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Identifier: 15679405

GI number: 15679405

Start: 1273908

End: 1274483

Strand: Direct

Name: Not Available

Synonym: MTH1406

Alternate gene names: 15679405

Gene position: 1273908-1274483 (Clockwise)

Preceding gene: 15679404

Following gene: 15679409

Centisome position: 72.74

GC content: 52.6

Gene sequence:

>576_bases
GTGATACACTTGAACCCGGTAAGAGAAGTCGTTGATGTTTCACTTCATATTTACAGGACCGGCCTTGTATCCGGCATAGG
TGGAAATGTGAGTGCAAGAATGGGTGATAGGGTCTTCATAACCCCGACCATGGTCCCCCTGGGGGAGGTTTCACTCAGGA
ATGTCGTTTTGGTGGACCTCAATGGAAGGGTCATCAGGGGAGGGAGGCCATCATCCGAACTGGGACTCCACCTTGAGGTA
TACAGGGCACGGCCAGATGTGGGTGGAATAGTGCACACCCATTCGCCCCATGCGAGGGCCTTCTCCATTGCAGGAGTCCA
GATTGAGAAGATGGAGGGATTCATGGGTCTCGGGAGGGGTTACATACCCATGGTCCCGTACCACCCGCCAGGTAGCAGAG
AACTTGCAGCTGAATGTGGCAGGGTAATGGTTGATGAGGATGCTGCCATCCTGGAGAACCATGGAGTTGTATGTGCAGGT
GAAGGTTTAAGGGACGCCCTTCTACTGGCGGAATTCATTGAGGAGTCTGCAAGGACCCAGTTCATAGCCGAGACCCTGAA
ATCCATGAAAAAATAA

Upstream 100 bases:

>100_bases
CCAGGTCCCGGTGCTTAACAGGGGTGTGATGAAACTCCTTGAATTCAGCTGAATGTTATATACACCTGAACCCTGCAACT
GTATGTTGATGTAATCCAAG

Downstream 100 bases:

>100_bases
TCAGCACTTAAGTGCACAGGCAGAACCCTCAAAAAATCCAGGAAAAAGATATCATCACTTAAAAATAGTAAAACTATCTT
AACCTCTGGAAAACCCTGAA

Product: fuculose-1-phosphate aldolase

Products: NA

Alternate protein names: L-fuculose-1-phosphate aldolase [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MIHLNPVREVVDVSLHIYRTGLVSGIGGNVSARMGDRVFITPTMVPLGEVSLRNVVLVDLNGRVIRGGRPSSELGLHLEV
YRARPDVGGIVHTHSPHARAFSIAGVQIEKMEGFMGLGRGYIPMVPYHPPGSRELAAECGRVMVDEDAAILENHGVVCAG
EGLRDALLLAEFIEESARTQFIAETLKSMKK

Sequences:

>Translated_191_residues
MIHLNPVREVVDVSLHIYRTGLVSGIGGNVSARMGDRVFITPTMVPLGEVSLRNVVLVDLNGRVIRGGRPSSELGLHLEV
YRARPDVGGIVHTHSPHARAFSIAGVQIEKMEGFMGLGRGYIPMVPYHPPGSRELAAECGRVMVDEDAAILENHGVVCAG
EGLRDALLLAEFIEESARTQFIAETLKSMKK
>Mature_191_residues
MIHLNPVREVVDVSLHIYRTGLVSGIGGNVSARMGDRVFITPTMVPLGEVSLRNVVLVDLNGRVIRGGRPSSELGLHLEV
YRARPDVGGIVHTHSPHARAFSIAGVQIEKMEGFMGLGRGYIPMVPYHPPGSRELAAECGRVMVDEDAAILENHGVVCAG
EGLRDALLLAEFIEESARTQFIAETLKSMKK

Specific function: Catalyzes the reversible aldol cleavage of L-fuculose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. The substrate preference order is glyceraldehyde > DL- lactaldehyde, glycolaldehyde > acrolein > formaldehyde, methylglyoxal > acet

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family. AraD/FucA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789164, Length=168, Percent_Identity=35.1190476190476, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1789094, Length=180, Percent_Identity=31.1111111111111, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1790642, Length=197, Percent_Identity=32.48730964467, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1786247, Length=190, Percent_Identity=32.6315789473684, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1790008, Length=180, Percent_Identity=29.4444444444444, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: =4.1.2.17 [H]

Molecular weight: Translated: 20702; Mature: 20702

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHLNPVREVVDVSLHIYRTGLVSGIGGNVSARMGDRVFITPTMVPLGEVSLRNVVLVDL
CCCCCHHHHHHHHHHHEEEHHHHHCCCCCEEEECCCEEEEEECCCCCCCCCCCEEEEEEC
NGRVIRGGRPSSELGLHLEVYRARPDVGGIVHTHSPHARAFSIAGVQIEKMEGFMGLGRG
CCEEEECCCCCHHCCEEEEEEECCCCCCCEEECCCCCCCEEEECCEEEEECCCHHHCCCC
YIPMVPYHPPGSRELAAECGRVMVDEDAAILENHGVVCAGEGLRDALLLAEFIEESARTQ
CCCCCCCCCCCCHHHHHHCCCEEECCCCHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHH
FIAETLKSMKK
HHHHHHHHHCC
>Mature Secondary Structure
MIHLNPVREVVDVSLHIYRTGLVSGIGGNVSARMGDRVFITPTMVPLGEVSLRNVVLVDL
CCCCCHHHHHHHHHHHEEEHHHHHCCCCCEEEECCCEEEEEECCCCCCCCCCCEEEEEEC
NGRVIRGGRPSSELGLHLEVYRARPDVGGIVHTHSPHARAFSIAGVQIEKMEGFMGLGRG
CCEEEECCCCCHHCCEEEEEEECCCCCCCEEECCCCCCCEEEECCEEEEECCCHHHCCCC
YIPMVPYHPPGSRELAAECGRVMVDEDAAILENHGVVCAGEGLRDALLLAEFIEESARTQ
CCCCCCCCCCCCHHHHHHCCCEEECCCCHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHH
FIAETLKSMKK
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]