BacMap

Definition	Methanothermobacter thermautotrophicus str. Delta H chromosome, complete genome.
Accession	NC_000916
Length	1,751,377

Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15679213

GI number: 15679213

Start: 1104499

End: 1105131

Strand: Direct

Name: Not Available

Synonym: MTH1202

Alternate gene names: 15679213

Gene position: 1104499-1105131 (Clockwise)

Preceding gene: 15679212

Following gene: 15679214

Centisome position: 63.06

GC content: 49.61

Gene sequence:

>633_bases
ATGAACGATAAAAACACGCTGAAAGGCACCACAACTGTTGGCATAACATGCAAGGATGGAGTTGTTTTTGCCACAGAGAG
AAGGGCCAGTATGGGCAACCTCATAGCCCATAAGGCTACAGACAAGATTTTTAAAATAGATGAACACATAGCCGCGACCA
TTGCAGGTTCAGTGGCGGATGCCCAGAGCCTCATGAAGTACCTCAAGGCTGAGGCTGCACTTTACCGCATGAGAAACTCA
GAAAAGATAAGCATAGAGGCCGCTGCTGCACTCGCAGCTAATATACTACACTCATCACGTTTCTATCCATTCATAGTACA
GACACTCCTTGGAGGCGTCGACGAGAACGGTGCAAAGATCTACTCCCTTGACCCGTCAGGGGGGATGATACCAGACAAGT
TCGTCTCAACGGGTTCCGGTTCACCGGTTGCCTACGGGGTCCTTGAGGACAGATACAGTGATGAACTGTACGTGGACGAG
GCAGTGGATGTGGCCATAAGGGCCATAAAATCCGCCATGGAGAGGGACACCTACTCAGGTAACGGAATCCTTGTGGCGAC
CGTCACAGAGGAGGAAGGTTTCAGGATGCTTAGTGAAGAGGAAATCCAGAAAAGGATTGAAAACCTCAACTGA

Upstream 100 bases:

>100_bases
GGACAGCCCTTTGCAGGGTTAAATGAAAACCCTTTATATACCATAAAAACACAATGGGATCCAGGACTGGTTTTTTATTA
TTTTTATTAGAGGTGTATCT

Downstream 100 bases:

>100_bases
TTTTTCTCCTATTTTTAATTGCAGTAAACACCTGTTTACTGATATTCCCTGTTTTTTAGAAGTGATCTTATGGTTTCAGA
GATGCTTGAAGAAATCAAAA

Product: proteasome, beta subunit

Products: NA

Alternate protein names: 20S proteasome beta subunit; Proteasome core protein PsmB

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MNDKNTLKGTTTVGITCKDGVVFATERRASMGNLIAHKATDKIFKIDEHIAATIAGSVADAQSLMKYLKAEAALYRMRNS
EKISIEAAAALAANILHSSRFYPFIVQTLLGGVDENGAKIYSLDPSGGMIPDKFVSTGSGSPVAYGVLEDRYSDELYVDE
AVDVAIRAIKSAMERDTYSGNGILVATVTEEEGFRMLSEEEIQKRIENLN

Sequences:

>Translated_210_residues
MNDKNTLKGTTTVGITCKDGVVFATERRASMGNLIAHKATDKIFKIDEHIAATIAGSVADAQSLMKYLKAEAALYRMRNS
EKISIEAAAALAANILHSSRFYPFIVQTLLGGVDENGAKIYSLDPSGGMIPDKFVSTGSGSPVAYGVLEDRYSDELYVDE
AVDVAIRAIKSAMERDTYSGNGILVATVTEEEGFRMLSEEEIQKRIENLN
>Mature_210_residues
MNDKNTLKGTTTVGITCKDGVVFATERRASMGNLIAHKATDKIFKIDEHIAATIAGSVADAQSLMKYLKAEAALYRMRNS
EKISIEAAAALAANILHSSRFYPFIVQTLLGGVDENGAKIYSLDPSGGMIPDKFVSTGSGSPVAYGVLEDRYSDELYVDE
AVDVAIRAIKSAMERDTYSGNGILVATVTEEEGFRMLSEEEIQKRIENLN

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI4506201, Length=193, Percent_Identity=35.7512953367876, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI73747875, Length=186, Percent_Identity=34.9462365591398, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4758970, Length=186, Percent_Identity=34.9462365591398, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI23110942, Length=210, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4506193, Length=209, Percent_Identity=30.622009569378, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI153791216, Length=207, Percent_Identity=30.9178743961353, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI195539356, Length=146, Percent_Identity=36.3013698630137, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI156713442, Length=205, Percent_Identity=29.7560975609756, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4506185, Length=205, Percent_Identity=29.7560975609756, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI22538465, Length=178, Percent_Identity=26.9662921348315, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4506203, Length=185, Percent_Identity=29.1891891891892, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI23110925, Length=183, Percent_Identity=28.4153005464481, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4506189, Length=205, Percent_Identity=28.2926829268293, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI4506191, Length=195, Percent_Identity=28.7179487179487, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4506183, Length=123, Percent_Identity=34.1463414634146, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI222144262, Length=121, Percent_Identity=31.404958677686, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI68303563, Length=203, Percent_Identity=26.1083743842365, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI4506181, Length=199, Percent_Identity=26.6331658291457, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI23110939, Length=122, Percent_Identity=32.7868852459016, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4506205, Length=183, Percent_Identity=29.5081967213115, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4506179, Length=210, Percent_Identity=26.1904761904762, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI23110935, Length=210, Percent_Identity=26.1904761904762, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI68303561, Length=209, Percent_Identity=25.3588516746411, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17508493, Length=216, Percent_Identity=32.8703703703704, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508499, Length=196, Percent_Identity=33.6734693877551, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17508495, Length=205, Percent_Identity=32.6829268292683, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17535357, Length=188, Percent_Identity=27.1276595744681, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17508491, Length=204, Percent_Identity=29.9019607843137, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17541700, Length=184, Percent_Identity=27.7173913043478, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25143215, Length=197, Percent_Identity=28.9340101522843, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562790, Length=207, Percent_Identity=26.5700483091787, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554384, Length=190, Percent_Identity=24.2105263157895, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562792, Length=146, Percent_Identity=30.1369863013699, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6325360, Length=184, Percent_Identity=31.5217391304348, Blast_Score=108, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324938, Length=173, Percent_Identity=36.4161849710983, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323547, Length=223, Percent_Identity=30.0448430493274, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6321692, Length=215, Percent_Identity=27.4418604651163, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321574, Length=183, Percent_Identity=27.3224043715847, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324731, Length=186, Percent_Identity=28.494623655914, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319430, Length=202, Percent_Identity=26.2376237623762, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322459, Length=199, Percent_Identity=25.6281407035176, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324535, Length=211, Percent_Identity=26.0663507109005, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21355573, Length=190, Percent_Identity=37.3684210526316, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24652553, Length=190, Percent_Identity=37.3684210526316, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24654391, Length=212, Percent_Identity=29.7169811320755, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24654389, Length=212, Percent_Identity=29.7169811320755, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20130281, Length=194, Percent_Identity=31.9587628865979, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24584895, Length=200, Percent_Identity=28, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28573221, Length=200, Percent_Identity=29, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24639979, Length=182, Percent_Identity=29.1208791208791, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24664391, Length=177, Percent_Identity=30.5084745762712, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921232, Length=206, Percent_Identity=29.126213592233, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17737605, Length=195, Percent_Identity=28.7179487179487, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI281360341, Length=205, Percent_Identity=26.3414634146341, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24586406, Length=205, Percent_Identity=26.3414634146341, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24586400, Length=205, Percent_Identity=26.3414634146341, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24586402, Length=205, Percent_Identity=26.3414634146341, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737927, Length=205, Percent_Identity=27.3170731707317, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24653999, Length=198, Percent_Identity=24.7474747474747, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922898, Length=201, Percent_Identity=27.363184079602, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17933602, Length=202, Percent_Identity=28.2178217821782, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21355629, Length=202, Percent_Identity=23.7623762376238, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651571, Length=213, Percent_Identity=30.0469483568075, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356137, Length=211, Percent_Identity=27.0142180094787, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737405, Length=208, Percent_Identity=29.3269230769231, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17136420, Length=209, Percent_Identity=24.8803827751196, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB_METTH (O27270)

Other databases:

- EMBL:   AE000666
- PIR:   E69027
- RefSeq:   NP_276330.1
- ProteinModelPortal:   O27270
- SMR:   O27270
- IntAct:   O27270
- STRING:   O27270
- MEROPS:   T01.002
- GeneID:   1471610
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1202
- NMPDR:   fig|187420.1.peg.1185
- eggNOG:   arNOG10234
- HOGENOM:   HBG499923
- OMA:   VFATERR
- PhylomeDB:   O27270
- ProtClustDB:   CLSK798103
- BioCyc:   MTHE187420:MTH1202-MONOMER
- BRENDA:   3.4.25.1
- GO:   GO:0005737
- HAMAP:   MF_02113_A
- InterPro:   IPR019983
- InterPro:   IPR000243
- InterPro:   IPR016050
- InterPro:   IPR001353
- PRINTS:   PR00141
- TIGRFAMs:   TIGR03634

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 22765; Mature: 22765

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 10-10

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKNTLKGTTTVGITCKDGVVFATERRASMGNLIAHKATDKIFKIDEHIAATIAGSVAD
CCCCCCCCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSLMKYLKAEAALYRMRNSEKISIEAAAALAANILHSSRFYPFIVQTLLGGVDENGAKI
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEE
YSLDPSGGMIPDKFVSTGSGSPVAYGVLEDRYSDELYVDEAVDVAIRAIKSAMERDTYSG
EEECCCCCCCCHHHHCCCCCCCEEEEEHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCC
NGILVATVTEEEGFRMLSEEEIQKRIENLN
CCEEEEEEECCCCCHHHCHHHHHHHHHCCC
>Mature Secondary Structure
MNDKNTLKGTTTVGITCKDGVVFATERRASMGNLIAHKATDKIFKIDEHIAATIAGSVAD
CCCCCCCCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSLMKYLKAEAALYRMRNSEKISIEAAAALAANILHSSRFYPFIVQTLLGGVDENGAKI
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEE
YSLDPSGGMIPDKFVSTGSGSPVAYGVLEDRYSDELYVDEAVDVAIRAIKSAMERDTYSG
EEECCCCCCCCHHHHCCCCCCCEEEEEHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCC
NGILVATVTEEEGFRMLSEEEIQKRIENLN
CCEEEEEEECCCCCHHHCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463