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Identifier: 15679201

GI number: 15679201

Start: 1093804

End: 1094946

Strand: Direct

Name: Not Available

Synonym: MTH1190

Alternate gene names: 15679201

Gene position: 1093804-1094946 (Clockwise)

Preceding gene: 15679198

Following gene: 15679203

Centisome position: 62.45

GC content: 53.19

Gene sequence:

>1143_bases
ATGATAACGGTAAATGAGGGTTCAGTCACCATAAGGGTCCCTGATTTCAGTAAGGTCTCGGCCAGGGCACCTGTATTCTA
CAACCCTGCCATGGAGTTCAACAGGGATGTGTCAGTGGTCGCGCTCCAGGTTTTCCAGAGACTCCTCGGTGGGGAGATTA
GCGTTGCAGACACCTTCTCAGGAAGCGGTATAAGGGCCATAAGGTATCTGGTTGAGGTTGAAGGAGTCTCTGAGGCCTTT
GCAAATGACATAAACCCGCTTGCAGTTGAATGCATAAAAAATAACTCAGTGATAAACTCGGTGTCCCCTGAGGTCAGCAG
AGAGGACGCCAGCATCTTCCTCAGGAGTAACCATGGCCGCTTTGATGTTATAGACATCGACCCCTTCGGGACCCCTGCAC
CCTTCATGGACTCTGCGGCGGCTTCTGCAAGGAACAATTCACTCCTTGCTGTTACAGCCACCGACACCTCAAGCCTCTGC
GGCACCTACATAAAGCCCTGTCTGAGGAAGTACTCCTCAAGGCCCCTTAAAACAGAGTACTGCCATGAGACGGGACTGAG
GATACTCGCAGGCTTCACAGCCATGAACCTTGCAAGGTACAGGAAGGCGGCCTCGGTACTCCTCTCCCACAGCAGCCAGC
ACTACATGAGGCTATACATCCGCGTGAGGAGGGGTGCAAGAAGGGCCGATGAATCCATCAGGAATATCGGATTCATGCTT
CACTGCTTCAGATGCCTTCACCATGAACACGTGAATGGATTTGCGCCCCTGAAACGTGAGTGCCCCCACTGCGGTGCCGA
AATGGATGTGGCCGGCCCCCTCTGGGTCGGTGATATCCAGGACAGTAAATTCATCGGTGAGATGATAGGGGAGGTTGAGA
ACAAGGAACTCAACACGGCCGGAGATGTCCTTAAACTTCTGAAGGGATGTCTTGATGAAGCAGGGATGCCCCCTGGATTC
TATGATATCCATGAGGTCTGCAGTAAGCTTGGAAGGAGTGCACCACCTCTGAGGGATGTTATGGATGGTCTTGAGGCGGC
CGGTTTCAGGGTTTCAAGGACCCATATAAGGCCGACGGGTATAAGGACCGACGCCGGTATAGGGGAGATTGAGGAGGTCC
TGGCAGGACTCATGCCGGAATAG

Upstream 100 bases:

>100_bases
ACTTACCTGATGACCATGAGTTTTTTTTAATAAATTACCGGTCATGTATCACACTAATCATCCGGCATTAATAAATATTT
TGAAGTGGGAGTGTTGAATT

Downstream 100 bases:

>100_bases
AAGTTGGGGGAGTTGAAGCAGTACTCACCCCCGGCTCTCGATCATTCATAGTTGAGCATGTTATGGGTGTAGTAATACTG
CAGTGACCTTGCATTCCTGA

Product: N(2),N(2)-dimethylguanosine tRNA methyltransferase

Products: NA

Alternate protein names: tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MITVNEGSVTIRVPDFSKVSARAPVFYNPAMEFNRDVSVVALQVFQRLLGGEISVADTFSGSGIRAIRYLVEVEGVSEAF
ANDINPLAVECIKNNSVINSVSPEVSREDASIFLRSNHGRFDVIDIDPFGTPAPFMDSAAASARNNSLLAVTATDTSSLC
GTYIKPCLRKYSSRPLKTEYCHETGLRILAGFTAMNLARYRKAASVLLSHSSQHYMRLYIRVRRGARRADESIRNIGFML
HCFRCLHHEHVNGFAPLKRECPHCGAEMDVAGPLWVGDIQDSKFIGEMIGEVENKELNTAGDVLKLLKGCLDEAGMPPGF
YDIHEVCSKLGRSAPPLRDVMDGLEAAGFRVSRTHIRPTGIRTDAGIGEIEEVLAGLMPE

Sequences:

>Translated_380_residues
MITVNEGSVTIRVPDFSKVSARAPVFYNPAMEFNRDVSVVALQVFQRLLGGEISVADTFSGSGIRAIRYLVEVEGVSEAF
ANDINPLAVECIKNNSVINSVSPEVSREDASIFLRSNHGRFDVIDIDPFGTPAPFMDSAAASARNNSLLAVTATDTSSLC
GTYIKPCLRKYSSRPLKTEYCHETGLRILAGFTAMNLARYRKAASVLLSHSSQHYMRLYIRVRRGARRADESIRNIGFML
HCFRCLHHEHVNGFAPLKRECPHCGAEMDVAGPLWVGDIQDSKFIGEMIGEVENKELNTAGDVLKLLKGCLDEAGMPPGF
YDIHEVCSKLGRSAPPLRDVMDGLEAAGFRVSRTHIRPTGIRTDAGIGEIEEVLAGLMPE
>Mature_380_residues
MITVNEGSVTIRVPDFSKVSARAPVFYNPAMEFNRDVSVVALQVFQRLLGGEISVADTFSGSGIRAIRYLVEVEGVSEAF
ANDINPLAVECIKNNSVINSVSPEVSREDASIFLRSNHGRFDVIDIDPFGTPAPFMDSAAASARNNSLLAVTATDTSSLC
GTYIKPCLRKYSSRPLKTEYCHETGLRILAGFTAMNLARYRKAASVLLSHSSQHYMRLYIRVRRGARRADESIRNIGFML
HCFRCLHHEHVNGFAPLKRECPHCGAEMDVAGPLWVGDIQDSKFIGEMIGEVENKELNTAGDVLKLLKGCLDEAGMPPGF
YDIHEVCSKLGRSAPPLRDVMDGLEAAGFRVSRTHIRPTGIRTDAGIGEIEEVLAGLMPE

Specific function: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups

COG id: COG1867

COG function: function code J; N2,N2-dimethylguanosine tRNA methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TRM1 family

Homologues:

Organism=Homo sapiens, GI8923219, Length=450, Percent_Identity=27.5555555555556, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI209862871, Length=450, Percent_Identity=27.5555555555556, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI216548445, Length=433, Percent_Identity=28.6374133949192, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI163792194, Length=468, Percent_Identity=24.1452991452991, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17564890, Length=419, Percent_Identity=29.8329355608592, Blast_Score=165, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320325, Length=453, Percent_Identity=27.8145695364238, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI19921190, Length=419, Percent_Identity=27.4463007159904, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRM1_METTH (O27258)

Other databases:

- EMBL:   AE000666
- PIR:   G69025
- RefSeq:   NP_276318.1
- ProteinModelPortal:   O27258
- SMR:   O27258
- STRING:   O27258
- GeneID:   1471598
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1190
- NMPDR:   fig|187420.1.peg.1173
- eggNOG:   arNOG04822
- HOGENOM:   HBG577872
- OMA:   DAPVFYN
- PhylomeDB:   O27258
- ProtClustDB:   PRK04338
- BioCyc:   MTHE187420:MTH1190-MONOMER
- BRENDA:   2.1.1.32
- HAMAP:   MF_00290
- InterPro:   IPR022923
- InterPro:   IPR002905
- PANTHER:   PTHR10631
- TIGRFAMs:   TIGR00308

Pfam domain/function: PF02005 TRM

EC number: =2.1.1.32

Molecular weight: Translated: 41679; Mature: 41679

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVNEGSVTIRVPDFSKVSARAPVFYNPAMEFNRDVSVVALQVFQRLLGGEISVADTFS
CEEECCCEEEEECCCCHHHCCCCCEEECCCHHCCCCHHHHHHHHHHHHHCCCEEEECCCC
GSGIRAIRYLVEVEGVSEAFANDINPLAVECIKNNSVINSVSPEVSREDASIFLRSNHGR
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEECCCCCCCCCCCCEEEEECCCCE
FDVIDIDPFGTPAPFMDSAAASARNNSLLAVTATDTSSLCGTYIKPCLRKYSSRPLKTEY
EEEEECCCCCCCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHH
CHETGLRILAGFTAMNLARYRKAASVLLSHSSQHYMRLYIRVRRGARRADESIRNIGFML
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HCFRCLHHEHVNGFAPLKRECPHCGAEMDVAGPLWVGDIQDSKFIGEMIGEVENKELNTA
HHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCHH
GDVLKLLKGCLDEAGMPPGFYDIHEVCSKLGRSAPPLRDVMDGLEAAGFRVSRTHIRPTG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEECEECCCC
IRTDAGIGEIEEVLAGLMPE
CCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MITVNEGSVTIRVPDFSKVSARAPVFYNPAMEFNRDVSVVALQVFQRLLGGEISVADTFS
CEEECCCEEEEECCCCHHHCCCCCEEECCCHHCCCCHHHHHHHHHHHHHCCCEEEECCCC
GSGIRAIRYLVEVEGVSEAFANDINPLAVECIKNNSVINSVSPEVSREDASIFLRSNHGR
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEECCCCCCCCCCCCEEEEECCCCE
FDVIDIDPFGTPAPFMDSAAASARNNSLLAVTATDTSSLCGTYIKPCLRKYSSRPLKTEY
EEEEECCCCCCCCCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHH
CHETGLRILAGFTAMNLARYRKAASVLLSHSSQHYMRLYIRVRRGARRADESIRNIGFML
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HCFRCLHHEHVNGFAPLKRECPHCGAEMDVAGPLWVGDIQDSKFIGEMIGEVENKELNTA
HHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCHH
GDVLKLLKGCLDEAGMPPGFYDIHEVCSKLGRSAPPLRDVMDGLEAAGFRVSRTHIRPTG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEECEECCCC
IRTDAGIGEIEEVLAGLMPE
CCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463