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Identifier: 15679432

GI number: 15679432

Start: 1298051

End: 1298839

Strand: Direct

Name: Not Available

Synonym: MTH1435

Alternate gene names: 15679432

Gene position: 1298051-1298839 (Clockwise)

Preceding gene: 15679430

Following gene: 15679433

Centisome position: 74.12

GC content: 52.6

Gene sequence:

>789_bases
ATGAAGATTCTTATAACAAATGATGATGGAGTTAACTCTTCAGGCATCATTGCAGCAAGAAGGGCCGTTGAGGACCTTGG
GGAGACAATCATAGTGGCCCCCGCCACGCAGCAGAGCGGGATAGGTCATGCGCTGACACTCTTTGAACCTGTGAGGGTAA
GTGAGGTCACCCTCAGGGATGGCTCAGGGGCCTATGCTGTTTCGGGGACACACACTGACGCTGTTATCATAGGGATATTC
GAGCTTATGGATGAAAAGCCCGACCTCGTGATATCAGGGATAAATATGGGTGAGAACCTTGGTAAATCAGAACTGACAAC
ATCAGGGACAATAGGGGCGGCAATGGAGGCTGCAGTGCATGGGGTGCCATCCCTGGCAGTTTCTCTCCAGGTGAGACGGG
GTGATATCAAGTTCCATGACGGACATGTTGACGTTGACTTTTCACTGGCAGCTGAACTCACAGGGAGGGTTGCATCGAGG
ATACTCAGGAGGGGACTCCCGGAGGGTGTTGACTTCCTGAATCTGAATGTCCCATCTCATCCAGCAAGCGATGAGATAAG
GATCACGAGGCTGGGGGACCGGATGTACAATGTTCACATAAAGAAAAGGCTGGATCCCCGTGGACGCCCATACTACTGGA
TAGATGGTGACCCTGCAGGTACAGACTTCCGGGTACAGATGTCCACACACTTAAGGCTGAAAACACCGCCACCCTCACCC
CCATATCACTCGACTGCACAGCAGGCCCTGACTCAATGGAGGGCTGGCTTGATTAGAGCCCGGAACTGA

Upstream 100 bases:

>100_bases
TGGATCCATAGAAGAAGATAAGGGCGAGGATTAACATAATTGAGCATAAGATAATGATGATTGGTATCAGTTTAGTTCAA
ATGGAGGAAGATGATCAGCA

Downstream 100 bases:

>100_bases
TTTTTAAAAATTTTTTATCCACAGCCATCCAGGTCTCAACGTGACCTGTTTATCCCTGTGAATCTGGTGGAGATCTGGGT
CTAAATCCGGAAAAATTTCT

Product: survival protein SurE

Products: NA

Alternate protein names: Nucleoside 5'-monophosphate phosphohydrolase

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MKILITNDDGVNSSGIIAARRAVEDLGETIIVAPATQQSGIGHALTLFEPVRVSEVTLRDGSGAYAVSGTHTDAVIIGIF
ELMDEKPDLVISGINMGENLGKSELTTSGTIGAAMEAAVHGVPSLAVSLQVRRGDIKFHDGHVDVDFSLAAELTGRVASR
ILRRGLPEGVDFLNLNVPSHPASDEIRITRLGDRMYNVHIKKRLDPRGRPYYWIDGDPAGTDFRVQMSTHLRLKTPPPSP
PYHSTAQQALTQWRAGLIRARN

Sequences:

>Translated_262_residues
MKILITNDDGVNSSGIIAARRAVEDLGETIIVAPATQQSGIGHALTLFEPVRVSEVTLRDGSGAYAVSGTHTDAVIIGIF
ELMDEKPDLVISGINMGENLGKSELTTSGTIGAAMEAAVHGVPSLAVSLQVRRGDIKFHDGHVDVDFSLAAELTGRVASR
ILRRGLPEGVDFLNLNVPSHPASDEIRITRLGDRMYNVHIKKRLDPRGRPYYWIDGDPAGTDFRVQMSTHLRLKTPPPSP
PYHSTAQQALTQWRAGLIRARN
>Mature_262_residues
MKILITNDDGVNSSGIIAARRAVEDLGETIIVAPATQQSGIGHALTLFEPVRVSEVTLRDGSGAYAVSGTHTDAVIIGIF
ELMDEKPDLVISGINMGENLGKSELTTSGTIGAAMEAAVHGVPSLAVSLQVRRGDIKFHDGHVDVDFSLAAELTGRVASR
ILRRGLPEGVDFLNLNVPSHPASDEIRITRLGDRMYNVHIKKRLDPRGRPYYWIDGDPAGTDFRVQMSTHLRLKTPPPSP
PYHSTAQQALTQWRAGLIRARN

Specific function: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates

COG id: COG0496

COG function: function code R; Predicted acid phosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the surE nucleotidase family

Homologues:

Organism=Escherichia coli, GI1789101, Length=262, Percent_Identity=36.2595419847328, Blast_Score=122, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SURE_METTH (O27484)

Other databases:

- EMBL:   AE000666
- PIR:   A69058
- RefSeq:   NP_276549.1
- ProteinModelPortal:   O27484
- SMR:   O27484
- STRING:   O27484
- GeneID:   1471704
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1435
- NMPDR:   fig|187420.1.peg.1404
- eggNOG:   arNOG05083
- HOGENOM:   HBG600532
- OMA:   HTTEHHE
- PhylomeDB:   O27484
- ProtClustDB:   CLSK2750576
- BioCyc:   MTHE187420:MTH1435-MONOMER
- BRENDA:   3.1.3.5
- GO:   GO:0005737
- HAMAP:   MF_00060
- InterPro:   IPR002828
- Gene3D:   G3DSA:3.40.1210.10
- TIGRFAMs:   TIGR00087

Pfam domain/function: PF01975 SurE; SSF64167 SurE-like_Pase/nucleotidase

EC number: =3.1.3.5

Molecular weight: Translated: 28372; Mature: 28372

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILITNDDGVNSSGIIAARRAVEDLGETIIVAPATQQSGIGHALTLFEPVRVSEVTLRD
CEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCEEEEEEEEC
GSGAYAVSGTHTDAVIIGIFELMDEKPDLVISGINMGENLGKSELTTSGTIGAAMEAAVH
CCCEEEEECCCCCCCEEEHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHC
GVPSLAVSLQVRRGDIKFHDGHVDVDFSLAAELTGRVASRILRRGLPEGVDFLNLNVPSH
CCCCEEEEEEEEECCEEEECCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
PASDEIRITRLGDRMYNVHIKKRLDPRGRPYYWIDGDPAGTDFRVQMSTHLRLKTPPPSP
CCCCCEEEEEECCEEEEEEEEECCCCCCCEEEEECCCCCCCEEEEEEEEEEEEECCCCCC
PYHSTAQQALTQWRAGLIRARN
CCCHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure
MKILITNDDGVNSSGIIAARRAVEDLGETIIVAPATQQSGIGHALTLFEPVRVSEVTLRD
CEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEECCCEEEEEEEEC
GSGAYAVSGTHTDAVIIGIFELMDEKPDLVISGINMGENLGKSELTTSGTIGAAMEAAVH
CCCEEEEECCCCCCCEEEHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHC
GVPSLAVSLQVRRGDIKFHDGHVDVDFSLAAELTGRVASRILRRGLPEGVDFLNLNVPSH
CCCCEEEEEEEEECCEEEECCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
PASDEIRITRLGDRMYNVHIKKRLDPRGRPYYWIDGDPAGTDFRVQMSTHLRLKTPPPSP
CCCCCEEEEEECCEEEEEEEEECCCCCCCEEEEECCCCCCCEEEEEEEEEEEEECCCCCC
PYHSTAQQALTQWRAGLIRARN
CCCHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463