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Identifier: 15679243

GI number: 15679243

Start: 1131661

End: 1132932

Strand: Direct

Name: Not Available

Synonym: MTH1232

Alternate gene names: 15679243

Gene position: 1131661-1132932 (Clockwise)

Preceding gene: 15679242

Following gene: 15679244

Centisome position: 64.62

GC content: 51.97

Gene sequence:

>1272_bases
GTGAACATTGGACTCATAGGATTTGGAACAATAGGGGCAGGTGTGGTGGAAATATTCAACACCAACCCTGATATCATAAT
GAAAAAGACAGGGATGGAGCTCAGGCTCAGGAGGGTGGTTGACCTTGACATTGAAACCGACCGTGGCGTTGAAATAGATC
CGGGGATCCTGTCAACCGACGCAGATGACATTCTCGAGGATCCTGAAATAGACATCGTCATAGAACTCATAGGTGGCTAT
GAACCGGCGCGTAGCTTCATCCTGAAGGCCATAGAAAATGGTAAACATGTTGTAACAGCCAACAAGGCACTCCTTGCAAG
GCACTGGGATGAGATAATGGATGCTGCCAGGGAGCATGGCGTGAGGGTTGCATTTGAGGCCAGTGTTGGTGGTGGTATAC
CCGTCCTCAGGGCCCTCAACGAGTCCCTCGCAGCCAACAGAATAGAATCCATATATGGAATAATAAACGGTACCGCCAAT
TACATACTGACCAGGATGGCCTCAGAGGGCATGGAATTTGATGATGTTCTGCGGGAGGCCCAGAGGCTCGGATATGCTGA
AAGGGATCCCACCTTCGACATAGAGGGCCATGACACCGCACAGAAGCTAATAATACTCACACTGCTTGGTTTTGGTGTCC
ATGTACCGGAGGATGAACTCCATGTTGAGGGTATAAGCAGTATAAGGAGGGATGACATTGAATATGCCACTGCAGAGCTT
GGATGCAGTGTGAAGCTCCTTGCAACAGCCAGGCTCAATGATGGTGAACTGGAGCTGGGTGTTACACCAACCCTTGTACC
ACACCATCACCTCCTCTCCTCTGTGAACGGTGTCTTCAACGGGATATACATCACAGGGGACTTCACAGGGCCAGTCATGT
TCTATGGGAAGGGTGCAGGCAGGAGGGCCACTGCAAGTGCAGTTGTCGCAGACTGCATGGATATTGCAGTTAACCCTGAG
GGATCAATGCCCACAGGTCCGGGCATCAGGGTTGTTGAGTCAGTGCGGGACTTCTCCAGGACATCCTCAAGGTACTACAT
AAGGCTTGATGCCGTAGACAGGGCAGGGGTGCTCCATGAAATAGCCGGAGCCTTCAGCAGGCACGGTATAAGTATAGAAT
CAGTGACCCAGAAGGGCGCCCATGAGGGTGAAACTGTGCCGATCTACATCGTAACCCATGAGGCAAGTGAGGGGGCCATC
CAGGGGGCCCTCTCTGAGATATCAGAGATCAGGTGGGTGAGGGGTGAACCCCTGCGCCTCCGGATACTCTGA

Upstream 100 bases:

>100_bases
TACAGGGTGGTTGTTGGAACAACCAGGGAAGCCATGAATGAATTCATAAAGCTGAAGGATCTCAGACTGGAGTAAACAGA
AAATATGTGGAGGTTTTTGT

Downstream 100 bases:

>100_bases
ACCAATAAATTTTTTAAATGTTAGTAATAATTTAATATTAATTAATATTATAAAGTGTGGTGATCAGATGTCGGTTGCTG
TGTCCATGATATCCGAATTC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MNIGLIGFGTIGAGVVEIFNTNPDIIMKKTGMELRLRRVVDLDIETDRGVEIDPGILSTDADDILEDPEIDIVIELIGGY
EPARSFILKAIENGKHVVTANKALLARHWDEIMDAAREHGVRVAFEASVGGGIPVLRALNESLAANRIESIYGIINGTAN
YILTRMASEGMEFDDVLREAQRLGYAERDPTFDIEGHDTAQKLIILTLLGFGVHVPEDELHVEGISSIRRDDIEYATAEL
GCSVKLLATARLNDGELELGVTPTLVPHHHLLSSVNGVFNGIYITGDFTGPVMFYGKGAGRRATASAVVADCMDIAVNPE
GSMPTGPGIRVVESVRDFSRTSSRYYIRLDAVDRAGVLHEIAGAFSRHGISIESVTQKGAHEGETVPIYIVTHEASEGAI
QGALSEISEIRWVRGEPLRLRIL

Sequences:

>Translated_423_residues
MNIGLIGFGTIGAGVVEIFNTNPDIIMKKTGMELRLRRVVDLDIETDRGVEIDPGILSTDADDILEDPEIDIVIELIGGY
EPARSFILKAIENGKHVVTANKALLARHWDEIMDAAREHGVRVAFEASVGGGIPVLRALNESLAANRIESIYGIINGTAN
YILTRMASEGMEFDDVLREAQRLGYAERDPTFDIEGHDTAQKLIILTLLGFGVHVPEDELHVEGISSIRRDDIEYATAEL
GCSVKLLATARLNDGELELGVTPTLVPHHHLLSSVNGVFNGIYITGDFTGPVMFYGKGAGRRATASAVVADCMDIAVNPE
GSMPTGPGIRVVESVRDFSRTSSRYYIRLDAVDRAGVLHEIAGAFSRHGISIESVTQKGAHEGETVPIYIVTHEASEGAI
QGALSEISEIRWVRGEPLRLRIL
>Mature_423_residues
MNIGLIGFGTIGAGVVEIFNTNPDIIMKKTGMELRLRRVVDLDIETDRGVEIDPGILSTDADDILEDPEIDIVIELIGGY
EPARSFILKAIENGKHVVTANKALLARHWDEIMDAAREHGVRVAFEASVGGGIPVLRALNESLAANRIESIYGIINGTAN
YILTRMASEGMEFDDVLREAQRLGYAERDPTFDIEGHDTAQKLIILTLLGFGVHVPEDELHVEGISSIRRDDIEYATAEL
GCSVKLLATARLNDGELELGVTPTLVPHHHLLSSVNGVFNGIYITGDFTGPVMFYGKGAGRRATASAVVADCMDIAVNPE
GSMPTGPGIRVVESVRDFSRTSSRYYIRLDAVDRAGVLHEIAGAFSRHGISIESVTQKGAHEGETVPIYIVTHEASEGAI
QGALSEISEIRWVRGEPLRLRIL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=353, Percent_Identity=25.4957507082153, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1786183, Length=120, Percent_Identity=34.1666666666667, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=128, Percent_Identity=33.59375, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45914; Mature: 45914

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGLIGFGTIGAGVVEIFNTNPDIIMKKTGMELRLRRVVDLDIETDRGVEIDPGILSTD
CCEEEEEECCCCCCEEEEECCCCCEEEECCCCCEEEEEEEEEEECCCCCCEECCCCCCCC
ADDILEDPEIDIVIELIGGYEPARSFILKAIENGKHVVTANKALLARHWDEIMDAAREHG
HHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHCC
VRVAFEASVGGGIPVLRALNESLAANRIESIYGIINGTANYILTRMASEGMEFDDVLREA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHH
QRLGYAERDPTFDIEGHDTAQKLIILTLLGFGVHVPEDELHVEGISSIRRDDIEYATAEL
HHCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GCSVKLLATARLNDGELELGVTPTLVPHHHLLSSVNGVFNGIYITGDFTGPVMFYGKGAG
CCCEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCEEEEECCCC
RRATASAVVADCMDIAVNPEGSMPTGPGIRVVESVRDFSRTSSRYYIRLDAVDRAGVLHE
CCHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHH
IAGAFSRHGISIESVTQKGAHEGETVPIYIVTHEASEGAIQGALSEISEIRWVRGEPLRL
HHHHHHHCCCCHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEE
RIL
EEC
>Mature Secondary Structure
MNIGLIGFGTIGAGVVEIFNTNPDIIMKKTGMELRLRRVVDLDIETDRGVEIDPGILSTD
CCEEEEEECCCCCCEEEEECCCCCEEEECCCCCEEEEEEEEEEECCCCCCEECCCCCCCC
ADDILEDPEIDIVIELIGGYEPARSFILKAIENGKHVVTANKALLARHWDEIMDAAREHG
HHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHCC
VRVAFEASVGGGIPVLRALNESLAANRIESIYGIINGTANYILTRMASEGMEFDDVLREA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHH
QRLGYAERDPTFDIEGHDTAQKLIILTLLGFGVHVPEDELHVEGISSIRRDDIEYATAEL
HHCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GCSVKLLATARLNDGELELGVTPTLVPHHHLLSSVNGVFNGIYITGDFTGPVMFYGKGAG
CCCEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHEEEEEEECCCCCEEEEECCCC
RRATASAVVADCMDIAVNPEGSMPTGPGIRVVESVRDFSRTSSRYYIRLDAVDRAGVLHE
CCHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHH
IAGAFSRHGISIESVTQKGAHEGETVPIYIVTHEASEGAIQGALSEISEIRWVRGEPLRL
HHHHHHHCCCCHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEE
RIL
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]