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Identifier: 15679196

GI number: 15679196

Start: 1088477

End: 1090066

Strand: Direct

Name: Not Available

Synonym: MTH1185

Alternate gene names: 15679196

Gene position: 1088477-1090066 (Clockwise)

Preceding gene: 15679195

Following gene: 15679198

Centisome position: 62.15

GC content: 54.03

Gene sequence:

>1590_bases
ATGATAGAAGACCTCAGATCATTCACATCCCCTGGCGAGAGAAGGAACATAGAATTCAAGAAGGCCCTCTCAGCCAGGTA
TCACCTGAAGATGGACCGTAAGAAGGGCCTCATATCCCAGATGAAGTACCGTATGGAACGGGGTGACGGTAGGGCAGTGT
ACCTGCTGGGTGTGGAGGACAGCGGTGAACCGGTTGGCCTCCCTGCTGATAAACTGGATGAGTCAGTTGAGGTCCTCAGA
ACCCTCAGCAGTGAGATAGGTGCTGTTGTGGAGGAGGTTAACCTCCATGAGGGTACAGAGGGTATGGTGGCGGAGGTCAT
AATCTCAAGGAAGACGAAGACAGCGAGGGAGCACCTCCTCGTGGGGGTCGCCGGCCACGTGGACCACGGTAAGAGCACAC
TCCTCGGGACCCTCACAACAGGCACCCCTGATGATGGGAGCGGTAAGACGAGGATATTCCTTGATGTCCAGAAGCATGAA
ATAGAGAGGGGTCTATCGGCTGATCTGTCCTTTGCAATCTACGGCTTCAGGGACGGCAGGCCTATGAGGCTCAAAAACCC
CCTTGACAGGAAGGAGAAATCACGTCTCATGGACGAGGCTGACAGGGTCATATCCTTCGTTGACACCGTCGGCCATGAAC
CCTGGCTTCGAACAACCATAAGGGGGATTGTGGGTCAGAAACTCGACTACGGACTCCTCACAGTGGCAGCCGATGAGGGG
CCTACACACATAACAAGGGAGCACCTCGGTATAATGATCGCAATGGAGCTCCCGGTGATCGTGGTCCTCACAAAGTGTGA
TATGGCAGCCGATGAGAACAGGAGGGGTGTGAGGGAGAAGATATCCGAACTGCTTAAACTGGTTGGCAGGATCCCCTTCC
ATGTTAAGAGCCTGGACGCTGCAGCCGGGATAGCAGGTAAGATGAACCAGCACATAGTCCCCATAATCGAGACCTCCTCG
GTTACAGGGGAGGGCCTTGAAATCCTCGATGAGCTCTTCCTCAACCTCAGGGTCCGGCGCGATGTTAACGGGGATGAAGA
ACCATTCCTCATGTACATAGACAAGATATATTCCATCAGGGGTGTTGGTACCGTTGTCAGCGGGACAATTCAGCAGGGAC
TTGTCAGGAAGGGTGACACCCTCCTCCTGGGGCCCCTCAAGACCGGTAAATTCAGGGAGGTCACCGTCAAATCAATAGAG
ATGCACCACTACAGGATAGGCTGTGCAGAACCAGGCCACATCGTCGGCATATCCATATCCGGGGCCTCGCCGGATGAGAT
AGAGAGGGGTATGATACTGGCACACCCTGACTATGATCCCGAAGCTGTGAGGGAATTCGAGGCAGAGGTTGCCATACTGG
TGCATCCAACAACCATAAAGGCGGGCTATGAGAGTGTGACCCACATTGAAACCATAGCCGAGACAACCGTTCTTGAACCC
CTTGACTCTGATTTCATGTCTGCAGGTGACAGGGGCAGGGTGAGGATGAGGTTCAAGTACAGGCCCCACCATGTGAGGGA
GGGTCAGAAGATAATCTTCCGTGAGGGAAGGAGCAAGGGCATAGGTTCGGTGACAAGGATCCTGGGATAA

Upstream 100 bases:

>100_bases
GACTTCGAGGAAGCATCAGAACTGGTAAGAAAACTGCAGGAAGAGAAATATGGCTCCTGCCATTTCACAAATCCATCAAA
AAGGGAATAGATTCAGAGAT

Downstream 100 bases:

>100_bases
CCCCCACGCGACACAGCAGAGTACCACACTGATAGAATAAATCAGAAAACACGCGGCACAATAACATGCGCTTTAATCAG
CTTTTTATGAGTTCCAGGAA

Product: translation elongation factor, EF-1 alpha related protein

Products: GDP; phosphate

Alternate protein names: EF-1-alpha; Elongation factor Tu; EF-Tu [H]

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MIEDLRSFTSPGERRNIEFKKALSARYHLKMDRKKGLISQMKYRMERGDGRAVYLLGVEDSGEPVGLPADKLDESVEVLR
TLSSEIGAVVEEVNLHEGTEGMVAEVIISRKTKTAREHLLVGVAGHVDHGKSTLLGTLTTGTPDDGSGKTRIFLDVQKHE
IERGLSADLSFAIYGFRDGRPMRLKNPLDRKEKSRLMDEADRVISFVDTVGHEPWLRTTIRGIVGQKLDYGLLTVAADEG
PTHITREHLGIMIAMELPVIVVLTKCDMAADENRRGVREKISELLKLVGRIPFHVKSLDAAAGIAGKMNQHIVPIIETSS
VTGEGLEILDELFLNLRVRRDVNGDEEPFLMYIDKIYSIRGVGTVVSGTIQQGLVRKGDTLLLGPLKTGKFREVTVKSIE
MHHYRIGCAEPGHIVGISISGASPDEIERGMILAHPDYDPEAVREFEAEVAILVHPTTIKAGYESVTHIETIAETTVLEP
LDSDFMSAGDRGRVRMRFKYRPHHVREGQKIIFREGRSKGIGSVTRILG

Sequences:

>Translated_529_residues
MIEDLRSFTSPGERRNIEFKKALSARYHLKMDRKKGLISQMKYRMERGDGRAVYLLGVEDSGEPVGLPADKLDESVEVLR
TLSSEIGAVVEEVNLHEGTEGMVAEVIISRKTKTAREHLLVGVAGHVDHGKSTLLGTLTTGTPDDGSGKTRIFLDVQKHE
IERGLSADLSFAIYGFRDGRPMRLKNPLDRKEKSRLMDEADRVISFVDTVGHEPWLRTTIRGIVGQKLDYGLLTVAADEG
PTHITREHLGIMIAMELPVIVVLTKCDMAADENRRGVREKISELLKLVGRIPFHVKSLDAAAGIAGKMNQHIVPIIETSS
VTGEGLEILDELFLNLRVRRDVNGDEEPFLMYIDKIYSIRGVGTVVSGTIQQGLVRKGDTLLLGPLKTGKFREVTVKSIE
MHHYRIGCAEPGHIVGISISGASPDEIERGMILAHPDYDPEAVREFEAEVAILVHPTTIKAGYESVTHIETIAETTVLEP
LDSDFMSAGDRGRVRMRFKYRPHHVREGQKIIFREGRSKGIGSVTRILG
>Mature_529_residues
MIEDLRSFTSPGERRNIEFKKALSARYHLKMDRKKGLISQMKYRMERGDGRAVYLLGVEDSGEPVGLPADKLDESVEVLR
TLSSEIGAVVEEVNLHEGTEGMVAEVIISRKTKTAREHLLVGVAGHVDHGKSTLLGTLTTGTPDDGSGKTRIFLDVQKHE
IERGLSADLSFAIYGFRDGRPMRLKNPLDRKEKSRLMDEADRVISFVDTVGHEPWLRTTIRGIVGQKLDYGLLTVAADEG
PTHITREHLGIMIAMELPVIVVLTKCDMAADENRRGVREKISELLKLVGRIPFHVKSLDAAAGIAGKMNQHIVPIIETSS
VTGEGLEILDELFLNLRVRRDVNGDEEPFLMYIDKIYSIRGVGTVVSGTIQQGLVRKGDTLLLGPLKTGKFREVTVKSIE
MHHYRIGCAEPGHIVGISISGASPDEIERGMILAHPDYDPEAVREFEAEVAILVHPTTIKAGYESVTHIETIAETTVLEP
LDSDFMSAGDRGRVRMRFKYRPHHVREGQKIIFREGRSKGIGSVTRILG

Specific function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis [H]

COG id: COG5258

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily [H]

Homologues:

Organism=Homo sapiens, GI82546879, Length=500, Percent_Identity=35.8, Blast_Score=292, Evalue=5e-79,
Organism=Homo sapiens, GI45593140, Length=530, Percent_Identity=33.7735849056604, Blast_Score=290, Evalue=3e-78,
Organism=Homo sapiens, GI34147630, Length=436, Percent_Identity=25.6880733944954, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI54607086, Length=383, Percent_Identity=27.4151436031332, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4503475, Length=395, Percent_Identity=27.0886075949367, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4503471, Length=395, Percent_Identity=26.8354430379747, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI223555963, Length=424, Percent_Identity=24.7641509433962, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI5729864, Length=421, Percent_Identity=24.2280285035629, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI194018522, Length=421, Percent_Identity=25.8907363420428, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI194018520, Length=421, Percent_Identity=25.8907363420428, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI194097354, Length=421, Percent_Identity=25.8907363420428, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI46094014, Length=419, Percent_Identity=26.2529832935561, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1789737, Length=442, Percent_Identity=27.8280542986425, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1790412, Length=441, Percent_Identity=27.6643990929705, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI2367247, Length=326, Percent_Identity=29.4478527607362, Blast_Score=108, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17563834, Length=533, Percent_Identity=32.4577861163227, Blast_Score=271, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17565438, Length=522, Percent_Identity=32.3754789272031, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17556456, Length=433, Percent_Identity=25.1732101616628, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17552884, Length=393, Percent_Identity=25.4452926208651, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17569207, Length=393, Percent_Identity=25.4452926208651, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32566303, Length=373, Percent_Identity=25.7372654155496, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI25141371, Length=413, Percent_Identity=23.728813559322, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI32566629, Length=416, Percent_Identity=25, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324761, Length=441, Percent_Identity=27.437641723356, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325337, Length=393, Percent_Identity=26.7175572519084, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319594, Length=393, Percent_Identity=26.7175572519084, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320377, Length=417, Percent_Identity=25.1798561151079, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19922512, Length=500, Percent_Identity=34.8, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24654852, Length=500, Percent_Identity=34.8, Blast_Score=292, Evalue=3e-79,
Organism=Drosophila melanogaster, GI28573213, Length=555, Percent_Identity=29.7297297297297, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI221378008, Length=555, Percent_Identity=29.7297297297297, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24644462, Length=555, Percent_Identity=29.7297297297297, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24644464, Length=555, Percent_Identity=29.7297297297297, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24644466, Length=555, Percent_Identity=29.7297297297297, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI281363316, Length=427, Percent_Identity=26.2295081967213, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17864358, Length=427, Percent_Identity=26.2295081967213, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19922690, Length=322, Percent_Identity=31.055900621118, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17137380, Length=448, Percent_Identity=27.6785714285714, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45553807, Length=394, Percent_Identity=26.9035532994924, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45553816, Length=394, Percent_Identity=26.9035532994924, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24651721, Length=394, Percent_Identity=26.9035532994924, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17864154, Length=394, Percent_Identity=26.9035532994924, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24652838, Length=393, Percent_Identity=25.4452926208651, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17137572, Length=393, Percent_Identity=25.4452926208651, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19921738, Length=427, Percent_Identity=25.2927400468384, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550900, Length=378, Percent_Identity=23.015873015873, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: 20568 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009001
- InterPro:   IPR004539
- InterPro:   IPR004161
- InterPro:   IPR004160
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF03143 GTP_EFTU_D3 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 58670; Mature: 58670

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00039 DEAD_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEDLRSFTSPGERRNIEFKKALSARYHLKMDRKKGLISQMKYRMERGDGRAVYLLGVED
CCCHHHHHCCCCCCCCCHHHHHHCHHHEEEECHHCCHHHHHHHHHHCCCCCEEEEEEECC
SGEPVGLPADKLDESVEVLRTLSSEIGAVVEEVNLHEGTEGMVAEVIISRKTKTAREHLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHEE
VGVAGHVDHGKSTLLGTLTTGTPDDGSGKTRIFLDVQKHEIERGLSADLSFAIYGFRDGR
EEEECCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEHHHHHHCCCCCCCEEEEEEECCCC
PMRLKNPLDRKEKSRLMDEADRVISFVDTVGHEPWLRTTIRGIVGQKLDYGLLTVAADEG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEECCC
PTHITREHLGIMIAMELPVIVVLTKCDMAADENRRGVREKISELLKLVGRIPFHVKSLDA
CCCCCHHHCCEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHH
AAGIAGKMNQHIVPIIETSSVTGEGLEILDELFLNLRVRRDVNGDEEPFLMYIDKIYSIR
HHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCEEEEECCCCCCCCHHHEEHHHHHHC
GVGTVVSGTIQQGLVRKGDTLLLGPLKTGKFREVTVKSIEMHHYRIGCAEPGHIVGISIS
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEEEEEEEEECCCCCCEEEEEEEC
GASPDEIERGMILAHPDYDPEAVREFEAEVAILVHPTTIKAGYESVTHIETIAETTVLEP
CCCHHHHHCCEEEECCCCCHHHHHHHCCCEEEEEECCEECCCHHHHHHHHHHHHHHHHCC
LDSDFMSAGDRGRVRMRFKYRPHHVREGQKIIFREGRSKGIGSVTRILG
CCHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHCC
>Mature Secondary Structure
MIEDLRSFTSPGERRNIEFKKALSARYHLKMDRKKGLISQMKYRMERGDGRAVYLLGVED
CCCHHHHHCCCCCCCCCHHHHHHCHHHEEEECHHCCHHHHHHHHHHCCCCCEEEEEEECC
SGEPVGLPADKLDESVEVLRTLSSEIGAVVEEVNLHEGTEGMVAEVIISRKTKTAREHLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHEE
VGVAGHVDHGKSTLLGTLTTGTPDDGSGKTRIFLDVQKHEIERGLSADLSFAIYGFRDGR
EEEECCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEHHHHHHCCCCCCCEEEEEEECCCC
PMRLKNPLDRKEKSRLMDEADRVISFVDTVGHEPWLRTTIRGIVGQKLDYGLLTVAADEG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEECCC
PTHITREHLGIMIAMELPVIVVLTKCDMAADENRRGVREKISELLKLVGRIPFHVKSLDA
CCCCCHHHCCEEEEECCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHH
AAGIAGKMNQHIVPIIETSSVTGEGLEILDELFLNLRVRRDVNGDEEPFLMYIDKIYSIR
HHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCEEEEECCCCCCCCHHHEEHHHHHHC
GVGTVVSGTIQQGLVRKGDTLLLGPLKTGKFREVTVKSIEMHHYRIGCAEPGHIVGISIS
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEEEEEEEEECCCCCCEEEEEEEC
GASPDEIERGMILAHPDYDPEAVREFEAEVAILVHPTTIKAGYESVTHIETIAETTVLEP
CCCHHHHHCCEEEECCCCCHHHHHHHCCCEEEEEECCEECCCHHHHHHHHHHHHHHHHCC
LDSDFMSAGDRGRVRMRFKYRPHHVREGQKIIFREGRSKGIGSVTRILG
CCHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]