- NMPDR:   fig|187420.1.peg.1547
- eggNOG:   arNOG04596
- HOGENOM:   HBG570821
- OMA:   SIREGHE
- PhylomeDB:   Q50566
- ProtClustDB:   CLSK798208
- BioCyc:   MTHE187420:MTH1580-MONOMER
- BRENDA:   6.5.1.1
- HAMAP:   MF_00407
- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027
- Gene3D:   G3DSA:2.40.50.140
- TIGRFAMs:   TIGR00574

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N; SSF50249 Nucleic_acid_OB

EC number: =6.5.1.1

Molecular weight: Translated: 63090; Mature: 63090

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00697 DNA_LIGASE_A1; PS00333 DNA_LIGASE_A2; PS50160 DNA_LIGASE_A3

Important sites: ACT_SITE 251-251 BINDING 249-249 BINDING 256-256 BINDING 271-271 BINDING 301-301 BINDING 340-340 BINDING 417-417 BINDING 423-423

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELLYMELAEVYHRLESTTKRLEKTEILAELLRSVDKELLPDVTILMLGRVFPIWSEEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
LGVGIKLLMKAISLVVGVSMDEIEDEIREQGDIGLASEKLFSRKTQTTFFSQPLTVEFVY
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
SRLKALASASGDRAQSKKINILVEVLSQAKPLEARYITRTVLEELRVGVAEGIIRDAIAR
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFEVDPALVERAHMLTNDLGMVAAVAREEGEPGLGRLNLEPGRPVKPMLAQLASSIESAI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHH
TELGRAFCETKYDGIRVQIHRCGDEISIFTRRLENITAAVPEILEGVEEALPADDYIVEG
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
EIIVTMDGRPASFQYILQRVRRKYDVERLTREVPLSLFLFDVLYHREPLIDEPLRHRREV
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHH
LESILSEIPGRVEASRMVDVGPDNLNDALWLFEESIREGHEGIMIKDTEAPYIPGIRGKK
HHHHHHHCCCCCCHHHEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
MLKFKAEPETLDLIVVGGTYGRGKRAHLVGSYLLAARDEDSGDLVTVAHVATGLDDETLQ
EEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEHHHHHHCCCHHHHH
QLSERMEKLAIERKGRKLLVRPEIILEVAYSEIVKSPEYESGYSLRFPVVKRIRDDLCLD
HHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHCCCC
DVDTVGRIESLFQSGQPDQPG
CHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKELLYMELAEVYHRLESTTKRLEKTEILAELLRSVDKELLPDVTILMLGRVFPIWSEEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
LGVGIKLLMKAISLVVGVSMDEIEDEIREQGDIGLASEKLFSRKTQTTFFSQPLTVEFVY
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
SRLKALASASGDRAQSKKINILVEVLSQAKPLEARYITRTVLEELRVGVAEGIIRDAIAR
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFEVDPALVERAHMLTNDLGMVAAVAREEGEPGLGRLNLEPGRPVKPMLAQLASSIESAI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHH
TELGRAFCETKYDGIRVQIHRCGDEISIFTRRLENITAAVPEILEGVEEALPADDYIVEG
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEC
EIIVTMDGRPASFQYILQRVRRKYDVERLTREVPLSLFLFDVLYHREPLIDEPLRHRREV
EEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHH
LESILSEIPGRVEASRMVDVGPDNLNDALWLFEESIREGHEGIMIKDTEAPYIPGIRGKK
HHHHHHHCCCCCCHHHEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
MLKFKAEPETLDLIVVGGTYGRGKRAHLVGSYLLAARDEDSGDLVTVAHVATGLDDETLQ
EEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEHHHHHHCCCHHHHH
QLSERMEKLAIERKGRKLLVRPEIILEVAYSEIVKSPEYESGYSLRFPVVKRIRDDLCLD
HHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHCCCC
DVDTVGRIESLFQSGQPDQPG
CHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9006048; 9371463