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Identifier: 15679205

GI number: 15679205

Start: 1097147

End: 1098142

Strand: Direct

Name: Not Available

Synonym: MTH1194

Alternate gene names: NA

Gene position: 1097147-1098142 (Clockwise)

Preceding gene: 15679204

Following gene: 15679206

Centisome position: 62.64

GC content: 55.52

Gene sequence:

>996_bases
ATGGTTATCATCCACTCCCCATCCTATGACCTGCACAATCATGAGGGTCACGTTGAAAATAGTGGCAGGACCAGGGCCAT
CCTTAGGGCCATAGAATCCTCAGATCTCTCCCCAAGGTTCGTGGAACCCGGGATGGCTGGAATCGATGATATCCTCATGG
TACACAGCAGTACTCATGTGGAGTACCTTGAGGTCTTCGCAGGGAGGGGTGGCGGATGGCTTGACTATGACACCTACATG
ACCCCCGAGAGCTTCAGTGTCGCGAGGCTCTCAGCAGGTGGAGCCATGCTGGCTGCCGAGGAGGCCCTCAGGGATGGCTG
GTCCTACTCACTTGGAAGGCCCCCGGGCCACCATGCCACCTATGACCGCTCCATGGGTTTCTGCATATTCAACAACATAG
CCATAGCCATTGAGCATGCCCGCAGGAACCTCGGGGTCTCAAGGCCTCTGGTACTTGATTTCGACGTCCACCACGGGAAC
GGTACATCCAGCATATTCTACAGGGACAGGGATGTGATGTACATATCCATACACCAGGACCCACGGACCCTCTTCCCTGG
AACCGGGTTCATTGATGAGACCGGCTCCGGTGAGGGGGAGGGCTTCAACCTCAACATCCCCATGCCCAGGGGCTCGGGTA
ACCGTGAGTACCTCTGGATACTCGGGATGATACTCCCGGCGGTCCTGGAAGGATTCCGACCGGATATGATCTTTGTATCG
GCAGGCTTTGATGCCCACAGAAGGGATCCCCTTGCAGAGATCATGGTTGATGAGGAGTTCTTCTCATGGATCGGGTGGTT
CATCCATCAGACAGGACTCCCCTGCACCGCGGTTCTGGAGGGTGGCTATGACCCTGAGGCCCTTGGGAGATCAAACATCG
CATTCATGAGGGGTCTTGATGGTGAGGAATACGAACCTGAAACAGCGGCGCCCGGGGGTGTCTCTGAAATATTCAGTCAG
CTGAGTGACAGGTTTTCAGCATACTTCAACTTCTGA

Upstream 100 bases:

>100_bases
ACACACAGACCGTCCTAAACATCGTCAAGGAGGATATGACCTCCACCAAGATGATCGGAGATTAAATTATTTATCCCCTG
AATCAGAAAATGATAACCAT

Downstream 100 bases:

>100_bases
GAGGGTATTGAAATGGATAGGATCAGATTCGAACAGGCAGAGAAGCTTATAAGAAAGTCATGCATTAACCTCAAGAGGGA
ACAGGGATTCAGGGATGCCA

Product: acetylpolyamine aminohydolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MVIIHSPSYDLHNHEGHVENSGRTRAILRAIESSDLSPRFVEPGMAGIDDILMVHSSTHVEYLEVFAGRGGGWLDYDTYM
TPESFSVARLSAGGAMLAAEEALRDGWSYSLGRPPGHHATYDRSMGFCIFNNIAIAIEHARRNLGVSRPLVLDFDVHHGN
GTSSIFYRDRDVMYISIHQDPRTLFPGTGFIDETGSGEGEGFNLNIPMPRGSGNREYLWILGMILPAVLEGFRPDMIFVS
AGFDAHRRDPLAEIMVDEEFFSWIGWFIHQTGLPCTAVLEGGYDPEALGRSNIAFMRGLDGEEYEPETAAPGGVSEIFSQ
LSDRFSAYFNF

Sequences:

>Translated_331_residues
MVIIHSPSYDLHNHEGHVENSGRTRAILRAIESSDLSPRFVEPGMAGIDDILMVHSSTHVEYLEVFAGRGGGWLDYDTYM
TPESFSVARLSAGGAMLAAEEALRDGWSYSLGRPPGHHATYDRSMGFCIFNNIAIAIEHARRNLGVSRPLVLDFDVHHGN
GTSSIFYRDRDVMYISIHQDPRTLFPGTGFIDETGSGEGEGFNLNIPMPRGSGNREYLWILGMILPAVLEGFRPDMIFVS
AGFDAHRRDPLAEIMVDEEFFSWIGWFIHQTGLPCTAVLEGGYDPEALGRSNIAFMRGLDGEEYEPETAAPGGVSEIFSQ
LSDRFSAYFNF
>Mature_331_residues
MVIIHSPSYDLHNHEGHVENSGRTRAILRAIESSDLSPRFVEPGMAGIDDILMVHSSTHVEYLEVFAGRGGGWLDYDTYM
TPESFSVARLSAGGAMLAAEEALRDGWSYSLGRPPGHHATYDRSMGFCIFNNIAIAIEHARRNLGVSRPLVLDFDVHHGN
GTSSIFYRDRDVMYISIHQDPRTLFPGTGFIDETGSGEGEGFNLNIPMPRGSGNREYLWILGMILPAVLEGFRPDMIFVS
AGFDAHRRDPLAEIMVDEEFFSWIGWFIHQTGLPCTAVLEGGYDPEALGRSNIAFMRGLDGEEYEPETAAPGGVSEIFSQ
LSDRFSAYFNF

Specific function: Putative deacetylase

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family

Homologues:

Organism=Homo sapiens, GI30795204, Length=332, Percent_Identity=33.433734939759, Blast_Score=154, Evalue=9e-38,
Organism=Homo sapiens, GI148539870, Length=332, Percent_Identity=32.5301204819277, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI30795202, Length=332, Percent_Identity=33.433734939759, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI17158039, Length=332, Percent_Identity=33.433734939759, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI169234807, Length=332, Percent_Identity=32.5301204819277, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI153085395, Length=327, Percent_Identity=31.8042813455657, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI20070354, Length=316, Percent_Identity=32.9113924050633, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI13128864, Length=314, Percent_Identity=34.0764331210191, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI62750349, Length=332, Percent_Identity=31.0240963855422, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI62750347, Length=332, Percent_Identity=31.0240963855422, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI226529806, Length=316, Percent_Identity=30.0632911392405, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI8923769, Length=302, Percent_Identity=27.1523178807947, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI262073092, Length=232, Percent_Identity=28.8793103448276, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI13128860, Length=208, Percent_Identity=28.3653846153846, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI293336691, Length=168, Percent_Identity=32.1428571428571, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI262073088, Length=175, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI13128862, Length=260, Percent_Identity=24.2307692307692, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI209862883, Length=253, Percent_Identity=24.901185770751, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI217272877, Length=302, Percent_Identity=23.841059602649, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17540334, Length=312, Percent_Identity=33.6538461538462, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI193206283, Length=306, Percent_Identity=33.6601307189542, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17540332, Length=306, Percent_Identity=33.6601307189542, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI193209491, Length=324, Percent_Identity=33.0246913580247, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17537347, Length=304, Percent_Identity=32.5657894736842, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI25154022, Length=292, Percent_Identity=28.4246575342466, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17561978, Length=208, Percent_Identity=29.3269230769231, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25154020, Length=280, Percent_Identity=29.2857142857143, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17508561, Length=289, Percent_Identity=26.2975778546713, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17534739, Length=256, Percent_Identity=25.390625, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324307, Length=351, Percent_Identity=32.1937321937322, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6321244, Length=265, Percent_Identity=27.1698113207547, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323999, Length=208, Percent_Identity=27.8846153846154, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6325325, Length=128, Percent_Identity=28.125, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325141, Length=56, Percent_Identity=50, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24642144, Length=307, Percent_Identity=36.4820846905537, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24642146, Length=307, Percent_Identity=36.4820846905537, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24642142, Length=307, Percent_Identity=36.4820846905537, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI281360899, Length=306, Percent_Identity=35.6209150326797, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI281360799, Length=325, Percent_Identity=34.1538461538462, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24641720, Length=325, Percent_Identity=34.1538461538462, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI281360801, Length=325, Percent_Identity=34.1538461538462, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24657891, Length=263, Percent_Identity=28.5171102661597, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24644244, Length=267, Percent_Identity=25.4681647940075, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24649807, Length=219, Percent_Identity=26.027397260274, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1194_METTH (O27262)

Other databases:

- EMBL:   AE000666
- PIR:   C69026
- RefSeq:   NP_276322.1
- ProteinModelPortal:   O27262
- SMR:   O27262
- STRING:   O27262
- GeneID:   1471602
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1194
- NMPDR:   fig|187420.1.peg.1177
- eggNOG:   arNOG09294
- HOGENOM:   HBG713516
- OMA:   HIRSLSK
- ProtClustDB:   CLSK2750521
- BioCyc:   MTHE187420:MTH1194-MONOMER
- InterPro:   IPR000286
- Gene3D:   G3DSA:3.40.800.20
- PANTHER:   PTHR10625
- PRINTS:   PR01270

Pfam domain/function: PF00850 Hist_deacetyl

EC number: NA

Molecular weight: Translated: 36723; Mature: 36723

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIIHSPSYDLHNHEGHVENSGRTRAILRAIESSDLSPRFVEPGMAGIDDILMVHSSTHV
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCC
EYLEVFAGRGGGWLDYDTYMTPESFSVARLSAGGAMLAAEEALRDGWSYSLGRPPGHHAT
EEHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
YDRSMGFCIFNNIAIAIEHARRNLGVSRPLVLDFDVHHGNGTSSIFYRDRDVMYISIHQD
CCCCCCEEEECCEEEEEEHHHHHCCCCCCEEEEEEEECCCCCCEEEEECCEEEEEEEECC
PRTLFPGTGFIDETGSGEGEGFNLNIPMPRGSGNREYLWILGMILPAVLEGFRPDMIFVS
CCEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEE
AGFDAHRRDPLAEIMVDEEFFSWIGWFIHQTGLPCTAVLEGGYDPEALGRSNIAFMRGLD
CCCCCCCCCCHHHHEECHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCCCEEEEECCC
GEEYEPETAAPGGVSEIFSQLSDRFSAYFNF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVIIHSPSYDLHNHEGHVENSGRTRAILRAIESSDLSPRFVEPGMAGIDDILMVHSSTHV
CEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCC
EYLEVFAGRGGGWLDYDTYMTPESFSVARLSAGGAMLAAEEALRDGWSYSLGRPPGHHAT
EEHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
YDRSMGFCIFNNIAIAIEHARRNLGVSRPLVLDFDVHHGNGTSSIFYRDRDVMYISIHQD
CCCCCCEEEECCEEEEEEHHHHHCCCCCCEEEEEEEECCCCCCEEEEECCEEEEEEEECC
PRTLFPGTGFIDETGSGEGEGFNLNIPMPRGSGNREYLWILGMILPAVLEGFRPDMIFVS
CCEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEE
AGFDAHRRDPLAEIMVDEEFFSWIGWFIHQTGLPCTAVLEGGYDPEALGRSNIAFMRGLD
CCCCCCCCCCHHHHEECHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCCCEEEEECCC
GEEYEPETAAPGGVSEIFSQLSDRFSAYFNF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463