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Identifier: 15679520

GI number: 15679520

Start: 1384125

End: 1385129

Strand: Direct

Name: Not Available

Synonym: MTH1523

Alternate gene names: 15679520

Gene position: 1384125-1385129 (Clockwise)

Preceding gene: 15679519

Following gene: 15679521

Centisome position: 79.03

GC content: 47.66

Gene sequence:

>1005_bases
ATGGCTGAAACAGTTGGAATGATACTCTGCGGGGGATTCGGGAAACGTCTGAGACCCCTAACTGAGAAAATACCAAAACC
ACTCATCGAGATAAAGGAGGGCTACACCATCCTTGATAAACAGCTCTTTGACCTCAAAAATGCAGGCATAAACACGGTGT
ACCTCCTTACAGGTTTCCTTGGGGAAAGGATAGAGGAGAGGTATGGTGATAACTACAAGGGACTCAGAATAGAGTATGTA
AGGGAGGAGAAACCACTGGGGACCCTTAACGCCATAAGGCTTGGAATGGAGGCCATAGATGGAGAGAAACAGTGCATAAT
AAGGAATGGGGATGTTGTGGCTGACCTCAATATAAAGAAGATGATACACCTGGGTGAGATGTCAGATTATCCCCTGACCA
TGTTCATAACCAGGATGCAGTCACCATATGGCATAGTTGAAACCAGCGGTGATAAGATAATAAACTTCAGAGAGAAACCA
CTCCTTGACTATTACATCAACGCAGGGGTCTACTTCTCCAAGGGAAACCTTGACTTCGGTGACTTTGAGTCGGGGGACAT
CGAGAAGACACTCTTCCCCCTCATGGCAAAGGAGAACAAGCTGGGCTACTACAGGGAGGACGGTCTCTTCTGGATGGCCA
TCGACACCTCCAAAGAACTTGAGGAGATAAGGAAGGAGTACCGTAACCGGGAGGACAAGCCATGGGGCTATGAGAAGATC
CTCATAAACACCGAGAAGTACCTCACAAAGGAGCTCTTCATAAGGGAGGGCTACAGGACATCATTCCATTACCATGAGGA
GAAGGATGAGACCATGTACATAATCTCGGGTTCAGGTTACATAGAATTCGATAACCGGAAGGAGTACTTCAGCAAGAACG
ACACCATCCGCATAGAACCAGGGGAGAGGCACTCCATAGTGGCCATGGAGAACACCGTACTCCATGAGGTATCAACACCA
CACCTAAACGACACCGTGAGGGTCCAGGATTACTATACAAGGTGA

Upstream 100 bases:

>100_bases
TGGCTGAACTTGATGCCCATGCAAGGACACTGGGACAGAGGAGCATAGTGGAATCTGATTTTGGAGATGCCCTTAGAAGA
AACATTAAAAAGGTGATATG

Downstream 100 bases:

>100_bases
GATCGCTTGATAGCCATCATAGACTATGGAAGCGGAAACCTCAGGAGCATAGCCAATGCATTCAGGAAGATAGGGGCAGA
TGCCCTTGTGACATCAGATC

Product: glucose-1-phosphate adenylyltransferase related protein

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MAETVGMILCGGFGKRLRPLTEKIPKPLIEIKEGYTILDKQLFDLKNAGINTVYLLTGFLGERIEERYGDNYKGLRIEYV
REEKPLGTLNAIRLGMEAIDGEKQCIIRNGDVVADLNIKKMIHLGEMSDYPLTMFITRMQSPYGIVETSGDKIINFREKP
LLDYYINAGVYFSKGNLDFGDFESGDIEKTLFPLMAKENKLGYYREDGLFWMAIDTSKELEEIRKEYRNREDKPWGYEKI
LINTEKYLTKELFIREGYRTSFHYHEEKDETMYIISGSGYIEFDNRKEYFSKNDTIRIEPGERHSIVAMENTVLHEVSTP
HLNDTVRVQDYYTR

Sequences:

>Translated_334_residues
MAETVGMILCGGFGKRLRPLTEKIPKPLIEIKEGYTILDKQLFDLKNAGINTVYLLTGFLGERIEERYGDNYKGLRIEYV
REEKPLGTLNAIRLGMEAIDGEKQCIIRNGDVVADLNIKKMIHLGEMSDYPLTMFITRMQSPYGIVETSGDKIINFREKP
LLDYYINAGVYFSKGNLDFGDFESGDIEKTLFPLMAKENKLGYYREDGLFWMAIDTSKELEEIRKEYRNREDKPWGYEKI
LINTEKYLTKELFIREGYRTSFHYHEEKDETMYIISGSGYIEFDNRKEYFSKNDTIRIEPGERHSIVAMENTVLHEVSTP
HLNDTVRVQDYYTR
>Mature_333_residues
AETVGMILCGGFGKRLRPLTEKIPKPLIEIKEGYTILDKQLFDLKNAGINTVYLLTGFLGERIEERYGDNYKGLRIEYVR
EEKPLGTLNAIRLGMEAIDGEKQCIIRNGDVVADLNIKKMIHLGEMSDYPLTMFITRMQSPYGIVETSGDKIINFREKPL
LDYYINAGVYFSKGNLDFGDFESGDIEKTLFPLMAKENKLGYYREDGLFWMAIDTSKELEEIRKEYRNREDKPWGYEKIL
INTEKYLTKELFIREGYRTSFHYHEEKDETMYIISGSGYIEFDNRKEYFSKNDTIRIEPGERHSIVAMENTVLHEVSTPH
LNDTVRVQDYYTR

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=224, Percent_Identity=33.0357142857143, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI11761619, Length=224, Percent_Identity=33.0357142857143, Blast_Score=105, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI133931050, Length=225, Percent_Identity=33.7777777777778, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320148, Length=227, Percent_Identity=30.3964757709251, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21355443, Length=226, Percent_Identity=33.1858407079646, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24644084, Length=226, Percent_Identity=33.1858407079646, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 39008; Mature: 38877

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETVGMILCGGFGKRLRPLTEKIPKPLIEIKEGYTILDKQLFDLKNAGINTVYLLTGFL
CCCCEEEEEECCCCHHHHHHHHHCCCHHHHHHCCCEEEHHHHHHHHCCCCCEEEEHHHHH
GERIEERYGDNYKGLRIEYVREEKPLGTLNAIRLGMEAIDGEKQCIIRNGDVVADLNIKK
HHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEEECCHHH
MIHLGEMSDYPLTMFITRMQSPYGIVETSGDKIINFREKPLLDYYINAGVYFSKGNLDFG
EEEECCCCCCCCEEEEEHHCCCCCEEECCCCCEEEECCCCCEEEEECCCEEEECCCCCCC
DFESGDIEKTLFPLMAKENKLGYYREDGLFWMAIDTSKELEEIRKEYRNREDKPWGYEKI
CCCCCCHHHHHHHHHHCCCCCCEEEECCEEEEEECCHHHHHHHHHHHCCCCCCCCCCEEE
LINTEKYLTKELFIREGYRTSFHYHEEKDETMYIISGSGYIEFDNRKEYFSKNDTIRIEP
EEECHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEECCCEEEECCCHHHHCCCCEEEECC
GERHSIVAMENTVLHEVSTPHLNDTVRVQDYYTR
CCCCEEEEECCEEEEECCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
AETVGMILCGGFGKRLRPLTEKIPKPLIEIKEGYTILDKQLFDLKNAGINTVYLLTGFL
CCCEEEEEECCCCHHHHHHHHHCCCHHHHHHCCCEEEHHHHHHHHCCCCCEEEEHHHHH
GERIEERYGDNYKGLRIEYVREEKPLGTLNAIRLGMEAIDGEKQCIIRNGDVVADLNIKK
HHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEEECCHHH
MIHLGEMSDYPLTMFITRMQSPYGIVETSGDKIINFREKPLLDYYINAGVYFSKGNLDFG
EEEECCCCCCCCEEEEEHHCCCCCEEECCCCCEEEECCCCCEEEEECCCEEEECCCCCCC
DFESGDIEKTLFPLMAKENKLGYYREDGLFWMAIDTSKELEEIRKEYRNREDKPWGYEKI
CCCCCCHHHHHHHHHHCCCCCCEEEECCEEEEEECCHHHHHHHHHHHCCCCCCCCCCEEE
LINTEKYLTKELFIREGYRTSFHYHEEKDETMYIISGSGYIEFDNRKEYFSKNDTIRIEP
EEECHHHHHHHHHHHCCCCCCEEEECCCCCEEEEEECCCEEEECCCHHHHCCCCEEEECC
GERHSIVAMENTVLHEVSTPHLNDTVRVQDYYTR
CCCCEEEEECCEEEEECCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA