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Identifier: 15679207

GI number: 15679207

Start: 1099051

End: 1100007

Strand: Direct

Name: Not Available

Synonym: MTH1196

Alternate gene names: 15679207

Gene position: 1099051-1100007 (Clockwise)

Preceding gene: 15679206

Following gene: 15679208

Centisome position: 62.75

GC content: 51.83

Gene sequence:

>957_bases
TTGGGTTTAGTTTGTTTTCCAGATACACAGGACAAGATTCCTAGCATCCCCGTCCACCTCACAAGGGTGGGTGTTACAGG
TGTTAAGAAGCTTCTGAAGATAGAGCGGGAGGGCAGAAGGCCCATAATCCTGCTTCCAACATTTGATGCCTTCGTGGATC
TTCCGAGCAAACAGAGGGGGATCCACATGTCAAGGAACCCCGAGGCCATAAGTGACGTCCTCGAGGAGGTTGTTGAGAAC
AACGCACTTGAACTCGAATCCCTCTGCGCAGAGATAGTTAATGAACTCCTCAAGAAGCACAGGTACGCCCGGAGGGCCGA
GGTAAGTATGAACAGCGACTTCATGTTCATGAAAAGGTCGCCGGTGACCCGGAGGAAGAGTCAGGAGATGACAAAGATAA
TGGCAGACGCCATCGGTTACCGGGACGATGATGGGATAGTCATACGGAAGATGATAGGGGCAGAGGTTGTGGGTATGACC
GTGTGTCCCTGTGCACAGGAATCTGTCAGGGAAGCCTCACGCCAGAAGCTCCTTGAATTTCTTGACGATGAGACCGTCGA
GAGAGTCCTTGACTGTGTATCCTTCGCCTCCCACAACCAGAGTGGGCGTGGCATGATAATGATAGAGGTCCCTGAGGACC
AGACCATAAGGGCTGAGAAGCTCATAGACATCATAGAGAGCTCCATGAGTTCACCTGTCTATGAACTCCTCAAGAGACCC
GACGAGAACGCGGTGGTGATGAGTGCCCATGAAAATCCCATGTTCGTTGAGGACTGTGTCCGTAACATGGTCCACAGGAT
AGTCAGTGAGTACCCCCACCTGCCGGATGACACCATCGTTACCGTAAGGCAGATAAACGAGGAGAGCATACACAGACACA
ACGCCTTCGCAGAGAAGGTTGCGACCATGGGAGAACTCAGATACGAGATAGAAGAACTTAACGGTGCCGGGAGTTGA

Upstream 100 bases:

>100_bases
CAACTGATCAAATCAGTAATACTTCACCGGACAAGTATATAAGCAAAGTTCTCATACTATAGTTAAAACCTAGGTAACCA
TTACTCATGGGGTGTAAAAT

Downstream 100 bases:

>100_bases
TATGATTGATGAAACTGCACAGGATAGCCGGAGAAATCATGGGTTTCTTTGAAGCATTTGAGGGTTCCAGACCCGCACTT
GACTCCCGGGAAATTCTCAT

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MGLVCFPDTQDKIPSIPVHLTRVGVTGVKKLLKIEREGRRPIILLPTFDAFVDLPSKQRGIHMSRNPEAISDVLEEVVEN
NALELESLCAEIVNELLKKHRYARRAEVSMNSDFMFMKRSPVTRRKSQEMTKIMADAIGYRDDDGIVIRKMIGAEVVGMT
VCPCAQESVREASRQKLLEFLDDETVERVLDCVSFASHNQSGRGMIMIEVPEDQTIRAEKLIDIIESSMSSPVYELLKRP
DENAVVMSAHENPMFVEDCVRNMVHRIVSEYPHLPDDTIVTVRQINEESIHRHNAFAEKVATMGELRYEIEELNGAGS

Sequences:

>Translated_318_residues
MGLVCFPDTQDKIPSIPVHLTRVGVTGVKKLLKIEREGRRPIILLPTFDAFVDLPSKQRGIHMSRNPEAISDVLEEVVEN
NALELESLCAEIVNELLKKHRYARRAEVSMNSDFMFMKRSPVTRRKSQEMTKIMADAIGYRDDDGIVIRKMIGAEVVGMT
VCPCAQESVREASRQKLLEFLDDETVERVLDCVSFASHNQSGRGMIMIEVPEDQTIRAEKLIDIIESSMSSPVYELLKRP
DENAVVMSAHENPMFVEDCVRNMVHRIVSEYPHLPDDTIVTVRQINEESIHRHNAFAEKVATMGELRYEIEELNGAGS
>Mature_317_residues
GLVCFPDTQDKIPSIPVHLTRVGVTGVKKLLKIEREGRRPIILLPTFDAFVDLPSKQRGIHMSRNPEAISDVLEEVVENN
ALELESLCAEIVNELLKKHRYARRAEVSMNSDFMFMKRSPVTRRKSQEMTKIMADAIGYRDDDGIVIRKMIGAEVVGMTV
CPCAQESVREASRQKLLEFLDDETVERVLDCVSFASHNQSGRGMIMIEVPEDQTIRAEKLIDIIESSMSSPVYELLKRPD
ENAVVMSAHENPMFVEDCVRNMVHRIVSEYPHLPDDTIVTVRQINEESIHRHNAFAEKVATMGELRYEIEELNGAGS

Specific function: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MPTA_METTH (O27264)

Other databases:

- EMBL:   AE000666
- PIR:   E69026
- RefSeq:   NP_276324.1
- STRING:   O27264
- GeneID:   1471604
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1196
- NMPDR:   fig|187420.1.peg.1179
- eggNOG:   arNOG04823
- HOGENOM:   HBG626871
- OMA:   ACPCAQN
- ProtClustDB:   PRK13675
- BioCyc:   MTHE187420:MTH1196-MONOMER
- HAMAP:   MF_01527_A
- InterPro:   IPR003801
- InterPro:   IPR022840
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10
- TIGRFAMs:   TIGR00294

Pfam domain/function: PF02649 DUF198

EC number: NA

Molecular weight: Translated: 36036; Mature: 35905

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLVCFPDTQDKIPSIPVHLTRVGVTGVKKLLKIEREGRRPIILLPTFDAFVDLPSKQRG
CCEEECCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHCCCCCEEEEECHHHHHCCCCHHCC
IHMSRNPEAISDVLEEVVENNALELESLCAEIVNELLKKHRYARRAEVSMNSDFMFMKRS
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
PVTRRKSQEMTKIMADAIGYRDDDGIVIRKMIGAEVVGMTVCPCAQESVREASRQKLLEF
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHH
LDDETVERVLDCVSFASHNQSGRGMIMIEVPEDQTIRAEKLIDIIESSMSSPVYELLKRP
HCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHCC
DENAVVMSAHENPMFVEDCVRNMVHRIVSEYPHLPDDTIVTVRQINEESIHRHNAFAEKV
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHCCHHHHHHHHHHHHHH
ATMGELRYEIEELNGAGS
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GLVCFPDTQDKIPSIPVHLTRVGVTGVKKLLKIEREGRRPIILLPTFDAFVDLPSKQRG
CEEECCCCCCCCCCCCCHHHHHCHHHHHHHHHHHHCCCCCEEEEECHHHHHCCCCHHCC
IHMSRNPEAISDVLEEVVENNALELESLCAEIVNELLKKHRYARRAEVSMNSDFMFMKRS
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
PVTRRKSQEMTKIMADAIGYRDDDGIVIRKMIGAEVVGMTVCPCAQESVREASRQKLLEF
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHH
LDDETVERVLDCVSFASHNQSGRGMIMIEVPEDQTIRAEKLIDIIESSMSSPVYELLKRP
HCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHCC
DENAVVMSAHENPMFVEDCVRNMVHRIVSEYPHLPDDTIVTVRQINEESIHRHNAFAEKV
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHCCHHHHHHHHHHHHHH
ATMGELRYEIEELNGAGS
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463