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Identifier: 15679553

GI number: 15679553

Start: 1422850

End: 1424559

Strand: Direct

Name: Not Available

Synonym: MTH1557

Alternate gene names: 15679553

Gene position: 1422850-1424559 (Clockwise)

Preceding gene: 15679552

Following gene: 15679554

Centisome position: 81.24

GC content: 51.46

Gene sequence:

>1710_bases
ATGGAATACATAATCAAAAACGGATTTGTTTACTGTCCTCTTAACAACGTCGATGGAGAAAAGATGGACATCTGCGTCAA
GGATGGTAAAATAGTTGAAAGCGTCAGTGACAGCGCAAAGGTCATTGATGCATCTGGAAAAATGGTGATGCCAGGAGGTG
TCGACCCTCACTCCCACATAGCCGGTGCAAAGGTCAACGTGGGAAGGATGTACAGGCCAGAGGACAGCCGCAGGGACGCT
GAAAAATTCAGGGCCGGAAGGGCCGGAAGCGGTTTCTCAGTACCATCAACCTTCATGACAGGTTACAGGTACGCCCAGAT
GGGTTACACCACAGCAATGGAGGCAGCCATGCCACCACTGCTTGCAAGGCACACCCATGAGGAATTCCACGACACACCGA
TAATAGACCACGCAGCATACCCACTGTTCGGTAACAACTGGTTCGTGATGGAGTACCTGAAGGATGGCGACGTGGATGCC
TGTGCAGCCTACGCATCATGGCTCCTCAGGGCCACCAAAGGTTACGCAATAAAGATAGTTAACCCTGCCGGTACAGAGGC
ATGGGGATGGGGTGGAAACGTCCACGGAATCTATGACCCCGCACCCTACTTTGACATAACGCCCGCAGAGATCATAAAGG
GACTCGCAGAGGTCAACGAGAAACTCCAGCTACCACACTCAATACACCTCCACTGTAACGACCTTGGACACCCTGGAAAC
TACGAGACAACCCTGGCATCCTTTGACGTGCCAAAGAACATAAAACCAGACCCTGCAACCGGTGAAAGGGACACAGTACT
CTATGCAACCCATGTCCAGTTCCACAGCTACGGTGGAACAACCTGGAGGGACTTCGTATCAGAGGCACCAAAGGTTGCTG
ACTATGTAAACAGGAACGACCATGTTGTGATAGACGTTGGTCAGATAACCCTGGATGAGACAACCACCATGACCGCAGAC
GGTCCAATGGAATACGACCTCCACTCACTCAACGGCCTCAAATGGGCAAACTGTGACGTGGAACTCGAAACAGGTTCAGG
TGTCGTACCATTCATATACTCTGCAAGGGCACCGGTCCCAGCGGTCCAGTGGGCAATCGGAATGGAACTCTTCCTCCTCA
TAGACGACCCCGGCAAGGTGTGCCTCACAACAGACAGTCCAAATGCAGGGCCATTCACACGGTACCCCAGGGTCATCGCA
TGGCTCATGAGCAACAAGTACAGGATGAACCTCATTGAGGGAGAACTGCACAAGTGGGCCCAGAGGAAGAGTACAATAGC
AACAATCGACAGGGAGTACACCTTCTCAGAGATAGCACAGATCACAAGGGTAACATCTGCAAAGGTCCTGGGTCTCAGCG
AAACCAAGGGACACCTCGGCGCAGGTGCAGATGCAGATATAGCAGTCTACAACATCAACCCTGAAACAGTCGATCCATCA
GCAGATTACATGGCCATTGAGGAAGGATTCTCAAGGGCAGCATACGTCCTCAAGGACGGAGAAATAGTTGTTAAGGACGG
AGAAGTTGTGGCCTCACCACACGGAAGGACCTACTGGATTGACACCCAGGTGGATGAGTCCCTCTACAACGAGGTTCTCG
CCAGTGTTGAGAGCAAATTCAAACAGTACTACTCTGTCAACTTTGCAAACTACCCTGTGCAGGACGAGTACCTGCCAAAA
TCTGCTCCAGTTAAAGGGGTGATGTTATGA

Upstream 100 bases:

>100_bases
TGGAGATCATACCCACCGATGAAGAGGTTCCTGACATGCCAACCCTCATGAAGGTCTACGGTAAGGTAGGTCAGATCTAA
AGCTCAGCGGGAGGATTCAA

Downstream 100 bases:

>100_bases
GTGAAATAATACTAACTCCAAAGGAACAGCCCGAAGTGCCACTGGAGGCACCAAACATCAAACCTGATGTCTTCGCAGGA
AAGTCAATAGATGAGATCAG

Product: tungsten formylmethanofuran dehydrogenase, subunit A

Products: CO2; methanofuran; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MEYIIKNGFVYCPLNNVDGEKMDICVKDGKIVESVSDSAKVIDASGKMVMPGGVDPHSHIAGAKVNVGRMYRPEDSRRDA
EKFRAGRAGSGFSVPSTFMTGYRYAQMGYTTAMEAAMPPLLARHTHEEFHDTPIIDHAAYPLFGNNWFVMEYLKDGDVDA
CAAYASWLLRATKGYAIKIVNPAGTEAWGWGGNVHGIYDPAPYFDITPAEIIKGLAEVNEKLQLPHSIHLHCNDLGHPGN
YETTLASFDVPKNIKPDPATGERDTVLYATHVQFHSYGGTTWRDFVSEAPKVADYVNRNDHVVIDVGQITLDETTTMTAD
GPMEYDLHSLNGLKWANCDVELETGSGVVPFIYSARAPVPAVQWAIGMELFLLIDDPGKVCLTTDSPNAGPFTRYPRVIA
WLMSNKYRMNLIEGELHKWAQRKSTIATIDREYTFSEIAQITRVTSAKVLGLSETKGHLGAGADADIAVYNINPETVDPS
ADYMAIEEGFSRAAYVLKDGEIVVKDGEVVASPHGRTYWIDTQVDESLYNEVLASVESKFKQYYSVNFANYPVQDEYLPK
SAPVKGVML

Sequences:

>Translated_569_residues
MEYIIKNGFVYCPLNNVDGEKMDICVKDGKIVESVSDSAKVIDASGKMVMPGGVDPHSHIAGAKVNVGRMYRPEDSRRDA
EKFRAGRAGSGFSVPSTFMTGYRYAQMGYTTAMEAAMPPLLARHTHEEFHDTPIIDHAAYPLFGNNWFVMEYLKDGDVDA
CAAYASWLLRATKGYAIKIVNPAGTEAWGWGGNVHGIYDPAPYFDITPAEIIKGLAEVNEKLQLPHSIHLHCNDLGHPGN
YETTLASFDVPKNIKPDPATGERDTVLYATHVQFHSYGGTTWRDFVSEAPKVADYVNRNDHVVIDVGQITLDETTTMTAD
GPMEYDLHSLNGLKWANCDVELETGSGVVPFIYSARAPVPAVQWAIGMELFLLIDDPGKVCLTTDSPNAGPFTRYPRVIA
WLMSNKYRMNLIEGELHKWAQRKSTIATIDREYTFSEIAQITRVTSAKVLGLSETKGHLGAGADADIAVYNINPETVDPS
ADYMAIEEGFSRAAYVLKDGEIVVKDGEVVASPHGRTYWIDTQVDESLYNEVLASVESKFKQYYSVNFANYPVQDEYLPK
SAPVKGVML
>Mature_569_residues
MEYIIKNGFVYCPLNNVDGEKMDICVKDGKIVESVSDSAKVIDASGKMVMPGGVDPHSHIAGAKVNVGRMYRPEDSRRDA
EKFRAGRAGSGFSVPSTFMTGYRYAQMGYTTAMEAAMPPLLARHTHEEFHDTPIIDHAAYPLFGNNWFVMEYLKDGDVDA
CAAYASWLLRATKGYAIKIVNPAGTEAWGWGGNVHGIYDPAPYFDITPAEIIKGLAEVNEKLQLPHSIHLHCNDLGHPGN
YETTLASFDVPKNIKPDPATGERDTVLYATHVQFHSYGGTTWRDFVSEAPKVADYVNRNDHVVIDVGQITLDETTTMTAD
GPMEYDLHSLNGLKWANCDVELETGSGVVPFIYSARAPVPAVQWAIGMELFLLIDDPGKVCLTTDSPNAGPFTRYPRVIA
WLMSNKYRMNLIEGELHKWAQRKSTIATIDREYTFSEIAQITRVTSAKVLGLSETKGHLGAGADADIAVYNINPETVDPS
ADYMAIEEGFSRAAYVLKDGEIVVKDGEVVASPHGRTYWIDTQVDESLYNEVLASVESKFKQYYSVNFANYPVQDEYLPK
SAPVKGVML

Specific function: Unknown

COG id: COG1229

COG function: function code C; Formylmethanofuran dehydrogenase subunit A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013108
- InterPro:   IPR012027
- InterPro:   IPR011059 [H]

Pfam domain/function: PF07969 Amidohydro_3 [H]

EC number: 1.2.99.5

Molecular weight: Translated: 62856; Mature: 62856

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYIIKNGFVYCPLNNVDGEKMDICVKDGKIVESVSDSAKVIDASGKMVMPGGVDPHSHI
CCEEEECCEEEEECCCCCCCEEEEEEECCCHHHHCCCCCEEEECCCCEEECCCCCCCCCC
AGAKVNVGRMYRPEDSRRDAEKFRAGRAGSGFSVPSTFMTGYRYAQMGYTTAMEAAMPPL
CCCEEECCCEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHCEEEEHHCHHHHHHHHCCHH
LARHTHEEFHDTPIIDHAAYPLFGNNWFVMEYLKDGDVDACAAYASWLLRATKGYAIKIV
HHHHCHHHHCCCCCCCCCCCCEECCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEE
NPAGTEAWGWGGNVHGIYDPAPYFDITPAEIIKGLAEVNEKLQLPHSIHLHCNDLGHPGN
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
YETTLASFDVPKNIKPDPATGERDTVLYATHVQFHSYGGTTWRDFVSEAPKVADYVNRND
CCEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHCCCHHHHHHCCCC
HVVIDVGQITLDETTTMTADGPMEYDLHSLNGLKWANCDVELETGSGVVPFIYSARAPVP
EEEEEECEEEECCCEEEECCCCCCCCHHHCCCCEEECCEEEEECCCCEEEEEEECCCCCC
AVQWAIGMELFLLIDDPGKVCLTTDSPNAGPFTRYPRVIAWLMSNKYRMNLIEGELHKWA
HHHHEECEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHH
QRKSTIATIDREYTFSEIAQITRVTSAKVLGLSETKGHLGAGADADIAVYNINPETVDPS
HHCCCEEEECCCCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCC
ADYMAIEEGFSRAAYVLKDGEIVVKDGEVVASPHGRTYWIDTQVDESLYNEVLASVESKF
CCEEHHHHCCCCEEEEEECCEEEEECCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHH
KQYYSVNFANYPVQDEYLPKSAPVKGVML
HHHEEECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEYIIKNGFVYCPLNNVDGEKMDICVKDGKIVESVSDSAKVIDASGKMVMPGGVDPHSHI
CCEEEECCEEEEECCCCCCCEEEEEEECCCHHHHCCCCCEEEECCCCEEECCCCCCCCCC
AGAKVNVGRMYRPEDSRRDAEKFRAGRAGSGFSVPSTFMTGYRYAQMGYTTAMEAAMPPL
CCCEEECCCEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHCEEEEHHCHHHHHHHHCCHH
LARHTHEEFHDTPIIDHAAYPLFGNNWFVMEYLKDGDVDACAAYASWLLRATKGYAIKIV
HHHHCHHHHCCCCCCCCCCCCEECCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEE
NPAGTEAWGWGGNVHGIYDPAPYFDITPAEIIKGLAEVNEKLQLPHSIHLHCNDLGHPGN
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
YETTLASFDVPKNIKPDPATGERDTVLYATHVQFHSYGGTTWRDFVSEAPKVADYVNRND
CCEEEEECCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHCCCHHHHHHCCCC
HVVIDVGQITLDETTTMTADGPMEYDLHSLNGLKWANCDVELETGSGVVPFIYSARAPVP
EEEEEECEEEECCCEEEECCCCCCCCHHHCCCCEEECCEEEEECCCCEEEEEEECCCCCC
AVQWAIGMELFLLIDDPGKVCLTTDSPNAGPFTRYPRVIAWLMSNKYRMNLIEGELHKWA
HHHHEECEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHH
QRKSTIATIDREYTFSEIAQITRVTSAKVLGLSETKGHLGAGADADIAVYNINPETVDPS
HHCCCEEEECCCCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCC
ADYMAIEEGFSRAAYVLKDGEIVVKDGEVVASPHGRTYWIDTQVDESLYNEVLASVESKF
CCEEHHHHCCCCEEEEEECCEEEEECCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHH
KQYYSVNFANYPVQDEYLPKSAPVKGVML
HHHEEECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formylmethanofuran; H2O; acceptor

Specific reaction: formylmethanofuran + H2O + acceptor = CO2 + methanofuran + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]