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Identifier: 15679138

GI number: 15679138

Start: 1038412

End: 1039776

Strand: Direct

Name: Not Available

Synonym: MTH1127

Alternate gene names: 15679138

Gene position: 1038412-1039776 (Clockwise)

Preceding gene: 15679134

Following gene: 15679139

Centisome position: 59.29

GC content: 51.36

Gene sequence:

>1365_bases
ATGGAGTGGACGGTGTCAGAATGCTTGAGCCTTCAAAGGATAGTTCTGGATGGAGTGGACGGTGTCAGAATGTTTGATCT
TTCACTTGAAAACTGCAGGGTTGACAGGGACCTCACCGTGAATATAGGTGTGGATGATGGGAAGATAGTGCAGATATCCC
GTGGAAGGATTGATGCTTCAGAGAAGATTGACCTGAAGGGCTATTTCGTGCTGCCAGGACTGATCGACGCCCACGTGCAT
TTCAGGGACCCCGGGCTGGAGTACAAGGAGGACTTCAGGACAGGCTCAATGGCAGCTGCCCATGGGGGTTTTTCCACAGT
CCTTGACATGCCAAACACGGTCCCCCCAGCAGATAACGCAGCGGAATTTGAAAGGAAGATCAGGATAGGTGAAAGAAAGA
GTGTTGTTGATTTTGGGCTCCACGCTGGTTTCAGAAGTGTTTCAGACGTTAAAGGTATTCTCAGGTTCATGCCAGCCTCC
TTCAAGGTATTCATGGATCTCACGGGGATCAGTACAGTTGATGGGCTATTCAGAGAGCTTAAGGATCTATCAGCGCCGGT
GCCGGTCACCGTGCACTGCGAGAACAGGGATGTGGTCATGAAATCCATGAAGGAATTAAAGGATAGAAGTGATCCCTCAG
CCTATGCCCTTGCAAGACCTCCCCTCGCAGAGGAGGTCTCTGTGGCCGAGGTCCTGGCACTATCCATTCACCATGAACAC
CCCGTGCACATCTGTCATCTGAGCACAGTGAAGGCCCTTCAGCTTGTTGAACCCTTCAGGGAGTACGTGACATGTGAGGT
CACACCACACCACCTTCTGCTTGATTCAGGGGCCTTTAGAAGATTCGGGACAATGGTGAAAACAAATCCTCCTCTGAGGC
CCCCTGAGAGCCGGATTTATCCAGAGTTTCTTGATAGGATCAATATCATTGGAACCGATCATGCACCCCACGGTATCGAG
GAAAAGAGGAAGGGTATCTGGGACGCGCCACCAGGGATCCCCAACCTTGAGGTTGTACTTAAACTGTTACTTACACTGGT
CTCAAAGGGGAGGATGTCCCTTTCCACCATACGGAGGATGCTTGCAGAGGAGCCGGCAAGGATATTTGGTCTGAGGTCCA
AGGGACGTATAGCTGAGGGCATGGACGCTGATTTTACCGTCATCGATCTTAAAGAGACTGGCAGGATCAGGTCAGATGAA
TTCTACAGTAAGGCCCACTACACCCCCTTTGAGGGTTTCAGTTACACCGGAGGTCCCGTCATGACCATTGTCAGGGGCAG
GGCTGTCATGAGAGATGGGGAGGTGCTTGAGGGTAATGGCAGGTACATCCCTGCAGAGCATGATGGTAAACATGGGAGTG
CATGA

Upstream 100 bases:

>100_bases
CCGATGGCATAATATTAATCTGTCCCGCGAGATAAATAAGGATAGTTCTGGATGGAGTGGACGGTGTCAGAATGCTTGAG
CCTTCAAAGGATAGTTCTGG

Downstream 100 bases:

>100_bases
AGTGACTTTGACCTATCTTGATTAGAGAAACACGACTTTATTCAACTTTCTTTCGTCTCCTGCTTCCTCTTAACCATGTG
TTCGAATGGACTTCCTGCCT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MEWTVSECLSLQRIVLDGVDGVRMFDLSLENCRVDRDLTVNIGVDDGKIVQISRGRIDASEKIDLKGYFVLPGLIDAHVH
FRDPGLEYKEDFRTGSMAAAHGGFSTVLDMPNTVPPADNAAEFERKIRIGERKSVVDFGLHAGFRSVSDVKGILRFMPAS
FKVFMDLTGISTVDGLFRELKDLSAPVPVTVHCENRDVVMKSMKELKDRSDPSAYALARPPLAEEVSVAEVLALSIHHEH
PVHICHLSTVKALQLVEPFREYVTCEVTPHHLLLDSGAFRRFGTMVKTNPPLRPPESRIYPEFLDRINIIGTDHAPHGIE
EKRKGIWDAPPGIPNLEVVLKLLLTLVSKGRMSLSTIRRMLAEEPARIFGLRSKGRIAEGMDADFTVIDLKETGRIRSDE
FYSKAHYTPFEGFSYTGGPVMTIVRGRAVMRDGEVLEGNGRYIPAEHDGKHGSA

Sequences:

>Translated_454_residues
MEWTVSECLSLQRIVLDGVDGVRMFDLSLENCRVDRDLTVNIGVDDGKIVQISRGRIDASEKIDLKGYFVLPGLIDAHVH
FRDPGLEYKEDFRTGSMAAAHGGFSTVLDMPNTVPPADNAAEFERKIRIGERKSVVDFGLHAGFRSVSDVKGILRFMPAS
FKVFMDLTGISTVDGLFRELKDLSAPVPVTVHCENRDVVMKSMKELKDRSDPSAYALARPPLAEEVSVAEVLALSIHHEH
PVHICHLSTVKALQLVEPFREYVTCEVTPHHLLLDSGAFRRFGTMVKTNPPLRPPESRIYPEFLDRINIIGTDHAPHGIE
EKRKGIWDAPPGIPNLEVVLKLLLTLVSKGRMSLSTIRRMLAEEPARIFGLRSKGRIAEGMDADFTVIDLKETGRIRSDE
FYSKAHYTPFEGFSYTGGPVMTIVRGRAVMRDGEVLEGNGRYIPAEHDGKHGSA
>Mature_454_residues
MEWTVSECLSLQRIVLDGVDGVRMFDLSLENCRVDRDLTVNIGVDDGKIVQISRGRIDASEKIDLKGYFVLPGLIDAHVH
FRDPGLEYKEDFRTGSMAAAHGGFSTVLDMPNTVPPADNAAEFERKIRIGERKSVVDFGLHAGFRSVSDVKGILRFMPAS
FKVFMDLTGISTVDGLFRELKDLSAPVPVTVHCENRDVVMKSMKELKDRSDPSAYALARPPLAEEVSVAEVLALSIHHEH
PVHICHLSTVKALQLVEPFREYVTCEVTPHHLLLDSGAFRRFGTMVKTNPPLRPPESRIYPEFLDRINIIGTDHAPHGIE
EKRKGIWDAPPGIPNLEVVLKLLLTLVSKGRMSLSTIRRMLAEEPARIFGLRSKGRIAEGMDADFTVIDLKETGRIRSDE
FYSKAHYTPFEGFSYTGGPVMTIVRGRAVMRDGEVLEGNGRYIPAEHDGKHGSA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=382, Percent_Identity=33.2460732984293, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI4503379, Length=451, Percent_Identity=24.8337028824834, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI4503051, Length=448, Percent_Identity=26.5625, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI62422571, Length=448, Percent_Identity=26.5625, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI4503377, Length=451, Percent_Identity=26.1640798226164, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI4503375, Length=417, Percent_Identity=27.5779376498801, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI190194363, Length=448, Percent_Identity=25.4464285714286, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI19923821, Length=450, Percent_Identity=24.6666666666667, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1786722, Length=430, Percent_Identity=30.9302325581395, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI87082175, Length=415, Percent_Identity=28.9156626506024, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI193204318, Length=374, Percent_Identity=31.8181818181818, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71989490, Length=439, Percent_Identity=26.879271070615, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17539558, Length=446, Percent_Identity=24.4394618834081, Blast_Score=92, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=439, Percent_Identity=27.5626423690205, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24642586, Length=380, Percent_Identity=31.0526315789474, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI221377917, Length=421, Percent_Identity=28.2660332541568, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18859883, Length=423, Percent_Identity=29.5508274231678, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17137462, Length=419, Percent_Identity=28.1622911694511, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24644287, Length=271, Percent_Identity=27.6752767527675, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24644289, Length=193, Percent_Identity=31.0880829015544, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 50535; Mature: 50535

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWTVSECLSLQRIVLDGVDGVRMFDLSLENCRVDRDLTVNIGVDDGKIVQISRGRIDAS
CCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHCCCCCCEEEEEECCCCEEEEEECCCCCCC
EKIDLKGYFVLPGLIDAHVHFRDPGLEYKEDFRTGSMAAAHGGFSTVLDMPNTVPPADNA
CEEEECEEEECCCEEECEEEECCCCCCHHHHCCCCCEEECCCCCHHHHCCCCCCCCCCCH
AEFERKIRIGERKSVVDFGLHAGFRSVSDVKGILRFMPASFKVFMDLTGISTVDGLFREL
HHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHH
KDLSAPVPVTVHCENRDVVMKSMKELKDRSDPSAYALARPPLAEEVSVAEVLALSIHHEH
HHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCC
PVHICHLSTVKALQLVEPFREYVTCEVTPHHLLLDSGAFRRFGTMVKTNPPLRPPESRIY
CEEEEEHHHHHHHHHHHHHHHHEEEEECCCEEEECCCHHHHHCCCEECCCCCCCCCCCCC
PEFLDRINIIGTDHAPHGIEEKRKGIWDAPPGIPNLEVVLKLLLTLVSKGRMSLSTIRRM
HHHHCCEEEEECCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
LAEEPARIFGLRSKGRIAEGMDADFTVIDLKETGRIRSDEFYSKAHYTPFEGFSYTGGPV
HHHCCHHHEECCCCCCCCCCCCCCEEEEEEHHCCCCCCCHHHHHCCCCCCCCCCCCCCCE
MTIVRGRAVMRDGEVLEGNGRYIPAEHDGKHGSA
EEEECCCCEECCCCEEECCCCEECCCCCCCCCCC
>Mature Secondary Structure
MEWTVSECLSLQRIVLDGVDGVRMFDLSLENCRVDRDLTVNIGVDDGKIVQISRGRIDAS
CCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHCCCCCCEEEEEECCCCEEEEEECCCCCCC
EKIDLKGYFVLPGLIDAHVHFRDPGLEYKEDFRTGSMAAAHGGFSTVLDMPNTVPPADNA
CEEEECEEEECCCEEECEEEECCCCCCHHHHCCCCCEEECCCCCHHHHCCCCCCCCCCCH
AEFERKIRIGERKSVVDFGLHAGFRSVSDVKGILRFMPASFKVFMDLTGISTVDGLFREL
HHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHH
KDLSAPVPVTVHCENRDVVMKSMKELKDRSDPSAYALARPPLAEEVSVAEVLALSIHHEH
HHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCC
PVHICHLSTVKALQLVEPFREYVTCEVTPHHLLLDSGAFRRFGTMVKTNPPLRPPESRIY
CEEEEEHHHHHHHHHHHHHHHHEEEEECCCEEEECCCHHHHHCCCEECCCCCCCCCCCCC
PEFLDRINIIGTDHAPHGIEEKRKGIWDAPPGIPNLEVVLKLLLTLVSKGRMSLSTIRRM
HHHHCCEEEEECCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
LAEEPARIFGLRSKGRIAEGMDADFTVIDLKETGRIRSDEFYSKAHYTPFEGFSYTGGPV
HHHCCHHHEECCCCCCCCCCCCCCEEEEEEHHCCCCCCCHHHHHCCCCCCCCCCCCCCCE
MTIVRGRAVMRDGEVLEGNGRYIPAEHDGKHGSA
EEEECCCCEECCCCEEECCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463; 7929010 [H]