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Identifier: 15679504

GI number: 15679504

Start: 1363133

End: 1363915

Strand: Direct

Name: Not Available

Synonym: MTH1507

Alternate gene names: 15679504

Gene position: 1363133-1363915 (Clockwise)

Preceding gene: 15679503

Following gene: 15679508

Centisome position: 77.83

GC content: 52.11

Gene sequence:

>783_bases
GTGATTGAATTGAAATTCCTGAGGTTCATGAAGGATGGAAGGCTCCTTCACGGGTTCACAGAGAACAGAAGGATATTGGA
GATCCGGGAGGAGGAATACCTCTCAGATAACCCTGAGGTCATTGCTGAACATTCACTGGATGATGTGAGGATACTACCAC
CGGTATCCCCATCCAAGGTAGTCTGTGTGGGCCTCAACTACAGGGACCATGCCGCTGAACTTGGAATGGACATCCCGGAT
GAACCGATCATCTTCCTTAAACCGCCGACAACCGTGATAGGTTCTGGGGACACAGTGATATATCCTGAGATGTCCTCAGA
AGTTGACTATGAGGTTGAACTTGCAGCCGTCGTATCAGAGAGGGCCCGGAGGGTTGACTCCTCGGCGGCATCTGAGTTCA
TAGCAGGCTACACTGTCCTCAATGATGTAACTGCAAGGGACCTGCAGAGGAGGGACGGTCAGTGGACACGTGCAAAGAGT
TTTGACACCTTCTGCCCGATAGGGCCTGTAATAGAGACTGATGTAACTCCGGATAATCTTGATATATCCCTGAAACTCAA
TGGAGAGGTCAGACAGTCCTCAAACACGTCCAACATGATATTCACGGTCCACGAGCTCCTCGAGTTCATATCCCATGTCA
TGACACTGGAGCCAGGGGACGTCATAGCAACTGGCACACCTCCCGGCGTGGGCCAGATGGTACCTGGGGACACCGTGAGG
GCCACCGTTGAGGGTGTGGGGACCCTTGTGAACCGGGTTGAAAGGTCTGTGTGGATGGATTGA

Upstream 100 bases:

>100_bases
TGGTGGATGAAAAGGAGGTCTTCAACCTCATAAACAGGCTCAAGGCGGTGGGGGCAAGGGATATACTTGTTGTGCCCATT
GAGAGGATAATACCCTGAGG

Downstream 100 bases:

>100_bases
GGATTTTATCGACCATTGAGAAAGGATTCTTTTTTCATAATTTTTCAGAGAAAAGAGAGATGGGTCTGGATATTCTTTTG
AGGAATTCTCATTTTTTCAT

Product: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MIELKFLRFMKDGRLLHGFTENRRILEIREEEYLSDNPEVIAEHSLDDVRILPPVSPSKVVCVGLNYRDHAAELGMDIPD
EPIIFLKPPTTVIGSGDTVIYPEMSSEVDYEVELAAVVSERARRVDSSAASEFIAGYTVLNDVTARDLQRRDGQWTRAKS
FDTFCPIGPVIETDVTPDNLDISLKLNGEVRQSSNTSNMIFTVHELLEFISHVMTLEPGDVIATGTPPGVGQMVPGDTVR
ATVEGVGTLVNRVERSVWMD

Sequences:

>Translated_260_residues
MIELKFLRFMKDGRLLHGFTENRRILEIREEEYLSDNPEVIAEHSLDDVRILPPVSPSKVVCVGLNYRDHAAELGMDIPD
EPIIFLKPPTTVIGSGDTVIYPEMSSEVDYEVELAAVVSERARRVDSSAASEFIAGYTVLNDVTARDLQRRDGQWTRAKS
FDTFCPIGPVIETDVTPDNLDISLKLNGEVRQSSNTSNMIFTVHELLEFISHVMTLEPGDVIATGTPPGVGQMVPGDTVR
ATVEGVGTLVNRVERSVWMD
>Mature_260_residues
MIELKFLRFMKDGRLLHGFTENRRILEIREEEYLSDNPEVIAEHSLDDVRILPPVSPSKVVCVGLNYRDHAAELGMDIPD
EPIIFLKPPTTVIGSGDTVIYPEMSSEVDYEVELAAVVSERARRVDSSAASEFIAGYTVLNDVTARDLQRRDGQWTRAKS
FDTFCPIGPVIETDVTPDNLDISLKLNGEVRQSSNTSNMIFTVHELLEFISHVMTLEPGDVIATGTPPGVGQMVPGDTVR
ATVEGVGTLVNRVERSVWMD

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI40786394, Length=219, Percent_Identity=46.1187214611872, Blast_Score=197, Evalue=7e-51,
Organism=Homo sapiens, GI156231349, Length=219, Percent_Identity=45.662100456621, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI13654274, Length=202, Percent_Identity=38.1188118811881, Blast_Score=161, Evalue=7e-40,
Organism=Homo sapiens, GI215422413, Length=193, Percent_Identity=38.860103626943, Blast_Score=156, Evalue=1e-38,
Organism=Homo sapiens, GI66348062, Length=193, Percent_Identity=38.860103626943, Blast_Score=156, Evalue=2e-38,
Organism=Escherichia coli, GI1787428, Length=203, Percent_Identity=39.9014778325123, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17557057, Length=188, Percent_Identity=42.5531914893617, Blast_Score=153, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6324161, Length=221, Percent_Identity=31.2217194570136, Blast_Score=119, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28572127, Length=220, Percent_Identity=41.8181818181818, Blast_Score=181, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24663695, Length=220, Percent_Identity=36.8181818181818, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI28571789, Length=202, Percent_Identity=34.6534653465347, Blast_Score=130, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 28874; Mature: 28874

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELKFLRFMKDGRLLHGFTENRRILEIREEEYLSDNPEVIAEHSLDDVRILPPVSPSKV
CEEHHEEHHHHCCCEEECCCCCCEEEEEECHHHCCCCCCEEEECCCCCEEEECCCCCCCE
VCVGLNYRDHAAELGMDIPDEPIIFLKPPTTVIGSGDTVIYPEMSSEVDYEVELAAVVSE
EEEECCCCHHHHHCCCCCCCCCEEEECCCCEEEECCCEEEECCCCCCCCEEEHHHHHHHH
RARRVDSSAASEFIAGYTVLNDVTARDLQRRDGQWTRAKSFDTFCPIGPVIETDVTPDNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEEECCCCCCCE
DISLKLNGEVRQSSNTSNMIFTVHELLEFISHVMTLEPGDVIATGTPPGVGQMVPGDTVR
EEEEEECCCEECCCCCCCEEEEHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCHHH
ATVEGVGTLVNRVERSVWMD
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIELKFLRFMKDGRLLHGFTENRRILEIREEEYLSDNPEVIAEHSLDDVRILPPVSPSKV
CEEHHEEHHHHCCCEEECCCCCCEEEEEECHHHCCCCCCEEEECCCCCEEEECCCCCCCE
VCVGLNYRDHAAELGMDIPDEPIIFLKPPTTVIGSGDTVIYPEMSSEVDYEVELAAVVSE
EEEECCCCHHHHHCCCCCCCCCEEEECCCCEEEECCCEEEECCCCCCCCEEEHHHHHHHH
RARRVDSSAASEFIAGYTVLNDVTARDLQRRDGQWTRAKSFDTFCPIGPVIETDVTPDNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEEECCCCCCCE
DISLKLNGEVRQSSNTSNMIFTVHELLEFISHVMTLEPGDVIATGTPPGVGQMVPGDTVR
EEEEEECCCEECCCCCCCEEEEHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCHHH
ATVEGVGTLVNRVERSVWMD
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]