Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15679404

GI number: 15679404

Start: 1272411

End: 1273859

Strand: Direct

Name: Not Available

Synonym: MTH1405

Alternate gene names: 15679404

Gene position: 1272411-1273859 (Clockwise)

Preceding gene: 15679399

Following gene: 15679405

Centisome position: 72.65

GC content: 49.41

Gene sequence:

>1449_bases
ATGAACGAGATAATCGGAAAATTTGCAAGGGAAGGGATCCTCATAGAGGATAACGCCTACTTCCGGCTCAGGGAAATGGA
TGATCCTGCAAGCGTGTCCTCAGAACTCATAGTTAAGATAAAGAGCAATGGTGGTAAATTCACTGTTTTAACCTCTGAAA
TGCTTGATGAATTCTTTGAAATAGATAACCCCGCGGAGATAAAGGCCAGGGGTCCCCTCATGGTCCCGGCGGAGAGGGAC
TTCGATTTTGAGGTGATAAGTGATACAAGTAACCGGTCCTACACCAGTGGTGAGATAGGGGACATGATCGCATACTTCAA
CAGCCGCTACAGCAGCCTGAAGAACCTTCTCAGTAAGCGCCCTGAACTGAAGGGCCATATTCCAATTGCTGACCTCCGGG
GGGGAGAGGACGTCGTCAGCATCATCGGGATGGTCAATGATGTGAGGAACACCAAGAACAATCACAGGATTATTGAACTT
GAGGATGATACCGGCGAAATCAGTGTTGTTGTGCACAACGAAAACCATAAGCTCTTTGAGAAGTCCGAGAAAATCGTGAG
GGATGAGGTTGTGGGTGTCCATGGAACCAAGAAGGGAAGGTTCGTGGTTGCCTCCGAGATATTCCACCCTGGAGTCCCCA
GGATACAGGAGAAGGAGATGGACTTCTCAGTTGCCTTCATATCAGACGTTCATATAGGAAGCCAGACCTTCCTTGAGGAC
GCCTTCATGAAATTTGTGAAATGGATAAACGGGGATTTCGGTTCAGAGGAGCAGCGAAGCCTTGCAGCGGATGTTAAGTA
CCTGGTGGTTGCGGGTGACATCGTTGATGGCATTGGAATCTACCCTGGACAGGAAAAGGAACTCCTTATAAGGGACATCC
ATGAACAGTATGAGGAGGCTGCAAGGCTGTTCGGTGATATAAGGAGCGACATAAAGATCGTTATGATCCCGGGAAACCAC
GACTCCTCAAGGATAGCGGAGCCCCAGCCAGCAATACCCGAGGAATACGCAAAGTCCCTCTACAGTATCAGGAACATAGA
ATTTCTCAGCAACCCATCCCTTGTGAGCCTTGACGGTGTGAGGACCCTCATATACCATGGCCGTAGCTTTGATGACATGG
CCATGAGTGTCAACGGGCTCTCACATGAAAGGTCAGACCTCATAATGGAGGAACTCCTTGAGAAGAGGCACCTTGCACCG
ATATATGGTGAGAGAACACCGCTGGCATCTGAGATAGAGGACCACCTGGTCATCGATGAGGTCCCACACGTACTCCACAC
CGGCCATGTTCACATAAATGCCTACAAAAAGTACAAGGGAGTGCACCTCATAAATTCAGGGACCTTCCAGTCCCAGACAG
AGTTCCAGAAGATCTACAACATCGTCCCAACCTGCGGCCAGGTCCCGGTGCTTAACAGGGGTGTGATGAAACTCCTTGAA
TTCAGCTGA

Upstream 100 bases:

>100_bases
AAGAATATATGAACTCAATAAAATATTTTACTGCACACACATTTTAAAACTTTCTGAATTAGATGTTAAAAACCACCTTA
CAGGGCAGTGAAGGATTAAA

Downstream 100 bases:

>100_bases
ATGTTATATACACCTGAACCCTGCAACTGTATGTTGATGTAATCCAAGGTGATACACTTGAACCCGGTAAGAGAAGTCGT
TGATGTTTCACTTCATATTT

Product: DNA polymerase II small subunit

Products: NA

Alternate protein names: Pol II

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MNEIIGKFAREGILIEDNAYFRLREMDDPASVSSELIVKIKSNGGKFTVLTSEMLDEFFEIDNPAEIKARGPLMVPAERD
FDFEVISDTSNRSYTSGEIGDMIAYFNSRYSSLKNLLSKRPELKGHIPIADLRGGEDVVSIIGMVNDVRNTKNNHRIIEL
EDDTGEISVVVHNENHKLFEKSEKIVRDEVVGVHGTKKGRFVVASEIFHPGVPRIQEKEMDFSVAFISDVHIGSQTFLED
AFMKFVKWINGDFGSEEQRSLAADVKYLVVAGDIVDGIGIYPGQEKELLIRDIHEQYEEAARLFGDIRSDIKIVMIPGNH
DSSRIAEPQPAIPEEYAKSLYSIRNIEFLSNPSLVSLDGVRTLIYHGRSFDDMAMSVNGLSHERSDLIMEELLEKRHLAP
IYGERTPLASEIEDHLVIDEVPHVLHTGHVHINAYKKYKGVHLINSGTFQSQTEFQKIYNIVPTCGQVPVLNRGVMKLLE
FS

Sequences:

>Translated_482_residues
MNEIIGKFAREGILIEDNAYFRLREMDDPASVSSELIVKIKSNGGKFTVLTSEMLDEFFEIDNPAEIKARGPLMVPAERD
FDFEVISDTSNRSYTSGEIGDMIAYFNSRYSSLKNLLSKRPELKGHIPIADLRGGEDVVSIIGMVNDVRNTKNNHRIIEL
EDDTGEISVVVHNENHKLFEKSEKIVRDEVVGVHGTKKGRFVVASEIFHPGVPRIQEKEMDFSVAFISDVHIGSQTFLED
AFMKFVKWINGDFGSEEQRSLAADVKYLVVAGDIVDGIGIYPGQEKELLIRDIHEQYEEAARLFGDIRSDIKIVMIPGNH
DSSRIAEPQPAIPEEYAKSLYSIRNIEFLSNPSLVSLDGVRTLIYHGRSFDDMAMSVNGLSHERSDLIMEELLEKRHLAP
IYGERTPLASEIEDHLVIDEVPHVLHTGHVHINAYKKYKGVHLINSGTFQSQTEFQKIYNIVPTCGQVPVLNRGVMKLLE
FS
>Mature_482_residues
MNEIIGKFAREGILIEDNAYFRLREMDDPASVSSELIVKIKSNGGKFTVLTSEMLDEFFEIDNPAEIKARGPLMVPAERD
FDFEVISDTSNRSYTSGEIGDMIAYFNSRYSSLKNLLSKRPELKGHIPIADLRGGEDVVSIIGMVNDVRNTKNNHRIIEL
EDDTGEISVVVHNENHKLFEKSEKIVRDEVVGVHGTKKGRFVVASEIFHPGVPRIQEKEMDFSVAFISDVHIGSQTFLED
AFMKFVKWINGDFGSEEQRSLAADVKYLVVAGDIVDGIGIYPGQEKELLIRDIHEQYEEAARLFGDIRSDIKIVMIPGNH
DSSRIAEPQPAIPEEYAKSLYSIRNIEFLSNPSLVSLDGVRTLIYHGRSFDDMAMSVNGLSHERSDLIMEELLEKRHLAP
IYGERTPLASEIEDHLVIDEVPHVLHTGHVHINAYKKYKGVHLINSGTFQSQTEFQKIYNIVPTCGQVPVLNRGVMKLLE
FS

Specific function: Possesses two activities:a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase

COG id: COG1311

COG function: function code L; Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA polymerase delta/II small subunit family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DP2S_METTH (O27456)

Other databases:

- EMBL:   AE000666
- PIR:   B69054
- RefSeq:   NP_276521.1
- ProteinModelPortal:   O27456
- STRING:   O27456
- GeneID:   1471122
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1405
- NMPDR:   fig|187420.1.peg.1376
- eggNOG:   arNOG04007
- HOGENOM:   HBG512811
- OMA:   CPIAPEH
- ProtClustDB:   PRK04036
- BioCyc:   MTHE187420:MTH1405-MONOMER
- BRENDA:   2.7.7.7
- HAMAP:   MF_00325
- InterPro:   IPR004843
- InterPro:   IPR012340
- InterPro:   IPR004365
- InterPro:   IPR011149
- Gene3D:   G3DSA:2.40.50.140
- PIRSF:   PIRSF000803

Pfam domain/function: PF00149 Metallophos; PF01336 tRNA_anti

EC number: =2.7.7.7

Molecular weight: Translated: 54376; Mature: 54376

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIIGKFAREGILIEDNAYFRLREMDDPASVSSELIVKIKSNGGKFTVLTSEMLDEFFE
CCHHHHHHHHCCEEEECCCEEEEEECCCCCCCCCEEEEEEECCCCEEEEEHHHHHHHHHC
IDNPAEIKARGPLMVPAERDFDFEVISDTSNRSYTSGEIGDMIAYFNSRYSSLKNLLSKR
CCCCCEEEECCCEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PELKGHIPIADLRGGEDVVSIIGMVNDVRNTKNNHRIIELEDDTGEISVVVHNENHKLFE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCHHHH
KSEKIVRDEVVGVHGTKKGRFVVASEIFHPGVPRIQEKEMDFSVAFISDVHIGSQTFLED
HHHHHHHHHHEECCCCCCCCEEEEEHHCCCCCCCCCHHCCCEEEEEEEEECCCHHHHHHH
AFMKFVKWINGDFGSEEQRSLAADVKYLVVAGDIVDGIGIYPGQEKELLIRDIHEQYEEA
HHHHHHHHHCCCCCCHHHHHHHHCEEEEEEECCHHCCCCCCCCCCHHHHHHHHHHHHHHH
ARLFGDIRSDIKIVMIPGNHDSSRIAEPQPAIPEEYAKSLYSIRNIEFLSNPSLVSLDGV
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCEEEECCCCEEEECCH
RTLIYHGRSFDDMAMSVNGLSHERSDLIMEELLEKRHLAPIYGERTPLASEIEDHLVIDE
HEEHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHEEHHH
VPHVLHTGHVHINAYKKYKGVHLINSGTFQSQTEFQKIYNIVPTCGQVPVLNRGVMKLLE
CCHHHHCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
FS
CC
>Mature Secondary Structure
MNEIIGKFAREGILIEDNAYFRLREMDDPASVSSELIVKIKSNGGKFTVLTSEMLDEFFE
CCHHHHHHHHCCEEEECCCEEEEEECCCCCCCCCEEEEEEECCCCEEEEEHHHHHHHHHC
IDNPAEIKARGPLMVPAERDFDFEVISDTSNRSYTSGEIGDMIAYFNSRYSSLKNLLSKR
CCCCCEEEECCCEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PELKGHIPIADLRGGEDVVSIIGMVNDVRNTKNNHRIIELEDDTGEISVVVHNENHKLFE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCCCHHHH
KSEKIVRDEVVGVHGTKKGRFVVASEIFHPGVPRIQEKEMDFSVAFISDVHIGSQTFLED
HHHHHHHHHHEECCCCCCCCEEEEEHHCCCCCCCCCHHCCCEEEEEEEEECCCHHHHHHH
AFMKFVKWINGDFGSEEQRSLAADVKYLVVAGDIVDGIGIYPGQEKELLIRDIHEQYEEA
HHHHHHHHHCCCCCCHHHHHHHHCEEEEEEECCHHCCCCCCCCCCHHHHHHHHHHHHHHH
ARLFGDIRSDIKIVMIPGNHDSSRIAEPQPAIPEEYAKSLYSIRNIEFLSNPSLVSLDGV
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCEEEECCCCEEEECCH
RTLIYHGRSFDDMAMSVNGLSHERSDLIMEELLEKRHLAPIYGERTPLASEIEDHLVIDE
HEEHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHEEHHH
VPHVLHTGHVHINAYKKYKGVHLINSGTFQSQTEFQKIYNIVPTCGQVPVLNRGVMKLLE
CCHHHHCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
FS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463