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The map label for this gene is hisE

Identifier: 15679287

GI number: 15679287

Start: 1164690

End: 1164980

Strand: Direct

Name: hisE

Synonym: MTH1283

Alternate gene names: 15679287

Gene position: 1164690-1164980 (Clockwise)

Preceding gene: 15679286

Following gene: 15679289

Centisome position: 66.5

GC content: 48.8

Gene sequence:

>291_bases
ATGGTAGATGAGGGAATTTTAAGGGAAGTATACCGTGTGCTTGAGGATCGGAGGGACAGACCCATTGATTCATACACTTC
ACGCCTCATGAGGGATGATGATAAAATGGCAGAGGATAAGATCCTTGAGAAAATAGGGGAGGAGGCCGCAGAGGTCATAA
TAGCATCAAAGAATGATGAGAACCTCGTGGAGGAGGCAGCCGACCTCATATTCCACACTCTGCTCCTGCTGGTATACAAG
GGCGTGCCCCTTGACAGCCTCCTGGAGGAGTTTGCTGCAAGAAGAAAATAG

Upstream 100 bases:

>100_bases
GGTGTTCACACCCTGGAGGACATAGAGGTCATAGATGACGCCCAGCACCCACTGATTGCGATAACGACGAGCATGAGAAA
GGCCATGGCAGGTAAGAAGA

Downstream 100 bases:

>100_bases
GGAAAGACAGCTCCAACGATAGAAGCAGAACAGGAAATGGAATAGGCTGGTGGAAACTCAGATAAGAGATAATTCCATGC
GGTAGAACATTCTGTTTAAG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 96; Mature: 96

Protein sequence:

>96_residues
MVDEGILREVYRVLEDRRDRPIDSYTSRLMRDDDKMAEDKILEKIGEEAAEVIIASKNDENLVEEAADLIFHTLLLLVYK
GVPLDSLLEEFAARRK

Sequences:

>Translated_96_residues
MVDEGILREVYRVLEDRRDRPIDSYTSRLMRDDDKMAEDKILEKIGEEAAEVIIASKNDENLVEEAADLIFHTLLLLVYK
GVPLDSLLEEFAARRK
>Mature_96_residues
MVDEGILREVYRVLEDRRDRPIDSYTSRLMRDDDKMAEDKILEKIGEEAAEVIIASKNDENLVEEAADLIFHTLLLLVYK
GVPLDSLLEEFAARRK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_METTH (O27344)

Other databases:

- EMBL:   AE000666
- PIR:   G69037
- RefSeq:   NP_276404.1
- ProteinModelPortal:   O27344
- SMR:   O27344
- STRING:   O27344
- GeneID:   1471691
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1283
- NMPDR:   fig|187420.1.peg.1259
- eggNOG:   arNOG13425
- HOGENOM:   HBG646527
- OMA:   INKICEK
- ProtClustDB:   PRK00400
- BioCyc:   MTHE187420:MTH1283-MONOMER
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11122; Mature: 11122

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDEGILREVYRVLEDRRDRPIDSYTSRLMRDDDKMAEDKILEKIGEEAAEVIIASKNDE
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
NLVEEAADLIFHTLLLLVYKGVPLDSLLEEFAARRK
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MVDEGILREVYRVLEDRRDRPIDSYTSRLMRDDDKMAEDKILEKIGEEAAEVIIASKNDE
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
NLVEEAADLIFHTLLLLVYKGVPLDSLLEEFAARRK
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463